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Protein

Interleukin-18-binding protein

Gene

Il18bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-9012546 Interleukin-18 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18-binding protein
Short name:
IL-18BP
Alternative name(s):
Interferon gamma-inducing factor-binding protein
Gene namesi
Name:Il18bp
Synonyms:Igifbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1333800 Il18bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001477929 – 193Interleukin-18-binding proteinAdd BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi81 ↔ 145PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z0M9
PaxDbiQ9Z0M9
PeptideAtlasiQ9Z0M9
PRIDEiQ9Z0M9

Expressioni

Gene expression databases

BgeeiENSMUSG00000070427 Expressed in 151 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_IL18BP
ExpressionAtlasiQ9Z0M9 baseline and differential
GenevisibleiQ9Z0M9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091685

Structurei

3D structure databases

ProteinModelPortaliQ9Z0M9
SMRiQ9Z0M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 161Ig-like C2-typeAdd BLAST102

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J0UT Eukaryota
ENOG4111EES LUCA
GeneTreeiENSGT00390000004026
HOGENOMiHOG000056459
HOVERGENiHBG052064
InParanoidiQ9Z0M9
OMAiGQLWEGS
OrthoDBiEOG091G0WAG
PhylomeDBiQ9Z0M9
TreeFamiTF337962

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Z0M9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMRHCWTAG PSSWWVLLLY VHVILARATS APQTTATVLT GSSKDPCSSW
60 70 80 90 100
SPAVPTKQYP ALDVIWPEKE VPLNGTLTLS CTACSRFPYF SILYWLGNGS
110 120 130 140 150
FIEHLPGRLK EGHTSREHRN TSTWLHRALV LEELSPTLRS TNFSCLFVDP
160 170 180 190
GQVAQYHIIL AQLWDGLKTA PSPSQETLSS HSPVSRSAGP GVA
Length:193
Mass (Da):21,257
Last modified:July 7, 2009 - v2
Checksum:iD7AD4B0AB07C8248
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GT50A0A1B0GT50_MOUSE
Interleukin 18 binding protein, iso...
Il18bp mCG_6766
194Annotation score:
A0A1B0GSF2A0A1B0GSF2_MOUSE
Interleukin-18-binding protein
Il18bp
137Annotation score:

Sequence cautioni

The sequence AAD17193 differs from that shown. Intron retention.Curated
The sequence AAD17194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172S → P in AAD17194 (PubMed:10023777).Curated1
Sequence conflicti172S → P in CAJ18542 (Ref. 5) Curated1
Sequence conflicti172S → P in AAH18332 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019505 mRNA Translation: BAA76375.1
AF110802 mRNA Translation: AAD17193.1 Sequence problems.
AF110803 mRNA Translation: AAD17194.1 Different initiation.
AF122907 mRNA Translation: AAD41052.1
AK009721 mRNA Translation: BAB26462.1
AK003370 mRNA Translation: BAB22744.1
AK008452 mRNA Translation: BAB25677.1
AK009877 mRNA Translation: BAB26558.1
CT010164 mRNA Translation: CAJ18372.1
CT010334 mRNA Translation: CAJ18542.1
CH466531 Genomic DNA Translation: EDL16557.1
CH466531 Genomic DNA Translation: EDL16558.1
CH466531 Genomic DNA Translation: EDL16559.1
BC018332 mRNA Translation: AAH18332.1
CCDSiCCDS21522.1
RefSeqiNP_034661.1, NM_010531.1
UniGeneiMm.422756

Genome annotation databases

EnsembliENSMUST00000094134; ENSMUSP00000091685; ENSMUSG00000070427
ENSMUST00000209844; ENSMUSP00000148080; ENSMUSG00000070427
GeneIDi16068
KEGGimmu:16068
UCSCiuc009iqd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019505 mRNA Translation: BAA76375.1
AF110802 mRNA Translation: AAD17193.1 Sequence problems.
AF110803 mRNA Translation: AAD17194.1 Different initiation.
AF122907 mRNA Translation: AAD41052.1
AK009721 mRNA Translation: BAB26462.1
AK003370 mRNA Translation: BAB22744.1
AK008452 mRNA Translation: BAB25677.1
AK009877 mRNA Translation: BAB26558.1
CT010164 mRNA Translation: CAJ18372.1
CT010334 mRNA Translation: CAJ18542.1
CH466531 Genomic DNA Translation: EDL16557.1
CH466531 Genomic DNA Translation: EDL16558.1
CH466531 Genomic DNA Translation: EDL16559.1
BC018332 mRNA Translation: AAH18332.1
CCDSiCCDS21522.1
RefSeqiNP_034661.1, NM_010531.1
UniGeneiMm.422756

3D structure databases

ProteinModelPortaliQ9Z0M9
SMRiQ9Z0M9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091685

Proteomic databases

MaxQBiQ9Z0M9
PaxDbiQ9Z0M9
PeptideAtlasiQ9Z0M9
PRIDEiQ9Z0M9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094134; ENSMUSP00000091685; ENSMUSG00000070427
ENSMUST00000209844; ENSMUSP00000148080; ENSMUSG00000070427
GeneIDi16068
KEGGimmu:16068
UCSCiuc009iqd.1 mouse

Organism-specific databases

CTDi10068
MGIiMGI:1333800 Il18bp

Phylogenomic databases

eggNOGiENOG410J0UT Eukaryota
ENOG4111EES LUCA
GeneTreeiENSGT00390000004026
HOGENOMiHOG000056459
HOVERGENiHBG052064
InParanoidiQ9Z0M9
OMAiGQLWEGS
OrthoDBiEOG091G0WAG
PhylomeDBiQ9Z0M9
TreeFamiTF337962

Enzyme and pathway databases

ReactomeiR-MMU-9012546 Interleukin-18 signaling

Miscellaneous databases

PROiPR:Q9Z0M9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070427 Expressed in 151 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_IL18BP
ExpressionAtlasiQ9Z0M9 baseline and differential
GenevisibleiQ9Z0M9 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI18BP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0M9
Secondary accession number(s): Q4FJR8
, Q4FK87, Q9CV30, Q9QUH2, Q9Z0N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: July 7, 2009
Last modified: September 12, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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