UniProtKB - Q9Z0U9 (S1PR3_MOUSE)
Protein
Sphingosine 1-phosphate receptor 3
Gene
S1pr3
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- integrin binding Source: MGI
- sphingosine-1-phosphate receptor activity Source: InterPro
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- cytokine production Source: MGI
- inflammatory response Source: MGI
- negative regulation of establishment of endothelial barrier Source: MGI
- Notch signaling pathway Source: MGI
- regulation of interleukin-1 beta production Source: MGI
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-419408, Lysosphingolipid and LPA receptors R-MMU-9009391, Extra-nuclear estrogen signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Sphingosine 1-phosphate receptor 3Short name: S1P receptor 3 Short name: S1P3 Alternative name(s): Endothelial differentiation G-protein coupled receptor 3 Lysophospholipid receptor B3 Sphingosine 1-phosphate receptor Edg-3 Short name: S1P receptor Edg-3 |
Gene namesi | Name:S1pr3 Synonyms:Edg3, Lpb3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339365, S1pr3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | ExtracellularBy similarityAdd BLAST | 44 | |
Transmembranei | 45 – 65 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 66 – 74 | CytoplasmicBy similarity | 9 | |
Transmembranei | 75 – 95 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 96 – 115 | ExtracellularBy similarityAdd BLAST | 20 | |
Transmembranei | 116 – 136 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 137 – 154 | CytoplasmicBy similarityAdd BLAST | 18 | |
Transmembranei | 155 – 175 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 176 – 196 | ExtracellularBy similarityAdd BLAST | 21 | |
Transmembranei | 197 – 217 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 218 – 244 | CytoplasmicBy similarityAdd BLAST | 27 | |
Transmembranei | 245 – 265 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 266 – 281 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 282 – 302 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 303 – 378 | CytoplasmicBy similarityAdd BLAST | 76 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069422 | 1 – 378 | Sphingosine 1-phosphate receptor 3Add BLAST | 378 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 15 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 326 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q9Z0U9 |
PaxDbi | Q9Z0U9 |
PRIDEi | Q9Z0U9 |
PTM databases
GlyGeni | Q9Z0U9, 1 site |
iPTMneti | Q9Z0U9 |
PhosphoSitePlusi | Q9Z0U9 |
Expressioni
Tissue specificityi
Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000067586, Expressed in tracheobronchial tree and 284 other tissues |
Genevisiblei | Q9Z0U9, MM |
Interactioni
GO - Molecular functioni
- integrin binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000085293 |
Miscellaneous databases
RNActi | Q9Z0U9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R61K, Eukaryota |
GeneTreei | ENSGT00970000193365 |
HOGENOMi | CLU_047979_1_0_1 |
InParanoidi | Q9Z0U9 |
OMAi | DVACRVK |
OrthoDBi | 981486at2759 |
PhylomeDBi | Q9Z0U9 |
TreeFami | TF330052 |
Family and domain databases
InterProi | View protein in InterPro IPR004062, EDG3_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01524, EDG3RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Z0U9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTHAQGHQ PVLGNDTLRE HYDYVGKLAG RLRDPPEGGT LITTILFLVT
60 70 80 90 100
CSFIVLENLM VLIAIWKNNK FHNRMYFFIG NLALCDLLAG IAYKVNILMS
110 120 130 140 150
GRKTFSLSPT VWFLREGSMF VALGASTCSL LAIAIERHLT MIKMRPYDAN
160 170 180 190 200
KKHRVFLLIG MCWLIAFSLG ALPILGWNCL ENFPDCSTIL PLYSKKYIAF
210 220 230 240 250
LISIFTAILV TIVILYARIY CLVKSSSRRV ANHNSERSMA LLRTVVIVVS
260 270 280 290 300
VFIACWSPLF ILFLIDVACR AKECSILFKS QWFIMLAVLN SAMNPVIYTL
310 320 330 340 350
ASKEMRRAFF RLVCGCLVKG KGTQASPMQP ALDPSRSKSS SSNNSSHSPK
360 370
VKEDLPRVAT SSCIIDKNRS FQNGVLCK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | S → R in BAC37277 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF108021 Genomic DNA Translation: AAD16977.1 AK028043 mRNA Translation: BAC25715.1 AK029852 mRNA Translation: BAC26645.1 AK030134 mRNA Translation: BAC26800.1 AK047268 mRNA Translation: BAC33008.1 AK081919 mRNA Translation: BAC38373.1 AK084944 mRNA Translation: BAC39316.1 AK085180 mRNA Translation: BAC39383.1 AK078443 mRNA Translation: BAC37277.1 AB028143 mRNA Translation: BAA78207.1 BC064007 mRNA Translation: AAH64007.1 BC068176 mRNA Translation: AAH68176.1 |
CCDSi | CCDS26512.1 |
RefSeqi | NP_034231.1, NM_010101.4 |
Genome annotation databases
Ensembli | ENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586 |
GeneIDi | 13610 |
KEGGi | mmu:13610 |
UCSCi | uc007qmf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF108021 Genomic DNA Translation: AAD16977.1 AK028043 mRNA Translation: BAC25715.1 AK029852 mRNA Translation: BAC26645.1 AK030134 mRNA Translation: BAC26800.1 AK047268 mRNA Translation: BAC33008.1 AK081919 mRNA Translation: BAC38373.1 AK084944 mRNA Translation: BAC39316.1 AK085180 mRNA Translation: BAC39383.1 AK078443 mRNA Translation: BAC37277.1 AB028143 mRNA Translation: BAA78207.1 BC064007 mRNA Translation: AAH64007.1 BC068176 mRNA Translation: AAH68176.1 |
CCDSi | CCDS26512.1 |
RefSeqi | NP_034231.1, NM_010101.4 |
3D structure databases
SMRi | Q9Z0U9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000085293 |
Chemistry databases
GuidetoPHARMACOLOGYi | 277 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9Z0U9, 1 site |
iPTMneti | Q9Z0U9 |
PhosphoSitePlusi | Q9Z0U9 |
Proteomic databases
MaxQBi | Q9Z0U9 |
PaxDbi | Q9Z0U9 |
PRIDEi | Q9Z0U9 |
Protocols and materials databases
Antibodypediai | 13485, 523 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586 |
GeneIDi | 13610 |
KEGGi | mmu:13610 |
UCSCi | uc007qmf.2, mouse |
Organism-specific databases
CTDi | 1903 |
MGIi | MGI:1339365, S1pr3 |
Phylogenomic databases
eggNOGi | ENOG502R61K, Eukaryota |
GeneTreei | ENSGT00970000193365 |
HOGENOMi | CLU_047979_1_0_1 |
InParanoidi | Q9Z0U9 |
OMAi | DVACRVK |
OrthoDBi | 981486at2759 |
PhylomeDBi | Q9Z0U9 |
TreeFami | TF330052 |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-419408, Lysosphingolipid and LPA receptors R-MMU-9009391, Extra-nuclear estrogen signaling |
Miscellaneous databases
BioGRID-ORCSi | 13610, 0 hits in 17 CRISPR screens |
ChiTaRSi | S1pr3, mouse |
PROi | PR:Q9Z0U9 |
RNActi | Q9Z0U9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000067586, Expressed in tracheobronchial tree and 284 other tissues |
Genevisiblei | Q9Z0U9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004062, EDG3_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01524, EDG3RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S1PR3_MOUSE | |
Accessioni | Q9Z0U9Primary (citable) accession number: Q9Z0U9 Secondary accession number(s): Q8BP20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries