Cldn10

Functionⁱ

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function.By similarity3 Publications

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
ion transport Source: UniProtKB-KW
regulation of ion transport Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Transport

Biological process

Ion transport, Transport

Protein family/group databases

TCDBⁱ	1.H.1.1.10 the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.10 the claudin tight junction (claudin1) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-10
Gene namesⁱ	Name:Cldn10 Synonyms:Cldn10a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1913101 Cldn10

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	1 – 21	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	22 – 80	ExtracellularSequence analysisAdd BLAST	59
Transmembraneⁱ	81 – 101	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	102 – 115	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	116 – 136	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	137 – 160	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	161 – 181	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	182 – 231	CytoplasmicSequence analysisAdd BLAST	50

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Tight junction

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Conditional knockout in the thick ascending limb (TAL) of Henle's loop in kidney leads to hypocalcemia, hypermagnesemia, hyperphosphatemia and nephrocalcinosis.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144758	1 – 231	Claudin-10Add BLAST		231

Proteomic databases

PaxDbⁱ	Q9Z0S6
PRIDEⁱ	Q9Z0S6

PTM databases

iPTMnetⁱ	Q9Z0S6
PhosphoSitePlusⁱ	Q9Z0S6

Expressionⁱ

Tissue specificityⁱ

Strong expression detected in brain cortex and kidney and weak expression in lung and cecum. In kidney, detected in thick ascending limb (TAL) of Henle's loop and proximal convoluted tubule (PCT). Isoform 1 is widely expressed, with highest expression detected in brain cortex, kidney and lung. Isoform 2, isoform 3, isoform 4 and isoform 5 are only detected in kidney and uterus. In kidney, the expression of isoform 1 is highest in medulla, with transcripts being detected in medullary thick ascending limb of Henle's loop (mTAL) and outer and inner medullary collecting ducts, whereas isoform 2 (along with isoform 4) is more highly expressed in cortex, with transcripts being detected in PCT, mTAL and cortical collecting duct. Expressed in the inner ear where it is detected in organ of Corti, marginal cells of stria vascularis, Reissner's membrane and spiral limbus (at protein level) (PubMed:14698084). Expressed in salivary glands and skin (PubMed:28771254).5 Publications

Developmental stageⁱ

Detected in developing kidney at E14, with levels increasing towards adulthood. Expressed during tooth development: at E12, detected in the thickening tooth epithelium, at E13.5 in the lingual basal epithelium of the bud epithelium, at E14.5 in lingual epithelium and between E18 to postnatal day 0 in odontoblasts and stratum intermedium.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000022132 Expressed in 176 organ(s), highest expression level in submandibular gland
Genevisibleⁱ	Q9Z0S6 MM

Interactionⁱ

Subunit structureⁱ

Can form homodimers both in trans (interaction between CLDN10 molecules in opposing membranes) and in cis (interaction between CLDN10 molecules within one membrane).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CLDN19	Q8N6F1-2	2	EBI-15799971,EBI-12256978	From a different organism.

With

Entry

#Exp.

IntAct

Notes

CLDN19

Q8N6F1-2

2

EBI-15799971,EBI-12256978

From a different organism.

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-48952N DIP-48954N
IntActⁱ	Q9Z0S6, 4 interactors
STRINGⁱ	10090.ENSMUSP00000097889

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z0S6
SMRⁱ	Q9Z0S6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The fourth transmembrane region (161-181), which is missing in isoform 3, isoform 5 and isoform 6, is necessary for integration into tight junctions.1 Publication

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IQ7E Eukaryota ENOG410YF7U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119222
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	Q9Z0S6
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	GYAYNGA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MX2
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003554 Claudin10 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF13 PTHR12002:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01383 CLAUDIN10
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9Z0S6-1) [UniParc]FASTA Add to basket

Also known as: Cldn10b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTALEIVA FVVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYFANLW 
        60         70         80         90        100
KICVTDSTGV ANCKEFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG 
       110        120        130        140        150
MKCTKVGGSD QAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL 
       160        170        180        190        200
YMEQKYELGA ALFIGWAGAS LCIIGGVIFC FSISDNNKTP RMGYTYNGPT 
       210        220        230 
SAMSSRTKYQ GGEGDFKTTG PSKQFDKNAY V

Length:231

Mass (Da):24,695

Last modified:January 22, 2014 - v2

Checksum:ⁱ80A28863B258DED2

GO

Isoform 2 (identifier: Q9Z0S6-2) [UniParc]FASTA Add to basket

Also known as: Cldn10a

The sequence of this isoform differs from the canonical sequence as follows:
1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...RPHFTIFKVE

