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Protein

Gamma-aminobutyric acid type B receptor subunit 1

Gene

Gabbr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872315, PubMed:9872317, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:9872317, PubMed:10658574). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:9872315, PubMed:9872744, PubMed:10924501). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:9069281, PubMed:10457184, PubMed:9872315, PubMed:9872744, PubMed:10924501, PubMed:10692480). Calcium is required for high affinity binding to GABA (PubMed:10692480). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872744, PubMed:10924501, PubMed:10692480). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity).By similarity8 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei246AgonistBy similarity1
Binding sitei269AgonistBy similarity1
Binding sitei286AgonistBy similarity1
Binding sitei366AgonistBy similarity1
Binding sitei394AgonistBy similarity1
Binding sitei465AgonistBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix protein binding Source: CAFA
  • G protein-coupled GABA receptor activity Source: RGD
  • protein heterodimerization activity Source: CAFA
  • transcription factor binding Source: RGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1296041 Activation of G protein gated Potassium channels
R-RNO-418594 G alpha (i) signalling events
R-RNO-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-RNO-977444 GABA B receptor activation
R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 1
Short name:
GABA-B receptor 1
Short name:
GABA-B-R1
Short name:
GABA-BR1
Short name:
GABABR1
Short name:
Gb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gabbr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...
RGDi
621537 Gabbr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 590ExtracellularSequence analysisAdd BLAST574
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei591 – 611Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini612 – 630CytoplasmicSequence analysisAdd BLAST19
Transmembranei631 – 651Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini652 – 666ExtracellularSequence analysisAdd BLAST15
Transmembranei667 – 687Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini688 – 709CytoplasmicSequence analysisAdd BLAST22
Transmembranei710 – 730Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini731 – 797ExtracellularSequence analysisAdd BLAST67
Transmembranei798 – 818Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini819 – 834CytoplasmicSequence analysisAdd BLAST16
Transmembranei835 – 855Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini856 – 863ExtracellularSequence analysis8
Transmembranei864 – 884Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini885 – 991CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi247S → A: No change in the affinity for GABA. 1 Publication1
Mutagenesisi268S → A: No change in the affinity for GABA. 1 Publication1
Mutagenesisi269S → A: Decrease in the affinity for GABA. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2753

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
240

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001295117 – 991Gamma-aminobutyric acid type B receptor subunit 1Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi99 ↔ 144PROSITE-ProRule annotation1 Publication
Disulfide bondi130 ↔ 156PROSITE-ProRule annotation1 Publication
Disulfide bondi219 ↔ 245PROSITE-ProRule annotation
Disulfide bondi375 ↔ 409PROSITE-ProRule annotation
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei903PhosphothreonineBy similarity1
Modified residuei960PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0U4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z0U4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z0U4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z0U4

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q9Z0U4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in tissues including the forebrain, cerebellum, eye, atrium, ventricle, lung, stomach, small intestine, colon, liver, spleen, kidney, urinary bladder and skeletal muscle (PubMed:9875211). Expressed at low levels in testis, and more highly in brain regions (PubMed:9069281). Expression is high the brain regions including cerebral cortical layers, with higher expression in VIb than in the II-V layers, pyramidal CA1-CA3 cell layers and granular cell layers of the hippocampus, granular cell layers of the dentate gyrus, including the caudate, putamen, nucleus accumbens and olfactory tubercle, the granular layer cell layers of the medial habenula, in the cerebellum, predominantly in Purkinje cells, and in the granule cell layer (PubMed:9069281, PubMed:9872315 PubMed:9872744, PubMed:10727622). Also expressed in areas of the brain including the medial geniculate nucleus, substantia nigra, pars compacta, the ventral tegmental area, and in several thalamic, amygdaloid and hypothalamic nuclei, such as the arcuate nucleus of the hypothalamus and mammilary bodies of the hypothalamus (PubMed:9069281, PubMed:9872744). Expressed in the amacrine cell of the retina (PubMed:10924501). Isoform 1A: Expressed in the brain, spinal cord, stomach, testis, adrenal gland, pituitary, spleen and prostate (PubMed:10658574). Isoform 1B: Expressed in the brain, spinal cord, stomach, testis, kidney and liver (PubMed:10658574). Expressed in Isoform 1C: Ubiquitously expressed (PubMed:9875211). Isoform 1D: Expressed in the forebrain, cerebellum, eye, kidney and urinary bladder (PubMed:9875211). Isoform 1E: Ubiquitously expressed with high expression the pyramidal CA1-CA3 cell layers of the hippocampus, the granule cell layers of the dentate gyrus and olfactory tubercle, the whole cortex, and Purkinje cells of the cerebellum (PubMed:10457184). Moderate expression in the granule cell layer of the cerebellum (PubMed:10457184).8 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At E17 during embryonic development, highly expressed in brain regions including the striatum, olfactory bulb, septal nuclei, lateral habenula, pyramidal CA1-CA2 cell layers of the hippocampus and in the neuroepithelial cells of the ventricular zone. On the day of birth, expressed in the regions of the brain including hippocampus, thalamic nuclei, cortex and cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000000774 Expressed in 10 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z0U4 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of GABBR1 and GABBR2 (PubMed:9872315, PubMed:9872317, PubMed:9872744). Homodimers may form, but are inactive (PubMed:9872317). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (PubMed:10924501). Interacts with JAKMIP1 (PubMed:14718537).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Gabbr2O888718EBI-7090268,EBI-7090239

