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Entry version 185 (13 Nov 2019)
Sequence version 2 (02 May 2006)
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Protein

Tight junction protein ZO-2

Gene

Tjp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in tight junctions and adherens junctions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2028269 Signaling by Hippo
R-MMU-351906 Apoptotic cleavage of cell adhesion proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tight junction protein ZO-2
Alternative name(s):
Tight junction protein 2
Zona occludens protein 2
Zonula occludens protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tjp2
Synonyms:Zo2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1341872 Tjp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945441 – 1167Tight junction protein ZO-2Add BLAST1167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107PhosphoserineCombined sources1
Modified residuei127PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei140PhosphoserineCombined sources1
Modified residuei145PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei194PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei239PhosphoserineCombined sources1
Modified residuei305PhosphoserineBy similarity1
Modified residuei378PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei386PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei404PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei411PhosphoserineBy similarity1
Modified residuei435PhosphothreonineBy similarity1
Modified residuei479PhosphoserineCombined sources1
Modified residuei554PhosphotyrosineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei884PhosphoserineCombined sources1
Modified residuei887PhosphothreonineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei902PhosphoserineBy similarity1
Modified residuei907PhosphothreonineBy similarity1
Modified residuei915PhosphothreonineBy similarity1
Modified residuei948PhosphoserineBy similarity1
Modified residuei960PhosphoserineBy similarity1
Modified residuei968PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei1044PhosphoserineBy similarity1
Modified residuei1095PhosphotyrosineCombined sources1
Modified residuei1124PhosphoserineBy similarity1
Modified residuei1136PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Z0U1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Z0U1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Z0U1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0U1

PeptideAtlas

More...
PeptideAtlasi
Q9Z0U1

PRoteomics IDEntifications database

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PRIDEi
Q9Z0U1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Z0U1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z0U1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Z0U1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000024812 Expressed in 281 organ(s), highest expression level in ear vesicle

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Z0U1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z0U1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with ZO1.

Interacts with UBN1.

Interacts with SCRIB (By similarity).

Interacts with occludin and SAFB. Interaction with SAFB occurs in the nucleus.

Interacts with USP53 (via the C-terminal region) (PubMed:26609154).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204210, 4 interactors

Protein interaction database and analysis system

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IntActi
Q9Z0U1, 4 interactors

Molecular INTeraction database

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MINTi
Q9Z0U1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097154

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Z0U1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Z0U1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 97PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini287 – 365PDZ 2PROSITE-ProRule annotationAdd BLAST79
Domaini489 – 570PDZ 3PROSITE-ProRule annotationAdd BLAST82
Domaini584 – 649SH3PROSITE-ProRule annotationAdd BLAST66
Domaini660 – 858Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1165 – 1167Interaction with SCRIBBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1139 – 1142Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3580 Eukaryota
ENOG410XQP3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158634

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230923

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Z0U1

KEGG Orthology (KO)

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KOi
K06098

Identification of Orthologs from Complete Genome Data

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OMAi
KMDHKAK

Database of Orthologous Groups

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OrthoDBi
1175136at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Z0U1

