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Entry version 132 (02 Dec 2020)
Sequence version 2 (22 Jan 2014)
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Protein

Claudin-10

Gene

Cldn10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.H.1.1.10, the claudin tight junction (claudin1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claudin-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cldn10
Synonyms:Cldn10a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913101, Cldn10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 80ExtracellularSequence analysisAdd BLAST59
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 160ExtracellularSequence analysisAdd BLAST24
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 231CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Conditional knockout in the thick ascending limb (TAL) of Henle's loop in kidney leads to hypocalcemia, hypermagnesemia, hyperphosphatemia and nephrocalcinosis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447581 – 231Claudin-10Add BLAST231

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0S6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z0S6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z0S6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z0S6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strong expression detected in brain cortex and kidney and weak expression in lung and cecum. In kidney, detected in thick ascending limb (TAL) of Henle's loop and proximal convoluted tubule (PCT). Isoform 1 is widely expressed, with highest expression detected in brain cortex, kidney and lung. Isoform 2, isoform 3, isoform 4 and isoform 5 are only detected in kidney and uterus. In kidney, the expression of isoform 1 is highest in medulla, with transcripts being detected in medullary thick ascending limb of Henle's loop (mTAL) and outer and inner medullary collecting ducts, whereas isoform 2 (along with isoform 4) is more highly expressed in cortex, with transcripts being detected in PCT, mTAL and cortical collecting duct. Expressed in the inner ear where it is detected in organ of Corti, marginal cells of stria vascularis, Reissner's membrane and spiral limbus (at protein level) (PubMed:14698084). Expressed in salivary glands and skin (PubMed:28771254).5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in developing kidney at 14 dpc, with levels increasing towards adulthood. Expressed during tooth development: at 12 dpc, detected in the thickening tooth epithelium, at 13.5 dpc in the lingual basal epithelium of the bud epithelium, at 14.5 dpc in lingual epithelium and between 18 dpc to postnatal day 1 in odontoblasts and stratum intermedium.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022132, Expressed in submandibular gland and 200 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z0S6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers both in trans (interaction between CLDN10 molecules in opposing membranes) and in cis (interaction between CLDN10 molecules within one membrane).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-48952N
DIP-48954N

Protein interaction database and analysis system

More...
IntActi
Q9Z0S6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097889

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z0S6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z0S6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The fourth transmembrane region (161-181), which is missing in isoform 3, isoform 5 and isoform 6, is necessary for integration into tight junctions.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QPNP, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155232

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076370_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z0S6

Identification of Orthologs from Complete Genome Data

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OMAi
WILESST

Database of Orthologous Groups

More...
OrthoDBi
1164514at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331936

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006187, Claudin
IPR003554, Claudin10
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin

The PANTHER Classification System

More...
PANTHERi
PTHR12002, PTHR12002, 1 hit
PTHR12002:SF13, PTHR12002:SF13, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00822, PMP22_Claudin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01383, CLAUDIN10

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01346, CLAUDIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z0S6-1) [UniParc]FASTAAdd to basket
Also known as: Cldn10b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTALEIVA FVVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYFANLW
60 70 80 90 100
KICVTDSTGV ANCKEFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG
110 120 130 140 150
MKCTKVGGSD QAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL
160 170 180 190 200
YMEQKYELGA ALFIGWAGAS LCIIGGVIFC FSISDNNKTP RMGYTYNGPT
210 220 230
SAMSSRTKYQ GGEGDFKTTG PSKQFDKNAY V
Length:231
Mass (Da):24,695
Last modified:January 22, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80A28863B258DED2
GO
Isoform 2 (identifier: Q9Z0S6-2) [UniParc]FASTAAdd to basket
Also known as: Cldn10a

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...RPHFTIFKVE

Show »
Length:229
Mass (Da):24,451
Checksum:i3FF402779730858E
GO
Isoform 3 (identifier: Q9Z0S6-3) [UniParc]FASTAAdd to basket
Also known as: Cldn10a_i2

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...RPHFTIFKVE
     156-191: Missing.

Show »
Length:193
Mass (Da):20,664
Checksum:iA55E86F351B7AE8C
GO
Isoform 4 (identifier: Q9Z0S6-4) [UniParc]FASTAAdd to basket
Also known as: Cldn10a_i1

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...VYQGLWMNCA

Note: Produced by alternative splicing of isoform 2.Curated
Show »
Length:210
Mass (Da):22,309
Checksum:i8BB45CC596FD9D3D
GO
Isoform 5 (identifier: Q9Z0S6-5) [UniParc]FASTAAdd to basket
Also known as: Cldn10a_i3

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTALEIVA...KEFPSMLALD → MSRAQISALV...VYQGLWMNCA
     156-191: Missing.

Note: Produced by alternative splicing of isoform 3.Curated
Show »
Length:174
Mass (Da):18,521
Checksum:i597B914F3B16D98E
GO
Isoform 6 (identifier: Q9Z0S6-6) [UniParc]FASTAAdd to basket
Also known as: Cldn10b_i1

The sequence of this isoform differs from the canonical sequence as follows:
     156-191: Missing.

