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Protein

Dynactin subunit 3

Gene

Dctn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with dynein may be involved in spindle assembly and cytokinesis.By similarity

GO - Biological processi

  • cytoskeleton-dependent cytokinesis Source: UniProtKB
  • microtubule-based process Source: MGI

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 3
Alternative name(s):
Dynactin light chain p24
Gene namesi
Name:Dctn3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1859251 Dctn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002256042 – 186Dynactin subunit 3Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z0Y1
MaxQBiQ9Z0Y1
PaxDbiQ9Z0Y1
PeptideAtlasiQ9Z0Y1
PRIDEiQ9Z0Y1

PTM databases

iPTMnetiQ9Z0Y1
PhosphoSitePlusiQ9Z0Y1

Expressioni

Gene expression databases

BgeeiENSMUSG00000028447 Expressed in 284 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_DCTN3
ExpressionAtlasiQ9Z0Y1 baseline and differential
GenevisibleiQ9Z0Y1 MM

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein.

Protein-protein interaction databases

BioGridi207318, 73 interactors
IntActiQ9Z0Y1, 73 interactors
MINTiQ9Z0Y1
STRINGi10090.ENSMUSP00000030158

Structurei

3D structure databases

ProteinModelPortaliQ9Z0Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili46 – 66Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the dynactin subunit 3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXN7 Eukaryota
ENOG410Y8FP LUCA
GeneTreeiENSGT00390000016210
HOGENOMiHOG000231666
HOVERGENiHBG053181
InParanoidiQ9Z0Y1
KOiK10425
OMAiYNKMMFL
OrthoDBiEOG091G0MGW
PhylomeDBiQ9Z0Y1
TreeFamiTF105248

Family and domain databases

InterProiView protein in InterPro
IPR009991 Dynactin_p22
PfamiView protein in Pfam
PF07426 Dynactin_p22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z0Y1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALTDVQRL QSRVEELERW VYGPGGTRGS RKVADGLVKV QVALGNIASK
60 70 80 90 100
RERVKILYKK IEDLIKYLDP EYIDRIAIPE ASKLQFILAE EQFILSQVAL
110 120 130 140 150
LEQVNALVPV LDSASIKAVP EHAARLQRLA QIHIQQQDQC VAITEESKAL
160 170 180
LEGYNKTTML LSKQFVQWDE LLCQLEAAKQ VKPAEE
Length:186
Mass (Da):20,978
Last modified:March 7, 2006 - v2
Checksum:i2630EA16F629D414
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q919E9Q919_MOUSE
Dynactin subunit 3
Dctn3
159Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → G in BAB27872 (PubMed:16141072).Curated1
Sequence conflicti131Q → E in AAD16226 (PubMed:9786090).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098508 mRNA Translation: AAD16226.1
AK003255 mRNA Translation: BAB22671.1
AK002720 mRNA Translation: BAB22307.1
AK011840 mRNA Translation: BAB27872.1
AK159344 mRNA Translation: BAE35006.1
BC061120 mRNA Translation: AAH61120.1
CCDSiCCDS18069.1
RefSeqiNP_001153037.1, NM_001159565.1
NP_058586.3, NM_016890.4
UniGeneiMm.29025

Genome annotation databases

EnsembliENSMUST00000030158; ENSMUSP00000030158; ENSMUSG00000028447
GeneIDi53598
KEGGimmu:53598
UCSCiuc008sji.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098508 mRNA Translation: AAD16226.1
AK003255 mRNA Translation: BAB22671.1
AK002720 mRNA Translation: BAB22307.1
AK011840 mRNA Translation: BAB27872.1
AK159344 mRNA Translation: BAE35006.1
BC061120 mRNA Translation: AAH61120.1
CCDSiCCDS18069.1
RefSeqiNP_001153037.1, NM_001159565.1
NP_058586.3, NM_016890.4
UniGeneiMm.29025

3D structure databases

ProteinModelPortaliQ9Z0Y1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207318, 73 interactors
IntActiQ9Z0Y1, 73 interactors
MINTiQ9Z0Y1
STRINGi10090.ENSMUSP00000030158

PTM databases

iPTMnetiQ9Z0Y1
PhosphoSitePlusiQ9Z0Y1

Proteomic databases

EPDiQ9Z0Y1
MaxQBiQ9Z0Y1
PaxDbiQ9Z0Y1
PeptideAtlasiQ9Z0Y1
PRIDEiQ9Z0Y1

Protocols and materials databases

DNASUi53598
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030158; ENSMUSP00000030158; ENSMUSG00000028447
GeneIDi53598
KEGGimmu:53598
UCSCiuc008sji.2 mouse

Organism-specific databases

CTDi11258
MGIiMGI:1859251 Dctn3

Phylogenomic databases

eggNOGiENOG410IXN7 Eukaryota
ENOG410Y8FP LUCA
GeneTreeiENSGT00390000016210
HOGENOMiHOG000231666
HOVERGENiHBG053181
InParanoidiQ9Z0Y1
KOiK10425
OMAiYNKMMFL
OrthoDBiEOG091G0MGW
PhylomeDBiQ9Z0Y1
TreeFamiTF105248

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:Q9Z0Y1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028447 Expressed in 284 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_DCTN3
ExpressionAtlasiQ9Z0Y1 baseline and differential
GenevisibleiQ9Z0Y1 MM

Family and domain databases

InterProiView protein in InterPro
IPR009991 Dynactin_p22
PfamiView protein in Pfam
PF07426 Dynactin_p22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0Y1
Secondary accession number(s): Q9CR43, Q9D039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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