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
249557, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-404 GABA-B receptor complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Z0U4

Protein interaction database and analysis system

More...
IntActi
Q9Z0U4, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9Z0U4

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047788

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1991
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00463

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Z0U4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Z0U4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Z0U4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 95Sushi 1PROSITE-ProRule annotationAdd BLAST67
Domaini97 – 158Sushi 2PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni918 – 946Interaction with ATF41 PublicationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili901 – 955Sequence analysisAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably plays a role in the specificity for G-protein coupling.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1055 Eukaryota
ENOG410XNN1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157642

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016575

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051688

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z0U4

KEGG Orthology (KO)

More...
KOi
K04615

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Z0U4

TreeFam database of animal gene trees

More...
TreeFami
TF313965

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15291 7tmC_GABA-B-R1, 1 hit
cd00033 CCP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR002456 GPCR_3_GABA_rcpt_B1
IPR028082 Peripla_BP_I
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10519 PTHR10519, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF00084 Sushi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit
SSF57535 SSF57535, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
PS50923 SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1EImported (identifier: Q9Z0U4-1) [UniParc]FASTAAdd to basket
Also known as: 1C1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MLLLLLVPLF LRPLGAGGAQ TPNATSEGCQ IIHPPWEGGI RYRGLTRDQV
60 70 80 90 100
KAINFLPVDY EIEYVCRGER EVVGPKVRKC LANGSWTDMD TPSRCVRICS
110 120 130 140 150
KSYLTLENGK VFLTGGDLPA LDGARVEFRC DPDFHLVGSS RSVCSQGQWS
160 170 180 190 200
TPKPHCQVNR TPHSERRAVY IGALFPMSGG WPGGQACQPA VEMALEDVNS
210 220 230 240 250
RRDILPDYEL KLIHHDSKCD PGQATKYLYE LLYNDPIKII LMPGCSSVST
260 270 280 290 300
LVAEAARMWN LIVLSYGSSS PALSNRQRFP TFFRTHPSAT LHNPTRVKLF
310 320 330 340 350
EKWGWKKIAT IQQTTEVFTS TLDDLEERVK EAGIEITFRQ SFFSDPAVPV
360 370 380 390 400
KNLKRQDARI IVGLFYETEA RKVFCEVYKE RLFGKKYVWF LIGWYADNWF
410 420 430 440 450
KTYDPSINCT VEEMTEAVEG HITTEIVMLN PANTRSISNM TSQEFVEKLT
460 470 480 490 500
KRLKRHPEET GGFQEAPLAY DAIWALALAL NKTSGGGGRS GVRLEDFNYN
510 520 530 540 550
NQTITDQIYR AMNSSSFEGV SGHVVFDASG SRMAWTLIEQ LQGGSYKKIG
560 570 580 590 600
YYDSTKDDLS WSKTDKWIGG SPPADQTLVI KTFRFLSQKL FISVSVLSSL
610 620 630 640 650
GIVLAVVCLS FNIYNSHVRY IQNSQPNLNN LTAVGCSLAL AAVFPLGLDG
660 670 680 690 700
YHIGRSQFPF VCQARLWLLG LGFSLGYGSM FTKIWWVHTV FTKKEEKKEW
710 720 730 740 750
RKTLEPWKLY ATVGLLVGMD VLTLAIWQIV DPLHRTIETF AKEEPKEDID
760 770 780 790 800
VSILPQLEHC SSKKMNTWLG ELWSFAVSSD VQRRATVGGD SPICVWPAPE
810 820 830 840 850
SIFYGYKGLL LLLGIFLAYE TKSVSTEKIN DHRAVGMAIY NVAVLCLITA
860 870 880 890 900
PVTMILSSQQ DAAFAFASLA IVFSSYITLV VLFVPKMRRL ITRGEWQSET
910 920 930 940 950
QDTMKTGSST NNNEEEKSRL LEKENRELEK IIAEKEERVS ELRHQLQSRQ
960 970 980 990
QLRSRRHPPT PPDPSGGLPR GPSEPPDRLS CDGSRVHLLY K
Length:991
Mass (Da):111,534
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i012CD293D4B444A2
GO
Isoform 1A (identifier: Q9Z0U4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-801: Missing.

