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Entry version 167 (29 Sep 2021)
Sequence version 2 (14 Oct 2015)
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Protein

Activity-dependent neuroprotector homeobox protein

Gene

Adnp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Miscellaneous

When isolated from the sequence, the neuroprotective peptide provides neuroprotection at subfemtomolar concentrations against toxicity associated with tetrodoxin (electrical blockade), the amyloid-beta peptide (the Alzheimer disease neurotoxin), N-methyl-aspartate (excitotoxicity), and the human immunideficiency virus (HIV) envelope protein.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri74 – 97C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri107 – 129C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri221 – 244C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri446 – 468C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri511 – 534C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri621 – 646C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri661 – 685C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi753 – 813HomeoboxPROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein
Alternative name(s):
Activity-dependent neuroprotective protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adnp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1338758, Adnp

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000051149

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000488081 – 1108Activity-dependent neuroprotector homeobox proteinAdd BLAST1108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei98PhosphoserineBy similarity1
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki335Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei348Asymmetric dimethylarginineCombined sources1
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki407Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei408PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Cross-linki426Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki605Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei607PhosphoserineBy similarity1
Cross-linki615Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki631Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei708PhosphoserineCombined sources1
Cross-linki715Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki727Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki730Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei737PhosphoserineCombined sources1
Cross-linki744Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei804PhosphoserineBy similarity1
Cross-linki806Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki828Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki834Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei875PhosphoserineBy similarity1
Modified residuei877PhosphoserineBy similarity1
Modified residuei885PhosphoserineBy similarity1
Modified residuei888PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Cross-linki913Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki928Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki941Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei959PhosphoserineCombined sources1
Modified residuei961PhosphoserineBy similarity1
Cross-linki1022Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1041N6-acetyllysine; alternateBy similarity1
Cross-linki1041Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1048N6-acetyllysine; alternateBy similarity1
Cross-linki1048Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1077PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Z103

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Z103

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Z103

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Z103

PeptideAtlas

More...
PeptideAtlasi
Q9Z103

PRoteomics IDEntifications database

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PRIDEi
Q9Z103

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
285555

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Z103

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Z103

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, with a higher expression in cerebellum and hippocampus. Weakly expressed in lung, kidney and intestine, and expressed at intermediate level in testis.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By the neuroprotective peptide VIP.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000051149, Expressed in forelimb bud and 91 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9Z103, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9Z103

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000085316

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z103, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 154DisorderedSequence analysisAdd BLAST22
Regioni354 – 361Neuroprotective peptide1 Publication8
Regioni360 – 438DisorderedSequence analysisAdd BLAST79
Regioni690 – 711DisorderedSequence analysisAdd BLAST22
Regioni851 – 1037DisorderedSequence analysisAdd BLAST187
Regioni1050 – 1108DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi391 – 427Polar residuesSequence analysisAdd BLAST37
Compositional biasi692 – 707Polar residuesSequence analysisAdd BLAST16
Compositional biasi851 – 883Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi940 – 962Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi978 – 992Polar residuesSequence analysisAdd BLAST15
Compositional biasi1009 – 1029Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1050 – 1080Polar residuesSequence analysisAdd BLAST31

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 97C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri107 – 129C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri221 – 244C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri446 – 468C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri511 – 534C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri621 – 646C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri661 – 685C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QSYX, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00530000063631

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Z103

Identification of Orthologs from Complete Genome Data

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OMAi
PYCTFNG

Database of Orthologous Groups

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OrthoDBi
135860at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Z103

