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Protein

LIM/homeobox protein Lhx2

Gene

Lhx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx2
Short name:
Homeobox protein LH-2
Short name:
LIM homeobox protein 2
Gene namesi
Name:Lhx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96785 Lhx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53C → A: Reduces transcriptional activation; when associated with A-56. 1 Publication1
Mutagenesisi56C → A: Reduces transcriptional activation; when associated with A-53. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757791 – 406LIM/homeobox protein Lhx2Add BLAST406

Proteomic databases

MaxQBiQ9Z0S2
PaxDbiQ9Z0S2
PRIDEiQ9Z0S2

PTM databases

PhosphoSitePlusiQ9Z0S2

Expressioni

Gene expression databases

BgeeiENSMUSG00000000247 Expressed in 157 organ(s), highest expression level in telencephalon
CleanExiMM_LHX2
ExpressionAtlasiQ9Z0S2 baseline and differential
GenevisibleiQ9Z0S2 MM

Interactioni

Subunit structurei

Interacts (via LIM domains) with CITED2 (PubMed:10593900). Interacts with POU4F2 isoform 1 (PubMed:24643061).2 Publications

Protein-protein interaction databases

BioGridi201155, 6 interactors
STRINGi10090.ENSMUSP00000000253

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S2
SMRiQ9Z0S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini115 – 168LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 323Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 196Poly-Ala10

Domaini

LIM domains are necessary for transcription activation.

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000034022
HOVERGENiHBG006262
InParanoidiQ9Z0S2
KOiK09373
OrthoDBiEOG091G13BH
PhylomeDBiQ9Z0S2
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z0S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA
60 70 80 90 100
ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI
110 120 130 140 150
YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML
160 170 180 190 200
TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG
210 220 230 240 250
LGSAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND
260 270 280 290 300
AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA
310 320 330 340 350
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKTSDAT LQTGTPSGPA
360 370 380 390 400
SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT

TLTNLF
Length:406
Mass (Da):44,419
Last modified:May 1, 1999 - v1
Checksum:iFE7B4E76454D6A90
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z9H5F6Z9H5_MOUSE
LIM/homeobox protein Lhx2
Lhx2
365Annotation score:
F6SM03F6SM03_MOUSE
LIM/homeobox protein Lhx2
Lhx2
192Annotation score:
A0A0A0MQK9A0A0A0MQK9_MOUSE
LIM/homeobox protein Lhx2
Lhx2
108Annotation score:
H3BKI3H3BKI3_MOUSE
LIM/homeobox protein Lhx2
Lhx2
49Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124734 mRNA Translation: AAD20012.1
BC055741 mRNA Translation: AAH55741.1
CCDSiCCDS16008.1
RefSeqiNP_034840.1, NM_010710.4
UniGeneiMm.142856

Genome annotation databases

EnsembliENSMUST00000000253; ENSMUSP00000000253; ENSMUSG00000000247
GeneIDi16870
KEGGimmu:16870
UCSCiuc008jnk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124734 mRNA Translation: AAD20012.1
BC055741 mRNA Translation: AAH55741.1
CCDSiCCDS16008.1
RefSeqiNP_034840.1, NM_010710.4
UniGeneiMm.142856

3D structure databases

ProteinModelPortaliQ9Z0S2
SMRiQ9Z0S2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201155, 6 interactors
STRINGi10090.ENSMUSP00000000253

PTM databases

PhosphoSitePlusiQ9Z0S2

Proteomic databases

MaxQBiQ9Z0S2
PaxDbiQ9Z0S2
PRIDEiQ9Z0S2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000253; ENSMUSP00000000253; ENSMUSG00000000247
GeneIDi16870
KEGGimmu:16870
UCSCiuc008jnk.2 mouse

Organism-specific databases

CTDi9355
MGIiMGI:96785 Lhx2

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000034022
HOVERGENiHBG006262
InParanoidiQ9Z0S2
KOiK09373
OrthoDBiEOG091G13BH
PhylomeDBiQ9Z0S2
TreeFamiTF315442

Miscellaneous databases

PROiPR:Q9Z0S2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000247 Expressed in 157 organ(s), highest expression level in telencephalon
CleanExiMM_LHX2
ExpressionAtlasiQ9Z0S2 baseline and differential
GenevisibleiQ9Z0S2 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLHX2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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