Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-14

Gene

Cldn14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-14
Gene namesi
Name:Cldn14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1860425 Cldn14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 115CytoplasmicSequence analysisAdd BLAST13
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 162ExtracellularSequence analysisAdd BLAST26
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 239CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447701 – 239Claudin-14Add BLAST239

Proteomic databases

PaxDbiQ9Z0S3
PRIDEiQ9Z0S3

PTM databases

iPTMnetiQ9Z0S3
PhosphoSitePlusiQ9Z0S3

Expressioni

Tissue specificityi

Expressed in all sensory epithelia of the inner ear vestibular organs, as well as in liver and kidney.1 Publication

Developmental stagei

At postnatal day 4, expression is apically located in the inner and outer hair cell region of the entire organ of Corti. By postnatal day 8, expression is highest in the supporting cells of the organ of Corti.

Gene expression databases

BgeeiENSMUSG00000047109 Expressed in 133 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_CLDN14
ExpressionAtlasiQ9Z0S3 baseline and differential
GenevisibleiQ9Z0S3 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLDN16Q9Y5I73EBI-7774956,EBI-7774981From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z0S3, 2 interactors
MINTiQ9Z0S3
STRINGi10090.ENSMUSP00000062045

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP71 Eukaryota
ENOG4111FCQ LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z0S3
KOiK06087
OMAiPYQAQPR
OrthoDBiEOG091G0MX2
PhylomeDBiQ9Z0S3
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003556 Claudin14
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF99 PTHR12002:SF99, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Z0S3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL
60 70 80 90 100
WMECVWHSTG IYQCQIYRSL LALPRDLQAA RALMVISCLL SGMACACAVV
110 120 130 140 150
GMKCTRCAKG TPAKTTFAVL GGALFLLAGL LCMVAVSWTT NDVVQNFYNP
160 170 180 190 200
LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYPPQSRA
210 220 230
GATTTATAPA YRPPAAYKDN RAPSVTSAAH SGYRLNDYV
Length:239
Mass (Da):25,614
Last modified:August 14, 2001 - v2
Checksum:i24DE6AEADA56BB61
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P6X8A0A338P6X8_MOUSE
Claudin
Cldn14
69Annotation score:
A0A338P6L6A0A338P6L6_MOUSE
Claudin-14
Cldn14
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115T → N in AAD17323 (Ref. 1) Curated1
Sequence conflicti119V → M in BAB32041 (PubMed:16141072).Curated1
Sequence conflicti129G → A in AAD17323 (Ref. 1) Curated1
Sequence conflicti166L → M in AAD17323 (Ref. 1) Curated1
Sequence conflicti187D → E in AAD17323 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124429 mRNA Translation: AAD17323.1
AF314089 mRNA Translation: AAG60051.2
AK020255 mRNA Translation: BAB32041.1
CCDSiCCDS28345.1
RefSeqiNP_001159397.1, NM_001165925.1
NP_001159398.1, NM_001165926.1
NP_062373.3, NM_019500.4
XP_006523130.1, XM_006523067.3
UniGeneiMm.328716

Genome annotation databases

EnsembliENSMUST00000050962; ENSMUSP00000062045; ENSMUSG00000047109
ENSMUST00000169391; ENSMUSP00000126455; ENSMUSG00000047109
ENSMUST00000177648; ENSMUSP00000136156; ENSMUSG00000047109
GeneIDi56173
KEGGimmu:56173
UCSCiuc008aad.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124429 mRNA Translation: AAD17323.1
AF314089 mRNA Translation: AAG60051.2
AK020255 mRNA Translation: BAB32041.1
CCDSiCCDS28345.1
RefSeqiNP_001159397.1, NM_001165925.1
NP_001159398.1, NM_001165926.1
NP_062373.3, NM_019500.4
XP_006523130.1, XM_006523067.3
UniGeneiMm.328716

3D structure databases

ProteinModelPortaliQ9Z0S3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z0S3, 2 interactors
MINTiQ9Z0S3
STRINGi10090.ENSMUSP00000062045

PTM databases

iPTMnetiQ9Z0S3
PhosphoSitePlusiQ9Z0S3

Proteomic databases

PaxDbiQ9Z0S3
PRIDEiQ9Z0S3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050962; ENSMUSP00000062045; ENSMUSG00000047109
ENSMUST00000169391; ENSMUSP00000126455; ENSMUSG00000047109
ENSMUST00000177648; ENSMUSP00000136156; ENSMUSG00000047109
GeneIDi56173
KEGGimmu:56173
UCSCiuc008aad.2 mouse

Organism-specific databases

CTDi23562
MGIiMGI:1860425 Cldn14

Phylogenomic databases

eggNOGiENOG410IP71 Eukaryota
ENOG4111FCQ LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z0S3
KOiK06087
OMAiPYQAQPR
OrthoDBiEOG091G0MX2
PhylomeDBiQ9Z0S3
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q9Z0S3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047109 Expressed in 133 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_CLDN14
ExpressionAtlasiQ9Z0S3 baseline and differential
GenevisibleiQ9Z0S3 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003556 Claudin14
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF99 PTHR12002:SF99, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD14_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S3
Secondary accession number(s): Q9D284
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 14, 2001
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again