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Protein

Integrin beta-6

Gene

Itgb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398).By similarity1 Publication

GO - Molecular functioni

  • integrin binding Source: MGI
  • signaling receptor activity Source: InterPro

GO - Biological processi

  • cell adhesion mediated by integrin Source: CAFA
  • cell-matrix adhesion Source: GO_Central
  • cell migration Source: GO_Central
  • inflammatory response Source: MGI
  • integrin-mediated signaling pathway Source: GO_Central
  • regulation of transforming growth factor beta activation Source: UniProtKB
  • transforming growth factor-beta secretion Source: CAFA

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-6
Gene namesi
Name:Itgb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96615 Itgb6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 708ExtracellularSequence analysisAdd BLAST687
Transmembranei709 – 729HelicalSequence analysisAdd BLAST21
Topological domaini730 – 787CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001635122 – 787Integrin beta-6Add BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 454By similarity
Disulfide bondi31 ↔ 41By similarity
Disulfide bondi34 ↔ 70By similarity
Disulfide bondi44 ↔ 59By similarity
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi197 ↔ 204By similarity
Disulfide bondi252 ↔ 293By similarity
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi394 ↔ 406By similarity
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi426 ↔ 669By similarity
Disulfide bondi452 ↔ 456By similarity
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi467 ↔ 479By similarity
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi476 ↔ 511By similarity
Disulfide bondi481 ↔ 490By similarity
Disulfide bondi492 ↔ 502By similarity
Disulfide bondi517 ↔ 522By similarity
Disulfide bondi519 ↔ 552By similarity
Disulfide bondi524 ↔ 537By similarity
Disulfide bondi539 ↔ 544By similarity
Glycosylationi541N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi558 ↔ 563By similarity
Disulfide bondi560 ↔ 591By similarity
Disulfide bondi565 ↔ 574By similarity
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi576 ↔ 583By similarity
Disulfide bondi597 ↔ 602By similarity
Disulfide bondi599 ↔ 645By similarity
Disulfide bondi604 ↔ 614By similarity
Disulfide bondi617 ↔ 620By similarity
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi630 ↔ 701By similarity
Disulfide bondi649 ↔ 677By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z0T9
PaxDbiQ9Z0T9
PRIDEiQ9Z0T9

PTM databases

CarbonylDBiQ9Z0T9
iPTMnetiQ9Z0T9
PhosphoSitePlusiQ9Z0T9

Expressioni

Gene expression databases

BgeeiENSMUSG00000026971 Expressed in 108 organ(s), highest expression level in metanephros
CleanExiMM_ITGB6
ExpressionAtlasiQ9Z0T9 baseline and differential
GenevisibleiQ9Z0T9 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit (PubMed:10025398). Interacts with FLNB (By similarity). Interacts with HAX1 (By similarity). ITGAV:ITGB6 interacts with FBN1 (By similarity). ITGAV:ITGB6 interacts with TGFB1 (PubMed:10025398).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3132 Integrin alphav-beta6 complex
STRINGi10090.ENSMUSP00000028348

Structurei

3D structure databases

ProteinModelPortaliQ9Z0T9
SMRiQ9Z0T9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 371VWFAAdd BLAST241
Repeati456 – 501IAdd BLAST46
Repeati502 – 543IIAdd BLAST42
Repeati544 – 582IIIAdd BLAST39
Repeati583 – 619IVAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni456 – 619Cysteine-rich tandem repeatsAdd BLAST164
Regioni730 – 757Interaction with HAX1By similarityAdd BLAST28

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiQ9Z0T9
KOiK06589
OMAiVSIPNCE
OrthoDBiEOG091G029W
PhylomeDBiQ9Z0T9
TreeFamiTF105392

