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Protein

V-set and immunoglobulin domain-containing protein 2

Gene

Vsig2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 2
Alternative name(s):
Cortical thymocyte-like protein
Short name:
CT-like protein
Gene namesi
Name:Vsig2
Synonyms:Ctm, Ctxl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1928009 Vsig2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 244ExtracellularSequence analysisAdd BLAST220
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 328CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001500525 – 328V-set and immunoglobulin domain-containing protein 2Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 122PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi167 ↔ 218PROSITE-ProRule annotation
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z109
PRIDEiQ9Z109

PTM databases

PhosphoSitePlusiQ9Z109

Expressioni

Tissue specificityi

Expressed in the stomach, colon and prostate.1 Publication

Gene expression databases

BgeeiENSMUSG00000001943 Expressed in 76 organ(s), highest expression level in pyloric antrum
CleanExiMM_VSIG2
ExpressionAtlasiQ9Z109 baseline and differential
GenevisibleiQ9Z109 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002008

Structurei

3D structure databases

ProteinModelPortaliQ9Z109
SMRiQ9Z109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 138Ig-like V-typeAdd BLAST114
Domaini145 – 234Ig-like C2-typeAdd BLAST90

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJI Eukaryota
ENOG410YI21 LUCA
GeneTreeiENSGT00760000119145
HOGENOMiHOG000134690
HOVERGENiHBG086709
InParanoidiQ9Z109
OMAiTASCELT
OrthoDBiEOG091G05PI
PhylomeDBiQ9Z109
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z109-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWPLVGAFL CGHLLGFVCL SGLAVEVTVP TEPLSVPKGK TAELSCSYKT
60 70 80 90 100
SVGDNFALEW SFVQPGKPIS ASVPVLYFTN GHLYPTGSKA DRAILLHDPP
110 120 130 140 150
TGGLATLKLT DLRPSDTGTY LCNVNNPPDF YTNGLGLINL TVLVPPSHPL
160 170 180 190 200
CSQSGQTSVG GSAALGCRSS EGAPKPVYNW ERLGSSPTPP PGSMVQDEVS
210 220 230 240 250
GQLILTNLSL TSSGTYRCVA SNQMGSASCE LNLSVTDSSE GRVAGTLIGV
260 270 280 290 300
LLGVLLLSVA AFCLIRFQKE RKKEPKETYG GSDLREDATA PGVFEQASMR
310 320
ADHSKELLEK SPCASTMTTT KSKLSMVV
Length:328
Mass (Da):34,514
Last modified:June 21, 2005 - v2
Checksum:iC57A121CC64E9617
GO
Isoform 2 (identifier: Q9Z109-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-101: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):26,033
Checksum:iA846D8F8484E0B49
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4KL36Q4KL36_MOUSE
V-set and immunoglobulin domain-con...
Vsig2
235Annotation score:
A0A1L1SQK8A0A1L1SQK8_MOUSE
V-set and immunoglobulin domain-con...
Vsig2
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158S → L in AAD17524 (PubMed:9862345).Curated1
Sequence conflicti184G → C in AAD17524 (PubMed:9862345).Curated1
Sequence conflicti222N → H in AAD17524 (PubMed:9862345).Curated1
Sequence conflicti240E → D in AAD17524 (PubMed:9862345).Curated1
Sequence conflicti269 – 274KERKKE → TEGTGA (PubMed:9862345).Curated6
Sequence conflicti276K → R in BAB23323 (PubMed:9862345).Curated1
Sequence conflicti296Q → P in AAD17524 (PubMed:9862345).Curated1
Sequence conflicti316T → A in AAD17524 (PubMed:9862345).Curated1
Sequence conflicti319T → P in AAD17524 (PubMed:9862345).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01412022 – 101Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061024 Genomic DNA Translation: AAD17524.1
AK004478 mRNA Translation: BAB23323.1
AK008920 mRNA Translation: BAB25968.1
CCDSiCCDS22980.1 [Q9Z109-1]
RefSeqiNP_065264.2, NM_020518.2 [Q9Z109-1]
UniGeneiMm.27478

Genome annotation databases

EnsembliENSMUST00000002008; ENSMUSP00000002008; ENSMUSG00000001943 [Q9Z109-1]
ENSMUST00000215271; ENSMUSP00000150115; ENSMUSG00000001943 [Q9Z109-2]
GeneIDi57276
KEGGimmu:57276
UCSCiuc009ovb.1 mouse [Q9Z109-1]
uc012gra.1 mouse [Q9Z109-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061024 Genomic DNA Translation: AAD17524.1
AK004478 mRNA Translation: BAB23323.1
AK008920 mRNA Translation: BAB25968.1
CCDSiCCDS22980.1 [Q9Z109-1]
RefSeqiNP_065264.2, NM_020518.2 [Q9Z109-1]
UniGeneiMm.27478

3D structure databases

ProteinModelPortaliQ9Z109
SMRiQ9Z109
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002008

PTM databases

PhosphoSitePlusiQ9Z109

Proteomic databases

PaxDbiQ9Z109
PRIDEiQ9Z109

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002008; ENSMUSP00000002008; ENSMUSG00000001943 [Q9Z109-1]
ENSMUST00000215271; ENSMUSP00000150115; ENSMUSG00000001943 [Q9Z109-2]
GeneIDi57276
KEGGimmu:57276
UCSCiuc009ovb.1 mouse [Q9Z109-1]
uc012gra.1 mouse [Q9Z109-2]

Organism-specific databases

CTDi23584
MGIiMGI:1928009 Vsig2

Phylogenomic databases

eggNOGiENOG410IVJI Eukaryota
ENOG410YI21 LUCA
GeneTreeiENSGT00760000119145
HOGENOMiHOG000134690
HOVERGENiHBG086709
InParanoidiQ9Z109
OMAiTASCELT
OrthoDBiEOG091G05PI
PhylomeDBiQ9Z109
TreeFamiTF330875

Miscellaneous databases

PROiPR:Q9Z109
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001943 Expressed in 76 organ(s), highest expression level in pyloric antrum
CleanExiMM_VSIG2
ExpressionAtlasiQ9Z109 baseline and differential
GenevisibleiQ9Z109 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiVSIG2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z109
Secondary accession number(s): Q9CVA4, Q9D0T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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