Show »
Length:195
Mass (Da):20,907
Checksum:i1103AEA5508A6DF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104T → S in BAB32005 (Ref. 1) Curated1
Sequence conflicti202A → V in AAD17320 (Ref. 1) Curated1
Sequence conflicti202A → V in AAH21770 (PubMed:15489334).Curated1
Sequence conflicti202A → V in AAH29019 (PubMed:15489334).Curated1
Sequence conflicti219T → A in AAD17320 (Ref. 1) Curated1
Sequence conflicti219T → A in AAH21770 (PubMed:15489334).Curated1
Sequence conflicti219T → A in AAH29019 (PubMed:15489334).Curated1
Sequence conflicti219T → A no nucleotide entry (PubMed:19383724).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0535511 – 73MASTA…MLALD → MSRAQISALVCGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVE in isoform 2 and isoform 3. 4 PublicationsAdd BLAST73
Alternative sequenceiVSP_0535521 – 73MASTA…MLALD → MSRAQISALVCGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCA in isoform 4 and isoform 5. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_053553156 – 191Missing in isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF124425 mRNA Translation: AAD17320.1
AK020131 mRNA Translation: BAB32005.1
AC154377 Genomic DNA No translation available.
CT025524 Genomic DNA No translation available.
BC021770 mRNA Translation: AAH21770.1
BC029019 mRNA Translation: AAH29019.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37009.1 [Q9Z0S6-2]
CCDS37010.1 [Q9Z0S6-1]
CCDS49566.1 [Q9Z0S6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001153568.1, NM_001160096.1 [Q9Z0S6-4]
NP_001153569.1, NM_001160097.1 [Q9Z0S6-3]
NP_001153570.1, NM_001160098.1 [Q9Z0S6-5]
NP_001153571.1, NM_001160099.1 [Q9Z0S6-6]
NP_067361.2, NM_021386.4 [Q9Z0S6-1]
NP_076367.2, NM_023878.3 [Q9Z0S6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047761; ENSMUSP00000041616; ENSMUSG00000022132 [Q9Z0S6-2]
ENSMUST00000071546; ENSMUSP00000071476; ENSMUSG00000022132 [Q9Z0S6-3]
ENSMUST00000100314; ENSMUSP00000097889; ENSMUSG00000022132 [Q9Z0S6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58187

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:58187

UCSC genome browser

More...
UCSCi
uc007uyw.2, mouse [Q9Z0S6-2]
uc007uyx.2, mouse [Q9Z0S6-1]
uc011zqb.1, mouse [Q9Z0S6-4]
uc011zqc.1, mouse [Q9Z0S6-5]
uc011zqd.1, mouse [Q9Z0S6-3]
uc011zqe.1, mouse [Q9Z0S6-6]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124425 mRNA Translation: AAD17320.1
AK020131 mRNA Translation: BAB32005.1
AC154377 Genomic DNA No translation available.
CT025524 Genomic DNA No translation available.
BC021770 mRNA Translation: AAH21770.1
BC029019 mRNA Translation: AAH29019.1
CCDSiCCDS37009.1 [Q9Z0S6-2]
CCDS37010.1 [Q9Z0S6-1]
CCDS49566.1 [Q9Z0S6-3]
RefSeqiNP_001153568.1, NM_001160096.1 [Q9Z0S6-4]
NP_001153569.1, NM_001160097.1 [Q9Z0S6-3]
NP_001153570.1, NM_001160098.1 [Q9Z0S6-5]
NP_001153571.1, NM_001160099.1 [Q9Z0S6-6]
NP_067361.2, NM_021386.4 [Q9Z0S6-1]
NP_076367.2, NM_023878.3 [Q9Z0S6-2]

3D structure databases

SMRiQ9Z0S6
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-48952N
DIP-48954N
IntActiQ9Z0S6, 4 interactors
STRINGi10090.ENSMUSP00000097889

Protein family/group databases

TCDBi1.H.1.1.10, the claudin tight junction (claudin1) family

PTM databases

iPTMnetiQ9Z0S6
PhosphoSitePlusiQ9Z0S6

Proteomic databases

PaxDbiQ9Z0S6
PRIDEiQ9Z0S6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4562, 256 antibodies

Genome annotation databases

EnsembliENSMUST00000047761; ENSMUSP00000041616; ENSMUSG00000022132 [Q9Z0S6-2]
ENSMUST00000071546; ENSMUSP00000071476; ENSMUSG00000022132 [Q9Z0S6-3]
ENSMUST00000100314; ENSMUSP00000097889; ENSMUSG00000022132 [Q9Z0S6-1]
GeneIDi58187
KEGGimmu:58187
UCSCiuc007uyw.2, mouse [Q9Z0S6-2]
uc007uyx.2, mouse [Q9Z0S6-1]
uc011zqb.1, mouse [Q9Z0S6-4]
uc011zqc.1, mouse [Q9Z0S6-5]
uc011zqd.1, mouse [Q9Z0S6-3]
uc011zqe.1, mouse [Q9Z0S6-6]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9071
MGIiMGI:1913101, Cldn10

Phylogenomic databases

eggNOGiENOG502QPNP, Eukaryota
GeneTreeiENSGT00940000155232
HOGENOMiCLU_076370_0_0_1
InParanoidiQ9Z0S6
OMAiWILESST
OrthoDBi1164514at2759
TreeFamiTF331936

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
58187, 1 hit in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cldn10, mouse

Protein Ontology

More...
PROi
PR:Q9Z0S6
RNActiQ9Z0S6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022132, Expressed in submandibular gland and 200 other tissues
GenevisibleiQ9Z0S6, MM

Family and domain databases

InterProiView protein in InterPro
IPR006187, Claudin
IPR003554, Claudin10
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002, PTHR12002, 1 hit
PTHR12002:SF13, PTHR12002:SF13, 1 hit
PfamiView protein in Pfam
PF00822, PMP22_Claudin, 1 hit
PRINTSiPR01383, CLAUDIN10
PROSITEiView protein in PROSITE
PS01346, CLAUDIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLD10_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0S6
Secondary accession number(s): E9PVC8
, E9PWP4, E9QMP1, Q8VC62, Q9CX57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 22, 2014
Last modified: December 2, 2020
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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