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Entry version 128 (13 Feb 2019)
Sequence version 1 (01 May 1999)
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Protein

Prenylated Rab acceptor protein 1

Gene

Rabac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1 (By similarity).By similarity1 Publication

Caution

Interaction with the Ras-like GTPases failed to be confirmed in other species.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prenylated Rab acceptor protein 1
Alternative name(s):
PRA1 family protein 1
Prenylin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rabac1
Synonyms:Pra, Pra1, Praf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1201692 Rabac1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 78Cytoplasmic1 PublicationAdd BLAST78
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei79 – 94HelicalAdd BLAST16
Transmembranei95 – 112HelicalAdd BLAST18
Topological domaini113 – 131Cytoplasmic1 PublicationAdd BLAST19
Transmembranei132 – 148HelicalAdd BLAST17
Transmembranei149 – 165HelicalAdd BLAST17
Topological domaini166 – 185Cytoplasmic1 PublicationAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi176D → A: No effect. 1 Publication1
Mutagenesisi177G → A: No effect. 1 Publication1
Mutagenesisi178E → A: No effect. 1 Publication1
Mutagenesisi179E → A: No effect. 1 Publication1
Mutagenesisi185V → A, C, I or P: Partial retention in the endoplasmic reticulum. 1 Publication1
Mutagenesisi185V → D or K: Retention in the endoplasmic reticulum; does not form homodimers. 1 Publication1
Mutagenesisi185V → M, N, Y, H, E, Q, T, S, L, W, F or G: Retention in the endoplasmic reticulum. 1 Publication1
Mutagenesisi185V → R: No effect. 1 Publication1
Mutagenesisi185Missing : Partial retention in the endoplasmic reticulum; still forms homodimers. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002208791 – 185Prenylated Rab acceptor protein 1Add BLAST185

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Z0S9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Z0S9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0S9

PeptideAtlas

More...
PeptideAtlasi
Q9Z0S9

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z0S9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z0S9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z0S9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000003380 Expressed in 282 organ(s), highest expression level in pons

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z0S9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z0S9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, NRDG1 and PCLO (By similarity). Interacts with prenylated Rab proteins (including RAB5 and RAB6), and with the members of the Ras superfamily HRAS, RHOA, TC21, and RAP1A.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
199848, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Z0S9, 45 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000076227

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 54Required for interaction with prenylated RAB3A and VAMP2By similarityAdd BLAST25
Regioni165 – 185Required for interaction with GDI1By similarityAdd BLAST21
Regioni175 – 185HomodimerizationAdd BLAST11
Regioni175 – 185Required for interaction with prenylated RAB3A and VAMP2By similarityAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3142 Eukaryota
COG5130 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010549

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230621

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053660

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z0S9

KEGG Orthology (KO)

More...
KOi
K20359

Identification of Orthologs from Complete Genome Data

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OMAi
FAPEPMQ

Database of Orthologous Groups

More...
OrthoDBi
1344798at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z0S9

TreeFam database of animal gene trees

More...
TreeFami
TF324857

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004895 Prenylated_rab_accept_PRA1

The PANTHER Classification System

More...
PANTHERi
PTHR19317 PTHR19317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03208 PRA1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z0S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQKDQQKD AEGEGLSATT LLPKLIPSGA GREWLERRRA TIRPWGTFVD
60 70 80 90 100
QQRFSRPRNV GELCQRLVRN VEYYQSNYVF VFLGLILYCV VTSPMLLVAL
110 120 130 140 150
AVFFGACYIL YLRTLQSKLV LFGREVSPAH QYALAGGVSF PFFWLAGAGS
160 170 180
AVFWVLGATL VLIGSHAAFH QMEPADGEEL QMEPV
Length:185
Mass (Da):20,619
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86C82C0502B5CB5B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RPM3A0A0U1RPM3_MOUSE
PRA1 family protein
Rabac1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF252856 mRNA Translation: AAF68476.1
AF120162 mRNA Translation: AAD17296.1
AK008559 mRNA Translation: BAB25744.1
AK009726 mRNA Translation: BAB26465.1
AK150681 mRNA Translation: BAE29761.1
AK170289 mRNA Translation: BAE41689.1
BC008242 mRNA Translation: AAH08242.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20968.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7369

NCBI Reference Sequences

More...
RefSeqi
NP_034391.1, NM_010261.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.22473

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000076961; ENSMUSP00000076227; ENSMUSG00000003380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14470

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14470

UCSC genome browser

More...
UCSCi
uc009frd.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252856 mRNA Translation: AAF68476.1
AF120162 mRNA Translation: AAD17296.1
AK008559 mRNA Translation: BAB25744.1
AK009726 mRNA Translation: BAB26465.1
AK150681 mRNA Translation: BAE29761.1
AK170289 mRNA Translation: BAE41689.1
BC008242 mRNA Translation: AAH08242.1
CCDSiCCDS20968.1
PIRiJC7369
RefSeqiNP_034391.1, NM_010261.2
UniGeneiMm.22473

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

BioGridi199848, 2 interactors
IntActiQ9Z0S9, 45 interactors
STRINGi10090.ENSMUSP00000076227

PTM databases

iPTMnetiQ9Z0S9
PhosphoSitePlusiQ9Z0S9

Proteomic databases

EPDiQ9Z0S9
MaxQBiQ9Z0S9
PaxDbiQ9Z0S9
PeptideAtlasiQ9Z0S9
PRIDEiQ9Z0S9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076961; ENSMUSP00000076227; ENSMUSG00000003380
GeneIDi14470
KEGGimmu:14470
UCSCiuc009frd.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10567
MGIiMGI:1201692 Rabac1

Phylogenomic databases

eggNOGiKOG3142 Eukaryota
COG5130 LUCA
GeneTreeiENSGT00390000010549
HOGENOMiHOG000230621
HOVERGENiHBG053660
InParanoidiQ9Z0S9
KOiK20359
OMAiFAPEPMQ
OrthoDBi1344798at2759
PhylomeDBiQ9Z0S9
TreeFamiTF324857

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9Z0S9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000003380 Expressed in 282 organ(s), highest expression level in pons
ExpressionAtlasiQ9Z0S9 baseline and differential
GenevisibleiQ9Z0S9 MM

Family and domain databases

InterProiView protein in InterPro
IPR004895 Prenylated_rab_accept_PRA1
PANTHERiPTHR19317 PTHR19317, 1 hit
PfamiView protein in Pfam
PF03208 PRA1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRAF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0S9
Secondary accession number(s): Q3TDB4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 1999
Last modified: February 13, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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