« Hide

        10         20         30         40         50
MSRAQISALV CGVGGFGALV AATTSNEWKV TTRASSVITA TWVYQGLWMN 
        60         70         80         90        100
CAGNALGSFH CRPHFTIFKV EGYIQACRGL MIAAVSLGFF GSIFALFGMK 
       110        120        130        140        150
CTKVGGSDQA KAKIACLAGI VFILSGLCSM TGCSLYANKI TTEFFDPLYM 
       160        170        180        190        200
EQKYELGAAL FIGWAGASLC IIGGVIFCFS ISDNNKTPRM GYTYNGPTSA 
       210        220 
MSSRTKYQGG EGDFKTTGPS KQFDKNAYV

Show »

Length:229

Mass (Da):24,451

Checksum:ⁱ3FF402779730858E

GO

Isoform 3 (identifier: Q9Z0S6-3) [UniParc]FASTA Add to basket

Also known as: Cldn10a_i2

The sequence of this isoform differs from the canonical sequence as follows:
1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...RPHFTIFKVE
156-191: Missing.

« Hide

        10         20         30         40         50
MSRAQISALV CGVGGFGALV AATTSNEWKV TTRASSVITA TWVYQGLWMN 
        60         70         80         90        100
CAGNALGSFH CRPHFTIFKV EGYIQACRGL MIAAVSLGFF GSIFALFGMK 
       110        120        130        140        150
CTKVGGSDQA KAKIACLAGI VFILSGLCSM TGCSLYANKI TTEFFDPLYM 
       160        170        180        190 
EQKMGYTYNG PTSAMSSRTK YQGGEGDFKT TGPSKQFDKN AYV

Show »

Length:193

Mass (Da):20,664

Checksum:ⁱA55E86F351B7AE8C

GO

Isoform 4 (identifier: Q9Z0S6-4) [UniParc]FASTA Add to basket

Also known as: Cldn10a_i1

The sequence of this isoform differs from the canonical sequence as follows:
1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...VYQGLWMNCA

« Hide

        10         20         30         40         50
MSRAQISALV CGVGGFGALV AATTSNEWKV TTRASSVITA TWVYQGLWMN 
        60         70         80         90        100
CAGYIQACRG LMIAAVSLGF FGSIFALFGM KCTKVGGSDQ AKAKIACLAG 
       110        120        130        140        150
IVFILSGLCS MTGCSLYANK ITTEFFDPLY MEQKYELGAA LFIGWAGASL 
       160        170        180        190        200
CIIGGVIFCF SISDNNKTPR MGYTYNGPTS AMSSRTKYQG GEGDFKTTGP 
       210
SKQFDKNAYV

Note: Produced by alternative splicing of isoform 2.

Show »

Length:210

Mass (Da):22,309

Checksum:ⁱ8BB45CC596FD9D3D

GO

Isoform 5 (identifier: Q9Z0S6-5) [UniParc]FASTA Add to basket

Also known as: Cldn10a_i3

The sequence of this isoform differs from the canonical sequence as follows:
1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...VYQGLWMNCA
156-191: Missing.

« Hide

        10         20         30         40         50
MSRAQISALV CGVGGFGALV AATTSNEWKV TTRASSVITA TWVYQGLWMN 
        60         70         80         90        100
CAGYIQACRG LMIAAVSLGF FGSIFALFGM KCTKVGGSDQ AKAKIACLAG 
       110        120        130        140        150
IVFILSGLCS MTGCSLYANK ITTEFFDPLY MEQKMGYTYN GPTSAMSSRT 
       160        170 
KYQGGEGDFK TTGPSKQFDK NAYV

Note: Produced by alternative splicing of isoform 3.

Show »

Length:174

Mass (Da):18,521

Checksum:ⁱ597B914F3B16D98E

GO

Isoform 6 (identifier: Q9Z0S6-6) [UniParc]FASTA Add to basket

Also known as: Cldn10b_i1

The sequence of this isoform differs from the canonical sequence as follows:
156-191: Missing.

