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Protein

Conserved oligomeric Golgi complex subunit 1

Gene

Cog1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 1
Short name:
COG complex subunit 1
Alternative name(s):
Component of oligomeric Golgi complex 1
Low density lipoprotein receptor defect B-complementing protein
Gene namesi
Name:Cog1
Synonyms:Ldlb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333873 Cog1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002134922 – 980Conserved oligomeric Golgi complex subunit 1Add BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei598N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z160
MaxQBiQ9Z160
PaxDbiQ9Z160
PRIDEiQ9Z160

PTM databases

iPTMnetiQ9Z160
PhosphoSitePlusiQ9Z160

Expressioni

Gene expression databases

BgeeiENSMUSG00000018661 Expressed in 267 organ(s), highest expression level in substantia nigra
CleanExiMM_COG1
ExpressionAtlasiQ9Z160 baseline and differential
GenevisibleiQ9Z160 MM

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Protein-protein interaction databases

BioGridi201132, 1 interactor
STRINGi10090.ENSMUSP00000018805

Structurei

3D structure databases

ProteinModelPortaliQ9Z160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG1 family.Curated

Phylogenomic databases

eggNOGiKOG2033 Eukaryota
ENOG410XR7E LUCA
GeneTreeiENSGT00390000017136
HOGENOMiHOG000231051
HOVERGENiHBG031402
InParanoidiQ9Z160
KOiK20288
OMAiHAVLFMA
OrthoDBiEOG091G02C8
PhylomeDBiQ9Z160
TreeFamiTF314678

Family and domain databases

InterProiView protein in InterPro
IPR033370 COG1
PANTHERiPTHR31658 PTHR31658, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9Z160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAATASSAL KRLDLRDPNA LFETHGAEEI RGLERQVRAE IEHKKEELRQ
60 70 80 90 100
MVGERYRDLI EAADTIGQMR RCAEGLVDAV QATDQYCARL RQAGSVAPRV
110 120 130 140 150
PRAPQPQPPS EKFYSMAAQI KLLLEIPEKI WSAMEASQHL QATQLYLLCC
160 170 180 190 200
HLHSLLQLDS SNSRYSPILS RFPILIRQVA AASHFRSTIL HESKMLLKCQ
210 220 230 240 250
AVSDQAVAEA LCSIMLLEES SPRQALTDFL LARKATIQTL LNQSHHGAGI
260 270 280 290 300
KAQICSLVEL LATTLNQAHA LFYTLPEGVL PDPSLPCGLL FSTLETVTRQ
310 320 330 340 350
HPTGKGIGAL QGEMKLCSWF RHLPTSIIEF QPTLRTLAHP ISQEYLKDTL
360 370 380 390 400
QKWIDMCNED IKNGIGNLLM YVKSMKGLAG IRDAIWDLLS NESASHSWEV
410 420 430 440 450
VCQRLLEKPL LFWEDLMQQL FLDRLQTLTR EGFESISNSS KELLVSALQE
460 470 480 490 500
LETNNSTSNK HVHFEQNMSF FLWSESPNDL PSDAAWVSVA NRAQFASSGL
510 520 530 540 550
SMKAQAISPC VQNFCSALDS KLKVKLDDLL AYLPSSDTPL LKDTTPTHQP
560 570 580 590 600
KNSAFDRYAD AGTVQDMLRT QSVACIKSVV GCIQAELCTI EEVTREQKDV
610 620 630 640 650
LHSTKLHAVL FMARLCQSLG ELCPHLKQCV VGQCGGSEKP AREARALKKQ
660 670 680 690 700
GKGRAQDVLP AQAQWQGVKE VLLQQSVMAY RVWSTALVKF LICGFTRSLL
710 720 730 740 750
LRDAGSVLAT ATNWDELEIQ EETESGSSVT SKIRLPTQPS WYVQSFLFSL
760 770 780 790 800
CQEVNRVGGH ALPKVTLQEM LKTCMAQVIA AYEQLTEENQ IKKEGAFPMT
810 820 830 840 850
QNRALQLLYD LRYLTMVLSS KGEEVKSGRS KADSRMEKMT ERLEALIDPF
860 870 880 890 900
DLDVFTPHLN SNLNRLVQRT SVLFGLVTGT ENQFASRSST FNSQEPHNIL
910 920 930 940 950
PLASSQIRFG LLPLSMTSTR KARATSRSVE TQAQVGPPAL SRVGDPTTHP
960 970 980
GSLFRQLASE EDDSPAPSLF KLAWLSSMTK
Length:980
Mass (Da):109,050
Last modified:May 2, 2006 - v3
Checksum:iF0CDC1104663FAD7
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A6N9A2A6N9_MOUSE
Conserved oligomeric Golgi complex ...
Cog1
217Annotation score:
Q810S7Q810S7_MOUSE
Cog1 protein
Cog1
396Annotation score:
F6RK91F6RK91_MOUSE
Conserved oligomeric Golgi complex ...
Cog1
99Annotation score:
F6V3F1F6V3F1_MOUSE
Conserved oligomeric Golgi complex ...
Cog1
117Annotation score:
F6QQB5F6QQB5_MOUSE
Conserved oligomeric Golgi complex ...
Cog1
204Annotation score:
F6YD49F6YD49_MOUSE
Conserved oligomeric Golgi complex ...
Cog1
81Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti320F → L in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti561A → T in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti630V → I in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti722E → G in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti772K → E in AAD13780 (PubMed:9927668).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109377 mRNA Translation: AAD13780.2
AK034636 mRNA Translation: BAE43288.1
BC063056 mRNA Translation: AAH63056.1
CCDSiCCDS25599.1
RefSeqiNP_038609.3, NM_013581.3
UniGeneiMm.261620
Mm.351688

