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Entry version 161 (29 Sep 2021)
Sequence version 2 (05 Dec 2001)
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Protein

Otoconin-90

Gene

Oc90

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear (PubMed:17300776).

Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure (PubMed:21655225, PubMed:24748133).

Together with OTOL1, modulates calcite crystal morphology and growth kinetics (PubMed:24748133).

It is unlikely that this protein has phospholipase A2 activity (PubMed:17300776).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Otoconin-90
Short name:
Oc90
Alternative name(s):
Otoconin-951 Publication
Short name:
Oc951 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Oc90Imported
Synonyms:Onc-951 Publication, Pla2ll
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1313269, Oc90

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000015001

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Otoconia show a strongly reduced matrix-calcium.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 171 PublicationAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002299418 – 485Otoconin-90Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi84 ↔ 144By similarity
Disulfide bondi98 ↔ 189By similarity
Disulfide bondi100 ↔ 116By similarity
Disulfide bondi115 ↔ 171By similarity
Disulfide bondi122 ↔ 164By similarity
Disulfide bondi131 ↔ 157By similarity
Disulfide bondi151 ↔ 162By similarity
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0L3

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z0L3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
294062 [Q9Z0L3-1]
294063 [Q9Z0L3-2]
294064 [Q9Z0L3-3]
294065 [Q9Z0L3-4]
294066 [Q9Z0L3-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9Z0L3, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z0L3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z0L3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the embryo, highly expressed in the developing otocyst with weak expression in the brain. Also expressed in nonsensory epithelia of both the vestibular and cochlear portions of the developing inner ear. Not expressed in adult or embryonic macular sensory epithelia.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from embryonic day 9.5.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000015001, Expressed in vestibular epithelium and 67 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z0L3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z0L3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with OTOL1.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201892, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9Z0L3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000062865

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z0L3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z0L3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 189Phospholipase A2-like 1Add BLAST115
Regioni315 – 371Phospholipase A2-like 2Add BLAST57
Regioni383 – 435Phospholipase A2-like 3Add BLAST53
Regioni444 – 485DisorderedSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of 3 PA2-type domains.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4087, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159042

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z0L3

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCEHLLC

Database of Orthologous Groups

More...
OrthoDBi
1422829at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z0L3

TreeFam database of animal gene trees

More...
TreeFami
TF353106

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04707, otoconin_90, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.90.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041798, Otoconin-90
IPR001211, PLipase_A2
IPR033112, PLipase_A2_Asp_AS
IPR016090, PLipase_A2_dom
IPR036444, PLipase_A2_dom_sf
IPR033113, PLipase_A2_His_AS

The PANTHER Classification System

More...
PANTHERi
PTHR11716, PTHR11716, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00068, Phospholip_A2_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00389, PHPHLIPASEA2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00085, PA2c, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48619, SSF48619, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00119, PA2_ASP, 1 hit
PS00118, PA2_HIS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z0L3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIMLLMVGML MAPCVGAHAL DTPNPQELPP GLSKNINITF FNGVFKNVES
60 70 80 90 100
VAEIFDCLGS HFTWLQAVFT NFPLLLQFVN SMRCVTGLCP RDFEDYGCAC
110 120 130 140 150
RFEMEGMPVD ESDICCFQHR RCYEEAVEMD CLQDPAKLSA DVDCTNKQIT
160 170 180 190 200
CESEDPCERL LCTCDKAAVE CLAQSGINSS LNFLDASFCL PQTPETTSGK
210 220 230 240 250
AATLLPRGIP EKPTDTSQIA LSGEVAGEVR ADTLTTLSRT KSVQDLQDTQ
260 270 280 290 300
ASRTTSSPGS AEIIALAKGT THSAGIKPLR LGVSSVDNGS QEAAGKACDR
310 320 330 340 350
LAFVHLGDGD SMTAMLQLGE MLFCLTSHCP EEFETYGCYC GREGRGEPRD
360 370 380 390 400
TLDRCCLSHH CCLEQMRQVG CLHGRRSQSS VVCEDHMAKC VGQSLCEKLL
410 420 430 440 450
CACDQMAAEC MASAFFNQSL KSPDGAECQG EPVSCEDGML QGTLASSVDS
460 470 480
SSEENSEEAP PQMERLRRFL EKPPGPLGAR PLGGK
Length:485
Mass (Da):52,445
Last modified:December 5, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07C21BE695CFE0E8
GO
Isoform 2 (identifier: Q9Z0L3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-224: Missing.

Show »
Length:468
Mass (Da):50,720
Checksum:iB8E34A29FB33BB4A
GO
Isoform 3 (identifier: Q9Z0L3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-240: Missing.
     241-241: K → D

Show »
Length:452
Mass (Da):49,035
Checksum:i8484B9436F783EDA
GO
Isoform 4 (identifier: Q9Z0L3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     297-330: Missing.

