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Protein

SHC SH2 domain-binding protein 1

Gene

Shcbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.2 Publications

GO - Molecular functioni

  • SH2 domain binding Source: MGI

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • regulation of neural precursor cell proliferation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
SHC SH2 domain-binding protein 1
Alternative name(s):
Protein expressed in activated lymphocytes
Short name:
mPAL
SHC-binding protein
Gene namesi
Name:Shcbp1
Synonyms:Pal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338802 Shcbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000763162 – 668SHC SH2 domain-binding protein 1Add BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei273PhosphoserineBy similarity1
Modified residuei630PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z179
MaxQBiQ9Z179
PaxDbiQ9Z179
PeptideAtlasiQ9Z179
PRIDEiQ9Z179

PTM databases

iPTMnetiQ9Z179
PhosphoSitePlusiQ9Z179

Expressioni

Tissue specificityi

Expressed in spleen, lung and heart with higher expression in testis. No expression in brain, liver and skeletal muscle. Elevated expression in actively cycling cells.1 Publication

Inductioni

Down-regulated upon growth inhibition.1 Publication

Gene expression databases

BgeeiENSMUSG00000022322 Expressed in 206 organ(s), highest expression level in otic placode
CleanExiMM_SHCBP1
ExpressionAtlasiQ9Z179 baseline and differential
GenevisibleiQ9Z179 MM

Interactioni

Subunit structurei

Interacts directly with isoform p52shc of SHC1 via its SH2 domain (PubMed:10086341). Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (PubMed:22508726). Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Shc1P980835EBI-644352,EBI-300201

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203217, 18 interactors
IntActiQ9Z179, 24 interactors
STRINGi10090.ENSMUSP00000022945

Structurei

3D structure databases

ProteinModelPortaliQ9Z179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati428 – 451PbH1 1Add BLAST24
Repeati452 – 473PbH1 2Add BLAST22
Repeati474 – 496PbH1 3Add BLAST23
Repeati497 – 518PbH1 4Add BLAST22
Repeati526 – 548PbH1 5Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 216Poly-Glu6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIV2 Eukaryota
ENOG410XXTE LUCA
GeneTreeiENSGT00530000063807
HOGENOMiHOG000154313
HOVERGENiHBG060212
InParanoidiQ9Z179
OMAiTDLMCLH
OrthoDBiEOG091G0UP6
PhylomeDBiQ9Z179
TreeFamiTF329196

Family and domain databases

Gene3Di2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR039448 Beta_helix
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF13229 Beta_helix, 1 hit
SMARTiView protein in SMART
SM00710 PbH1, 5 hits
SUPFAMiSSF51126 SSF51126, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Z179-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDLRAGGV LEPIAMVPPR PDLAAEKEPA SWKEGLFLDA DPCSDQGYHA
60 70 80 90 100
NPGATVKTLI PEGKTPFPRI IQTNELLFYE RFRAYQDYIL ADCKASEVKE
110 120 130 140 150
FTVSFLEKVL EPSGWWAVWH TNVFEVLVEV TNVDFPSLKA VVRLAEPCIY
160 170 180 190 200
ESKLSTFTLA NVKELLDLKE FHLPLQELWV VSDDSHEFHQ MALAIEHVRF
210 220 230 240 250
FYKHIWRSWD EEEEDEYDYF VRCVEPRLRL YYDILEDRVP SGLIVDYHNL
260 270 280 290 300
LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLNLYS EIEQLKQKLK
310 320 330 340 350
LIENPLLRYV FGYQKNSNIQ GKGTRQNGQK VIHVVSSTMK TGLLRSLFKD
360 370 380 390 400
RFCEESCKEE TEIKFHSDLL SGINACYDGD TVIICPGHYV VHGTCSIADS
410 420 430 440 450
IELEGYGLPD DIVIEKRGKG DTFVDCTGMD VKISGIKFIQ HDSVEGILII
460 470 480 490 500
HHGKTTLENC VLQCETTGVT VRTSAELFMK NSDVYGAKGA GIEIYPGSKC
510 520 530 540 550
TLTDNGIHHC KEGILIKDFL DEHYDIPKIS MINNVIHNNE GYGVVLVKPT
560 570 580 590 600
IFCDLQENTQ DEINDNMVQK NKEADVTEGL DLEEMLQCVA SKMEPYATAD
610 620 630 640 650
FNEQAKGNCE IINELLAISM QKGRMKKRLS ELGITQADDN IMSQEMFIEI
660
MGNQFKWNGK GSFGTFLY
Length:668
Mass (Da):75,917
Last modified:May 1, 1999 - v1
Checksum:iEC614A982B744591
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHK7A0A140LHK7_MOUSE
SHC SH2 domain-binding protein 1
Shcbp1
207Annotation score:
A0A140LHA7A0A140LHA7_MOUSE
SHC SH2 domain-binding protein 1
Shcbp1
170Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53G → D in BAE26159 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017152 mRNA Translation: AAD01613.1
AK144966 mRNA Translation: BAE26159.1
AK149580 mRNA Translation: BAE28972.1
BC070455 mRNA Translation: AAH70455.1
CCDSiCCDS22088.1
RefSeqiNP_035499.1, NM_011369.3
UniGeneiMm.37801

Genome annotation databases

EnsembliENSMUST00000022945; ENSMUSP00000022945; ENSMUSG00000022322
GeneIDi20419
KEGGimmu:20419
UCSCiuc009kua.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017152 mRNA Translation: AAD01613.1
AK144966 mRNA Translation: BAE26159.1
AK149580 mRNA Translation: BAE28972.1
BC070455 mRNA Translation: AAH70455.1
CCDSiCCDS22088.1
RefSeqiNP_035499.1, NM_011369.3
UniGeneiMm.37801

3D structure databases

ProteinModelPortaliQ9Z179
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203217, 18 interactors
IntActiQ9Z179, 24 interactors
STRINGi10090.ENSMUSP00000022945

PTM databases

iPTMnetiQ9Z179
PhosphoSitePlusiQ9Z179

Proteomic databases

EPDiQ9Z179
MaxQBiQ9Z179
PaxDbiQ9Z179
PeptideAtlasiQ9Z179
PRIDEiQ9Z179

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022945; ENSMUSP00000022945; ENSMUSG00000022322
GeneIDi20419
KEGGimmu:20419
UCSCiuc009kua.1 mouse

Organism-specific databases

CTDi79801
MGIiMGI:1338802 Shcbp1

Phylogenomic databases

eggNOGiENOG410IIV2 Eukaryota
ENOG410XXTE LUCA
GeneTreeiENSGT00530000063807
HOGENOMiHOG000154313
HOVERGENiHBG060212
InParanoidiQ9Z179
OMAiTDLMCLH
OrthoDBiEOG091G0UP6
PhylomeDBiQ9Z179
TreeFamiTF329196

Miscellaneous databases

PROiPR:Q9Z179
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022322 Expressed in 206 organ(s), highest expression level in otic placode
CleanExiMM_SHCBP1
ExpressionAtlasiQ9Z179 baseline and differential
GenevisibleiQ9Z179 MM

Family and domain databases

Gene3Di2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR039448 Beta_helix
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF13229 Beta_helix, 1 hit
SMARTiView protein in SMART
SM00710 PbH1, 5 hits
SUPFAMiSSF51126 SSF51126, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHCBP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z179
Secondary accession number(s): Q3UED9, Q3UMD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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