Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Z110 (P5CS_MOUSE)

Entry version 177 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Delta-1-pyrroline-5-carboxylate synthase

Gene

Aldh18a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Isoform Short: Inhibited by L-ornithine with a Ki of approximately 0.25 mm. Isoform Long: Insensitive to ornithine inhibition. Thus, the two amino acid insert in the long isoform abolishes feedback inhibition of P5CS activity by L-ornithine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-proline biosynthesis

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Delta-1-pyrroline-5-carboxylate synthase (Aldh18a1), Gamma-glutamyl kinase (Aldh18a1), Delta-1-pyrroline-5-carboxylate synthase (Aldh18a1)
  2. Delta-1-pyrroline-5-carboxylate synthase (Aldh18a1), Gamma-glutamyl kinase (Aldh18a1), Delta-1-pyrroline-5-carboxylate synthase (Aldh18a1)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117SubstrateBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei246Substrate; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi266 – 267ATPBy similarity2
Nucleotide bindingi305 – 311ATPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Multifunctional enzyme, Oxidoreductase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandATP-binding, NADP, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.2.1.41, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-8964539, Glutamate and glutamine metabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00098;UER00359
UPA00098;UER00360

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-1-pyrroline-5-carboxylate synthase
Short name:
P5CS
Alternative name(s):
Aldehyde dehydrogenase family 18 member A1
Including the following 2 domains:
Glutamate 5-kinase (EC:2.7.2.11By similarity)
Short name:
GK
Alternative name(s):
Gamma-glutamyl kinase
Gamma-glutamyl phosphate reductase (EC:1.2.1.41By similarity)
Short name:
GPR
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aldh18a1
Synonyms:P5cs, Pycs
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1888908, Aldh18a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001097701 – 795Delta-1-pyrroline-5-carboxylate synthaseAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei311N6-succinyllysineCombined sources1
Modified residuei347N6-succinyllysineCombined sources1
Modified residuei550N6-succinyllysineCombined sources1

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Z110

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Z110

PeptideAtlas

More...PeptideAtlasi		Q9Z110

PRoteomics IDEntifications database

More...PRIDEi		Q9Z110

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9Z110-1 [Q9Z110-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Z110

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Z110

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Z110

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000025007, Expressed in epithelium of small intestine and 318 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Z110, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Z110, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer or homotetramer.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		207993, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q9Z110, 7 interactors

Molecular INTeraction database

More...MINTi		Q9Z110

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000025979

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Z110, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Z110

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 361Glutamate 5-kinaseAdd BLAST361
Regioni362 – 795Gamma-glutamyl phosphate reductaseAdd BLAST434

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the glutamate 5-kinase family.Curated
In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1154, Eukaryota
KOG4165, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00500000044903

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016144_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Z110

KEGG Orthology (KO)

More...KOi		K12657

Identification of Orthologs from Complete Genome Data

More...OMAi		EGRECIM

Database of Orthologous Groups

More...OrthoDBi		832430at2759

TreeFam database of animal gene trees

More...TreeFami		TF314372

Family and domain databases

Conserved Domains Database

More...CDDi		cd04256, AAK_P5CS_ProBA, 1 hit
cd07079, ALDH_F18-19_ProA-GPR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1160.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00412, ProA, 1 hit
MF_00456, ProB, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036393, AceGlu_kinase-like_sf
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR001048, Asp/Glu/Uridylate_kinase
IPR020593, G-glutamylP_reductase_CS
IPR041744, G5K_ProBA
IPR001057, Glu/AcGlu_kinase
IPR005715, Glu_5kinase/COase_Synthase
IPR019797, Glutamate_5-kinase_CS
IPR000965, GPR_dom
IPR005766, P5_carboxy_syn

