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Entry version 141 (17 Jun 2020)
Sequence version 3 (16 May 2006)
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Protein

Voltage-dependent T-type calcium channel subunit alpha-1I

Gene

Cacna1i

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei355Calcium ion selectivity and permeabilityBy similarity1
Sitei779Calcium ion selectivity and permeabilityBy similarity1
Sitei1339Calcium ion selectivity and permeabilityBy similarity1
Sitei1637Calcium ion selectivity and permeabilityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1I
Alternative name(s):
CaVT.3
Voltage-gated calcium channel subunit alpha Cav3.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1i
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
68944 Cacna1i

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97Helical; Name=S1 of repeat ISequence analysisAdd BLAST21
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 137Helical; Name=S2 of repeat ISequence analysisAdd BLAST22
Topological domaini138 – 146CytoplasmicSequence analysis9
Transmembranei147 – 166Helical; Name=S3 of repeat ISequence analysisAdd BLAST20
Topological domaini167 – 171ExtracellularSequence analysis5
Transmembranei172 – 189Helical; Name=S4 of repeat ISequence analysisAdd BLAST18
Topological domaini190 – 209CytoplasmicSequence analysisAdd BLAST20
Transmembranei210 – 230Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini231 – 371ExtracellularSequence analysisAdd BLAST141
Transmembranei372 – 396Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini397 – 598CytoplasmicSequence analysisAdd BLAST202
Transmembranei599 – 619Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini620 – 632ExtracellularSequence analysisAdd BLAST13
Transmembranei633 – 654Helical; Name=S2 of repeat IISequence analysisAdd BLAST22
Topological domaini655 – 660CytoplasmicSequence analysis6
Transmembranei661 – 679Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini680 – 687ExtracellularSequence analysis8
Transmembranei688 – 711Helical; Name=S4 of repeat IISequence analysisAdd BLAST24
Topological domaini712 – 722CytoplasmicSequence analysisAdd BLAST11
Transmembranei723 – 743Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini744 – 795ExtracellularSequence analysisAdd BLAST52
Transmembranei796 – 820Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini821 – 1125CytoplasmicSequence analysisAdd BLAST305
Transmembranei1126 – 1148Helical; Name=S1 of repeat IIISequence analysisAdd BLAST23
Topological domaini1149 – 1166ExtracellularSequence analysisAdd BLAST18
Transmembranei1167 – 1187Helical; Name=S2 of repeat IIISequence analysisAdd BLAST21
Topological domaini1188 – 1197CytoplasmicSequence analysis10
Transmembranei1198 – 1217Helical; Name=S3 of repeat IIISequence analysisAdd BLAST20
Topological domaini1218 – 1231ExtracellularSequence analysisAdd BLAST14
Transmembranei1232 – 1253Helical; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1254 – 1263CytoplasmicSequence analysis10
Transmembranei1264 – 1287Helical; Name=S5 of repeat IIISequence analysisAdd BLAST24
Topological domaini1288 – 1364ExtracellularSequence analysisAdd BLAST77
Transmembranei1365 – 1390Helical; Name=S6 of repeat IIISequence analysisAdd BLAST26
Topological domaini1391 – 1445CytoplasmicSequence analysisAdd BLAST55
Transmembranei1446 – 1466Helical; Name=S1 of repeat IVSequence analysisAdd BLAST21
Topological domaini1467 – 1480ExtracellularSequence analysisAdd BLAST14
Transmembranei1481 – 1502Helical; Name=S2 of repeat IVSequence analysisAdd BLAST22
Topological domaini1503 – 1509CytoplasmicSequence analysis7
Transmembranei1510 – 1528Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1529 – 1542ExtracellularSequence analysisAdd BLAST14
Transmembranei1543 – 1566Helical; Name=S4 of repeat IVSequence analysisAdd BLAST24
Topological domaini1567 – 1580CytoplasmicSequence analysisAdd BLAST14
Transmembranei1581 – 1601Helical; Name=S5 of repeat IVSequence analysisAdd BLAST21
Topological domaini1602 – 1664ExtracellularSequence analysisAdd BLAST63
Transmembranei1665 – 1692Helical; Name=S6 of repeat IVSequence analysisAdd BLAST28
Topological domaini1693 – 1835CytoplasmicSequence analysisAdd BLAST143

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5459

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
537

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539581 – 2201Voltage-dependent T-type calcium channel subunit alpha-1IAdd BLAST2201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1017PhosphoserineCombined sources1
Glycosylationi1301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1304N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0Y8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z0Y8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z0Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z0Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000046091

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati64 – 399IAdd BLAST336
Repeati584 – 823IIAdd BLAST240
Repeati1116 – 1393IIIAdd BLAST278
Repeati1431 – 1692IVAdd BLAST262

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2302 Eukaryota
ENOG410XNP6 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z0Y8

KEGG Orthology (KO)

