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Protein

Tyrosine-protein kinase transmembrane receptor ROR2

Gene

Ror2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (PubMed:10700181). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotationBy similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei507ATPPROSITE-ProRule annotation1
Active sitei615Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi479 – 487ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • frizzled binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • mitogen-activated protein kinase kinase kinase binding Source: WormBase
  • transmembrane receptor protein tyrosine kinase activity Source: MGI
  • Wnt-protein binding Source: MGI

GO - Biological processi

  • astrocyte development Source: MGI
  • BMP signaling pathway Source: MGI
  • bone mineralization Source: Ensembl
  • cartilage condensation Source: MGI
  • cell differentiation Source: MGI
  • cell fate commitment Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic genitalia morphogenesis Source: MGI
  • inner ear morphogenesis Source: MGI
  • JNK cascade Source: MGI
  • macrophage migration Source: MGI
  • male genitalia development Source: Ensembl
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of cell migration Source: MGI
  • positive regulation of JUN kinase activity Source: MGI
  • positive regulation of macrophage differentiation Source: MGI
  • positive regulation of protein kinase C activity Source: MGI
  • positive regulation of synaptic transmission, glutamatergic Source: MGI
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • regulation of canonical Wnt signaling pathway Source: MGI
  • skeletal system development Source: MGI
  • SMAD protein signal transduction Source: MGI
  • smoothened signaling pathway Source: MGI
  • somitogenesis Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
  • Wnt signaling pathway, calcium modulating pathway Source: MGI
  • Wnt signaling pathway, planar cell polarity pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor ROR2 (EC:2.7.10.1By similarity)
Short name:
mROR2
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 2
Gene namesi
Name:Ror2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347521 Ror2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 403ExtracellularSequence analysisAdd BLAST370
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 944CytoplasmicSequence analysisAdd BLAST520

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000002446134 – 944Tyrosine-protein kinase transmembrane receptor ROR2Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 135By similarity
Disulfide bondi174 ↔ 239By similarity
Disulfide bondi182 ↔ 232By similarity
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 264By similarity
Disulfide bondi252 ↔ 300By similarity
Disulfide bondi256 ↔ 286By similarity
Disulfide bondi316 ↔ 394By similarity
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi337 ↔ 377By similarity
Disulfide bondi365 ↔ 389By similarity
Modified residuei646Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei785Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Z138
MaxQBiQ9Z138
PaxDbiQ9Z138
PRIDEiQ9Z138

PTM databases

iPTMnetiQ9Z138
PhosphoSitePlusiQ9Z138
SwissPalmiQ9Z138

Expressioni

Developmental stagei

From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000021464
CleanExiMM_ROR2
ExpressionAtlasiQ9Z138 baseline and differential
GenevisibleiQ9Z138 MM

Interactioni

Subunit structurei

Homodimer; promotes osteogenesis. Binds YWHAB (By similarity). Interacts with WTIP (PubMed:19785987).By similarity1 Publication

GO - Molecular functioni

  • frizzled binding Source: BHF-UCL
  • mitogen-activated protein kinase kinase kinase binding Source: WormBase
  • Wnt-protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021918

Structurei

3D structure databases

ProteinModelPortaliQ9Z138
SMRiQ9Z138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 145Ig-like C2-typeAdd BLAST91
Domaini169 – 303FZPROSITE-ProRule annotationAdd BLAST135
Domaini316 – 394KringlePROSITE-ProRule annotationAdd BLAST79
Domaini473 – 746Protein kinasePROSITE-ProRule annotationAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 782Ser/Thr-richAdd BLAST30
Compositional biasi784 – 857Pro-richAdd BLAST74
Compositional biasi859 – 882Ser/Thr-richAdd BLAST24

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMMJ Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000049104
HOVERGENiHBG017736
InParanoidiQ9Z138
OMAiFIPMKGQ
OrthoDBiEOG091G02W3
TreeFamiTF106465

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR016247 Tyr_kinase_rcpt_ROR
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 1 hit
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000624 TyrPK_TMrec_ROR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00130 KR, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGWVRPSR VPLCARAVWT AAALLLWTPW TAGEVEDSEA IDTLGQPDGP
60 70 80 90 100
DSPLPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA
110 120 130 140 150
PVVQEPRRVI IRKTEYGSRL RIQDLDTTDT GYYQCVATNG LKTITATGVL
160 170 180 190 200
YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG
210 220 230 240 250
EIENRITAAF TMIGTSTQLS DQCSQFAIPS FCHFVFPLCD ARSRAPKPRE
260 270 280 290 300
LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC
310 320 330 340 350
MRIGIPAERL GRYHQCYNGS GADYRGMAST TKSGHQCQPW ALQHPHSHRL
360 370 380 390 400
SSTEFPELGG GHAYCRNPGG QVEGPWCFTQ NKNVRVELCD VPPCSPRDGS
410 420 430 440 450
KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ
460 470 480 490 500
DMEMPLISQH KQAKLKEISL STVRFMEELG EDRFGKVYKG HLFGPAPGEP
510 520 530 540 550
TQAVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL GVVTKDQPLS
560 570 580 590 600
MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA
610 620 630 640 650
AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG
660 670 680 690 700
NSLLPIRWMS PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD
710 720 730 740 750
VVEMIRSRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRSWG
760 770 780 790 800
NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYMAPK QKAQPFPQPQ
810 820 830 840 850
FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ
860 870 880 890 900
VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDAQNI
910 920 930 940
AEDVAQSPVQ EAEEEEEGSV PETELLGDND TLQVTEAAHV QLEA
Length:944
Mass (Da):105,005
Last modified:July 27, 2011 - v2
Checksum:i03B00784CFFF4489
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110I → V in BAA75481 (PubMed:10231392).Curated1
Sequence conflicti242R → C in BAA75481 (PubMed:10231392).Curated1
Sequence conflicti372V → M in BAA75481 (PubMed:10231392).Curated1
Sequence conflicti398D → Y in BAA75481 (PubMed:10231392).Curated1
Sequence conflicti612V → C in BAA75481 (PubMed:10231392).Curated1
Sequence conflicti897A → V in BAA75481 (PubMed:10231392).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010384 mRNA Translation: BAA75481.1
AC111017 Genomic DNA No translation available.
CCDSiCCDS26520.1
UniGeneiMm.342774

Genome annotation databases

EnsembliENSMUST00000021918; ENSMUSP00000021918; ENSMUSG00000021464

Similar proteinsi

Entry informationi

Entry nameiROR2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z138
Secondary accession number(s): E9QKB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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