Suppressor of fused homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 11477086
• protein kinase binding Source: MGI
• transcription factor binding Source: MGIInferred from sequence orthologyⁱ
  • 10564661

GO - Biological processⁱ

• aorta development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 25807483
• coronary vasculature development Source: MGIInferred from mutant phenotypeⁱ
  • 25807483
• cytoplasmic sequestering of transcription factor Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 16316410
• determination of left/right symmetry Source: MGIInferred from mutant phenotypeⁱ
  • 16155214
• heart looping Source: MGIInferred from mutant phenotypeⁱ
  • 16155214
• negative regulation of DNA-binding transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of smoothened signaling pathway Source: MGIInferred from direct assayⁱ
  • 10531011
• negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGIInferred from mutant phenotypeⁱ
  • 19684112
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 16459298
  • 10531011
• negative regulation of ubiquitin-dependent protein catabolic process Source: MGIInferred from genetic interactionⁱ
  • 19684112
• neural tube closure Source: MGIInferred from mutant phenotypeⁱ
  • 16155214
• skin development Source: MGIInferred from mutant phenotypeⁱ
  • 16459298
• smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGIInferred from mutant phenotypeⁱ
  • 19684112
• smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGIInferred from mutant phenotypeⁱ
  • 19684112
• spinal cord dorsal/ventral patterning Source: MGIInferred from mutant phenotypeⁱ
  • 16459298
• ventricular septum development Source: MGIInferred from mutant phenotypeⁱ
  • 25807483

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: MGIInferred from direct assayⁱ
  • 11477086
• protein kinase binding Source: MGI
• transcription factor binding Source: MGIInferred from sequence orthologyⁱ
  • 10564661

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN 
        60         70         80         90        100
PLQVTAIVKY WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG 
       110        120        130        140        150
DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ 
       160        170        180        190        200
SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVRT PFGVVTFLQI 
       210        220        230        240        250
VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH 
       260        270        280        290        300
LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDEEDSRS ICLGTQPRRL 
       310        320        330        340        350
SGKDTEQIRE TLRRGLEINS KPVLPPINSQ RQNGLTHDRA PSRKDSLGSD 
       360        370        380        390        400
SSTAIIPHEL IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI 
       410        420        430        440        450
TGDMAITFVS TGVEGAFATE EHPYAAHGPW LQILLTEEFV EKMLEDLEDL 
       460        470        480 
TSPEEFKLPK EYSWPEKKLK VSILPDVVFD SPLH                  

        10         20         30         40         50
MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN 
        60         70         80         90        100
PLQVTAIVKY WFTGTDGPSG FGFELTFRLK RETGESAPPT WPAELMQGLA 
       110        120        130        140        150
RYVFQSENTF CSGDHVSWHS PLDNSESRIQ HMLLTEDPQM QPVRTPFGVV 
       160        170        180        190        200
TFLQIVGVCT EELHSAQQWN GQGILELLRT VPIAGGPWLI TDMRRGETIF 
       210        220        230        240        250
EIDPHLQQER VDKGIETDGS NLSGVSAKCA WDDLSRPPED EEDSRSICLG 
       260        270        280        290        300
TQPRRLSGKD TEQIRETLRR GLEINSKPVL PPINSQRQNG LTHDRAPSRK 
       310        320        330        340        350
DSLGSDSSTA IIPHELIRTR QLESVHLKFN QESGALIPLC LRGRLLHGRH 
       360        370        380        390        400
FTYKSITGDM AITFVSTGVE GAFATEEHPY AAHGPWLQIL LTEEFVEKML 
       410        420        430        440
EDLEDLTSPE EFKLPKEYSW PEKKLKVSIL PDVVFDSPLH            

        10         20         30         40         50
MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN 
        60         70         80         90        100
PLQVTAIVKY WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG 
       110        120        130        140        150
DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ 
       160        170        180        190        200
SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVRT PFGVVTFLQI 
       210        220        230        240        250
VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH 
       260        270        280        290        300
LQQERVDKGI ETDGSNLSGV SAKCAWDDLS RPPEDEEDSR SICLGTQPRR 
       310        320        330        340        350
LSGKDTEQIR ETLRRGLEIN SKPVLPPINS QRQNGLTHDR APSRKDSLGS 
       360        370        380        390        400
DSSTAIIPHE LIRTRQLESV HLKFNQESGA LIPLCLRGRL LHGRHFTYKS 
       410        420        430        440        450
ITGDMAITFV STGVEGAFAT EEHPYAAHGP WLQVRRSLSS FSSSSCSSLA 
       460 
ACPPLPHHPK DRPLWLPC                                    

        10         20         30         40         50
MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN 
        60         70         80         90        100
PLQVTAIVKY WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG 
       110        120        130        140        150
DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ 
       160        170        180        190        200
SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVRT PFGVVTFLQI 
       210        220        230        240        250
VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH 
       260        270        280        290        300
LQQERVDKGI ETDGSNLSGV SAKCAWDDLS RPPEDEEDSR SICLGTQPRR 
       310        320        330        340        350
LSGKDTEQIR ETLRRGLEIN SKPVLPPINS QRQNGLTHDR APSRKDSLGS 
       360        370        380        390        400
DSSTAIIPHE LIRTRQLESV HLKFNQESGA LIPLCLRGRL LHGRHFTYKS 
       410        420        430        440        450
ITGDMAITFV STGVEGAFAT EEHPYAAHGP WLQILLTEEF VEKMLEDLED 
       460        470        480 
LTSPEEFKLP KEYSWPEKKL KVSILPDVVF DSPLH                 

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot