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UniProtKB - Q9Z0U1 (ZO2_MOUSE)

Entry version 193 (29 Sep 2021)
Sequence version 2 (02 May 2006)
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Protein

Tight junction protein ZO-2

Gene

Tjp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in tight junctions and adherens junctions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2028269, Signaling by Hippo
R-MMU-351906, Apoptotic cleavage of cell adhesion proteins
R-MMU-8980692, RHOA GTPase cycle
R-MMU-9013026, RHOB GTPase cycle
R-MMU-9013106, RHOC GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tight junction protein ZO-2
Alternative name(s):
Tight junction protein 2
Zona occludens protein 2
Zonula occludens protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tjp2
Synonyms:Zo2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1341872, Tjp2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000024812

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945441 – 1167Tight junction protein ZO-2Add BLAST1167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107PhosphoserineCombined sources1
Modified residuei127PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei140PhosphoserineCombined sources1
Modified residuei145PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei194PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei239PhosphoserineCombined sources1
Modified residuei305PhosphoserineBy similarity1
Modified residuei378PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei386PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei404PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei411PhosphoserineBy similarity1
Modified residuei435PhosphothreonineBy similarity1
Modified residuei479PhosphoserineCombined sources1
Modified residuei554PhosphotyrosineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei884PhosphoserineCombined sources1
Modified residuei887PhosphothreonineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei902PhosphoserineBy similarity1
Modified residuei907PhosphothreonineBy similarity1
Modified residuei915PhosphothreonineBy similarity1
Modified residuei948PhosphoserineBy similarity1
Modified residuei960PhosphoserineBy similarity1
Modified residuei968PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei1044PhosphoserineBy similarity1
Modified residuei1095PhosphotyrosineCombined sources1
Modified residuei1124PhosphoserineBy similarity1
Modified residuei1136PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Z0U1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Z0U1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Z0U1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Z0U1

PeptideAtlas

More...PeptideAtlasi		Q9Z0U1

PRoteomics IDEntifications database

More...PRIDEi		Q9Z0U1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		275312

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Z0U1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Z0U1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Z0U1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000024812, Expressed in ear vesicle and 306 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Z0U1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Z0U1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with ZO1.

Interacts with UBN1.

Interacts with SCRIB (By similarity).

Interacts with occludin and SAFB. Interaction with SAFB occurs in the nucleus.

Interacts with USP53 (via the C-terminal region) (PubMed:26609154).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		204210, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q9Z0U1, 3 interactors

Molecular INTeraction database

More...MINTi		Q9Z0U1

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000097154

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Z0U1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Z0U1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Z0U1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 97PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini287 – 365PDZ 2PROSITE-ProRule annotationAdd BLAST79
Domaini489 – 570PDZ 3PROSITE-ProRule annotationAdd BLAST82
Domaini584 – 649SH3PROSITE-ProRule annotationAdd BLAST66
Domaini660 – 858Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 195DisorderedSequence analysisAdd BLAST67
Regioni225 – 286DisorderedSequence analysisAdd BLAST62
Regioni381 – 485DisorderedSequence analysisAdd BLAST105
Regioni904 – 1055DisorderedSequence analysisAdd BLAST152
Regioni1095 – 1167DisorderedSequence analysisAdd BLAST73
Regioni1165 – 1167Interaction with SCRIBBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 283Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi385 – 425Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi426 – 448Polar residuesSequence analysisAdd BLAST23
Compositional biasi909 – 923Acidic residuesSequence analysisAdd BLAST15
Compositional biasi938 – 963Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1103 – 1117Pro residuesSequence analysisAdd BLAST15
Compositional biasi1134 – 1148Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3580, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158634

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006234_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Z0U1

Identification of Orthologs from Complete Genome Data

More...OMAi		DTRGSYS

Database of Orthologous Groups

More...OrthoDBi		1175136at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Z0U1

TreeFam database of animal gene trees

More...TreeFami		TF315957

Family and domain databases

Conserved Domains Database

More...CDDi		cd12027, SH3_ZO-2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 3 hits
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR005417, ZO
IPR005419, ZO-2
IPR035598, ZO-2_SH3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF00595, PDZ, 3 hits
PF07653, SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01597, ZONOCCLUDNS
PR01599, ZONOCCLUDNS2

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00072, GuKc, 1 hit
SM00228, PDZ, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 3 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS50106, PDZ, 3 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z0U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEVIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG 
        60         70         80         90        100
PADGLLQEND RVVMVNGTPM EDVLHSFAVQ QLRKSGKIAA IVVKRPRKVQ 
       110        120        130        140        150
VAPLQGSPPL SHDDRGFEVI EEFDGRSFRS GYSERSRHSS HDMLSHSWEG 
       160        170        180        190        200
NRERGRPHQR TQSRERERSR GRSLERGLDQ EDYGRSRERS RGRSLERGLD 
       210        220        230        240        250
RDFVSRDHSR GRSIDRDYDR DYERSYHEAY EPDYGGGYSP SYDRRAHPET 
       260        270        280        290        300
RYERSRSREH LRSRSPSPES RSRHEHKGQH DPDRPIGVLL TKSKANEEYG 
       310        320        330        340        350
LRLGSQIFIK EMTRTGLATK DGNLHEGDII LKINGTVTEN MSLTDARKLI 
       360        370        380        390        400
EKSRGKLQLV VLRDSKQTLI NIPALNDSDS EVEDISEIES NRSFSPEERR 
       410        420        430        440        450
QQYSDQDYHS STEKLKERPS SREETSGRLS RMGATPTPFK STGDITAAGV 
       460        470        480        490        500
TEASREPRYQ EEGPVPQPRT APRVFLRPSP EDEAIYGPNT KMVRFKKGDS 
       510        520        530        540        550
VGLRLAGGND VGIFVAGIQE GTSAEQEGLQ EGDQILKVNT QDFRGLVRED 
       560        570        580        590        600
AVLYLLEIPK GETVTILAQS RADVYRDILA CGRGDSFFIR SHFECEKETP 
       610        620        630        640        650
QSLAFTRGEV FRVVDTLYDG KLGHWLAVRI GNELEKGLIP NKSRAEQMAS 
       660        670        680        690        700
VQNAQRENAG DRADFWRMRG QRSSGGVKKN LRKSREDLAA AVSVSTKFPA 
       710        720        730        740        750
YEKVLLREAG FKRPVVLFGP IADIAMERLA TELPDLFQTA KTEPKDAGSE 
       760        770        780        790        800
KSSGVVRLNT VRQIIEQDKH ALLDVTPKAV DLLNYTQWFP IVIFFNPDSR 
       810        820        830        840        850
QGVKTIRQRL SPTSNKSSRK LFDQANKLKK TCSHLFTATI NVNSANDGWF 
       860        870        880        890        900
GSLKDSIQQQ QNEAVWVSEG KMEGMDDDAE DRMSYLTAMG ADYLSCDSRL 
       910        920        930        940        950
ISDFEDTDGE GGAYTDNELE EPAEEPLVSS ITRSSEPVQH EENIRKSSPE 
       960        970        980        990       1000
PRAQMRRAAS RDQLRDASPP PAFKPEPPKA RSQNREDSFD YSKSNLPATA 
      1010       1020       1030       1040       1050
GSEIPGGSTK GYPPPIAAKP AFGRPILKPS TPVPMPESEE VGESTEEQED 
      1060       1070       1080       1090       1100
APRSVLGRVK IFEKMDHKAK LQRMQELQEA QNARIEIAQK HPDIYAVPIK 
      1110       1120       1130       1140       1150
APKPDAGLPP HMSSRPPEPQ KAPSRLYQDT RGSYGSDPEE EEYRQQLAAH 
      1160 
SKRGYYSQPS RYRDTEL
Length:1,167
Mass (Da):131,280
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC29AF94F423A3A70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B2WCN9A0A3B2WCN9_MOUSE
Tight junction protein ZO-2
Tjp2
1,190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WBH9A0A3B2WBH9_MOUSE
Tight junction protein ZO-2
Tjp2
1,165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9E6A0A494B9E6_MOUSE
Tight junction protein ZO-2
Tjp2
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BAA0A0A494BAA0_MOUSE
Tight junction protein ZO-2
Tjp2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100Q → L in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti105 – 107QGS → LGC in AAD19964 (PubMed:10026224).Curated3
Sequence conflicti111 – 112SH → CL in AAD19964 (PubMed:10026224).Curated2
Sequence conflicti156R → G in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti292K → Q in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti378S → R in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti447A → P in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti454S → T in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti470T → A in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti506A → P in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti633E → D in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti649A → D in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti664D → V in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti667R → W in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti670G → R in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti674S → R in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti677V → D in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti680N → T in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti690 – 691AA → RS in AAD19964 (PubMed:10026224).Curated2
Sequence conflicti731T → N in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti1035M → I in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti1038S → T in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti1069A → P in AAD19964 (PubMed:10026224).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF113005 mRNA Translation: AAD19964.1
BC034677 mRNA Translation: AAH34677.1
BC039924 mRNA Translation: AAH39924.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS89365.1