Show »
Length:960
Mass (Da):108,204
Checksum:i05B7FBBCBE9DBF94
GO
Isoform 1B (identifier: Q9Z0U4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: MLLLLLVPLF...PHCQVNRTPH → MGPGGPCTPV...PHPRVPPHPS
     771-801: Missing.

Show »
Length:844
Mass (Da):95,038
Checksum:iB3417F53BE4877E9
GO
Isoform 1C (identifier: Q9Z0U4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: MLLLLLVPLF...PHCQVNRTPH → MGPGGPCTPV...PHPRVPPHPS

Show »
Length:875
Mass (Da):98,368
Checksum:iE7E9EDA9132D37F2
GO
Isoform 1D (identifier: Q9Z0U4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: MLLLLLVPLF...PHCQVNRTPH → MGPGGPCTPV...PHPRVPPHPS
     771-801: Missing.
     935-991: KEERVSELRH...DGSRVHLLYK → VCGDKQPGPPVSEGGLPVVGPSIEV

Show »
Length:812
Mass (Da):90,921
Checksum:i5EFD7B169A727FDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q924M0Q924M0_RAT
GABA type B receptor 1f
Gabbr1 rCG_58602
984Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5D5S8B5D5S8_RAT
GABA-B1j
Gabbr1
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5CC44Q5CC44_RAT
GABA-BR1h receptor
Gabbr1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5CC43Q5CC43_RAT
GABA-BR1i receptor
Gabbr1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JUQ1A0A0G2JUQ1_RAT
Gamma-aminobutyric acid type B rece...
Gabbr1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0020441 – 163MLLLL…NRTPH → MGPGGPCTPVGWPLPLLLVM AAGVAPVWASHSPHLPRPHP RVPPHPS in isoform 1B, isoform 1C and isoform 1D. 2 PublicationsAdd BLAST163
Alternative sequenceiVSP_002045771 – 801Missing in isoform 1A, isoform 1B and isoform 1D. 3 PublicationsAdd BLAST31
Alternative sequenceiVSP_002046935 – 991KEERV…HLLYK → VCGDKQPGPPVSEGGLPVVG PSIEV in isoform 1D. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y10369 mRNA Translation: CAA71398.1
Y10370 mRNA Translation: CAA71399.1
AB016160 mRNA Translation: BAA34708.1
AB016161 mRNA Translation: BAA34709.1
AF110797, AF110796 Genomic DNA Translation: AAD19656.1
AF110797, AF110796 Genomic DNA Translation: AAD19657.1
AF110797, AF110796 Genomic DNA Translation: AAD19658.1
AF110797, AF110796 Genomic DNA Translation: AAD19659.1

NCBI Reference Sequences

More...
RefSeqi
NP_112290.2, NM_031028.3 [Q9Z0U4-2]
XP_006255941.1, XM_006255879.3 [Q9Z0U4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.30059

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000051634; ENSRNOP00000047498; ENSRNOG00000000774 [Q9Z0U4-2]
ENSRNOT00000082545; ENSRNOP00000075630; ENSRNOG00000000774 [Q9Z0U4-5]
ENSRNOT00000084582; ENSRNOP00000075610; ENSRNOG00000000774 [Q9Z0U4-3]
ENSRNOT00000085050; ENSRNOP00000075181; ENSRNOG00000000774 [Q9Z0U4-4]
ENSRNOT00000088396; ENSRNOP00000072226; ENSRNOG00000000774 [Q9Z0U4-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:81657

UCSC genome browser

More...
UCSCi
RGD:621537 rat [Q9Z0U4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10369 mRNA Translation: CAA71398.1
Y10370 mRNA Translation: CAA71399.1
AB016160 mRNA Translation: BAA34708.1
AB016161 mRNA Translation: BAA34709.1
AF110797, AF110796 Genomic DNA Translation: AAD19656.1
AF110797, AF110796 Genomic DNA Translation: AAD19657.1
AF110797, AF110796 Genomic DNA Translation: AAD19658.1
AF110797, AF110796 Genomic DNA Translation: AAD19659.1
RefSeqiNP_112290.2, NM_031028.3 [Q9Z0U4-2]
XP_006255941.1, XM_006255879.3 [Q9Z0U4-1]
UniGeneiRn.30059

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SRZNMR-A96-159[»]
1SS2NMR-A96-159[»]
DisProtiDP00463
ProteinModelPortaliQ9Z0U4
SMRiQ9Z0U4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249557, 2 interactors
ComplexPortaliCPX-404 GABA-B receptor complex
CORUMiQ9Z0U4
IntActiQ9Z0U4, 2 interactors
MINTiQ9Z0U4
STRINGi10116.ENSRNOP00000047788

Chemistry databases

ChEMBLiCHEMBL2753
GuidetoPHARMACOLOGYi240

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ9Z0U4
PhosphoSitePlusiQ9Z0U4
UniCarbKBiQ9Z0U4

Proteomic databases

PaxDbiQ9Z0U4
PRIDEiQ9Z0U4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051634; ENSRNOP00000047498; ENSRNOG00000000774 [Q9Z0U4-2]
ENSRNOT00000082545; ENSRNOP00000075630; ENSRNOG00000000774 [Q9Z0U4-5]
ENSRNOT00000084582; ENSRNOP00000075610; ENSRNOG00000000774 [Q9Z0U4-3]
ENSRNOT00000085050; ENSRNOP00000075181; ENSRNOG00000000774 [Q9Z0U4-4]
ENSRNOT00000088396; ENSRNOP00000072226; ENSRNOG00000000774 [Q9Z0U4-3]
GeneIDi81657
KEGGirno:81657
UCSCiRGD:621537 rat [Q9Z0U4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2550
RGDi621537 Gabbr1

Phylogenomic databases

eggNOGiKOG1055 Eukaryota
ENOG410XNN1 LUCA
GeneTreeiENSGT00940000157642
HOGENOMiHOG000016575
HOVERGENiHBG051688
InParanoidiQ9Z0U4
KOiK04615
PhylomeDBiQ9Z0U4
TreeFamiTF313965

Enzyme and pathway databases

ReactomeiR-RNO-1296041 Activation of G protein gated Potassium channels
R-RNO-418594 G alpha (i) signalling events
R-RNO-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-RNO-977444 GABA B receptor activation
R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

EvolutionaryTraceiQ9Z0U4

Protein Ontology

More...
PROi
PR:Q9Z0U4

Gene expression databases

BgeeiENSRNOG00000000774 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiQ9Z0U4 baseline and differential

Family and domain databases

CDDicd15291 7tmC_GABA-B-R1, 1 hit
cd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR002456 GPCR_3_GABA_rcpt_B1
IPR028082 Peripla_BP_I
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10519 PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF53822 SSF53822, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
PS50923 SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGABR1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0U4
Secondary accession number(s): O08620
, O08621, Q9Z0F9, Q9Z308
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: December 5, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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