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Protein

Prenylated Rab acceptor protein 1

Gene

Rabac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1 (By similarity).By similarity1 Publication

Caution

Interaction with the Ras-like GTPases failed to be confirmed in other species.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Prenylated Rab acceptor protein 1
Alternative name(s):
PRA1 family protein 1
Prenylin
Gene namesi
Name:Rabac1
Synonyms:Pra, Pra1, Praf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1201692 Rabac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78Cytoplasmic1 PublicationAdd BLAST78
Transmembranei79 – 94HelicalAdd BLAST16
Transmembranei95 – 112HelicalAdd BLAST18
Topological domaini113 – 131Cytoplasmic1 PublicationAdd BLAST19
Transmembranei132 – 148HelicalAdd BLAST17
Transmembranei149 – 165HelicalAdd BLAST17
Topological domaini166 – 185Cytoplasmic1 PublicationAdd BLAST20

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi176D → A: No effect. 1 Publication1
Mutagenesisi177G → A: No effect. 1 Publication1
Mutagenesisi178E → A: No effect. 1 Publication1
Mutagenesisi179E → A: No effect. 1 Publication1
Mutagenesisi185V → A, C, I or P: Partial retention in the endoplasmic reticulum. 1 Publication1
Mutagenesisi185V → D or K: Retention in the endoplasmic reticulum; does not form homodimers. 1 Publication1
Mutagenesisi185V → M, N, Y, H, E, Q, T, S, L, W, F or G: Retention in the endoplasmic reticulum. 1 Publication1
Mutagenesisi185V → R: No effect. 1 Publication1
Mutagenesisi185Missing : Partial retention in the endoplasmic reticulum; still forms homodimers. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208791 – 185Prenylated Rab acceptor protein 1Add BLAST185

Proteomic databases

EPDiQ9Z0S9
MaxQBiQ9Z0S9
PaxDbiQ9Z0S9
PeptideAtlasiQ9Z0S9
PRIDEiQ9Z0S9

PTM databases

iPTMnetiQ9Z0S9
PhosphoSitePlusiQ9Z0S9

Expressioni

Gene expression databases

BgeeiENSMUSG00000003380 Expressed in 282 organ(s), highest expression level in pons
CleanExiMM_RABAC1
ExpressionAtlasiQ9Z0S9 baseline and differential
GenevisibleiQ9Z0S9 MM

Interactioni

Subunit structurei

Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, NRDG1 and PCLO (By similarity). Interacts with prenylated Rab proteins (including RAB5 and RAB6), and with the members of the Ras superfamily HRAS, RHOA, TC21, and RAP1A.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199848, 1 interactor
IntActiQ9Z0S9, 5 interactors
STRINGi10090.ENSMUSP00000076227

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 54Required for interaction with prenylated RAB3A and VAMP2By similarityAdd BLAST25
Regioni165 – 185Required for interaction with GDI1By similarityAdd BLAST21
Regioni175 – 185HomodimerizationAdd BLAST11
Regioni175 – 185Required for interaction with prenylated RAB3A and VAMP2By similarityAdd BLAST11

Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3142 Eukaryota
COG5130 LUCA
GeneTreeiENSGT00390000010549
HOGENOMiHOG000230621
HOVERGENiHBG053660
InParanoidiQ9Z0S9
KOiK20359
OMAiFAPEPMQ
OrthoDBiEOG091G0M2S
PhylomeDBiQ9Z0S9
TreeFamiTF324857

Family and domain databases

InterProiView protein in InterPro
IPR004895 Prenylated_rab_accept_PRA1
PANTHERiPTHR19317 PTHR19317, 1 hit
PfamiView protein in Pfam
PF03208 PRA1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z0S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQKDQQKD AEGEGLSATT LLPKLIPSGA GREWLERRRA TIRPWGTFVD
60 70 80 90 100
QQRFSRPRNV GELCQRLVRN VEYYQSNYVF VFLGLILYCV VTSPMLLVAL
110 120 130 140 150
AVFFGACYIL YLRTLQSKLV LFGREVSPAH QYALAGGVSF PFFWLAGAGS
160 170 180
AVFWVLGATL VLIGSHAAFH QMEPADGEEL QMEPV
Length:185
Mass (Da):20,619
Last modified:May 1, 1999 - v1
Checksum:i86C82C0502B5CB5B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RPM3A0A0U1RPM3_MOUSE
PRA1 family protein
Rabac1
226Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252856 mRNA Translation: AAF68476.1
AF120162 mRNA Translation: AAD17296.1
AK008559 mRNA Translation: BAB25744.1
AK009726 mRNA Translation: BAB26465.1
AK150681 mRNA Translation: BAE29761.1
AK170289 mRNA Translation: BAE41689.1
BC008242 mRNA Translation: AAH08242.1
CCDSiCCDS20968.1
PIRiJC7369
RefSeqiNP_034391.1, NM_010261.2
UniGeneiMm.22473

Genome annotation databases

EnsembliENSMUST00000076961; ENSMUSP00000076227; ENSMUSG00000003380
GeneIDi14470
KEGGimmu:14470
UCSCiuc009frd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252856 mRNA Translation: AAF68476.1
AF120162 mRNA Translation: AAD17296.1
AK008559 mRNA Translation: BAB25744.1
AK009726 mRNA Translation: BAB26465.1
AK150681 mRNA Translation: BAE29761.1
AK170289 mRNA Translation: BAE41689.1
BC008242 mRNA Translation: AAH08242.1
CCDSiCCDS20968.1
PIRiJC7369
RefSeqiNP_034391.1, NM_010261.2
UniGeneiMm.22473

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199848, 1 interactor
IntActiQ9Z0S9, 5 interactors
STRINGi10090.ENSMUSP00000076227

PTM databases

iPTMnetiQ9Z0S9
PhosphoSitePlusiQ9Z0S9

Proteomic databases

EPDiQ9Z0S9
MaxQBiQ9Z0S9
PaxDbiQ9Z0S9
PeptideAtlasiQ9Z0S9
PRIDEiQ9Z0S9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076961; ENSMUSP00000076227; ENSMUSG00000003380
GeneIDi14470
KEGGimmu:14470
UCSCiuc009frd.1 mouse

Organism-specific databases

CTDi10567
MGIiMGI:1201692 Rabac1

Phylogenomic databases

eggNOGiKOG3142 Eukaryota
COG5130 LUCA
GeneTreeiENSGT00390000010549
HOGENOMiHOG000230621
HOVERGENiHBG053660
InParanoidiQ9Z0S9
KOiK20359
OMAiFAPEPMQ
OrthoDBiEOG091G0M2S
PhylomeDBiQ9Z0S9
TreeFamiTF324857

Miscellaneous databases

PROiPR:Q9Z0S9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003380 Expressed in 282 organ(s), highest expression level in pons
CleanExiMM_RABAC1
ExpressionAtlasiQ9Z0S9 baseline and differential
GenevisibleiQ9Z0S9 MM

Family and domain databases

InterProiView protein in InterPro
IPR004895 Prenylated_rab_accept_PRA1
PANTHERiPTHR19317 PTHR19317, 1 hit
PfamiView protein in Pfam
PF03208 PRA1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRAF1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S9
Secondary accession number(s): Q3TDB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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