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00696, AA_kinase, 1 hit
PF00171, Aldedh, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036429, P5C_syn, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00474, GLU5KINASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53633, SSF53633, 1 hit
SSF53720, SSF53720, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01092, P5CS, 1 hit
TIGR00407, proA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00902, GLUTAMATE_5_KINASE, 1 hit
PS01223, PROA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q9Z110-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRHMHRSGV QPFRQRLLPW VQSIAVPRSN RVQPSAIRHV RSWSNIPFIT 
        60         70         80         90        100
VPLSRAHGKP FAHRSELKHA KRIVVKLGSA VVTRGDECGL ALGRLASIVE 
       110        120        130        140        150
QVSVLQNQGR EMMLVTSGAV AFGKQRLRHE ILLSQSVRQA LHSGQNHLKE 
       160        170        180        190        200
MAIPVLEARA CAAAGQSGLM ALYEAMFTQY SICAAQILVT NLDFHDEQKR 
       210        220        230        240        250
RNLNGTLHEL LRMNIVPIVN TNDAVVPPAE PNSDLQGVNV ISVKDNDSLA 
       260        270        280        290        300
ARLAVEMKTD LLIVLSDVEG LFDSPPGSDD AKLIDIFYPG DQQSVTFGTK 
       310        320        330        340        350
SRVGLGGMEA KVKAALWALQ GGTSVVIANG THPKVSGHVI TDIVEGKKVG 
       360        370        380        390        400
TFFSEVKPAG PTVEQQGEMA RSGGRMLATL EPEQRAEIIN HLADLLTDQR 
       410        420        430        440        450
EEILLANKKD LEEAEGRLAS PLLKRLSLST SKLNSLAIGL RQIAASSQES 
       460        470        480        490        500
VGRVLRRTRI AKNLELEQVT VPIGVLLVIF ESRPDCLPQV AALAIASGNG 
       510        520        530        540        550
LLLKGGKEAA HSNRILHLLT QEALSIHGVK EAIQLVNTRE EVEDLCRLDK 
       560        570        580        590        600
IIDLIIPRGS SQLVRDIQKA AKGIPVMGHS EGICHMYVDS EASVDKVTRL 
       610        620        630        640        650
VRDSKCEYPA ACNALETLLI HRDLLRTPLF DQIIDMLRVE QVKIHAGPKF 
       660        670        680        690        700
ASYLTFSPSE VKSLRTEYGD LEVCIEVVDS VQEAIDHIHK YGSSHTDVIV 
       710        720        730        740        750
TENEKTAEFF LQHVDSACVF WNASTRFSDG YRFGLGAEVG ISTSRIHARG 
       760        770        780        790 
PVGLEGLLTT KWLLRGQDHV VSDFSEHGSL KYLHENLPVP QRNFS
Length:795
Mass (Da):87,266
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i877DF1A7B5F84247
GO
Isoform Short (identifier: Q9Z110-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-240: Missing.

Show »
Length:793
Mass (Da):87,053
Checksum:iF0076527C19FCDCD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0B4D3Z0B4_MOUSE
Delta-1-pyrroline-5-carboxylate syn...
Aldh18a1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKK0H3BKK0_MOUSE
Delta-1-pyrroline-5-carboxylate syn...
Aldh18a1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLE8H3BLE8_MOUSE
Delta-1-pyrroline-5-carboxylate syn...
Aldh18a1
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKJ8H3BKJ8_MOUSE
Delta-1-pyrroline-5-carboxylate syn...
Aldh18a1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti582G → S in AAD17517 (PubMed:10037775).Curated1
Sequence conflicti582G → S in AAD17518 (PubMed:10037775).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005216239 – 240Missing in isoform Short. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF056573 mRNA Translation: AAD17517.1
AF056574 mRNA Translation: AAD17518.1
AK151072 mRNA Translation: BAE30088.1
AK153946 mRNA Translation: BAE32270.1
AK168905 mRNA Translation: BAE40719.1
CH466534 Genomic DNA Translation: EDL41837.1
BC033427 mRNA Translation: AAH33427.1
BC037699 mRNA Translation: AAH37699.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS29803.1 [Q9Z110-1]
CCDS57144.1 [Q9Z110-2]

NCBI Reference Sequences

More...RefSeqi		NP_062672.2, NM_019698.2 [Q9Z110-1]
NP_705782.2, NM_153554.2 [Q9Z110-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000025979; ENSMUSP00000025979; ENSMUSG00000025007 [Q9Z110-1]
ENSMUST00000176939; ENSMUSP00000135426; ENSMUSG00000025007 [Q9Z110-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56454