NCBI Reference Sequences

More...RefSeqi		NP_035727.2, NM_011597.4
XP_006526971.1, XM_006526908.3
XP_011245521.1, XM_011247219.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000099558; ENSMUSP00000097154; ENSMUSG00000024812
ENSMUST00000233658; ENSMUSP00000156728; ENSMUSG00000024812

Database of genes from NCBI RefSeq genomes

More...GeneIDi		21873

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:21873

UCSC genome browser

More...UCSCi		uc008ham.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113005 mRNA Translation: AAD19964.1
BC034677 mRNA Translation: AAH34677.1
BC039924 mRNA Translation: AAH39924.1
CCDSiCCDS89365.1
RefSeqiNP_035727.2, NM_011597.4
XP_006526971.1, XM_006526908.3
XP_011245521.1, XM_011247219.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSJNMR-A1-104[»]
SMRiQ9Z0U1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi204210, 6 interactors
IntActiQ9Z0U1, 3 interactors
MINTiQ9Z0U1
STRINGi10090.ENSMUSP00000097154

PTM databases

iPTMnetiQ9Z0U1
PhosphoSitePlusiQ9Z0U1
SwissPalmiQ9Z0U1

Proteomic databases

EPDiQ9Z0U1
jPOSTiQ9Z0U1
MaxQBiQ9Z0U1
PaxDbiQ9Z0U1
PeptideAtlasiQ9Z0U1
PRIDEiQ9Z0U1
ProteomicsDBi275312

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		21873

Genome annotation databases

EnsembliENSMUST00000099558; ENSMUSP00000097154; ENSMUSG00000024812
ENSMUST00000233658; ENSMUSP00000156728; ENSMUSG00000024812
GeneIDi21873
KEGGimmu:21873
UCSCiuc008ham.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9414
MGIiMGI:1341872, Tjp2
VEuPathDBiHostDB:ENSMUSG00000024812

Phylogenomic databases

eggNOGiKOG3580, Eukaryota
GeneTreeiENSGT00940000158634
HOGENOMiCLU_006234_1_0_1
InParanoidiQ9Z0U1
OMAiDTRGSYS
OrthoDBi1175136at2759
PhylomeDBiQ9Z0U1
TreeFamiTF315957

Enzyme and pathway databases

ReactomeiR-MMU-2028269, Signaling by Hippo
R-MMU-351906, Apoptotic cleavage of cell adhesion proteins
R-MMU-8980692, RHOA GTPase cycle
R-MMU-9013026, RHOB GTPase cycle
R-MMU-9013106, RHOC GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		21873, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tjp2, mouse
EvolutionaryTraceiQ9Z0U1

Protein Ontology

More...PROi		PR:Q9Z0U1
RNActiQ9Z0U1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000024812, Expressed in ear vesicle and 306 other tissues
ExpressionAtlasiQ9Z0U1, baseline and differential
GenevisibleiQ9Z0U1, MM

Family and domain databases

CDDicd12027, SH3_ZO-2, 1 hit
Gene3Di2.30.42.10, 3 hits
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR005417, ZO
IPR005419, ZO-2
IPR035598, ZO-2_SH3
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF00595, PDZ, 3 hits
PF07653, SH3_2, 1 hit
PRINTSiPR01597, ZONOCCLUDNS
PR01599, ZONOCCLUDNS2
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00228, PDZ, 3 hits
SUPFAMiSSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 3 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS50106, PDZ, 3 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZO2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0U1
Secondary accession number(s): Q8K210
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 2, 2006
Last modified: September 29, 2021
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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