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Protein

C-C motif chemokine 8

Gene

Ccl8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:Ccl8
Synonyms:Mcp2, Scya8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:101878 Ccl8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000519024 – 97C-C motif chemokine 8Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9Z121
PaxDbiQ9Z121
PRIDEiQ9Z121

PTM databases

iPTMnetiQ9Z121
PhosphoSitePlusiQ9Z121

Expressioni

Gene expression databases

BgeeiENSMUSG00000009185 Expressed in 98 organ(s), highest expression level in zone of skin
CleanExiMM_CCL8
ExpressionAtlasiQ9Z121 baseline and differential
GenevisibleiQ9Z121 MM

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009329

Structurei

3D structure databases

ProteinModelPortaliQ9Z121
SMRiQ9Z121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiQ9Z121
KOiK16596
OMAiSTCCFIF
OrthoDBiEOG091G14KV
PhylomeDBiQ9Z121
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z121-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIYAVLLCL LLIAVPVSPE KLTGPDKAPV TCCFHVLKLK IPLRVLKSYE
60 70 80 90
RINNIQCPME AVVFQTKQGM SLCVDPTQKW VSEYMEILDQ KSQILQP
Length:97
Mass (Da):11,017
Last modified:May 1, 1999 - v1
Checksum:i65BB3722F2F98D54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023418 mRNA Translation: BAA75014.1
AK007942 mRNA Translation: BAB25365.1
CCDSiCCDS36248.1
RefSeqiNP_067418.1, NM_021443.3
UniGeneiMm.42029

Genome annotation databases

EnsembliENSMUST00000009329; ENSMUSP00000009329; ENSMUSG00000009185
GeneIDi20307
KEGGimmu:20307
UCSCiuc007kmt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCCL8_MOUSE
AccessioniPrimary (citable) accession number: Q9Z121
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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