TreeFam database of animal gene trees

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TreeFami
TF328818

Family and domain databases

Conserved Domains Database

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CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038861, ADNP/ADNP2
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR013087, Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR15740, PTHR15740, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Z103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN
60 70 80 90 100
TTWEDVGLWD PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED
110 120 130 140 150
FENRILLNCP YCTFNADKKT LETHIKIFHA PNSSAPSSSL STFKDKNKND
160 170 180 190 200
GLKPKQADNV EQAVYYCKKC TYRDPLYEIV RKHIYREHFQ HVAAPYIAKA
210 220 230 240 250
GEKSLNGAVS LGTNAREECN IHCKRCLFMP KSYEALVQHV IEDHERIGYQ
260 270 280 290 300
VTAMIGHTNV VVPRAKPLML IAPKPQDKKG MGLPPRISSL ASGNVRSLPS
310 320 330 340 350
QQMVNRLSIP KPNLNSTGVN MMSNVHLQQN NYGVKSVGQS YGVGQSVRLG
360 370 380 390 400
LGGNAPVSIP QQSQSVKQLL PSGNGRSFGL GAEQRPPAAA RYSLQTANTS
410 420 430 440 450
LPPGQVKSPS VSQSQASRVL GQSSSKPPPA ATGPPPSNHC ATQKWKICTI
460 470 480 490 500
CNELFPENVY SVHFEKEHKA EKVPAVANYI MKIHNFTSKC LYCNRYLPTD
510 520 530 540 550
TLLNHMLIHG LSCPYCRSTF NDVEKMAAHM RMVHIDEEMG PKTDSTLSFD
560 570 580 590 600
LTLQQGSHTN IHLLVTTYNL RDAPAESVAY HAQNNAPVPP KPQPKVQEKA
610 620 630 640 650
DVPVKSSPQA AVPYKKDVGK TLCPLCFSIL KGPISDALAH HLRERHQVIQ
660 670 680 690 700
TVHPVEKKLT YKCIHCLGVY TSNMTASTIT LHLVHCRGVG KTQNGQDKTN
710 720 730 740 750
APSRLNQSPG LAPVKRTYEQ MEFPLLKKRK LEEDADSPSC FEEKPEEPVV
760 770 780 790 800
LALDPKGHED DSYEARKSFL TKYFNKQPYP TRREIEKLAA SLWLWKSDIA
810 820 830 840 850
SHFSNKRKKC VRDCEKYKPG VLLGFNMKEL NKVKHEMDFD AEWLFENHDE
860 870 880 890 900
KDSRVNASKT VDKKHNLGKE DDSFSDSFEH LEEESNGSGS PFDPVFEVEP
910 920 930 940 950
KIPSDNLEEP VPKVIPEGAL ESEKLDQKEE EEEEEEEDGS KYETIHLTEE
960 970 980 990 1000
PAKLMHDASD SEVDQDDVVE WKDGASPSES GPGSQQISDF EDNTCEMKPG
1010 1020 1030 1040 1050
TWSDESSQSE DARSSKPAAK KKATVQDDTE QLKWKNSSYG KVEGFWSKDQ
1060 1070 1080 1090 1100
SQWENASENA ERLPNPQIEW QNSTIDSEDG EQFDSMTDGV ADPMHGSLTG

VKLSSQQA
Length:1,108
Mass (Da):124,308
Last modified:October 14, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC69498C5DFC9150B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX005039 Genomic DNA No translation available.
AF068198 mRNA Translation: AAD19843.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38342.1

NCBI Reference Sequences

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RefSeqi
NP_001297015.1, NM_001310086.1
NP_033758.2, NM_009628.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000057793; ENSMUSP00000056809; ENSMUSG00000051149
ENSMUST00000088001; ENSMUSP00000085316; ENSMUSG00000051149

Database of genes from NCBI RefSeq genomes

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GeneIDi
11538

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:11538

UCSC genome browser

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UCSCi
uc008oaq.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005039 Genomic DNA No translation available.
AF068198 mRNA Translation: AAD19843.1
CCDSiCCDS38342.1
RefSeqiNP_001297015.1, NM_001310086.1
NP_033758.2, NM_009628.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9Z103, 2 interactors
MINTiQ9Z103
STRINGi10090.ENSMUSP00000085316

PTM databases

iPTMnetiQ9Z103
PhosphoSitePlusiQ9Z103

Proteomic databases

EPDiQ9Z103
jPOSTiQ9Z103
MaxQBiQ9Z103
PaxDbiQ9Z103
PeptideAtlasiQ9Z103
PRIDEiQ9Z103
ProteomicsDBi285555

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1423, 351 antibodies

The DNASU plasmid repository

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DNASUi
11538

Genome annotation databases

EnsembliENSMUST00000057793; ENSMUSP00000056809; ENSMUSG00000051149
ENSMUST00000088001; ENSMUSP00000085316; ENSMUSG00000051149
GeneIDi11538
KEGGimmu:11538
UCSCiuc008oaq.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23394
MGIiMGI:1338758, Adnp
VEuPathDBiHostDB:ENSMUSG00000051149

Phylogenomic databases

eggNOGiENOG502QSYX, Eukaryota
GeneTreeiENSGT00530000063631
InParanoidiQ9Z103
OMAiPYCTFNG
OrthoDBi135860at2759
PhylomeDBiQ9Z103
TreeFamiTF328818

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11538, 7 hits in 64 CRISPR screens

Protein Ontology

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PROi
PR:Q9Z103
RNActiQ9Z103, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000051149, Expressed in forelimb bud and 91 other tissues

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR038861, ADNP/ADNP2
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR013087, Znf_C2H2_type
PANTHERiPTHR15740, PTHR15740, 1 hit
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADNP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z103
Secondary accession number(s): A2BDX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 14, 2015
Last modified: September 29, 2021
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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