TreeFam database of animal gene trees

More...
TreeFami
TF315957

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12027 SH3_ZO-2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005419 ZO-2
IPR035598 ZO-2_SH3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01597 ZONOCCLUDNS
PR01599 ZONOCCLUDNS2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z0U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEVIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG
60 70 80 90 100
PADGLLQEND RVVMVNGTPM EDVLHSFAVQ QLRKSGKIAA IVVKRPRKVQ
110 120 130 140 150
VAPLQGSPPL SHDDRGFEVI EEFDGRSFRS GYSERSRHSS HDMLSHSWEG
160 170 180 190 200
NRERGRPHQR TQSRERERSR GRSLERGLDQ EDYGRSRERS RGRSLERGLD
210 220 230 240 250
RDFVSRDHSR GRSIDRDYDR DYERSYHEAY EPDYGGGYSP SYDRRAHPET
260 270 280 290 300
RYERSRSREH LRSRSPSPES RSRHEHKGQH DPDRPIGVLL TKSKANEEYG
310 320 330 340 350
LRLGSQIFIK EMTRTGLATK DGNLHEGDII LKINGTVTEN MSLTDARKLI
360 370 380 390 400
EKSRGKLQLV VLRDSKQTLI NIPALNDSDS EVEDISEIES NRSFSPEERR
410 420 430 440 450
QQYSDQDYHS STEKLKERPS SREETSGRLS RMGATPTPFK STGDITAAGV
460 470 480 490 500
TEASREPRYQ EEGPVPQPRT APRVFLRPSP EDEAIYGPNT KMVRFKKGDS
510 520 530 540 550
VGLRLAGGND VGIFVAGIQE GTSAEQEGLQ EGDQILKVNT QDFRGLVRED
560 570 580 590 600
AVLYLLEIPK GETVTILAQS RADVYRDILA CGRGDSFFIR SHFECEKETP
610 620 630 640 650
QSLAFTRGEV FRVVDTLYDG KLGHWLAVRI GNELEKGLIP NKSRAEQMAS
660 670 680 690 700
VQNAQRENAG DRADFWRMRG QRSSGGVKKN LRKSREDLAA AVSVSTKFPA
710 720 730 740 750
YEKVLLREAG FKRPVVLFGP IADIAMERLA TELPDLFQTA KTEPKDAGSE
760 770 780 790 800
KSSGVVRLNT VRQIIEQDKH ALLDVTPKAV DLLNYTQWFP IVIFFNPDSR
810 820 830 840 850
QGVKTIRQRL SPTSNKSSRK LFDQANKLKK TCSHLFTATI NVNSANDGWF
860 870 880 890 900
GSLKDSIQQQ QNEAVWVSEG KMEGMDDDAE DRMSYLTAMG ADYLSCDSRL
910 920 930 940 950
ISDFEDTDGE GGAYTDNELE EPAEEPLVSS ITRSSEPVQH EENIRKSSPE
960 970 980 990 1000
PRAQMRRAAS RDQLRDASPP PAFKPEPPKA RSQNREDSFD YSKSNLPATA
1010 1020 1030 1040 1050
GSEIPGGSTK GYPPPIAAKP AFGRPILKPS TPVPMPESEE VGESTEEQED
1060 1070 1080 1090 1100
APRSVLGRVK IFEKMDHKAK LQRMQELQEA QNARIEIAQK HPDIYAVPIK
1110 1120 1130 1140 1150
APKPDAGLPP HMSSRPPEPQ KAPSRLYQDT RGSYGSDPEE EEYRQQLAAH
1160
SKRGYYSQPS RYRDTEL
Length:1,167
Mass (Da):131,280
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC29AF94F423A3A70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B2WCN9A0A3B2WCN9_MOUSE
Tight junction protein 2, isoform C...
Tjp2 mCG_14589
1,190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WBH9A0A3B2WBH9_MOUSE
Tight junction protein ZO-2
Tjp2
1,165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9E6A0A494B9E6_MOUSE
Tight junction protein ZO-2
Tjp2
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BAA0A0A494BAA0_MOUSE
Tight junction protein ZO-2
Tjp2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100Q → L in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti105 – 107QGS → LGC in AAD19964 (PubMed:10026224).Curated3
Sequence conflicti111 – 112SH → CL in AAD19964 (PubMed:10026224).Curated2
Sequence conflicti156R → G in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti292K → Q in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti378S → R in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti447A → P in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti454S → T in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti470T → A in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti506A → P in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti633E → D in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti649A → D in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti664D → V in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti667R → W in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti670G → R in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti674S → R in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti677V → D in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti680N → T in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti690 – 691AA → RS in AAD19964 (PubMed:10026224).Curated2
Sequence conflicti731T → N in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti1035M → I in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti1038S → T in AAD19964 (PubMed:10026224).Curated1
Sequence conflicti1069A → P in AAD19964 (PubMed:10026224).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF113005 mRNA Translation: AAD19964.1
BC034677 mRNA Translation: AAH34677.1
BC039924 mRNA Translation: AAH39924.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37939.1

NCBI Reference Sequences

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RefSeqi
NP_035727.2, NM_011597.4
XP_006526971.1, XM_006526908.3
XP_011245521.1, XM_011247219.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000099558; ENSMUSP00000097154; ENSMUSG00000024812
ENSMUST00000233658; ENSMUSP00000156728; ENSMUSG00000024812

Database of genes from NCBI RefSeq genomes

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GeneIDi
21873

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21873

UCSC genome browser

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UCSCi
uc008ham.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113005 mRNA Translation: AAD19964.1
BC034677 mRNA Translation: AAH34677.1
BC039924 mRNA Translation: AAH39924.1
CCDSiCCDS37939.1
RefSeqiNP_035727.2, NM_011597.4
XP_006526971.1, XM_006526908.3
XP_011245521.1, XM_011247219.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSJNMR-A1-104[»]
SMRiQ9Z0U1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi204210, 4 interactors
IntActiQ9Z0U1, 4 interactors
MINTiQ9Z0U1
STRINGi10090.ENSMUSP00000097154

PTM databases

iPTMnetiQ9Z0U1
PhosphoSitePlusiQ9Z0U1
SwissPalmiQ9Z0U1

Proteomic databases

EPDiQ9Z0U1
jPOSTiQ9Z0U1
MaxQBiQ9Z0U1
PaxDbiQ9Z0U1
PeptideAtlasiQ9Z0U1
PRIDEiQ9Z0U1

Genome annotation databases

EnsembliENSMUST00000099558; ENSMUSP00000097154; ENSMUSG00000024812
ENSMUST00000233658; ENSMUSP00000156728; ENSMUSG00000024812
GeneIDi21873
KEGGimmu:21873
UCSCiuc008ham.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9414
MGIiMGI:1341872 Tjp2

Phylogenomic databases

eggNOGiKOG3580 Eukaryota
ENOG410XQP3 LUCA
GeneTreeiENSGT00940000158634
HOGENOMiHOG000230923
InParanoidiQ9Z0U1
KOiK06098
OMAiKMDHKAK
OrthoDBi1175136at2759
PhylomeDBiQ9Z0U1
TreeFamiTF315957

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo
R-MMU-351906 Apoptotic cleavage of cell adhesion proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tjp2 mouse
EvolutionaryTraceiQ9Z0U1

Protein Ontology

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PROi
PR:Q9Z0U1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024812 Expressed in 281 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ9Z0U1 baseline and differential
GenevisibleiQ9Z0U1 MM

Family and domain databases

CDDicd12027 SH3_ZO-2, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005419 ZO-2
IPR035598 ZO-2_SH3
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01597 ZONOCCLUDNS
PR01599 ZONOCCLUDNS2
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZO2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0U1
Secondary accession number(s): Q8K210
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 2, 2006
Last modified: November 13, 2019
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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