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Protein

SH3 domain-binding protein 5

Gene

Sh3bp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.1 Publication

GO - Molecular functioni

  • protein kinase inhibitor activity Source: MGI
  • SH3 domain binding Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: MGI
  • negative regulation of protein kinase activity Source: UniProtKB
  • negative regulation of protein tyrosine kinase activity Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 5
Short name:
SH3BP-5
Alternative name(s):
SH3 domain-binding protein that preferentially associates with BTK
Gene namesi
Name:Sh3bp5
Synonyms:Sab
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1344391 Sh3bp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643691 – 463SH3 domain-binding protein 5Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei354Phosphoserine; by MAPK12 and MAPK9By similarity1
Modified residuei378PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei421PhosphoserineBy similarity1
Modified residuei424PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z131
PeptideAtlasiQ9Z131
PRIDEiQ9Z131

PTM databases

iPTMnetiQ9Z131
PhosphoSitePlusiQ9Z131

Expressioni

Gene expression databases

BgeeiENSMUSG00000021892 Expressed in 272 organ(s), highest expression level in brain blood vessel
CleanExiMM_SH3BP5
GenevisibleiQ9Z131 MM

Interactioni

Subunit structurei

Interacts with BTK (By similarity). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (By similarity). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204869, 1 interactor
IntActiQ9Z131, 1 interactor
STRINGi10090.ENSMUSP00000089517

Structurei

3D structure databases

SMRiQ9Z131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 70Glu-richAdd BLAST59
Compositional biasi38 – 43Poly-Glu6

Sequence similaritiesi

Belongs to the SH3BP5 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2008 Eukaryota
ENOG410ZK48 LUCA
GeneTreeiENSGT00390000018500
HOGENOMiHOG000212681
HOVERGENiHBG018168
InParanoidiQ9Z131
OMAiPECDLER
OrthoDBiEOG091G08YD
PhylomeDBiQ9Z131
TreeFamiTF105573

Family and domain databases

InterProiView protein in InterPro
IPR007940 SH3BP5
PANTHERiPTHR19423 PTHR19423, 1 hit
PfamiView protein in Pfam
PF05276 SH3BP5, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z131-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTALKRSRS DEPAELPPPA REVEEKEEEE ERMEQGLEEE EEEVDPRIQG
60 70 80 90 100
ELEKLNQSTD DINRRETELE DARQKFRSVL VEATVKLDEL AKKIGKAVED
110 120 130 140 150
SKPYWEARRV ARQAQLEAQK ATQDFQRATE VLRAAKETIS LAEQRLLEDD
160 170 180 190 200
KRQFDSAWQE MLNHATQRVM EAEQTKTRSE LVHKETAARY NAAMGRMRQL
210 220 230 240 250
EKKLKRAINK SKPYFELKAK YYVQLEQLKK TVDDLQAKLA LAKGEYKAAL
260 270 280 290 300
KSLERISDEI HERRRSNAMG PRGCGVGAEG SIASVENLPV SKPEPDAISV
310 320 330 340 350
ASEAFEDDNC SNLVSEDDSE TQSVSSFSSG PTSPSEMPDQ FPAVARPGSL
360 370 380 390 400
DLPSPVSLSE FGMMFPILGP RSECSGASSP ECEVERGDRA EGAENKMSDK
410 420 430 440 450
ANNNRVLGST NGGSGRSRSQ SSTSLESQAL ETRMKQLSLQ CSKGRDGIIA
460
DIKMIFIFYT FLQ
Note: No experimental confirmation available.
Length:463
Mass (Da):51,807
Last modified:January 23, 2007 - v3
Checksum:iA4274A91DDD91670
GO
Isoform 2 (identifier: Q9Z131-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-463: IFIFYTFLQ → VQIG

Show »
Length:458
Mass (Da):51,031
Checksum:iA8A66F8F904B1C3C
GO
Isoform 3 (identifier: Q9Z131-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: MDTALKRSRS...DINRRETELE → MDWARTVMAS...SFKPCCGVVK
     455-463: IFIFYTFLQ → VQIG

