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Protein

Small ubiquitin-related modifier 3

Gene

Sumo3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: MGI
  • protein tag Source: GO_Central
  • SUMO transferase activity Source: MGI

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-3065679 SUMO is proteolytically processed
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3232118 SUMOylation of transcription factors
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4090294 SUMOylation of intracellular receptors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-4755510 SUMOylation of immune response proteins
R-MMU-5696395 Formation of Incision Complex in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3Curated
Short name:
SUMO-3Curated
Alternative name(s):
SMT3 homolog 1Imported
Ubiquitin-like protein SMT3A1 Publication
Short name:
Smt3A1 Publication
Gene namesi
Name:Sumo3Imported
Synonyms:Smt3a1 Publication, Smt3h1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1336201 Sumo3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000359591 – 92Small ubiquitin-related modifier 3Add BLAST92
PropeptideiPRO_000003596093 – 110By similarityAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9Z172
PaxDbiQ9Z172
PeptideAtlasiQ9Z172
PRIDEiQ9Z172

PTM databases

iPTMnetiQ9Z172
PhosphoSitePlusiQ9Z172

Expressioni

Gene expression databases

BgeeiENSMUSG00000020265 Expressed in 51 organ(s), highest expression level in cerebellum
CleanExiMM_SUMO3
ExpressionAtlasiQ9Z172 baseline and differential
GenevisibleiQ9Z172 MM

Interactioni

Subunit structurei

Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity (By similarity). Interacts with ARNTL/BMAL1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203358, 18 interactors
ComplexPortaliCPX-3048 activated SUMO3-E1 ligase complex
CPX-3054 sumoylated E2 ligase complex (SUMO3)
IntActiQ9Z172, 17 interactors
MINTiQ9Z172
STRINGi10090.ENSMUSP00000020501

Structurei

3D structure databases

ProteinModelPortaliQ9Z172
SMRiQ9Z172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 92Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
GeneTreeiENSGT00390000018808
HOGENOMiHOG000207495
HOVERGENiHBG053025
InParanoidiQ9Z172
KOiK12160
PhylomeDBiQ9Z172
TreeFamiTF315116

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z172-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ
60 70 80 90 100
GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGSASRGSVP
110
TPNRCPDLCY
Length:110
Mass (Da):12,430
Last modified:May 1, 1999 - v1
Checksum:i2950B8B1A3F88DC8
GO
Isoform 2 (identifier: Q9Z172-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MSEEKPK → MTTVLAQ

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):12,345
Checksum:iC7BD3DAAB055D5F2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZA7G3UZA7_MOUSE
Small ubiquitin-related modifier
Sumo3
113Annotation score:
G3UWX9G3UWX9_MOUSE
SMT3 suppressor of mif two 3 homolo...
Sumo3 mCG_3381
96Annotation score:
G3UWI9G3UWI9_MOUSE
SMT3 suppressor of mif two 3 homolo...
Sumo3 mCG_3381
82Annotation score:
G3UZX6G3UZX6_MOUSE
Small ubiquitin-related modifier 3
Sumo3
47Annotation score:
G3UXQ9G3UXQ9_MOUSE
Small ubiquitin-related modifier 3
Sumo3
51Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0219481 – 7MSEEKPK → MTTVLAQ in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063847 mRNA Translation: AAC99333.1
AK012742 mRNA Translation: BAB28442.1
AK013019 mRNA Translation: BAB28601.1
AK148306 mRNA Translation: BAE28469.1
AK150063 mRNA Translation: BAE29276.1
AK150200 mRNA Translation: BAE29374.1
AK160169 mRNA Translation: BAE35670.1
AK162035 mRNA Translation: BAE36692.1
AK167207 mRNA Translation: BAE39334.1
AK168988 mRNA Translation: BAE40788.1
AK171169 mRNA Translation: BAE42290.1
AK170896 mRNA Translation: BAE42100.1
BC115488 mRNA Translation: AAI15489.1
BC115489 mRNA Translation: AAI15490.1
CCDSiCCDS23958.1 [Q9Z172-1]
CCDS78843.1 [Q9Z172-2]
RefSeqiNP_001288600.1, NM_001301671.1 [Q9Z172-2]
NP_001288601.1, NM_001301672.1
NP_001288602.1, NM_001301673.1
NP_064313.1, NM_019929.4 [Q9Z172-1]
UniGeneiMm.24433

