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Entry version 172 (02 Jun 2021)
Sequence version 2 (20 Apr 2010)
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Protein

Intersectin-2

Gene

Itsn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.

By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1602CalciumPROSITE-ProRule annotation1
Metal bindingi1605CalciumPROSITE-ProRule annotation1
Metal bindingi1608CalciumPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi67 – 79PROSITE-ProRule annotationAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Endocytosis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intersectin-2
Alternative name(s):
EH domain and SH3 domain regulator of endocytosis 2
Short name:
EH and SH3 domains protein 2
SH3 domain-containing protein 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itsn2
Synonyms:Ese2, Sh3d1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1338049, Itsn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809621 – 1659Intersectin-2Add BLAST1659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110PhosphoserineBy similarity1
Modified residuei211PhosphoserineCombined sources1
Modified residuei231PhosphoserineBy similarity1
Modified residuei554PhosphotyrosineCombined sources1
Modified residuei574PhosphothreonineBy similarity1
Modified residuei836PhosphothreonineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei843PhosphoserineCombined sources1
Modified residuei922PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Z0R6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Z0R6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0R6

PeptideAtlas

More...
PeptideAtlasi
Q9Z0R6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z0R6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269019 [Q9Z0R6-1]
269020 [Q9Z0R6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z0R6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z0R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult tissues.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely distributed throughout the adult forebrain. Prominent expression was observed in the neocortex, the piriform cortex, the pyramidal cell layers of hippocampus, the dentate gyrus, in several nuclei of the thalamus and hypothalamus and in the amygdala.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process.

Interacts with ADAM15.

Interacts with FASLG (By similarity).

Interacts with ANKRD54.

Interacts with FCHO2.

By similarity2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9Z0R6, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9Z0R6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000052758

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z0R6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z0R6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 110EH 1PROSITE-ProRule annotationAdd BLAST89
Domaini54 – 89EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini245 – 334EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini718 – 779SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini852 – 910SH3 2PROSITE-ProRule annotationAdd BLAST59
Domaini942 – 1000SH3 3PROSITE-ProRule annotationAdd BLAST59
Domaini1014 – 1078SH3 4PROSITE-ProRule annotationAdd BLAST65
Domaini1088 – 1147SH3 5PROSITE-ProRule annotationAdd BLAST60
Domaini1170 – 1357DHPROSITE-ProRule annotationAdd BLAST188
Domaini1396 – 1506PHPROSITE-ProRule annotationAdd BLAST111
Domaini1514 – 1630C2PROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni220 – 242DisorderedSequence analysisAdd BLAST23
Regioni335 – 382DisorderedSequence analysisAdd BLAST48
Regioni689 – 715DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili365 – 717Sequence analysisAdd BLAST353

