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Protein

Inactive tyrosine-protein kinase transmembrane receptor ROR1

Gene

Ror1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (By similarity). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei506ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi479 – 487ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive tyrosine-protein kinase transmembrane receptor ROR1By similarity
Short name:
mROR1
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 1
Gene namesi
Name:Ror1
Synonyms:Ntrkr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1347520 Ror1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 406ExtracellularSequence analysisAdd BLAST377
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 937CytoplasmicSequence analysisAdd BLAST510

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are severely deaf, with preserved otoacoustic emissions. They have malformed cochleae with fasciculation defects in axons of spiral ganglion neurons. Type I neurons show impaired synapses with inner hair cells and type II neurons display aberrant projections through the cochlear sensory epithelium.1 Publication

Chemistry databases

ChEMBLiCHEMBL2176781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002445930 – 937Inactive tyrosine-protein kinase transmembrane receptor ROR1Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 131By similarity
Disulfide bondi170 ↔ 235By similarity
Disulfide bondi178 ↔ 228By similarity
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi219 ↔ 260By similarity
Disulfide bondi248 ↔ 296By similarity
Disulfide bondi252 ↔ 282By similarity
Disulfide bondi313 ↔ 391By similarity
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi334 ↔ 374By similarity
Disulfide bondi362 ↔ 386By similarity
Modified residuei645Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z139
PaxDbiQ9Z139
PRIDEiQ9Z139

PTM databases

PhosphoSitePlusiQ9Z139

Expressioni

Tissue specificityi

At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear.1 Publication

Developmental stagei

At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear (PubMed:27162350). In the inner ear, at E14.5, detected in spiral ganglia, the cochlear epithelium and the vesitbule. At E17.5, expression increases in spiral ganglion neurons axon terminals adjacent to auditory hair cells. In the differentiating cochlear epithelium, the expression is intense in the stria vascularis. By P0, expression in the stria vascularis is weakened (PubMed:27162350).1 Publication

Gene expression databases

BgeeiENSMUSG00000035305 Expressed in 235 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_ROR1
GenevisibleiQ9Z139 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205021, 1 interactor
STRINGi10090.ENSMUSP00000048171

Structurei

3D structure databases

ProteinModelPortaliQ9Z139
SMRiQ9Z139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 141Ig-like C2-typeAdd BLAST100
Domaini165 – 299FZPROSITE-ProRule annotationAdd BLAST135
Domaini312 – 391KringlePROSITE-ProRule annotationAdd BLAST80
Domaini473 – 746Protein kinasePROSITE-ProRule annotationAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 782Ser/Thr-richAdd BLAST30
Compositional biasi784 – 851Pro-richAdd BLAST68
Compositional biasi853 – 876Ser/Thr-richAdd BLAST24

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000049104
HOVERGENiHBG017736
InParanoidiQ9Z139
KOiK05122
OMAiECWHEQS
OrthoDBiEOG091G02W3
TreeFamiTF106465