More...
KOi
K04856

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z0Y8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030162 CACNA1I
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR043203 VGCC_Ca_Na
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037 PTHR10037, 1 hit
PTHR10037:SF209 PTHR10037:SF209, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01629 TVDCCALPHA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z0Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADSNLPPSS AAAPAPEPGI TEQPGPRSPP PSPPGLEEPL EGTNPDVPHP
60 70 80 90 100
DLAPVAFFCL RQTTSPRNWC IKMVCNPWFE CVSMLVILLN CVTLGMYQPC
110 120 130 140 150
DDMECLSDRC KILQVFDDFI FIFFAMEMVL KMVALGIFGK KCYLGDTWNR
160 170 180 190 200
LDFFIVMAGM VEYSLDLQNI NLSAIRTVRV LRPLKAINRV PSMRILVNLL
210 220 230 240 250
LDTLPMLGNV LLLCFFVFFI FGIIGVQLWA GLLRNRCFLE ENFTIQGDVA
260 270 280 290 300
LPPYYQPEED DEMPFICSLT GDNGIMGCHE IPPLKEQGRE CCLSKDDVYD
310 320 330 340 350
FGAGRQDLNA SGLCVNWNRY YNVCRTGNAN PHKGAINFDN IGYAWIVIFQ
360 370 380 390 400
VITLEGWVEI MYYVMDAHSF YNFIYFILLI IVGSFFMINL CLVVIATQFS
410 420 430 440 450
ETKQREHRLM LEQRQRYLSS STVASYAEPG DCYEEIFQYV CHILRKAKRR
460 470 480 490 500
ALGLYQALQN RRQAMGPGTP APAKPGPHAK EPSHCKLCPR HSPLDPTPHT
510 520 530 540 550
LVQPISAILA SDPSSCPHCQ HEAGRRPSGL GSTDSGQEGS GSGGSAEAEA
560 570 580 590 600
NGDGPQSSED GVSSDLGKEE EQEDGAARLC GDVWRETREK LRGIVDSKYF
610 620 630 640 650
NRGIMMAILV NTVSMGIEHH EQPEELTNIL EICNVVFTSM FALEMILKLA
660 670 680 690 700
AFGLFDYLRN PYNIFDSIIV IISIWEIVGQ ADGGLSVLRT FRLLRVLKLV
710 720 730 740 750
RFMPALRRQL VVLMKTMDNV ATFCMLLMLF IFIFSILGMH IFGCKFSLRT
760 770 780 790 800
DTGDTVPDRK NFDSLLWAIV TVFQILTQED WNVVLYNGMA STTPWASLYF
810 820 830 840 850
VALMTFGNYV LFNLLVAILV EGFQAEGDAN RSYSDEDQSS SNLEEFDKLP
860 870 880 890 900
EGLDNSRDLK LCPIPMTPNG HLDPSLPLGA HLGPAGTMGT APRLSLQPDP
910 920 930 940 950
VLVALDSRKS SVMSLGRMSY DQRSLSSSRS SYYGPWGRSG TWASRRSSWN
960 970 980 990 1000
SLKHKPPSAE HESLLSGEGG GSCVRACEGA REEAPTRTAP LHAPHAHHAH
1010 1020 1030 1040 1050
HGPHLAHRHR HHRRTLSLDT RDSVDLGELV PVVGAHSRAA WRGAGQAPGH
1060 1070 1080 1090 1100
EDCNGRMPNI AKDVFTKMDD CRDRGEDEEE IDYTLCFRVR KMIDVYKPDW
1110 1120 1130 1140 1150
CEVREDWSVY LFSPENKFRI LCQTIIAHKL FDYVVLAFIF LNCITIALER
1160 1170 1180 1190 1200
PQIEAGSTER IFLTVSNYIF TAIFVGEMTL KVVSLGLYFG EQAYLRSSWN
1210 1220 1230 1240 1250
VLDGFLVFVS IIDIVVSVAS AGGAKILGVL RVLRLLRTLR PLRVISRAPG
1260 1270 1280 1290 1300
LKLVVETLIS SLKPIGNIVL ICCAFFIIFG ILGVQLFKGK FYHCLGVDTR
1310 1320 1330 1340 1350
NITNRSDCVA ANYRWVHHKY NFDNLGQALM SLFVLASKDG WVNIMYNGLD
1360 1370 1380 1390 1400
AVAVDQQPVT NHNPWMLLYF ISFLLIVSFF VLNMFVGVVV ENFHKCRQHQ
1410 1420 1430 1440 1450
EAEEARRREE KRLRRLEKKR RKAQRLPYYA TYCPTRLLIH SMCTSHYLDI
1460 1470 1480 1490 1500
FITFIICLNV VTMSLEHYNQ PTSLETALKY CNYMFTTVFV LEAVLKLVAF
1510 1520 1530 1540 1550
GLRRFFKDRW NQLDLAIVLL SVMGITLEEI EINAALPINP TIIRIMRVLR
1560 1570 1580 1590 1600
IARVLKLLKM ATGMRALLDT VVQALPQVGN LGLLFMLLFF IYAALGVELF
1610 1620 1630 1640 1650
GKLVCNDENP CEGMSRHATF ENFGMAFLTL FQVSTGDNWN GIMKDTLRDC
1660 1670 1680 1690 1700
THDERSCLSS LQFVSPLYFV SFVLTAQFVL INVVVAVLMK HLDDSNKEAQ
1710 1720 1730 1740 1750
EDAEMDAEIE LEMAHGLGPC PGPCPGPCPC PWPLAPVLAR GCPLVLLGAT
1760 1770 1780 1790 1800
GARIGRGRCW RRHRESPVPS TRYSPAQETL WLDSVSLIIK DSLEGELTII
1810 1820 1830 1840 1850
DNLSGSVFHH YASPDGCGKC HHDKQEVQLA ETEAFSLNSD RSSSILLGDD
1860 1870 1880 1890 1900
LSLEDPTACP PGRKDSKGEL DPPEPMRVGD LGECFFPLSS TAVSPDPENF
1910 1920 1930 1940 1950
LCEMEEIPFN PVQSWLKHDS SQAPPSPFSP DGSSPLLQMP AEFFHPAVSA
1960 1970 1980 1990 2000
SQKGPEKGTG TGTLPKIALQ GSWASLRSPS VNCTLLRQAT GSDTSLDASP
2010 2020 2030 2040 2050
SSSAGSLQTT LEDSLTLSDS PRRALGPPVQ VPGPRASLSP ATRRRLSLRG
2060 2070 2080 2090 2100
RGLFSLRGLR AHQRSHSSGG STSPGCTHHD SMDPSDEEGR GGAGGGGAGS
2110 2120 2130 2140 2150
EHSETLSSLS LTSLFCLPPT LPPPGLTPAR KFNSTSSLAA GPGRPGSTVS
2160 2170 2180 2190 2200
ARGLVRSPSW AADRSKDPPG QAQLVSGLGS SAPGPQPPPG ESTDAASKRK

