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Protein

Heterogeneous nuclear ribonucleoprotein D-like

Gene

Hnrnpdl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Promotes transcription repression (By similarity). Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences (By similarity). Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs (By similarity). Binds both to nuclear and cytoplasmic poly(A) mRNAs (By similarity). Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers (By similarity). Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein D-like
Short name:
hnRNP D-like
Short name:
hnRNP DL
Alternative name(s):
JKT41-binding protein
Gene namesi
Name:Hnrnpdl
Synonyms:Hnrpdl, Jktbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1355299 Hnrnpdl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872401 – 301Heterogeneous nuclear ribonucleoprotein D-likeAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-methyllysineBy similarity1
Cross-linki90Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei97N6-acetyllysineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei289Dimethylated arginine; alternateBy similarity1
Modified residuei289Omega-N-methylarginine; alternateCombined sources1
Modified residuei289Omega-N-methylated arginine; alternateBy similarity1

Post-translational modificationi

Dimethylation of Arg-289 is probably of the asymmetric type.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Z130
MaxQBiQ9Z130
PaxDbiQ9Z130
PeptideAtlasiQ9Z130
PRIDEiQ9Z130

PTM databases

iPTMnetiQ9Z130
PhosphoSitePlusiQ9Z130

Expressioni

Tissue specificityi

Expressed in skeletal muscle, myoblast, myotube, heart, brain, liver, kidney, heart, lung, stomach, small intestine, large intestine, spleen, and testis (at protein level). Expressed in brain, skeletal muscle, heart, lung, liver, stomach, small intestine, large intestine, kidney, spleen and testis.1 Publication

Gene expression databases

CleanExiMM_HNRPDL

Interactioni

Subunit structurei

Interacts with TNPO1 (By similarity). Interacts with ZNF148.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9Z130, 5 interactors
MINTiQ9Z130
STRINGi10090.ENSMUSP00000084114

Structurei

3D structure databases

ProteinModelPortaliQ9Z130
SMRiQ9Z130
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 111RRM 1PROSITE-ProRule annotationAdd BLAST83
Domaini114 – 193RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 301Necessary for interaction with TNPO1By similarityAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi197 – 202Poly-Gln6
Compositional biasi204 – 292Gly-richAdd BLAST89
Compositional biasi234 – 277Tyr-richAdd BLAST44

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQWX Eukaryota
ENOG4111SPT LUCA
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ9Z130

Family and domain databases

CDDicd12758 RRM1_hnRPDL, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034847 hnRPDL_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Z130-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDMNEYSNI EEFAEGSKIN ASKNQQDDGK MFIGGLSWDT SKKDLTEYLS
60 70 80 90 100
RFGEVVDCTI KTDPVTGRSR GFGFVLFKDA ASVDKVLELK EHKLDGKLID
110 120 130 140 150
PKRAKALKGK EPPKKVFVGG LSPDTSEEQI KEYFGAFGEI ENIELPMDTK
160 170 180 190 200
TNERRGFCFI TYTDEEPVKK LLESRYHQIG SGKCEIKVAQ PKEVYRQQQQ
210 220 230 240 250
QQKGGRGAAA GGRGGARGRG RGQGQNWNQG FNNYYDQGYG NYNSAYGGDQ
260 270 280 290 300
NYSGYGGYDY TGYNYGNYGY GQGYADYSGQ QSTYGKASRG GGNHQNNYQP

Y
Length:301
Mass (Da):33,559
Last modified:May 1, 1999 - v1
Checksum:i8AB2787FEB73311C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VQH5F6VQH5_MOUSE
Heterogeneous nuclear ribonucleopro...
Hnrnpdl Hnrnpdl1, Hnrpdl
323Annotation score:
D3YTQ3D3YTQ3_MOUSE
Heterogeneous nuclear ribonucleopro...
Hnrnpdl
420Annotation score:
F6ZKM7F6ZKM7_MOUSE
Heterogeneous nuclear ribonucleopro...
Hnrnpdl Hnrnpdl1, Hnrpdl
100Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017020 mRNA Translation: BAA75479.1
AK011581 mRNA Translation: BAB27715.1
AK172629 mRNA Translation: BAE43104.1
BC021374 mRNA Translation: AAH21374.1
UniGeneiMm.389579

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017020 mRNA Translation: BAA75479.1
AK011581 mRNA Translation: BAB27715.1
AK172629 mRNA Translation: BAE43104.1
BC021374 mRNA Translation: AAH21374.1
UniGeneiMm.389579

3D structure databases

ProteinModelPortaliQ9Z130
SMRiQ9Z130
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z130, 5 interactors
MINTiQ9Z130
STRINGi10090.ENSMUSP00000084114

PTM databases

iPTMnetiQ9Z130
PhosphoSitePlusiQ9Z130

Proteomic databases

EPDiQ9Z130
MaxQBiQ9Z130
PaxDbiQ9Z130
PeptideAtlasiQ9Z130
PRIDEiQ9Z130

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1355299 Hnrnpdl

Phylogenomic databases

eggNOGiENOG410IQWX Eukaryota
ENOG4111SPT LUCA
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ9Z130

Miscellaneous databases

ChiTaRSiHnrnpdl mouse
PROiPR:Q9Z130
SOURCEiSearch...

Gene expression databases

CleanExiMM_HNRPDL

Family and domain databases

CDDicd12758 RRM1_hnRPDL, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034847 hnRPDL_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHNRDL_MOUSE
AccessioniPrimary (citable) accession number: Q9Z130
Secondary accession number(s): Q9CT01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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