Family and domain databases

CDDicd00108 KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR016247 Tyr_kinase_rcpt_ROR
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 1 hit
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000624 TyrPK_TMrec_ROR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00130 KR, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z139-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRPRRRGTR PPPLALLAAL LLAARGADAQ ETELSVSAEL VPTSSWNTSS
60 70 80 90 100
EIDKGSYLTL DEPMNNITTS LGQTAELHCK VSGNPPPSIR WFKNDAPVVQ
110 120 130 140 150
EPRRISFRAT NYGSRLRIRN LDTTDTGYFQ CVATNGKKVV STTGVLFVKF
160 170 180 190 200
GPPPTASPGS SDEYEEDGFC QPYRGIACAR FIGNRTVYME SLHMQGEIEN
210 220 230 240 250
QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS VPKPRDLCRD
260 270 280 290 300
ECEVLENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG
310 320 330 340 350
IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHSFTAL
360 370 380 390 400
RFPELNGGHS YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN
410 420 430 440 450
KMEILYILVP SVAIPLAIAF LFFFICVCRN NQKSSSPPVQ RQPKPVRGQN
460 470 480 490 500
VEMSMLNAYK PKSKAKELPL SAVRFMEELG ECTFGKIYKG HLYLPGMDHA
510 520 530 540 550
QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG AVTQEQPVCM
560 570 580 590 600
LFEYMNQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA
610 620 630 640 650
AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS
660 670 680 690 700
KSSLPIRWMP PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE
710 720 730 740 750
VIEMVRKRQL LPCSEDCPPR MYSLMTECWN EIPSRRPRFK DIHVRLRSWE
760 770 780 790 800
GLSSHTSSTT PSGGNATTQT TSLSASPVSN LSNPRFPNYM FPSQGITPQG
810 820 830 840 850
QIAGFIGPAI PQNQRFIPIN GYPIPPGYAA FPAAHYQPAG PPRVIQHCPP
860 870 880 890 900
PKSRSPSSAS GSTSTGHVAS LPSSGSNQEA NVPLLPHMSI PNHPGGMGIT
910 920 930
VFGNKSQKPY KIDSKQSSLL GDSHIHGHTE SMISAEV
Length:937
Mass (Da):104,088
Last modified:July 27, 2011 - v2
Checksum:iD6F2D84E67D03C69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti860S → R in BAA75480 (PubMed:10231392).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010383 mRNA Translation: BAA75480.1
AK046699 mRNA Translation: BAC32840.1
AK049369 mRNA Translation: BAC33714.1
AL670246, AL772259 Genomic DNA Translation: CAM20163.1
AL772259, AL670246 Genomic DNA Translation: CAM23558.1
BC138794 mRNA Translation: AAI38795.1
BC138810 mRNA Translation: AAI38811.1
CCDSiCCDS18389.1
RefSeqiNP_001299619.1, NM_001312690.1
NP_038873.2, NM_013845.5
UniGeneiMm.485829
Mm.57252

Genome annotation databases

EnsembliENSMUST00000039630; ENSMUSP00000048171; ENSMUSG00000035305
GeneIDi26563
KEGGimmu:26563
UCSCiuc008tvd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010383 mRNA Translation: BAA75480.1
AK046699 mRNA Translation: BAC32840.1
AK049369 mRNA Translation: BAC33714.1
AL670246, AL772259 Genomic DNA Translation: CAM20163.1
AL772259, AL670246 Genomic DNA Translation: CAM23558.1
BC138794 mRNA Translation: AAI38795.1
BC138810 mRNA Translation: AAI38811.1
CCDSiCCDS18389.1
RefSeqiNP_001299619.1, NM_001312690.1
NP_038873.2, NM_013845.5
UniGeneiMm.485829
Mm.57252

3D structure databases

ProteinModelPortaliQ9Z139
SMRiQ9Z139
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205021, 1 interactor
STRINGi10090.ENSMUSP00000048171

Chemistry databases

ChEMBLiCHEMBL2176781

PTM databases

PhosphoSitePlusiQ9Z139

Proteomic databases

MaxQBiQ9Z139
PaxDbiQ9Z139
PRIDEiQ9Z139

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039630; ENSMUSP00000048171; ENSMUSG00000035305
GeneIDi26563
KEGGimmu:26563
UCSCiuc008tvd.1 mouse

Organism-specific databases

CTDi4919
MGIiMGI:1347520 Ror1

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000049104
HOVERGENiHBG017736
InParanoidiQ9Z139
KOiK05122
OMAiECWHEQS
OrthoDBiEOG091G02W3
TreeFamiTF106465

Enzyme and pathway databases

ReactomeiR-MMU-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Miscellaneous databases

ChiTaRSiRor1 mouse
PROiPR:Q9Z139
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035305 Expressed in 235 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_ROR1
GenevisibleiQ9Z139 MM

Family and domain databases

CDDicd00108 KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR016247 Tyr_kinase_rcpt_ROR
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 1 hit
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000624 TyrPK_TMrec_ROR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00130 KR, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiROR1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z139
Secondary accession number(s): Q8BG10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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