« Hide

        10         20         30         40         50
MASTALEIVA FVVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYFANLW 
        60         70         80         90        100
KICVTDSTGV ANCKEFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG 
       110        120        130        140        150
MKCTKVGGSD QAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL 
       160        170        180        190 
YMEQKMGYTY NGPTSAMSSR TKYQGGEGDF KTTGPSKQFD KNAYV

Show »

Length:195

Mass (Da):20,907

Checksum:ⁱ1103AEA5508A6DF7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	104	T → S in BAB32005 (Ref. 1) Curated	1
Sequence conflictⁱ	202	A → V in AAD17320 (Ref. 1) Curated	1
Sequence conflictⁱ	202	A → V in AAH21770 (PubMed:15489334).Curated	1
Sequence conflictⁱ	202	A → V in AAH29019 (PubMed:15489334).Curated	1
Sequence conflictⁱ	219	T → A in AAD17320 (Ref. 1) Curated	1
Sequence conflictⁱ	219	T → A in AAH21770 (PubMed:15489334).Curated	1
Sequence conflictⁱ	219	T → A in AAH29019 (PubMed:15489334).Curated	1
Sequence conflictⁱ	219	T → A no nucleotide entry (PubMed:19383724).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053551	1 – 73	MASTA…MLALD → MSRAQISALVCGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVE in isoform 2 and isoform 3. 4 PublicationsAdd BLAST	73
Alternative sequenceⁱVSP_053552	1 – 73	MASTA…MLALD → MSRAQISALVCGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCA in isoform 4 and isoform 5. 1 PublicationAdd BLAST	73
Alternative sequenceⁱVSP_053553	156 – 191	Missing in isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST	36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124425 mRNA Translation: AAD17320.1 AK020131 mRNA Translation: BAB32005.1 AC154377 Genomic DNA No translation available. CT025524 Genomic DNA No translation available. BC021770 mRNA Translation: AAH21770.1 BC029019 mRNA Translation: AAH29019.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37009.1 [Q9Z0S6-2] CCDS37010.1 [Q9Z0S6-1] CCDS49566.1 [Q9Z0S6-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153568.1, NM_001160096.1 [Q9Z0S6-4] NP_001153569.1, NM_001160097.1 [Q9Z0S6-3] NP_001153570.1, NM_001160098.1 [Q9Z0S6-5] NP_001153571.1, NM_001160099.1 [Q9Z0S6-6] NP_067361.2, NM_021386.4 [Q9Z0S6-1] NP_076367.2, NM_023878.3 [Q9Z0S6-2]
UniGeneⁱ	Mm.390755

Genome annotation databases

Ensemblⁱ	ENSMUST00000047761; ENSMUSP00000041616; ENSMUSG00000022132 [Q9Z0S6-2] ENSMUST00000071546; ENSMUSP00000071476; ENSMUSG00000022132 [Q9Z0S6-3] ENSMUST00000100314; ENSMUSP00000097889; ENSMUSG00000022132 [Q9Z0S6-1]
GeneIDⁱ	58187
KEGGⁱ	mmu:58187
UCSC genome browser More...UCSCⁱ	uc007uyw.2 mouse [Q9Z0S6-2] uc007uyx.2 mouse [Q9Z0S6-1] uc011zqb.1 mouse [Q9Z0S6-4] uc011zqc.1 mouse [Q9Z0S6-5] uc011zqd.1 mouse [Q9Z0S6-3] uc011zqe.1 mouse [Q9Z0S6-6]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z0S6	Claudin-10		BOVIN		231	UniRef90_Q9Z0S6
Claudin		RAT		286
Claudin		PHYCD		285
Claudin (Fragment)		MUSPF		235
Claudin		CANLF		233
+57
Q9Z0S6-2	Claudin		PIG		230	UniRef90_Q9Z0S6-2
Claudin		MESAU		229
Claudin		Florida manatee		229
Claudin		ICTTR		229
Claudin		TARSY		229
+78
Q9Z0S6-3	Claudin		RAT		193	UniRef90_Q9Z0S6-3
Claudin		CAVPO		193
Claudin		ICTTR		193
Claudin		PROCO		192
UPI00022F34F0		CRIGR		193
+9
Q9Z0S6-4	claudin-10 isoform X4		PHYCD		209	UniRef90_Q9Z0S6-4
claudin-10 isoform X3		LIPVE		209
claudin-10 isoform X3		Yangtze finless porpoise		209
Isoform 3 of Claudin-10		HUMAN		207
UPI00021067BF		PIG		211
+17
Q9Z0S6-6	Claudin		PROCO		194	UniRef90_Q9Z0S6-6
Claudin		Yangtze finless porpoise		194
Claudin		PTEAL		194
UPI00022F3508		CRIGR		195
UPI0003331B3B		JACJA		195
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9Z0S6	Claudin-10		BOVIN		231	UniRef50_Q9Z0S6
Claudin		RAT		286
Claudin		PHYCD		285
Claudin (Fragment)		MUSPF		235
Claudin		CANLF		233
+160
Q9Z0S6-3	Claudin		ICTTR		193	UniRef50_Q9Z0S6-3
Claudin		CAVPO		193
Claudin		RAT		193
Claudin		PROCO		192
Isoform 5 of Claudin-10		MOUSE		174
+18
Q9Z0S6-4	claudin-10 isoform X3		LIPVE		209	UniRef50_Q9Z0S6-4
claudin-10 isoform X3		Yangtze finless porpoise		209
claudin-10 isoform X4		PHYCD		209
Isoform 3 of Claudin-10		HUMAN		207
Claudin		FUNHE		239
+74
Q9Z0S6-5	Isoform 3 of Claudin-10		MOUSE		193	UniRef50_Q9Z0S6-3
Claudin		ICTTR		193
Claudin		CAVPO		193
Claudin		RAT		193
Claudin		PROCO		192
+18
Q9Z0S6-6	Claudin		PTEAL		194	UniRef50_Q9Z0S6-6
Claudin		Yangtze finless porpoise		194
Claudin		PROCO		194
Claudin		ICTPU		223
Claudin		DANRE		236
+37