Genome annotation databases

EnsembliENSMUST00000020501; ENSMUSP00000020501; ENSMUSG00000020265 [Q9Z172-1]
ENSMUST00000099538; ENSMUSP00000097136; ENSMUSG00000020265 [Q9Z172-2]
GeneIDi20610
KEGGimmu:20610
UCSCiuc007fvy.2 mouse [Q9Z172-1]
uc007fvz.2 mouse [Q9Z172-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063847 mRNA Translation: AAC99333.1
AK012742 mRNA Translation: BAB28442.1
AK013019 mRNA Translation: BAB28601.1
AK148306 mRNA Translation: BAE28469.1
AK150063 mRNA Translation: BAE29276.1
AK150200 mRNA Translation: BAE29374.1
AK160169 mRNA Translation: BAE35670.1
AK162035 mRNA Translation: BAE36692.1
AK167207 mRNA Translation: BAE39334.1
AK168988 mRNA Translation: BAE40788.1
AK171169 mRNA Translation: BAE42290.1
AK170896 mRNA Translation: BAE42100.1
BC115488 mRNA Translation: AAI15489.1
BC115489 mRNA Translation: AAI15490.1
CCDSiCCDS23958.1 [Q9Z172-1]
CCDS78843.1 [Q9Z172-2]
RefSeqiNP_001288600.1, NM_001301671.1 [Q9Z172-2]
NP_001288601.1, NM_001301672.1
NP_001288602.1, NM_001301673.1
NP_064313.1, NM_019929.4 [Q9Z172-1]
UniGeneiMm.24433

3D structure databases

ProteinModelPortaliQ9Z172
SMRiQ9Z172
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203358, 18 interactors
ComplexPortaliCPX-3048 activated SUMO3-E1 ligase complex
CPX-3054 sumoylated E2 ligase complex (SUMO3)
IntActiQ9Z172, 17 interactors
MINTiQ9Z172
STRINGi10090.ENSMUSP00000020501

PTM databases

iPTMnetiQ9Z172
PhosphoSitePlusiQ9Z172

Proteomic databases

EPDiQ9Z172
PaxDbiQ9Z172
PeptideAtlasiQ9Z172
PRIDEiQ9Z172

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020501; ENSMUSP00000020501; ENSMUSG00000020265 [Q9Z172-1]
ENSMUST00000099538; ENSMUSP00000097136; ENSMUSG00000020265 [Q9Z172-2]
GeneIDi20610
KEGGimmu:20610
UCSCiuc007fvy.2 mouse [Q9Z172-1]
uc007fvz.2 mouse [Q9Z172-2]

Organism-specific databases

CTDi6612
MGIiMGI:1336201 Sumo3

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
GeneTreeiENSGT00390000018808
HOGENOMiHOG000207495
HOVERGENiHBG053025
InParanoidiQ9Z172
KOiK12160
PhylomeDBiQ9Z172
TreeFamiTF315116

Enzyme and pathway databases

ReactomeiR-MMU-3065679 SUMO is proteolytically processed
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3232118 SUMOylation of transcription factors
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4090294 SUMOylation of intracellular receptors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-4755510 SUMOylation of immune response proteins
R-MMU-5696395 Formation of Incision Complex in GG-NER

Miscellaneous databases

ChiTaRSiSumo3 mouse
PROiPR:Q9Z172
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020265 Expressed in 51 organ(s), highest expression level in cerebellum
CleanExiMM_SUMO3
ExpressionAtlasiQ9Z172 baseline and differential
GenevisibleiQ9Z172 MM

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z172
Secondary accession number(s): Q14C17, Q3TBL9, Q3UDI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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