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Protein

Double-stranded RNA-binding protein Staufen homolog 1

Gene

Stau1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.

GO - Molecular functioni

  • double-stranded RNA binding Source: MGI
  • protein phosphatase 1 binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-binding protein Staufen homolog 1
Gene namesi
Name:Stau1
Synonyms:Stau
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1338864 Stau1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722441 – 487Double-stranded RNA-binding protein Staufen homolog 1Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Asymmetric dimethylarginineCombined sources1
Modified residuei27Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei27Omega-N-methylarginine; alternateBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9Z108
MaxQBiQ9Z108
PaxDbiQ9Z108
PeptideAtlasiQ9Z108
PRIDEiQ9Z108

PTM databases

iPTMnetiQ9Z108
PhosphoSitePlusiQ9Z108

Expressioni

Gene expression databases

BgeeiENSMUSG00000039536 Expressed in 297 organ(s), highest expression level in skin of back
ExpressionAtlasiQ9Z108 baseline and differential
GenevisibleiQ9Z108 MM

Interactioni

Subunit structurei

Binds tubulin. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203528, 4 interactors
IntActiQ9Z108, 2 interactors
MINTiQ9Z108
STRINGi10090.ENSMUSP00000104861

Structurei

3D structure databases

ProteinModelPortaliQ9Z108
SMRiQ9Z108
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 163DRBM 1PROSITE-ProRule annotationAdd BLAST68
Domaini196 – 264DRBM 2PROSITE-ProRule annotationAdd BLAST69

Domaini

One of the DRDB could be involved in RER binding.
The C-terminal contains the tubulin binding domain (TBD).

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3732 Eukaryota
ENOG410XSCK LUCA
GeneTreeiENSGT00900000140998
HOGENOMiHOG000231025
HOVERGENiHBG005013
InParanoidiQ9Z108
KOiK17597

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR032478 Staufen_C
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF16482 Staufen_C, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z108-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKPVDPHSR MQSTYSYGMR GGAYPPRYFY PFPVPPLLYQ VELSVGGQQF
60 70 80 90 100
NGKGKMRPPV KHDAPARALR TLQSEPLPER LEVNGREAEE ENLNKSEISQ
110 120 130 140 150
VFEIALKRNL PVNFEVARES GPPHMKNFVT RVSVGEFVGE GEGKSKKISK
160 170 180 190 200
KNAARAVLEQ LRRLPPLPAV ERVKPRIKKK SQPTCKTAPD YGQGMNPISR
210 220 230 240 250
LAQIQQAKKE KEPEYMLLTE RGLPRRREFV MQVKVGHHTA EGVGTNKKVA
260 270 280 290 300
KRNAAENMLE ILGFKVPQAQ PAKPALKSEE KTPVKKPGDG RKVTFFEPSP
310 320 330 340 350
GDENGTSNKD EEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT
360 370 380 390 400
RAAPNPAKAT VTAMIARELL YGGTSPTAET ILKSNISSGH VPHGPRTRPS
410 420 430 440 450
EQLYYLSRAQ GFQVEYKDFP KNNKNECVSL INCSSQPPLV SHGIGKDVES
460 470 480
CHDMAALNIL KLLSELDQQS TEMPRTGNGP VSACGRC
Length:487
Mass (Da):53,925
Last modified:May 1, 1999 - v1
Checksum:i840260693DC49180
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A5S3A2A5S3_MOUSE
Double-stranded RNA-binding protein...
Stau1
495Annotation score:
A2A5R8A2A5R8_MOUSE
Double-stranded RNA-binding protein...
Stau1
485Annotation score:
Q9DBE7Q9DBE7_MOUSE
Double-stranded RNA-binding protein...
Stau1 mCG_14603
489Annotation score:
V9GX87V9GX87_MOUSE
Double-stranded RNA-binding protein...
Stau1
436Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061942 mRNA Translation: AAD17529.1
CCDSiCCDS17093.1
RefSeqiNP_035620.1, NM_011490.4
UniGeneiMm.73276

Genome annotation databases

EnsembliENSMUST00000109236; ENSMUSP00000104859; ENSMUSG00000039536
GeneIDi20853
KEGGimmu:20853
UCSCiuc008nyv.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061942 mRNA Translation: AAD17529.1
CCDSiCCDS17093.1
RefSeqiNP_035620.1, NM_011490.4
UniGeneiMm.73276

3D structure databases

ProteinModelPortaliQ9Z108
SMRiQ9Z108
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203528, 4 interactors
IntActiQ9Z108, 2 interactors
MINTiQ9Z108
STRINGi10090.ENSMUSP00000104861

PTM databases

iPTMnetiQ9Z108
PhosphoSitePlusiQ9Z108

Proteomic databases

EPDiQ9Z108
MaxQBiQ9Z108
PaxDbiQ9Z108
PeptideAtlasiQ9Z108
PRIDEiQ9Z108

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109236; ENSMUSP00000104859; ENSMUSG00000039536
GeneIDi20853
KEGGimmu:20853
UCSCiuc008nyv.3 mouse

Organism-specific databases

CTDi6780
MGIiMGI:1338864 Stau1

Phylogenomic databases

eggNOGiKOG3732 Eukaryota
ENOG410XSCK LUCA
GeneTreeiENSGT00900000140998
HOGENOMiHOG000231025
HOVERGENiHBG005013
InParanoidiQ9Z108
KOiK17597

Miscellaneous databases

ChiTaRSiStau1 mouse
PROiPR:Q9Z108
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039536 Expressed in 297 organ(s), highest expression level in skin of back
ExpressionAtlasiQ9Z108 baseline and differential
GenevisibleiQ9Z108 MM

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR032478 Staufen_C
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF16482 Staufen_C, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSTAU1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z108
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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