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Protein

Claudin-9

Gene

Cldn9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-9
Gene namesi
Name:Cldn9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913100 Cldn9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 81ExtracellularSequence analysisAdd BLAST48
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 159ExtracellularSequence analysisAdd BLAST22
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 217CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447561 – 217Claudin-9Add BLAST217

Proteomic databases

PaxDbiQ9Z0S7
PRIDEiQ9Z0S7

PTM databases

PhosphoSitePlusiQ9Z0S7

Expressioni

Gene expression databases

BgeeiENSMUSG00000066720 Expressed in 121 organ(s), highest expression level in vestibular epithelium
CleanExiMM_CLDN9
GenevisibleiQ9Z0S7 MM

Interactioni

Subunit structurei

Interacts with CLDN1, CD81 and OCLN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093236

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z0S7
KOiK06087
OMAiCPPPQID
OrthoDBiEOG091G0MMR
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z0S7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVVALLL ALLGLLVAIT
110 120 130 140 150
GAQCTTCVED EGAKARIVLT AGVLLLLSGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA AALLMLGGGL LCCTCPPSHF ERPRGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,897
Last modified:October 3, 2012 - v2
Checksum:i793223BDB09DC398
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → F in AAD17319 (Ref. 1) Curated1
Sequence conflicti11M → R in AAD17319 (Ref. 1) Curated1
Sequence conflicti14A → V in AAD17319 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124424 Genomic DNA Translation: AAD17319.1
AC154766 Genomic DNA No translation available.
CH466606 Genomic DNA Translation: EDL22263.1
BC058186 mRNA Translation: AAH58186.1
CCDSiCCDS28458.1
RefSeqiNP_064689.2, NM_020293.3
UniGeneiMm.491368

Genome annotation databases

EnsembliENSMUST00000085989; ENSMUSP00000093236; ENSMUSG00000066720
GeneIDi56863
KEGGimmu:56863
UCSCiuc008asx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124424 Genomic DNA Translation: AAD17319.1
AC154766 Genomic DNA No translation available.
CH466606 Genomic DNA Translation: EDL22263.1
BC058186 mRNA Translation: AAH58186.1
CCDSiCCDS28458.1
RefSeqiNP_064689.2, NM_020293.3
UniGeneiMm.491368

3D structure databases

ProteinModelPortaliQ9Z0S7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093236

PTM databases

PhosphoSitePlusiQ9Z0S7

Proteomic databases

PaxDbiQ9Z0S7
PRIDEiQ9Z0S7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085989; ENSMUSP00000093236; ENSMUSG00000066720
GeneIDi56863
KEGGimmu:56863
UCSCiuc008asx.2 mouse

Organism-specific databases

CTDi9080
MGIiMGI:1913100 Cldn9

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z0S7
KOiK06087
OMAiCPPPQID
OrthoDBiEOG091G0MMR
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q9Z0S7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066720 Expressed in 121 organ(s), highest expression level in vestibular epithelium
CleanExiMM_CLDN9
GenevisibleiQ9Z0S7 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S7
Secondary accession number(s): Q6PEA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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