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 241Polar residuesSequence analysisAdd BLAST22
Compositional biasi337 – 351Polar residuesSequence analysisAdd BLAST15
Compositional biasi352 – 382Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi689 – 713Basic and acidic residuesSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1029, Eukaryota
KOG4305, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z0R6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052, EH, 2 hits
cd00160, RhoGEF, 1 hit
cd11988, SH3_Intersectin2_1, 1 hit
cd11990, SH3_Intersectin2_2, 1 hit
cd11992, SH3_Intersectin2_3, 1 hit
cd11994, SH3_Intersectin2_4, 1 hit
cd11996, SH3_Intersectin2_5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR027029, Intersectin-2
IPR035737, Intersectin-2_SH3_1
IPR035738, Intersectin-2_SH3_2
IPR035739, Intersectin-2_SH3_3
IPR035740, Intersectin-2_SH3_4
IPR035741, Intersectin-2_SH3_5
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR11216:SF29, PTHR11216:SF29, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF12763, EF-hand_4, 2 hits
PF16652, PH_13, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 2 hits
PF07653, SH3_2, 1 hit
PF14604, SH3_9, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00054, EFh, 2 hits
SM00027, EH, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50010, DH_2, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z0R6-1) [UniParc]FASTAAdd to basket
Also known as: Ese2L, Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIHQP LPPVAPIATP LSSATSGTSI
160 170 180 190 200
PPLMMPAPLV PSVSTSSLPN GTASLIQPLS IPYSSSTLPH ASSYSLMMGG
210 220 230 240 250
FGGASIQKAQ SLIDLGSSSS TSSTASLSGN SPKTGTSEWA VPQPSRLKYR
260 270 280 290 300
QKFNSLDKGM SGYLSGFQAR NALLQSNLSQ TQLATIWTLA DIDGDGQLKA
310 320 330 340 350
EEFILAMHLT DMAKAGQPLP LTLPPELVPP SFRGGKQVDS VNGTLPSYQK
360 370 380 390 400
TQEEEPQKKL PVTFEDKRKA NYERGNMELE KRRQVLMEQQ QREAERKAQK
410 420 430 440 450
EKEEWERKQR ELQEQEWKKQ LELEKRLEKQ RELERQREEE RRKEIERREA
460 470 480 490 500
AKQELERQRR LEWERLRRQE LLSQKTREQE DIVRLSSRKK SLHLELEAVN
510 520 530 540 550
GKHQQISGRL QDVQIRKQTQ KTELEVLDKQ CDLEIMEIKQ LQQELKEYQN
560 570 580 590 600
KLIYLVPEKQ LLNERIKNMQ LSNTPDSGIS LLHKKSSEKE ELCQRLKEQL
610 620 630 640 650
DALEKETASK LSEMDSFNNQ LKELRESYNT QQLALEQLHK IKRDKLKEIE
660 670 680 690 700
RKRLEQIQKK KLEDEAARKA KQGKENLWRE SIRKEEEEKQ KRLQEEKSQD
710 720 730 740 750
KTQEEERKAE AKQSETASAL VNYRALYPFE ARNHDEMSFS SGDIIQVDEK
760 770 780 790 800
TVGEPGWLYG SFQGKFGWFP CNYVEKVLSS EKALSPKKAL LPPTVSLSAT
810 820 830 840 850
STSSQPPASV TDYHNVSFSN LTVNTTWQQK SAFTRTVSPG SVSPIHGQGQ
860 870 880 890 900
AVENLKAQAL CSWTAKKENH LNFSKHDVIT VLEQQENWWF GEVHGGRGWF
910 920 930 940 950
PKSYVKLIPG NEVQRGEPEA LYAAVTKKPT STAYPVTSTA YPVGEDYIAL
960 970 980 990 1000
YSYSSVEPGD LTFTEGEEIL VTQKDGEWWT GSIGERTGIF PSNYVRPKDQ
1010 1020 1030 1040 1050
ENFGNASKSG ASNKKPEIAQ VTSAYAASGT EQLSLAPGQL ILILKKNTSG
1060 1070 1080 1090 1100
WWQGELQARG KKRQKGWFPA SHVKLLGPSS ERTMPTFHAV CQVIAMYDYM
1110 1120 1130 1140 1150
ANNEDELNFS KGQLINVMNK DDPDWWQGET NGLTGLFPSN YVKMTTDSDP
1160 1170 1180 1190 1200
SQQWCADLQA LDTMQPTERK RQGYIHELIQ TEERYMDDDL QLVIEVFQKR
1210 1220 1230 1240 1250
MAEEGFLTEA DMALIFVNWK ELIMSNTKLL RALRVRKKTG GEKMPVQMIG
1260 1270 1280 1290 1300
DILAAELSHM QAYIRFCSCQ LNGATLLQQK TDEDTDFKEF LKKLASDPRC
1310 1320 1330 1340 1350
KGMPLSSFLL KPMQRITRYP LLIRSILENT PQSHVDHSSL KLALERAEEL
1360 1370 1380 1390 1400
CSQVNEGVRE KENSDRLEWI QAHVQCEGLA EQLIFNSLTN CLGPRKLLHS
1410 1420 1430 1440 1450
GKLYKTKSNK ELHAFLFNDF LLLTYLVRQF AAASGHEKLF NSKSSAQFRM
1460 1470 1480 1490 1500
YKTPIFLNEV LVKLPTDPSG DEPVFHISHI DRVYTLRTDN INERTAWVQK
1510 1520 1530 1540 1550
IKGASEQYID TEKKKREKAY QARSQKTSGI GRLMVHVIEA TELKACKPNG
1560 1570 1580 1590 1600
KSNPYCEVSM GSQSYTTRTL QDTLNPKWNF NCQFFIKDLY QDVLCLTMFD
1610 1620 1630 1640 1650
RDQFSPDDFL GRTEVPVAKI RTEQESKGPT TRRLLLHEVP TGEVWVRFDL

