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Entry version 124 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Protein-arginine deiminase type-3

Gene

Padi3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the deimination of arginine residues of proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3247509, Chromatin modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.15By similarity)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Padi3
Synonyms:Pad3, Pdi3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1338891, Padi3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype. The skin of 7-week-old null mice appeared normal, but scanning electron microscopy revealed structural alterations in the whiskers and hair coat morphology (PubMed:27866708).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002200301 – 664Protein-arginine deiminase type-3Add BLAST664

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Z184

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z184

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z184

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z184

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z184

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Epidermis and hair follicles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025328, Expressed in skin of back and 67 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z184, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z184, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000026377

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z184, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z184

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVJA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153217

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021911_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z184

KEGG Orthology (KO)

More...
KOi
K01481

Database of Orthologous Groups

More...
OrthoDBi
787070at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331952

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1700, 1 hit
2.60.40.1860, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008972, Cupredoxin
IPR004303, PAD
IPR013530, PAD_C
IPR036556, PAD_central_sf
IPR013732, PAD_N
IPR038685, PAD_N_sf
IPR013733, Prot_Arg_deaminase_cen_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10837, PTHR10837, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03068, PAD, 1 hit
PF08527, PAD_M, 1 hit
PF08526, PAD_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001247, Protein-arginine_deiminase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110083, SSF110083, 1 hit
SSF49503, SSF49503, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z184-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQRIVRVS LEHPTSAVCV AGVETIVDIY GAVPEGTDMF EVYGTPGVDI
60 70 80 90 100
YVSPSMERSR ERADTRRWCF NKGLEIIVIM NSPSNDLNDS HVQIAYHSSR
110 120 130 140 150
EHLPLAYAVL YLTCVDITLD CDMNCADRQD RSFVDKRQWV WGPDGYGAIL
160 170 180 190 200
LVNCDRDNVD SNAQDNCDQY VRCLQDLEDM SVMVLRTQGP EALFEDHRLI
210 220 230 240 250
LHTSSCDAER ARVFHVCGPE DSCESYKCVL GPDRMSYEVP RLKGYEERFF
260 270 280 290 300
VEGLSFPDAG FPGLISFHVT LLDDSNEDFS ETPIFTDTAV FRVAPWIMTP
310 320 330 340 350
STLPPLEVYV CRVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD
360 370 380 390 400
EMELGYVQAP HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPKDSS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSRGR RVTQVVRNFL
460 470 480 490 500
HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA PDGKGFRLLL ASPGACFRLF
510 520 530 540 550
QEKQKWGHGR SLLFEGVIGD RRVQTVSINQ ILNNQSLINF NKFAQSCIDW
560 570 580 590 600
NREVLKRELG LAEGDIIDIP QLFKTEKRKA VAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
660
RREPFAFKWW HMVP
Length:664
Mass (Da):75,073
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA6E065DF5D9CB83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAM4E9QAM4_MOUSE
Protein-arginine deiminase
Padi3
654Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32A → S in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti52V → L in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti59S → N in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti79I → V in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti225S → A in BAA34182 (PubMed:10092850).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB013849 mRNA Translation: BAA34182.1
AL807805 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18855.1

NCBI Reference Sequences

More...
RefSeqi
NP_035190.3, NM_011060.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000026377; ENSMUSP00000026377; ENSMUSG00000025328

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18601

UCSC genome browser

More...
UCSCi
uc008vng.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013849 mRNA Translation: BAA34182.1
AL807805 Genomic DNA No translation available.
CCDSiCCDS18855.1
RefSeqiNP_035190.3, NM_011060.4

3D structure databases

SMRiQ9Z184
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026377

PTM databases

iPTMnetiQ9Z184
PhosphoSitePlusiQ9Z184

Proteomic databases

MaxQBiQ9Z184
PaxDbiQ9Z184
PRIDEiQ9Z184

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29341, 91 antibodies

Genome annotation databases

EnsembliENSMUST00000026377; ENSMUSP00000026377; ENSMUSG00000025328
GeneIDi18601
KEGGimmu:18601
UCSCiuc008vng.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51702
MGIiMGI:1338891, Padi3

Phylogenomic databases

eggNOGiENOG502QVJA, Eukaryota
GeneTreeiENSGT00940000153217
HOGENOMiCLU_021911_0_0_1
InParanoidiQ9Z184
KOiK01481
OrthoDBi787070at2759
TreeFamiTF331952

Enzyme and pathway databases

ReactomeiR-MMU-3247509, Chromatin modifying enzymes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18601, 0 hits in 18 CRISPR screens

Protein Ontology

More...
PROi
PR:Q9Z184
RNActiQ9Z184, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025328, Expressed in skin of back and 67 other tissues
ExpressionAtlasiQ9Z184, baseline and differential
GenevisibleiQ9Z184, MM

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972, Cupredoxin
IPR004303, PAD
IPR013530, PAD_C
IPR036556, PAD_central_sf
IPR013732, PAD_N
IPR038685, PAD_N_sf
IPR013733, Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837, PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068, PAD, 1 hit
PF08527, PAD_M, 1 hit
PF08526, PAD_N, 1 hit
PIRSFiPIRSF001247, Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083, SSF110083, 1 hit
SSF49503, SSF49503, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPADI3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z184
Secondary accession number(s): A2AMU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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