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015436 Integrin_bsu-6
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF11 PTHR10082:SF11, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS00243 INTEGRIN_BETA, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Z0T9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIELVCLFL LLLGRNDHVQ GGCAWGGAES CSDCLLTGPH CAWCSQENFT
60 70 80 90 100
HLSGAGERCD TPANLLAKGC QLPFIENPVS RIEVLQNKPL SVGRQKNSSD
110 120 130 140 150
IVQIAPQSLV LKLRPGREQT LQVQVRQTED YPVDLYYLMD LSASMDDDLN
160 170 180 190 200
TIKELGSRLA KEMSKLTSNF RLGFGSFVEK PVSPFMKTTP EEITNPCSSI
210 220 230 240 250
PYFCLPTFGF KHILPLTDDA ERFNEIVRKQ KISANIDTPE GGFDAIMQAA
260 270 280 290 300
VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDHRNE
310 320 330 340 350
YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV
360 370 380 390 400
GLLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TALCNNGVLF
410 420 430 440 450
PHQKKCSHMK VGDTASFNVT VSVSNCEKRS RNLIIKPVGL GDTLEILVSA
460 470 480 490 500
ECDCDCQREI ETNSSKCHNG NGSFQCGVCT CNPGHMGPHC ECGEDMVSTD
510 520 530 540 550
SCKESPGHPS CSGRGDCYCG QCICHLSPYG SIYGPYCQCD NFSCLRHKGL
560 570 580 590 600
LCGDNGDCDC GECVCRDGWT GEYCNCTTNR DSCTSEDGVL CSGRGDCVCG
610 620 630 640 650
KCVCRNPGAS GPTCERCPTC GDPCNSKRSC IECYLSADGQ AQEECADKCK
660 670 680 690 700
AIGATISEED FSKDTSVSCS LQGENECLIT FLITTDNEGK TIIHNINEKD
710 720 730 740 750
CPKPPNIPMI MLGVSLAILL IGVVLLCIWK LLVSFHDRKE VAKFEAERSK
760 770 780
AKWQTGTNPL YRGSTSTFKN VTYKHREKHK AGLSSDG
Length:787
Mass (Da):86,042
Last modified:May 1, 1999 - v1
Checksum:iC6438C6F1E6B7FBD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AYG6B1AYG6_MOUSE
Integrin beta
Itgb6
764Annotation score:
B1AYG7B1AYG7_MOUSE
Integrin beta
Itgb6
755Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115376 mRNA Translation: AAD17212.1
AK036439 mRNA Translation: BAC29430.1
BC049185 mRNA Translation: AAH49185.1
CCDSiCCDS16060.1
RefSeqiNP_001153036.1, NM_001159564.1
NP_067334.1, NM_021359.3
XP_006498871.1, XM_006498808.3
XP_006498872.1, XM_006498809.1
XP_006498873.1, XM_006498810.3
XP_006498874.1, XM_006498811.2
UniGeneiMm.98193

Genome annotation databases

EnsembliENSMUST00000028348; ENSMUSP00000028348; ENSMUSG00000026971
ENSMUST00000059888; ENSMUSP00000054944; ENSMUSG00000026971
GeneIDi16420
KEGGimmu:16420
UCSCiuc008juj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115376 mRNA Translation: AAD17212.1
AK036439 mRNA Translation: BAC29430.1
BC049185 mRNA Translation: AAH49185.1
CCDSiCCDS16060.1
RefSeqiNP_001153036.1, NM_001159564.1
NP_067334.1, NM_021359.3
XP_006498871.1, XM_006498808.3
XP_006498872.1, XM_006498809.1
XP_006498873.1, XM_006498810.3
XP_006498874.1, XM_006498811.2
UniGeneiMm.98193

3D structure databases

ProteinModelPortaliQ9Z0T9
SMRiQ9Z0T9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3132 Integrin alphav-beta6 complex
STRINGi10090.ENSMUSP00000028348

PTM databases

CarbonylDBiQ9Z0T9
iPTMnetiQ9Z0T9
PhosphoSitePlusiQ9Z0T9

Proteomic databases

MaxQBiQ9Z0T9
PaxDbiQ9Z0T9
PRIDEiQ9Z0T9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028348; ENSMUSP00000028348; ENSMUSG00000026971
ENSMUST00000059888; ENSMUSP00000054944; ENSMUSG00000026971
GeneIDi16420
KEGGimmu:16420
UCSCiuc008juj.2 mouse

Organism-specific databases

CTDi3694
MGIiMGI:96615 Itgb6

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiQ9Z0T9
KOiK06589
OMAiVSIPNCE
OrthoDBiEOG091G029W
PhylomeDBiQ9Z0T9
TreeFamiTF105392

Enzyme and pathway databases

ReactomeiR-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans

Miscellaneous databases

PROiPR:Q9Z0T9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026971 Expressed in 108 organ(s), highest expression level in metanephros
CleanExiMM_ITGB6
ExpressionAtlasiQ9Z0T9 baseline and differential
GenevisibleiQ9Z0T9 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015436 Integrin_bsu-6
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF11 PTHR10082:SF11, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS00243 INTEGRIN_BETA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiITB6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0T9
Secondary accession number(s): Q544J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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