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Protein

Parathyroid hormone

Gene

Pth

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormoneUniRule annotation
Short name:
PTHUniRule annotation
Gene namesi
Name:PthImported
ORF Names:mCG_15838Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:97799 Pth

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_501502408426 – 115Parathyroid hormoneUniRule annotationAdd BLAST90

Expressioni

Gene expression databases

BgeeiENSMUSG00000059077 Expressed in 19 organ(s), highest expression level in parathyroid gland

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078723

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J02X Eukaryota
ENOG410ZH2H LUCA
GeneTreeiENSGT00390000018603
HOGENOMiHOG000033707
HOVERGENiHBG008319
KOiK05261
OMAiEIQFMHN
OrthoDBiEOG091G13ZF
TreeFamiTF336197

Family and domain databases

InterProiView protein in InterPro
IPR003625 PTH
IPR001415 PTH/PTH-rel
PANTHERiPTHR10541:SF2 PTHR10541:SF2, 1 hit
PfamiView protein in Pfam
PF01279 Parathyroid, 1 hit
PIRSFiPIRSF001832 PTH, 1 hit
SMARTiView protein in SMART
SM00087 PTH, 1 hit
PROSITEiView protein in PROSITE
PS00335 PARATHYROID, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSANTVAKV MIIMLAVCLL TQTDGKPVRK RAVSEIQLMH NLGKHLASME
60 70 80 90 100
RMQWLRRKLQ DMHNFVSLGV QMAARDGSHQ KPTKKEENVL VDGNPKSLGE
110
GDKADVDVLV KSKSQ
Length:115
Mass (Da):12,825
Last modified:May 1, 1999 - v1
Checksum:iDA43FABBCB4E2FD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156987 Genomic DNA No translation available.
AH007117 Genomic DNA Translation: AAC99656.1
BC099456 mRNA Translation: AAH99456.1
AK138677 mRNA Translation: BAE23743.1
CH466531 Genomic DNA Translation: EDL17048.1
RefSeqiNP_065648.1, NM_020623.2
UniGeneiMm.284168

Genome annotation databases

EnsembliENSMUST00000079793; ENSMUSP00000078723; ENSMUSG00000059077
GeneIDi19226
KEGGimmu:19226
UCSCiuc009jhm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156987 Genomic DNA No translation available.
AH007117 Genomic DNA Translation: AAC99656.1
BC099456 mRNA Translation: AAH99456.1
AK138677 mRNA Translation: BAE23743.1
CH466531 Genomic DNA Translation: EDL17048.1
RefSeqiNP_065648.1, NM_020623.2
UniGeneiMm.284168

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078723

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079793; ENSMUSP00000078723; ENSMUSG00000059077
GeneIDi19226
KEGGimmu:19226
UCSCiuc009jhm.1 mouse

Organism-specific databases

CTDi5741
MGIiMGI:97799 Pth

Phylogenomic databases

eggNOGiENOG410J02X Eukaryota
ENOG410ZH2H LUCA
GeneTreeiENSGT00390000018603
HOGENOMiHOG000033707
HOVERGENiHBG008319
KOiK05261
OMAiEIQFMHN
OrthoDBiEOG091G13ZF
TreeFamiTF336197

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059077 Expressed in 19 organ(s), highest expression level in parathyroid gland

Family and domain databases

InterProiView protein in InterPro
IPR003625 PTH
IPR001415 PTH/PTH-rel
PANTHERiPTHR10541:SF2 PTHR10541:SF2, 1 hit
PfamiView protein in Pfam
PF01279 Parathyroid, 1 hit
PIRSFiPIRSF001832 PTH, 1 hit
SMARTiView protein in SMART
SM00087 PTH, 1 hit
PROSITEiView protein in PROSITE
PS00335 PARATHYROID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9Z0L6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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