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Protein

Krueppel-like factor 5

Gene

Klf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri362 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 416C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri422 – 444C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • cell-cell signaling via exosome Source: MGI
  • cellular response to leukemia inhibitory factor Source: MGI
  • cellular response to organic cyclic compound Source: Ensembl
  • cellular response to peptide Source: Ensembl
  • intestinal epithelial cell development Source: MGI
  • microvillus assembly Source: MGI
  • negative regulation of cardiac vascular smooth muscle cell differentiation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of microvillus assembly Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • skeletal muscle cell differentiation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 5
Alternative name(s):
Basic transcription element-binding protein 2
Short name:
BTE-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene namesi
Name:Klf5
Synonyms:Bteb2, Iklf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1338056 Klf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471701 – 446Krueppel-like factor 5Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9Z0Z7
PaxDbiQ9Z0Z7
PeptideAtlasiQ9Z0Z7
PRIDEiQ9Z0Z7

PTM databases

iPTMnetiQ9Z0Z7
PhosphoSitePlusiQ9Z0Z7

Expressioni

Tissue specificityi

Highest expression in digestive track.

Gene expression databases

BgeeiENSMUSG00000005148
CleanExiMM_KLF5
ExpressionAtlasiQ9Z0Z7 baseline and differential
GenevisibleiQ9Z0Z7 MM

Interactioni

Subunit structurei

Interacts with WWP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXW7Q969H02EBI-647919,EBI-359574From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198396, 6 interactors
CORUMiQ9Z0Z7
DIPiDIP-49582N
IntActiQ9Z0Z7, 6 interactors
MINTiQ9Z0Z7
STRINGi10090.ENSMUSP00000005279

Structurei

3D structure databases

ProteinModelPortaliQ9Z0Z7
SMRiQ9Z0Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni313 – 317Interaction with WWP1By similarity5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri362 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 416C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri422 – 444C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000261607
HOVERGENiHBG003474
InParanoidiQ9Z0Z7
KOiK09206
OMAiMPNQFLQ
OrthoDBiEOG091G1BN0
PhylomeDBiQ9Z0Z7
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR030401 KLF5
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44295:SF4 PTHR44295:SF4, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9Z0Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTRVLTMSA RLGPLPQPPA AQDEPVFAQL KPVLGAANPA RDAALFSGDD
60 70 80 90 100
LKHAHHHPPA PPPAAGPRLP SEELVQTRCE MEKYLTPQLP PVPIISEHKK
110 120 130 140 150
YRRDSASVVD QFFTDTEGIP YSINMNVFLP DITHLRTGLY KSQRPCVTQI
160 170 180 190 200
KTEPVTIFSH QSESTAPPPP PAPTQALPEF TSIFSSHQTT APPQEVNNIF
210 220 230 240 250
IKQELPIPDL HLSVPSQQGH LYQLLNTPDL DMPSSTNQTA VMDTLNVSMA
260 270 280 290 300
GLNPHPSAVP QTSMKQFQGM PPCTYTMPSQ FLPQQATYFP PSPPSSEPGS
310 320 330 340 350
PDRQAEMLQN LTPPPSYAAT IASKLAIHNP NLPATLPVNS PTLPPVRYNR
360 370 380 390 400
RSNPDLEKRR IHFCDYNGCT KVYTKSSHLK AHLRTHTGEK PYKCTWEGCD
410 420 430 440
WRFARSDELT RHYRKHTGAK PFQCMVCQRS FSRSDHLALH MKRHQN
Length:446
Mass (Da):49,754
Last modified:January 23, 2002 - v2
Checksum:iD8D1DBB952448AC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → A in AAD17696 (PubMed:10767086).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079852 mRNA Translation: AAD17696.1
AB025099 mRNA Translation: BAA92284.3
BC012958 mRNA Translation: AAH12958.1
CCDSiCCDS27311.1
RefSeqiNP_033899.2, NM_009769.4
UniGeneiMm.30262

Genome annotation databases

EnsembliENSMUST00000005279; ENSMUSP00000005279; ENSMUSG00000005148
GeneIDi12224
KEGGimmu:12224
UCSCiuc007uvf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKLF5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0Z7
Secondary accession number(s): Q9JMI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: June 20, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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