Genome annotation databases

EnsembliENSMUST00000018805; ENSMUSP00000018805; ENSMUSG00000018661
GeneIDi16834
KEGGimmu:16834
UCSCiuc007mer.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109377 mRNA Translation: AAD13780.2
AK034636 mRNA Translation: BAE43288.1
BC063056 mRNA Translation: AAH63056.1
CCDSiCCDS25599.1
RefSeqiNP_038609.3, NM_013581.3
UniGeneiMm.261620
Mm.351688

3D structure databases

ProteinModelPortaliQ9Z160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201132, 1 interactor
STRINGi10090.ENSMUSP00000018805

PTM databases

iPTMnetiQ9Z160
PhosphoSitePlusiQ9Z160

Proteomic databases

EPDiQ9Z160
MaxQBiQ9Z160
PaxDbiQ9Z160
PRIDEiQ9Z160

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018805; ENSMUSP00000018805; ENSMUSG00000018661
GeneIDi16834
KEGGimmu:16834
UCSCiuc007mer.2 mouse

Organism-specific databases

CTDi9382
MGIiMGI:1333873 Cog1

Phylogenomic databases

eggNOGiKOG2033 Eukaryota
ENOG410XR7E LUCA
GeneTreeiENSGT00390000017136
HOGENOMiHOG000231051
HOVERGENiHBG031402
InParanoidiQ9Z160
KOiK20288
OMAiHAVLFMA
OrthoDBiEOG091G02C8
PhylomeDBiQ9Z160
TreeFamiTF314678

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiCog1 mouse
PROiPR:Q9Z160
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018661 Expressed in 267 organ(s), highest expression level in substantia nigra
CleanExiMM_COG1
ExpressionAtlasiQ9Z160 baseline and differential
GenevisibleiQ9Z160 MM

Family and domain databases

InterProiView protein in InterPro
IPR033370 COG1
PANTHERiPTHR31658 PTHR31658, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOG1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z160
Secondary accession number(s): Q6P567
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 2, 2006
Last modified: November 7, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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