Show »
Length:451
Mass (Da):48,778
Checksum:iE3D4CA4D0628A1BD
GO
Isoform 5 (identifier: Q9Z0L3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-240: Missing.
     241-241: K → E

Show »
Length:469
Mass (Da):50,774
Checksum:iBCA8202ABA3EF946
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80ZM2Q80ZM2_MOUSE
Oc90 protein
Oc90
453Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6T2M1F6T2M1_MOUSE
Otoconin-90
Oc90
454Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZCJ0F6ZCJ0_MOUSE
Otoconin-90
Oc90
299Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114I → S in AAD08924 (PubMed:9892667).Curated1
Sequence conflicti297A → AA AA sequence (PubMed:9860971).Curated1
Sequence conflicti378Q → R in AAD08924 (PubMed:9892667).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004511208 – 240Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_004510208 – 224Missing in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_004512225 – 240Missing in isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_004513241K → D in isoform 3. 1 Publication1
Alternative sequenceiVSP_004514241K → E in isoform 5. 1 Publication1
Alternative sequenceiVSP_004515297 – 330Missing in isoform 4. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF093591 mRNA Translation: AAD08924.1
AF091846 mRNA Translation: AAC99455.1
AF091847 Genomic DNA Translation: AAC99456.1
AK012981 mRNA Translation: BAB28578.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27508.1 [Q9Z0L3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_035083.1, NM_010953.2 [Q9Z0L3-1]
XP_011243792.1, XM_011245490.1 [Q9Z0L3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000060522; ENSMUSP00000062865; ENSMUSG00000015001 [Q9Z0L3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18256

UCSC genome browser

More...
UCSCi
uc007vzx.2, mouse [Q9Z0L3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093591 mRNA Translation: AAD08924.1
AF091846 mRNA Translation: AAC99455.1
AF091847 Genomic DNA Translation: AAC99456.1
AK012981 mRNA Translation: BAB28578.1
CCDSiCCDS27508.1 [Q9Z0L3-1]
RefSeqiNP_035083.1, NM_010953.2 [Q9Z0L3-1]
XP_011243792.1, XM_011245490.1 [Q9Z0L3-5]

3D structure databases

SMRiQ9Z0L3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201892, 1 interactor
IntActiQ9Z0L3, 1 interactor
STRINGi10090.ENSMUSP00000062865

PTM databases

GlyGeniQ9Z0L3, 4 sites
iPTMnetiQ9Z0L3
PhosphoSitePlusiQ9Z0L3

Proteomic databases

PaxDbiQ9Z0L3
PRIDEiQ9Z0L3
ProteomicsDBi294062 [Q9Z0L3-1]
294063 [Q9Z0L3-2]
294064 [Q9Z0L3-3]
294065 [Q9Z0L3-4]
294066 [Q9Z0L3-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
18256

Genome annotation databases

EnsembliENSMUST00000060522; ENSMUSP00000062865; ENSMUSG00000015001 [Q9Z0L3-1]
GeneIDi18256
KEGGimmu:18256
UCSCiuc007vzx.2, mouse [Q9Z0L3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
729330
MGIiMGI:1313269, Oc90
VEuPathDBiHostDB:ENSMUSG00000015001

Phylogenomic databases

eggNOGiKOG4087, Eukaryota
GeneTreeiENSGT00940000159042
InParanoidiQ9Z0L3
OMAiHCEHLLC
OrthoDBi1422829at2759
PhylomeDBiQ9Z0L3
TreeFamiTF353106

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
18256, 0 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Oc90, mouse

Protein Ontology

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PROi
PR:Q9Z0L3
RNActiQ9Z0L3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000015001, Expressed in vestibular epithelium and 67 other tissues
ExpressionAtlasiQ9Z0L3, baseline and differential
GenevisibleiQ9Z0L3, MM

Family and domain databases

CDDicd04707, otoconin_90, 2 hits
Gene3Di1.20.90.10, 2 hits
InterProiView protein in InterPro
IPR041798, Otoconin-90
IPR001211, PLipase_A2
IPR033112, PLipase_A2_Asp_AS
IPR016090, PLipase_A2_dom
IPR036444, PLipase_A2_dom_sf
IPR033113, PLipase_A2_His_AS
PANTHERiPTHR11716, PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068, Phospholip_A2_1, 2 hits
PRINTSiPR00389, PHPHLIPASEA2
SMARTiView protein in SMART
SM00085, PA2c, 2 hits
SUPFAMiSSF48619, SSF48619, 2 hits
PROSITEiView protein in PROSITE
PS00119, PA2_ASP, 1 hit
PS00118, PA2_HIS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOC90_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0L3
Secondary accession number(s): Q9CZ60, Q9Z225
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 5, 2001
Last modified: September 29, 2021
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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