Note: No experimental confirmation available.
Show »
Length:456
Mass (Da):49,936
Checksum:iA0FB71574266B860
GO

Sequence cautioni

The sequence BAC31530 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299S → SS in BAC31530 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225721 – 70MDTAL…ETELE → MDWARTVMASTGLAPASAAP HTGSRAQPCLFLAPVPPHFA WFIFLDPALPCSTLAQSVSF KPCCGVVK in isoform 3. CuratedAdd BLAST70
Alternative sequenceiVSP_010882455 – 463IFIFYTFLQ → VQIG in isoform 2 and isoform 3. 3 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043375 mRNA Translation: BAC31530.1 Different initiation.
AK161427 mRNA Translation: BAE36389.1
BC018237 mRNA Translation: AAH18237.2
BC053741 mRNA Translation: AAH53741.2
AB016835 mRNA Translation: BAA75641.1
CCDSiCCDS36855.1 [Q9Z131-2]
CCDS84108.1 [Q9Z131-3]
RefSeqiNP_001334514.1, NM_001347585.1 [Q9Z131-3]
NP_036024.2, NM_011894.3 [Q9Z131-2]
UniGeneiMm.383198
Mm.438866

Genome annotation databases

EnsembliENSMUST00000091903; ENSMUSP00000089517; ENSMUSG00000021892 [Q9Z131-2]
ENSMUST00000100730; ENSMUSP00000098296; ENSMUSG00000021892 [Q9Z131-3]
ENSMUST00000140002; ENSMUSP00000117152; ENSMUSG00000021892 [Q9Z131-1]
GeneIDi24056
KEGGimmu:24056
UCSCiuc007sxp.1 mouse [Q9Z131-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043375 mRNA Translation: BAC31530.1 Different initiation.
AK161427 mRNA Translation: BAE36389.1
BC018237 mRNA Translation: AAH18237.2
BC053741 mRNA Translation: AAH53741.2
AB016835 mRNA Translation: BAA75641.1
CCDSiCCDS36855.1 [Q9Z131-2]
CCDS84108.1 [Q9Z131-3]
RefSeqiNP_001334514.1, NM_001347585.1 [Q9Z131-3]
NP_036024.2, NM_011894.3 [Q9Z131-2]
UniGeneiMm.383198
Mm.438866

3D structure databases

SMRiQ9Z131
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204869, 1 interactor
IntActiQ9Z131, 1 interactor
STRINGi10090.ENSMUSP00000089517

PTM databases

iPTMnetiQ9Z131
PhosphoSitePlusiQ9Z131

Proteomic databases

PaxDbiQ9Z131
PeptideAtlasiQ9Z131
PRIDEiQ9Z131

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091903; ENSMUSP00000089517; ENSMUSG00000021892 [Q9Z131-2]
ENSMUST00000100730; ENSMUSP00000098296; ENSMUSG00000021892 [Q9Z131-3]
ENSMUST00000140002; ENSMUSP00000117152; ENSMUSG00000021892 [Q9Z131-1]
GeneIDi24056
KEGGimmu:24056
UCSCiuc007sxp.1 mouse [Q9Z131-2]

Organism-specific databases

CTDi9467
MGIiMGI:1344391 Sh3bp5

Phylogenomic databases

eggNOGiKOG2008 Eukaryota
ENOG410ZK48 LUCA
GeneTreeiENSGT00390000018500
HOGENOMiHOG000212681
HOVERGENiHBG018168
InParanoidiQ9Z131
OMAiPECDLER
OrthoDBiEOG091G08YD
PhylomeDBiQ9Z131
TreeFamiTF105573

Miscellaneous databases

ChiTaRSiSh3bp5 mouse
PROiPR:Q9Z131
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021892 Expressed in 272 organ(s), highest expression level in brain blood vessel
CleanExiMM_SH3BP5
GenevisibleiQ9Z131 MM

Family and domain databases

InterProiView protein in InterPro
IPR007940 SH3BP5
PANTHERiPTHR19423 PTHR19423, 1 hit
PfamiView protein in Pfam
PF05276 SH3BP5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei3BP5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z131
Secondary accession number(s): Q3TTD6, Q8C903, Q8VCZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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