UniProtKB - Q9Z0L4 (BMP15_MOUSE)
Protein
Bone morphogenetic protein 15
Gene
Bmp15
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).By similarity
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- type I activin receptor binding Source: GO_Central
GO - Biological processi
- BMP signaling pathway Source: GO_Central
- granulosa cell development Source: InterPro
- ovarian follicle development Source: InterPro
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- positive regulation of transcription, DNA-templated Source: MGI
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Cytokine, Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein 15Short name: BMP-15 Alternative name(s): Growth/differentiation factor 9B Short name: GDF-9B |
Gene namesi | Name:Bmp15 Synonyms:Gdf9b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1316745, Bmp15 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
PropeptideiPRO_0000033894 | 26 – 267 | By similarityAdd BLAST | 242 | |
ChainiPRO_0000033895 | 268 – 392 | Bone morphogenetic protein 15Add BLAST | 125 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 213 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 236 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 291 ↔ 357 | By similarity | ||
Disulfide bondi | 320 ↔ 389 | By similarity | ||
Disulfide bondi | 324 ↔ 391 | By similarity | ||
Glycosylationi | 349 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 373 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9Z0L4 |
PRIDEi | Q9Z0L4 |
ProteomicsDBi | 273747 |
PTM databases
GlyGeni | Q9Z0L4, 5 sites |
iPTMneti | Q9Z0L4 |
PhosphoSitePlusi | Q9Z0L4 |
Expressioni
Tissue specificityi
Ovary specific.
Gene expression databases
Bgeei | ENSMUSG00000023279, Expressed in secondary oocyte and 59 other tissues |
Genevisiblei | Q9Z0L4, MM |
Interactioni
Subunit structurei
Homodimer (By similarity). But, in contrast to other members of this family, cannot be disulfide-linked.
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- type I activin receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000024049 |
Miscellaneous databases
RNActi | Q9Z0L4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160940 |
HOGENOMi | CLU_055377_0_0_1 |
InParanoidi | Q9Z0L4 |
OMAi | CQQQKGS |
OrthoDBi | 724783at2759 |
PhylomeDBi | Q9Z0L4 |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR015923, BMP-15 IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit PTHR11848:SF22, PTHR11848:SF22, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9Z0L4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLTILRIL LWGVVLFMEQ RVQMAKPGWP STALLADDPT LPSILDLAKE
60 70 80 90 100
APGKEMKQWP QGYPLRYMLK LYHRSADPHG HPRENRTIGA KMVRLVKPSA
110 120 130 140 150
NTVRPPRGSW HVQTLDFPLA SNQVAYELIR ATVVYRHQLH LVNYHLSCHV
160 170 180 190 200
ETWVPKCRTK HLPSSKSGSS KPSPMSKAWT EIDITHCIQQ KLWNRKGRSV
210 220 230 240 250
LRLRFMCQQQ KGNETREFRW HGMTSLDVAF LLLYFNDTDD RVQGKLLARG
260 270 280 290 300
QEELTDRESS FLMRSVRQAC SIESDASCPS QEHDGSVNNQ CSLHPYKVSF
310 320 330 340 350
HQLGWDHWII APRLYTPNYC KGICTRVLPY GLNSPNHAII QSLVNELVNH
360 370 380 390
SVPQPSCVPY NFLPMSILLI ETNGSILYKE YEGMIAQSCT CR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF082348 mRNA Translation: AAC99766.1 AJ010259 mRNA Translation: CAA09053.1 AJ132406 mRNA Translation: CAB40966.1 AK028735 mRNA Translation: BAC26090.1 AK135757 mRNA Translation: BAE22642.1 AK139773 mRNA Translation: BAE24134.1 BC055363 mRNA Translation: AAH55363.1 |
CCDSi | CCDS29958.1 |
RefSeqi | NP_033887.1, NM_009757.5 |
Genome annotation databases
Ensembli | ENSMUST00000024049; ENSMUSP00000024049; ENSMUSG00000023279 |
GeneIDi | 12155 |
KEGGi | mmu:12155 |
UCSCi | uc009skx.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF082348 mRNA Translation: AAC99766.1 AJ010259 mRNA Translation: CAA09053.1 AJ132406 mRNA Translation: CAB40966.1 AK028735 mRNA Translation: BAC26090.1 AK135757 mRNA Translation: BAE22642.1 AK139773 mRNA Translation: BAE24134.1 BC055363 mRNA Translation: AAH55363.1 |
CCDSi | CCDS29958.1 |
RefSeqi | NP_033887.1, NM_009757.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000024049 |
PTM databases
GlyGeni | Q9Z0L4, 5 sites |
iPTMneti | Q9Z0L4 |
PhosphoSitePlusi | Q9Z0L4 |
Proteomic databases
PaxDbi | Q9Z0L4 |
PRIDEi | Q9Z0L4 |
ProteomicsDBi | 273747 |
Protocols and materials databases
Antibodypediai | 26314, 348 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000024049; ENSMUSP00000024049; ENSMUSG00000023279 |
GeneIDi | 12155 |
KEGGi | mmu:12155 |
UCSCi | uc009skx.2, mouse |
Organism-specific databases
CTDi | 9210 |
MGIi | MGI:1316745, Bmp15 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160940 |
HOGENOMi | CLU_055377_0_0_1 |
InParanoidi | Q9Z0L4 |
OMAi | CQQQKGS |
OrthoDBi | 724783at2759 |
PhylomeDBi | Q9Z0L4 |
TreeFami | TF316134 |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 12155, 1 hit in 52 CRISPR screens |
PROi | PR:Q9Z0L4 |
RNActi | Q9Z0L4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023279, Expressed in secondary oocyte and 59 other tissues |
Genevisiblei | Q9Z0L4, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR015923, BMP-15 IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit PTHR11848:SF22, PTHR11848:SF22, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMP15_MOUSE | |
Accessioni | Q9Z0L4Primary (citable) accession number: Q9Z0L4 Secondary accession number(s): Q3UT46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families