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124425 mRNA Translation: AAD17320.1 AK020131 mRNA Translation: BAB32005.1 AC154377 Genomic DNA No translation available. CT025524 Genomic DNA No translation available. BC021770 mRNA Translation: AAH21770.1 BC029019 mRNA Translation: AAH29019.1
CCDSⁱ	CCDS37009.1 [Q9Z0S6-2] CCDS37010.1 [Q9Z0S6-1] CCDS49566.1 [Q9Z0S6-3]
RefSeqⁱ	NP_001153568.1, NM_001160096.1 [Q9Z0S6-4] NP_001153569.1, NM_001160097.1 [Q9Z0S6-3] NP_001153570.1, NM_001160098.1 [Q9Z0S6-5] NP_001153571.1, NM_001160099.1 [Q9Z0S6-6] NP_067361.2, NM_021386.4 [Q9Z0S6-1] NP_076367.2, NM_023878.3 [Q9Z0S6-2]
UniGeneⁱ	Mm.390755

3D structure databases

ProteinModelPortalⁱ	Q9Z0S6
SMRⁱ	Q9Z0S6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-48952N DIP-48954N
IntActⁱ	Q9Z0S6, 4 interactors
STRINGⁱ	10090.ENSMUSP00000097889

Protein family/group databases

TCDBⁱ	1.H.1.1.10 the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.10 the claudin tight junction (claudin1) family

PTM databases

iPTMnetⁱ	Q9Z0S6
PhosphoSitePlusⁱ	Q9Z0S6

Proteomic databases

PaxDbⁱ	Q9Z0S6
PRIDEⁱ	Q9Z0S6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047761; ENSMUSP00000041616; ENSMUSG00000022132 [Q9Z0S6-2] ENSMUST00000071546; ENSMUSP00000071476; ENSMUSG00000022132 [Q9Z0S6-3] ENSMUST00000100314; ENSMUSP00000097889; ENSMUSG00000022132 [Q9Z0S6-1]
GeneIDⁱ	58187
KEGGⁱ	mmu:58187
UCSCⁱ	uc007uyw.2 mouse [Q9Z0S6-2] uc007uyx.2 mouse [Q9Z0S6-1] uc011zqb.1 mouse [Q9Z0S6-4] uc011zqc.1 mouse [Q9Z0S6-5] uc011zqd.1 mouse [Q9Z0S6-3] uc011zqe.1 mouse [Q9Z0S6-6]

Organism-specific databases

CTDⁱ	9071
MGIⁱ	MGI:1913101 Cldn10

Phylogenomic databases

eggNOGⁱ	ENOG410IQ7E Eukaryota ENOG410YF7U LUCA
GeneTreeⁱ	ENSGT00760000119222
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	Q9Z0S6
KOⁱ	K06087
OMAⁱ	GYAYNGA
OrthoDBⁱ	EOG091G0MX2
TreeFamⁱ	TF331936

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9Z0S6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022132 Expressed in 176 organ(s), highest expression level in submandibular gland
Genevisibleⁱ	Q9Z0S6 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003554 Claudin10 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF13 PTHR12002:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01383 CLAUDIN10
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD10_MOUSE
Accessionⁱ	Q9Z0S6Primary (citable) accession number: Q9Z0S6 Secondary accession number(s): E9PVC8 , E9PWP4, E9QMP1, Q8VC62, Q9CX57
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 22, 2014
	Last modified:	September 12, 2018
	This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z0S6 (CLD10_MOUSE)

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Claudin-10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