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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Gene

Hmg20b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 138HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA-binding transcription factor activity Source: UniProtKB
  • four-way junction DNA binding Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chromatin organization Source: UniProtKB
  • chromatin remodeling Source: ProtInc
  • negative regulation of protein sumoylation Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB
  • skeletal muscle cell differentiation Source: MGI

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
Short name:
SMARCE1-related protein
Alternative name(s):
BRCA2-associated factor 35
HMG box-containing protein 20B
Structural DNA-binding protein BRAF35
Gene namesi
Name:Hmg20b
Synonyms:Braf35, Hmgx2, Smarce1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1341190 Hmg20b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485761 – 317SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-relatedAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei160PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Z104
MaxQBiQ9Z104
PaxDbiQ9Z104
PRIDEiQ9Z104

PTM databases

iPTMnetiQ9Z104
PhosphoSitePlusiQ9Z104

Expressioni

Tissue specificityi

Widely expressed in adult tissues, particularly kidney, skin, testis and uterus. Highly expressed in embryonic tissues with high mitotic index, such as the proliferating ventricular zones of the fore-, mid- and hindbrain.

Gene expression databases

BgeeiENSMUSG00000020232 Expressed in 213 organ(s), highest expression level in heart left ventricle
CleanExiMM_HMG20B
ExpressionAtlasiQ9Z104 baseline and differential
GenevisibleiQ9Z104 MM

Interactioni

Subunit structurei

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Traf1P394283EBI-646920,EBI-520123

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200335, 2 interactors
IntActiQ9Z104, 1 interactor
STRINGi10090.ENSMUSP00000020454

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Z104
SMRiQ9Z104
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z104

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 257Sequence analysisAdd BLAST68

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00730000110938
HOGENOMiHOG000247029
HOVERGENiHBG059870
InParanoidiQ9Z104
OMAiHNRSTEN
OrthoDBiEOG091G0IHZ
PhylomeDBiQ9Z104
TreeFamiTF106440

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Z104-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHGPRQPGA ATAPAGGKTP GQHGAFVVAV KQERSEGSRA GEKGPQEEEP
60 70 80 90 100
VKKRGWPKGK KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI
110 120 130 140 150
TKMLGAEWSK LQPAEKQRYL DEAEKEKQQY LKELWAYQQS EAYKVCTEKI
160 170 180 190 200
QENKIKKEDS SSGLMNTLLN GHKGVDCDGF STFDVPIFTE EFLDQNKARE
210 220 230 240 250
AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL EERRTLALQQ
260 270 280 290 300
QLQAVRQALT ASFASLPVPG TGETPTLGTL DFYMARLHGA IERDPAQHER
310
LIARVKEILA RVASEHL
Length:317
Mass (Da):35,870
Last modified:May 1, 1999 - v1
Checksum:i6C4D45D2EB1D403B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7AVN4F7AVN4_MOUSE
SWI/SNF-related matrix-associated a...
Hmg20b
246Annotation score:
E9Q2W1E9Q2W1_MOUSE
SWI/SNF-related matrix-associated a...
Hmg20b
235Annotation score:
Q05DT2Q05DT2_MOUSE
Hmg20b protein
Hmg20b
215Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067430 Genomic DNA Translation: AAD15897.1
AF146224 mRNA Translation: AAF66708.1
AL355734 mRNA Translation: CAB90813.1
AL355735 mRNA Translation: CAB90814.1
BC011334 mRNA Translation: AAH11334.1
CCDSiCCDS24055.1
RefSeqiNP_001156637.1, NM_001163165.1
NP_001156638.1, NM_001163166.1
NP_034570.1, NM_010440.3
UniGeneiMm.38474

Genome annotation databases

EnsembliENSMUST00000020454; ENSMUSP00000020454; ENSMUSG00000020232
ENSMUST00000105323; ENSMUSP00000100960; ENSMUSG00000020232
ENSMUST00000105324; ENSMUSP00000100961; ENSMUSG00000020232
ENSMUST00000167481; ENSMUSP00000128807; ENSMUSG00000020232
GeneIDi15353
KEGGimmu:15353
UCSCiuc007ghj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067430 Genomic DNA Translation: AAD15897.1
AF146224 mRNA Translation: AAF66708.1
AL355734 mRNA Translation: CAB90813.1
AL355735 mRNA Translation: CAB90814.1
BC011334 mRNA Translation: AAH11334.1
CCDSiCCDS24055.1
RefSeqiNP_001156637.1, NM_001163165.1
NP_001156638.1, NM_001163166.1
NP_034570.1, NM_010440.3
UniGeneiMm.38474

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRJNMR-A70-148[»]
ProteinModelPortaliQ9Z104
SMRiQ9Z104
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200335, 2 interactors
IntActiQ9Z104, 1 interactor
STRINGi10090.ENSMUSP00000020454

PTM databases

iPTMnetiQ9Z104
PhosphoSitePlusiQ9Z104

Proteomic databases

EPDiQ9Z104
MaxQBiQ9Z104
PaxDbiQ9Z104
PRIDEiQ9Z104

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020454; ENSMUSP00000020454; ENSMUSG00000020232
ENSMUST00000105323; ENSMUSP00000100960; ENSMUSG00000020232
ENSMUST00000105324; ENSMUSP00000100961; ENSMUSG00000020232
ENSMUST00000167481; ENSMUSP00000128807; ENSMUSG00000020232
GeneIDi15353
KEGGimmu:15353
UCSCiuc007ghj.2 mouse

Organism-specific databases

CTDi10362
MGIiMGI:1341190 Hmg20b

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00730000110938
HOGENOMiHOG000247029
HOVERGENiHBG059870
InParanoidiQ9Z104
OMAiHNRSTEN
OrthoDBiEOG091G0IHZ
PhylomeDBiQ9Z104
TreeFamiTF106440

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSiHmg20b mouse
EvolutionaryTraceiQ9Z104
PROiPR:Q9Z104
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020232 Expressed in 213 organ(s), highest expression level in heart left ventricle
CleanExiMM_HMG20B
ExpressionAtlasiQ9Z104 baseline and differential
GenevisibleiQ9Z104 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHM20B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z104
Secondary accession number(s): Q9NSF7, Q9NSF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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