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Protein

Glucagon-like peptide 2 receptor

Gene

Glp2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • glucagon receptor activity Source: RGD

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • cell surface receptor signaling pathway Source: InterPro
  • homeostatic process Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418555 G alpha (s) signalling events
R-RNO-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:Glp2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620270 Glp2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 173ExtracellularBy similarityAdd BLAST173
Transmembranei174 – 198Helical; Name=1By similarityAdd BLAST25
Topological domaini199 – 210CytoplasmicBy similarityAdd BLAST12
Transmembranei211 – 235Helical; Name=2By similarityAdd BLAST25
Topological domaini236 – 261ExtracellularBy similarityAdd BLAST26
Transmembranei262 – 285Helical; Name=3By similarityAdd BLAST24
Topological domaini286 – 299CytoplasmicBy similarityAdd BLAST14
Transmembranei300 – 321Helical; Name=4By similarityAdd BLAST22
Topological domaini322 – 339ExtracellularBy similarityAdd BLAST18
Transmembranei340 – 362Helical; Name=5By similarityAdd BLAST23
Topological domaini363 – 386CytoplasmicBy similarityAdd BLAST24
Transmembranei387 – 405Helical; Name=6By similarityAdd BLAST19
Topological domaini406 – 417ExtracellularBy similarityAdd BLAST12
Transmembranei418 – 438Helical; Name=7By similarityAdd BLAST21
Topological domaini439 – 550CytoplasmicBy similarityAdd BLAST112

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3822349
GuidetoPHARMACOLOGYi250

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000128391 – 550Glucagon-like peptide 2 receptorAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 105By similarity
Disulfide bondi96 ↔ 137By similarity
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 159By similarity
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0W0
PRIDEiQ9Z0W0

PTM databases

PhosphoSitePlusiQ9Z0W0

Expressioni

Gene expression databases

BgeeiENSRNOG00000003683
GenevisibleiQ9Z0W0 RN

Interactioni

Protein-protein interaction databases

BioGridi248832, 1 interactor
STRINGi10116.ENSRNOP00000004946

Chemistry databases

BindingDBiQ9Z0W0

Structurei

3D structure databases

ProteinModelPortaliQ9Z0W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiQ9Z0W0
KOiK04582
OMAiHEILFSF
OrthoDBiEOG091G0NF8
PhylomeDBiQ9Z0W0
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR039125 GLP2R
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF269 PTHR12011:SF269, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPQPSPAVP SRCREAPVPR VRAQPVGIPE AQGPVPLHSQ QMRLLWGPGR
60 70 80 90 100
PFLALLLLVS IKQVTGSLLK ETTQKWANYK EKCLEDLHNR LSGIFCNGTF
110 120 130 140 150
DRYVCWPHSY PGNVSVPCPS YLPWWNAESP GRAYRHCLAQ GTWQTRENTT
160 170 180 190 200
DIWQDESECS ENHSFRQNVD HYALLYTLQL MYTVGYSVSL ISLFLALTLF
210 220 230 240 250
LFLRKLHCTR NYIHMNLFAS FILKVLAVLV KDMVSHNSYS KRPDDESGWM
260 270 280 290 300
SYLSETSVSC RSVQVLLHYF VGTNHLWLLV EGLYLHTLLE PTVFPERRLW
310 320 330 340 350
PKYLVVGWAF PMLFVIPWGF ARAHLENTRC WATNGNLKIW WIIRGPMLLC
360 370 380 390 400
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLLL IPLLGVHEVL
410 420 430 440 450
FTFFPDDQVQ GFSKRIRLFI QLTLSSVHGF LVALQYGFAN GEVKAELRKS
460 470 480 490 500
WGRFLLARHW GCRTCVLGKN FRFLGKCSKK LSEGDGSETL QKLRFSTCSS
510 520 530 540 550
HLASETLGDV GVQPHRGRGA WPRGSSLSES SEGDFTLANT MEEILEESEI
Length:550
Mass (Da):63,102
Last modified:May 1, 1999 - v1
Checksum:i22E269F811E25226
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105368 mRNA Translation: AAD16896.1
RefSeqiNP_068620.1, NM_021848.1
UniGeneiRn.163105

Genome annotation databases

EnsembliENSRNOT00000004946; ENSRNOP00000004946; ENSRNOG00000003683
GeneIDi60432
KEGGirno:60432
UCSCiRGD:620270 rat

Similar proteinsi

Entry informationi

Entry nameiGLP2R_RAT
AccessioniPrimary (citable) accession number: Q9Z0W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: July 18, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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