R
Length:2,201
Mass (Da):243,693
Last modified:May 16, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5791A4FDD7B882FE
GO
Isoform 2 (identifier: Q9Z0Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1732-1772: WPLAPVLARG...HRESPVPSTR → CPCPCPGPRL...DTESHLCRHC
     1827-1837: VQLAETEAFSL → TGLHPSCWGMT
     1838-2201: Missing.

Show »
Length:1,835
Mass (Da):205,342
Checksum:i1C6E482E29848F55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti555P → L in AAD17796 (PubMed:10066244).Curated1
Sequence conflicti589E → K in AAD17796 (PubMed:10066244).Curated1
Sequence conflicti833Y → C in AAD17796 (PubMed:10066244).Curated1
Sequence conflicti1071C → R in AAD17796 (PubMed:10066244).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0183471732 – 1772WPLAP…VPSTR → CPCPCPGPRLPTSSPGAPGR GSGGAGAGGDTESHLCRHC in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0183481827 – 1837VQLAETEAFSL → TGLHPSCWGMT in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0183491838 – 2201Missing in isoform 2. 1 PublicationAdd BLAST364

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF086827 mRNA Translation: AAD17796.2
AF290214 mRNA Translation: AAG35188.4

NCBI Reference Sequences

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RefSeqi
NP_064469.3, NM_020084.3 [Q9Z0Y8-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
56827

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:56827

UCSC genome browser

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UCSCi
RGD:68944 rat [Q9Z0Y8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086827 mRNA Translation: AAD17796.2
AF290214 mRNA Translation: AAG35188.4
RefSeqiNP_064469.3, NM_020084.3 [Q9Z0Y8-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046091

Chemistry databases

ChEMBLiCHEMBL5459
GuidetoPHARMACOLOGYi537

PTM databases

iPTMnetiQ9Z0Y8
PhosphoSitePlusiQ9Z0Y8

Proteomic databases

PaxDbiQ9Z0Y8
PRIDEiQ9Z0Y8

Genome annotation databases

GeneIDi56827
KEGGirno:56827
UCSCiRGD:68944 rat [Q9Z0Y8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8911
RGDi68944 Cacna1i

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
InParanoidiQ9Z0Y8
KOiK04856
OrthoDBi172471at2759
PhylomeDBiQ9Z0Y8

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9Z0Y8

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR030162 CACNA1I
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR043203 VGCC_Ca_Na
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037 PTHR10037, 1 hit
PTHR10037:SF209 PTHR10037:SF209, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01629 TVDCCALPHA1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1I_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0Y8
Secondary accession number(s): Q9EQ59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: June 17, 2020
This is version 141 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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