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Protein

Platelet factor 4

Gene

Pf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity).By similarity

GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • heparin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet factor 4
Short name:
PF-4
Alternative name(s):
C-X-C motif chemokine 4
Gene namesi
Name:Pf4
Synonyms:Cxcl4, Scyb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1888711 Pf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000000506930 – 105Platelet factor 4Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi44 ↔ 71By similarity
Disulfide bondi46 ↔ 87By similarity
Modified residuei61PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z126
PaxDbiQ9Z126
PeptideAtlasiQ9Z126
PRIDEiQ9Z126

PTM databases

iPTMnetiQ9Z126
PhosphoSitePlusiQ9Z126

Expressioni

Gene expression databases

BgeeiENSMUSG00000029373 Expressed in 228 organ(s), highest expression level in blood
CleanExiMM_PF4
ExpressionAtlasiQ9Z126 baseline and differential
GenevisibleiQ9Z126 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61569N
IntActiQ9Z126, 4 interactors
MINTiQ9Z126
STRINGi10090.ENSMUSP00000031320

Structurei

3D structure databases

ProteinModelPortaliQ9Z126
SMRiQ9Z126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 102Heparin-bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J314 Eukaryota
ENOG4111556 LUCA
GeneTreeiENSGT00910000144355
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiQ9Z126
KOiK05407
OMAiCAVPQLI
OrthoDBiEOG091G14JD
PhylomeDBiQ9Z126
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF43 PTHR10179:SF43, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z126-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVAAVFRGL RPSPELLLLG LLFLPAVVAV TSAGPEESDG DLSCVCVKTI
60 70 80 90 100
SSGIHLKHIT SLEVIKAGRH CAVPQLIATL KNGRKICLDR QAPLYKKVIK

KILES
Length:105
Mass (Da):11,243
Last modified:May 1, 1999 - v1
Checksum:i94F0190EFACF1A6C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YTR7A0A0J9YTR7_MOUSE
Chemokine (C-X-C motif) ligand 4, i...
Pf4 Cxcl4, mCG_1704
77Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017491 mRNA Translation: BAA75660.1
AF349465 Genomic DNA Translation: AAK30163.1
CCDSiCCDS19416.1
RefSeqiNP_064316.1, NM_019932.4
UniGeneiMm.332490

Genome annotation databases

EnsembliENSMUST00000031320; ENSMUSP00000031320; ENSMUSG00000029373
GeneIDi56744
KEGGimmu:56744
UCSCiuc008ybi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017491 mRNA Translation: BAA75660.1
AF349465 Genomic DNA Translation: AAK30163.1
CCDSiCCDS19416.1
RefSeqiNP_064316.1, NM_019932.4
UniGeneiMm.332490

3D structure databases

ProteinModelPortaliQ9Z126
SMRiQ9Z126
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61569N
IntActiQ9Z126, 4 interactors
MINTiQ9Z126
STRINGi10090.ENSMUSP00000031320

PTM databases

iPTMnetiQ9Z126
PhosphoSitePlusiQ9Z126

Proteomic databases

MaxQBiQ9Z126
PaxDbiQ9Z126
PeptideAtlasiQ9Z126
PRIDEiQ9Z126

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031320; ENSMUSP00000031320; ENSMUSG00000029373
GeneIDi56744
KEGGimmu:56744
UCSCiuc008ybi.2 mouse

Organism-specific databases

CTDi5196
MGIiMGI:1888711 Pf4

Phylogenomic databases

eggNOGiENOG410J314 Eukaryota
ENOG4111556 LUCA
GeneTreeiENSGT00910000144355
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiQ9Z126
KOiK05407
OMAiCAVPQLI
OrthoDBiEOG091G14JD
PhylomeDBiQ9Z126
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:Q9Z126
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029373 Expressed in 228 organ(s), highest expression level in blood
CleanExiMM_PF4
ExpressionAtlasiQ9Z126 baseline and differential
GenevisibleiQ9Z126 MM

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF43 PTHR10179:SF43, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLF4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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