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:56454

UCSC genome browser

More...UCSCi		uc008hkw.2, mouse [Q9Z110-2]
uc008hkx.2, mouse [Q9Z110-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056573 mRNA Translation: AAD17517.1
AF056574 mRNA Translation: AAD17518.1
AK151072 mRNA Translation: BAE30088.1
AK153946 mRNA Translation: BAE32270.1
AK168905 mRNA Translation: BAE40719.1
CH466534 Genomic DNA Translation: EDL41837.1
BC033427 mRNA Translation: AAH33427.1
BC037699 mRNA Translation: AAH37699.1
CCDSiCCDS29803.1 [Q9Z110-1]
CCDS57144.1 [Q9Z110-2]
RefSeqiNP_062672.2, NM_019698.2 [Q9Z110-1]
NP_705782.2, NM_153554.2 [Q9Z110-2]

3D structure databases

SMRiQ9Z110
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207993, 3 interactors
IntActiQ9Z110, 7 interactors
MINTiQ9Z110
STRINGi10090.ENSMUSP00000025979

PTM databases

iPTMnetiQ9Z110
PhosphoSitePlusiQ9Z110
SwissPalmiQ9Z110

Proteomic databases

EPDiQ9Z110
PaxDbiQ9Z110
PeptideAtlasiQ9Z110
PRIDEiQ9Z110
TopDownProteomicsiQ9Z110-1 [Q9Z110-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2043, 200 antibodies

Genome annotation databases

EnsembliENSMUST00000025979; ENSMUSP00000025979; ENSMUSG00000025007 [Q9Z110-1]
ENSMUST00000176939; ENSMUSP00000135426; ENSMUSG00000025007 [Q9Z110-2]
GeneIDi56454
KEGGimmu:56454
UCSCiuc008hkw.2, mouse [Q9Z110-2]
uc008hkx.2, mouse [Q9Z110-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5832
MGIiMGI:1888908, Aldh18a1

Phylogenomic databases

eggNOGiKOG1154, Eukaryota
KOG4165, Eukaryota
GeneTreeiENSGT00500000044903
HOGENOMiCLU_016144_0_0_1
InParanoidiQ9Z110
KOiK12657
OMAiEGRECIM
OrthoDBi832430at2759
TreeFamiTF314372

Enzyme and pathway databases

UniPathwayiUPA00098;UER00359
UPA00098;UER00360
BRENDAi1.2.1.41, 3474
ReactomeiR-MMU-8964539, Glutamate and glutamine metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56454, 1 hit in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Aldh18a1, mouse

Protein Ontology

More...PROi		PR:Q9Z110
RNActiQ9Z110, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000025007, Expressed in epithelium of small intestine and 318 other tissues
ExpressionAtlasiQ9Z110, baseline and differential
GenevisibleiQ9Z110, MM

Family and domain databases

CDDicd04256, AAK_P5CS_ProBA, 1 hit
cd07079, ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.1160.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00412, ProA, 1 hit
MF_00456, ProB, 1 hit
InterProiView protein in InterPro
IPR036393, AceGlu_kinase-like_sf
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR001048, Asp/Glu/Uridylate_kinase
IPR020593, G-glutamylP_reductase_CS
IPR041744, G5K_ProBA
IPR001057, Glu/AcGlu_kinase
IPR005715, Glu_5kinase/COase_Synthase
IPR019797, Glutamate_5-kinase_CS
IPR000965, GPR_dom
IPR005766, P5_carboxy_syn
PfamiView protein in Pfam
PF00696, AA_kinase, 1 hit
PF00171, Aldedh, 1 hit
PIRSFiPIRSF036429, P5C_syn, 1 hit
PRINTSiPR00474, GLU5KINASE
SUPFAMiSSF53633, SSF53633, 1 hit
SSF53720, SSF53720, 1 hit
TIGRFAMsiTIGR01092, P5CS, 1 hit
TIGR00407, proA, 1 hit
PROSITEiView protein in PROSITE
PS00902, GLUTAMATE_5_KINASE, 1 hit
PS01223, PROA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP5CS_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z110
Secondary accession number(s): Q8BGM2, Q9R1P6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again