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Protein

Parathyroid hormone

Gene

Pth

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • activation of phospholipase C activity Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • bone mineralization Source: MGI
  • bone resorption Source: GO_Central
  • calcium ion homeostasis Source: MGI
  • calcium ion transport Source: MGI
  • cell-cell signaling Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cellular macromolecule biosynthetic process Source: MGI
  • homeostasis of number of cells within a tissue Source: MGI
  • magnesium ion homeostasis Source: MGI
  • negative regulation of apoptotic process in bone marrow Source: MGI
  • negative regulation of bone mineralization involved in bone maturation Source: MGI
  • negative regulation of chondrocyte differentiation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • phosphate ion homeostasis Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of cell proliferation in bone marrow Source: MGI
  • positive regulation of glucose import Source: MGI
  • positive regulation of glycogen biosynthetic process Source: MGI
  • positive regulation of inositol phosphate biosynthetic process Source: MGI
  • positive regulation of ossification Source: MGI
  • positive regulation of osteoclast proliferation Source: MGI
  • positive regulation of signal transduction Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of gene expression Source: MGI
  • response to cadmium ion Source: Ensembl
  • response to ethanol Source: Ensembl
  • response to fibroblast growth factor Source: Ensembl
  • response to lead ion Source: Ensembl
  • response to parathyroid hormone Source: Ensembl
  • response to vitamin D Source: Ensembl
  • Rho protein signal transduction Source: MGI
  • skeletal system development Source: GO_Central

Keywordsi

Molecular functionHormoneUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormoneUniRule annotation
Short name:
PTHUniRule annotation
Gene namesi
Name:PthImported
ORF Names:mCG_15838Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:97799 Pth

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_501521896726 – 115Parathyroid hormoneUniRule annotationAdd BLAST90

Expressioni

Gene expression databases

BgeeiENSMUSG00000059077

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078723

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J02X Eukaryota
ENOG410ZH2H LUCA
GeneTreeiENSGT00390000018603
HOGENOMiHOG000033707
HOVERGENiHBG008319
KOiK05261
OMAiEIQFMHN
OrthoDBiEOG091G13ZF
TreeFamiTF336197

Family and domain databases

InterProiView protein in InterPro
IPR003625 PTH
IPR001415 PTH/PTH-rel
PANTHERiPTHR10541:SF2 PTHR10541:SF2, 1 hit
PfamiView protein in Pfam
PF01279 Parathyroid, 1 hit
PIRSFiPIRSF001832 PTH, 1 hit
SMARTiView protein in SMART
SM00087 PTH, 1 hit
PROSITEiView protein in PROSITE
PS00335 PARATHYROID, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSANTVAKV MIIMLAVCLL TQTDGKPVRK RAVSEIQLMH NLGKHLASME
60 70 80 90 100
RMQWLRRKLQ DMHNFVSLGV QMAARDGSHQ KPTKKEENVL VDGNPKSLGE
110
GDKADVDVLV KSKSQ
Length:115
Mass (Da):12,825
Last modified:May 1, 1999 - v1
Checksum:iDA43FABBCB4E2FD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156987 Genomic DNA No translation available.
AH007117 Genomic DNA Translation: AAC99656.1
BC099456 mRNA Translation: AAH99456.1
AK138677 mRNA Translation: BAE23743.1
CH466531 Genomic DNA Translation: EDL17048.1
RefSeqiNP_065648.1, NM_020623.2
UniGeneiMm.284168

Genome annotation databases

EnsembliENSMUST00000079793; ENSMUSP00000078723; ENSMUSG00000059077
GeneIDi19226
KEGGimmu:19226
UCSCiuc009jhm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ9Z0L6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 18, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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