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Protein

Semaphorin-4F

Gene

Sema4f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has growth cone collapse activity against retinal ganglion-cell axons.By similarity

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4F
Alternative name(s):
Semaphorin-W
Short name:
Sema W
Gene namesi
Name:Sema4f
Synonyms:Semaw
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1340055 Sema4f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 667ExtracellularSequence analysisAdd BLAST627
Transmembranei668 – 688HelicalSequence analysisAdd BLAST21
Topological domaini689 – 777CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000003233141 – 777Semaphorin-4FAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 128PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 155PROSITE-ProRule annotation
Disulfide bondi279 ↔ 390PROSITE-ProRule annotation
Disulfide bondi303 ↔ 349PROSITE-ProRule annotation
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi519 ↔ 536PROSITE-ProRule annotation
Disulfide bondi528 ↔ 545PROSITE-ProRule annotation
Disulfide bondi593 ↔ 634PROSITE-ProRule annotation
Modified residuei725PhosphoserineCombined sources1
Modified residuei727PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z123
PaxDbiQ9Z123
PRIDEiQ9Z123

PTM databases

iPTMnetiQ9Z123
PhosphoSitePlusiQ9Z123

Expressioni

Gene expression databases

BgeeiENSMUSG00000000627 Expressed in 203 organ(s), highest expression level in trigeminal ganglion
ExpressionAtlasiQ9Z123 baseline and differential
GenevisibleiQ9Z123 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203170, 1 interactor
STRINGi10090.ENSMUSP00000000641

Structurei

3D structure databases

ProteinModelPortaliQ9Z123
SMRiQ9Z123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 516SemaPROSITE-ProRule annotationAdd BLAST469
Domaini518 – 569PSIAdd BLAST52
Domaini586 – 641Ig-like C2-typeAdd BLAST56

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG093234
InParanoidiQ9Z123
KOiK06521
OMAiQLSPRPC
OrthoDBiEOG091G01W0
TreeFamiTF352903

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015512 Semaphorin_4F
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PTHR11036:SF72 PTHR11036:SF72, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z123-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARAERPRP GPRPPPVSLF PPPSSLLLLL LAMLSAPVCG RVPRSVPRTS
60 70 80 90 100
LPISEADSYL TRFAAPHTYN YSALLVDPAS HTLYVGARDS IFALTLPFSG
110 120 130 140 150
EKPRRIDWMV PETHRQNCRK KGKKEDECHN FIQILAIANA SHLLTCGTFA
160 170 180 190 200
FDPKCGVIDV SSFQQVERLE SGRGKCPFEP AQRSAAVMAG GVLYTATVKN
210 220 230 240 250
FLGTEPIISR AVGRAEDWIR TETLSSWLNA PAFVAAMVLS PAEWGDEDGD
260 270 280 290 300
DEIFFFFTET SRVLDSYERI KVPRVARVCA GDLGGRKTLQ QRWTTFLKAD
310 320 330 340 350
LLCPGPEHGR ASGVLQDMTE LRPQPGAGTP LFYGIFSSQW EGAAISAVCA
360 370 380 390 400
FRPQDIRAVL NGPFRELKHD CNRGLPVMDN EVPQPRPGEC ITNNMKFQQF
410 420 430 440 450
GSSLSLPDRV LTFIRDHPLM DRPVFPADGR PLLVTTDTAY LRVVAHRVTS
460 470 480 490 500
LSGKEYDVLY LGTEDGHLHR AVRIGAQLSV LEDLALFPET QPVESMKLYH
510 520 530 540 550
DWLLVGSHTE VTQVNTSNCG RLQSCSECIL AQDPVCAWSF RLDACVAHAG
560 570 580 590 600
EHRGMVQDIE SADVSSLCPK EPGEHPVVFE VPVATVGHVV LPCSPSSAWA
610 620 630 640 650
SCVWHQPSGV TSLTPRRDGL EVVVTPGAMG AYACECQEGG AARVVAAYSL
660 670 680 690 700
VWGSQRGPAN RAHTVVGAGL VGFFLGVLAA SLTLLLIGRR QQRRRQRELL
710 720 730 740 750
ARDKVGLDLG APPSGTTSYS QDPPSPSPED ERLPLALGKR GSGFGGFPPP
760 770
FLLDSCPSPA HIRLTGAPLA TCDETSI
Length:777
Mass (Da):84,490
Last modified:July 27, 2011 - v2
Checksum:i3338F4F0AEFBF0DA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUN0A0A0N4SUN0_MOUSE
Semaphorin-4F
Sema4f
29Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti490T → P in strain: BALB/c. 1
Natural varianti659A → S in strain: BALB/c. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021291 mRNA Translation: BAA75630.1
AB022316 Genomic DNA Translation: BAA75634.1
CH466523 Genomic DNA Translation: EDK99043.1
BC094567 mRNA Translation: AAH94567.1
CCDSiCCDS20264.1
RefSeqiNP_035480.3, NM_011350.4
UniGeneiMm.270543

Genome annotation databases

EnsembliENSMUST00000000641; ENSMUSP00000000641; ENSMUSG00000000627
GeneIDi20355
KEGGimmu:20355
UCSCiuc009clo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021291 mRNA Translation: BAA75630.1
AB022316 Genomic DNA Translation: BAA75634.1
CH466523 Genomic DNA Translation: EDK99043.1
BC094567 mRNA Translation: AAH94567.1
CCDSiCCDS20264.1
RefSeqiNP_035480.3, NM_011350.4
UniGeneiMm.270543

3D structure databases

ProteinModelPortaliQ9Z123
SMRiQ9Z123
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203170, 1 interactor
STRINGi10090.ENSMUSP00000000641

PTM databases

iPTMnetiQ9Z123
PhosphoSitePlusiQ9Z123

Proteomic databases

MaxQBiQ9Z123
PaxDbiQ9Z123
PRIDEiQ9Z123

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000641; ENSMUSP00000000641; ENSMUSG00000000627
GeneIDi20355
KEGGimmu:20355
UCSCiuc009clo.2 mouse

Organism-specific databases

CTDi10505
MGIiMGI:1340055 Sema4f

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG093234
InParanoidiQ9Z123
KOiK06521
OMAiQLSPRPC
OrthoDBiEOG091G01W0
TreeFamiTF352903

Miscellaneous databases

PROiPR:Q9Z123
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000627 Expressed in 203 organ(s), highest expression level in trigeminal ganglion
ExpressionAtlasiQ9Z123 baseline and differential
GenevisibleiQ9Z123 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015512 Semaphorin_4F
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PTHR11036:SF72 PTHR11036:SF72, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4F_MOUSE
AccessioniPrimary (citable) accession number: Q9Z123
Secondary accession number(s): Q505G0, Q9R1Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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