QLFEQKTLL
Length:1,659
Mass (Da):188,908
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i840F16B3A0DACDD6
GO
Isoform 2 (identifier: Q9Z0R6-2) [UniParc]FASTAAdd to basket
Also known as: Ese2, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1188-1198: DDLQLVIEVFQ → GLQLFEQKTLL
     1199-1659: Missing.

Show »
Length:1,198
Mass (Da):135,782
Checksum:iE06BDE54E64D1425
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RR82B2RR82_MOUSE
Intersectin-2
Itsn2
1,685Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QNG1E9QNG1_MOUSE
Intersectin-2
Itsn2
1,658Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P775A0A1W2P775_MOUSE
Intersectin-2
Itsn2
712Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P7G8A0A1W2P7G8_MOUSE
Intersectin-2
Itsn2
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC31264 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti452 – 453KQ → NT in AAD19748 (PubMed:10064583).Curated2
Sequence conflicti1162D → G in AAD19748 (PubMed:10064583).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0038961188 – 1198DDLQLVIEVFQ → GLQLFEQKTLL in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0038971199 – 1659Missing in isoform 2. 1 PublicationAdd BLAST461

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK042449 mRNA Translation: BAC31264.1 Different initiation.
AF132479 mRNA Translation: AAD19747.1
AF132480 mRNA Translation: AAD19748.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc007mxy.1, mouse [Q9Z0R6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042449 mRNA Translation: BAC31264.1 Different initiation.
AF132479 mRNA Translation: AAD19747.1
AF132480 mRNA Translation: AAD19748.1

3D structure databases

SMRiQ9Z0R6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9Z0R6, 14 interactors
MINTiQ9Z0R6
STRINGi10090.ENSMUSP00000052758

PTM databases

iPTMnetiQ9Z0R6
PhosphoSitePlusiQ9Z0R6

Proteomic databases

EPDiQ9Z0R6
jPOSTiQ9Z0R6
PaxDbiQ9Z0R6
PeptideAtlasiQ9Z0R6
PRIDEiQ9Z0R6
ProteomicsDBi269019 [Q9Z0R6-1]
269020 [Q9Z0R6-2]

Genome annotation databases

UCSCiuc007mxy.1, mouse [Q9Z0R6-2]

Organism-specific databases

MGIiMGI:1338049, Itsn2

Phylogenomic databases

eggNOGiKOG1029, Eukaryota
KOG4305, Eukaryota
InParanoidiQ9Z0R6

Enzyme and pathway databases

ReactomeiR-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Itsn2, mouse

Protein Ontology

More...
PROi
PR:Q9Z0R6
RNActiQ9Z0R6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00052, EH, 2 hits
cd00160, RhoGEF, 1 hit
cd11988, SH3_Intersectin2_1, 1 hit
cd11990, SH3_Intersectin2_2, 1 hit
cd11992, SH3_Intersectin2_3, 1 hit
cd11994, SH3_Intersectin2_4, 1 hit
cd11996, SH3_Intersectin2_5, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR027029, Intersectin-2
IPR035737, Intersectin-2_SH3_1
IPR035738, Intersectin-2_SH3_2
IPR035739, Intersectin-2_SH3_3
IPR035740, Intersectin-2_SH3_4
IPR035741, Intersectin-2_SH3_5
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR11216:SF29, PTHR11216:SF29, 3 hits
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF12763, EF-hand_4, 2 hits
PF16652, PH_13, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 2 hits
PF07653, SH3_2, 1 hit
PF14604, SH3_9, 2 hits
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00054, EFh, 2 hits
SM00027, EH, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 5 hits
SUPFAMiSSF47473, SSF47473, 2 hits
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 5 hits
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50010, DH_2, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITSN2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0R6
Secondary accession number(s): Q8C9C3, Q9Z0R5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 20, 2010
Last modified: June 2, 2021
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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