UniProtKB - Q9Z0L2 (ARTN_MOUSE)
Protein
Artemin
Gene
Artn
Organism
Mus musculus (Mouse)
Status
Functioni
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.By similarity1 Publication
GO - Molecular functioni
- glial cell-derived neurotrophic factor receptor binding Source: MGI
- growth factor activity Source: GO_Central
- receptor tyrosine kinase binding Source: InterPro
- signaling receptor binding Source: MGI
GO - Biological processi
- axon guidance Source: MGI
- cell surface receptor signaling pathway Source: MGI
- induction of positive chemotaxis Source: MGI
- lymphocyte migration into lymphoid organs Source: UniProtKB
- peripheral nervous system development Source: MGI
- Peyer's patch morphogenesis Source: UniProtKB
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-5673001, RAF/MAP kinase cascade R-MMU-8853659, RET signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Artemin |
Gene namesi | Name:Artn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333791, Artn |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 39 | Sequence analysisAdd BLAST | 39 | |
PropeptideiPRO_0000240288 | 40 – 111 | Sequence analysisAdd BLAST | 72 | |
ChainiPRO_0000240289 | 112 – 224 | ArteminAdd BLAST | 113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 127 ↔ 192 | By similarity | ||
Disulfide bondi | 154 ↔ 220 | By similarity | ||
Disulfide bondi | 158 ↔ 222 | By similarity | ||
Disulfide bondi | 191 | InterchainBy similarity | ||
Glycosylationi | 206 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9Z0L2 |
PeptideAtlasi | Q9Z0L2 |
PRIDEi | Q9Z0L2 |
PTM databases
GlyGeni | Q9Z0L2, 1 site |
PhosphoSitePlusi | Q9Z0L2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028539, Expressed in spinal cord and 96 other tissues |
Genevisiblei | Q9Z0L2, MM |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (By similarity). Binds to RET.
By similarityGO - Molecular functioni
- glial cell-derived neurotrophic factor receptor binding Source: MGI
- growth factor activity Source: GO_Central
- receptor tyrosine kinase binding Source: InterPro
- signaling receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198213, 1 interactor |
STRINGi | 10090.ENSMUSP00000064521 |
Miscellaneous databases
RNActi | Q9Z0L2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 101 | Pro-richAdd BLAST | 59 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S53F, Eukaryota |
GeneTreei | ENSGT00950000182993 |
HOGENOMi | CLU_102221_0_0_1 |
InParanoidi | Q9Z0L2 |
OMAi | PVTQPCC |
OrthoDBi | 1373819at2759 |
PhylomeDBi | Q9Z0L2 |
TreeFami | TF332366 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR043401, GDNF_fam IPR001839, TGF-b_C |
PANTHERi | PTHR12173, PTHR12173, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS51362, TGF_BETA_2, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9Z0L2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELGLAEPTA LSHCLRPRWQ SAWWPTLAVL ALLSCVTEAS LDPMSRSPAA
60 70 80 90 100
RDGPSPVLAP PTDHLPGGHT AHLCSERTLR PPPQSPQPAP PPPGPALQSP
110 120 130 140 150
PAALRGARAA RAGTRSSRAR TTDARGCRLR SQLVPVSALG LGHSSDELIR
160 170 180 190 200
FRFCSGSCRR ARSQHDLSLA SLLGAGALRS PPGSRPISQP CCRPTRYEAV
210 220
SFMDVNSTWR TVDHLSATAC GCLG
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019337 | 1 – 43 | Missing in isoform 3. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_019338 | 67 – 79 | GGHTA…SERTL → AGYGGCRAQAPGR in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_019339 | 67 – 79 | GGHTA…SERTL → GYGGCRAQAPGR in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_019340 | 80 – 224 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 145 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109402 mRNA Translation: AAC98691.1 AK015393 mRNA Translation: BAB29827.1 AK053914 mRNA Translation: BAC35590.1 AK156507 mRNA Translation: BAE33737.1 BC104328 mRNA Translation: AAI04329.1 BC104329 mRNA Translation: AAI04330.1 |
CCDSi | CCDS18543.1 [Q9Z0L2-1] |
RefSeqi | NP_001271120.1, NM_001284191.1 [Q9Z0L2-1] NP_001271121.1, NM_001284192.1 NP_001271122.1, NM_001284193.1 [Q9Z0L2-1] NP_033841.1, NM_009711.4 [Q9Z0L2-1] XP_006502753.1, XM_006502690.3 [Q9Z0L2-1] XP_006502754.1, XM_006502691.3 [Q9Z0L2-1] XP_006502755.1, XM_006502692.3 [Q9Z0L2-1] XP_006502756.1, XM_006502693.3 [Q9Z0L2-1] XP_011238721.1, XM_011240419.2 [Q9Z0L2-1] |
Genome annotation databases
Ensembli | ENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539 [Q9Z0L2-1] ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539 [Q9Z0L2-1] |
GeneIDi | 11876 |
KEGGi | mmu:11876 |
UCSCi | uc008ujh.2, mouse [Q9Z0L2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109402 mRNA Translation: AAC98691.1 AK015393 mRNA Translation: BAB29827.1 AK053914 mRNA Translation: BAC35590.1 AK156507 mRNA Translation: BAE33737.1 BC104328 mRNA Translation: AAI04329.1 BC104329 mRNA Translation: AAI04330.1 |
CCDSi | CCDS18543.1 [Q9Z0L2-1] |
RefSeqi | NP_001271120.1, NM_001284191.1 [Q9Z0L2-1] NP_001271121.1, NM_001284192.1 NP_001271122.1, NM_001284193.1 [Q9Z0L2-1] NP_033841.1, NM_009711.4 [Q9Z0L2-1] XP_006502753.1, XM_006502690.3 [Q9Z0L2-1] XP_006502754.1, XM_006502691.3 [Q9Z0L2-1] XP_006502755.1, XM_006502692.3 [Q9Z0L2-1] XP_006502756.1, XM_006502693.3 [Q9Z0L2-1] XP_011238721.1, XM_011240419.2 [Q9Z0L2-1] |
3D structure databases
SMRi | Q9Z0L2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198213, 1 interactor |
STRINGi | 10090.ENSMUSP00000064521 |
PTM databases
GlyGeni | Q9Z0L2, 1 site |
PhosphoSitePlusi | Q9Z0L2 |
Proteomic databases
PaxDbi | Q9Z0L2 |
PeptideAtlasi | Q9Z0L2 |
PRIDEi | Q9Z0L2 |
Protocols and materials databases
Antibodypediai | 18382, 346 antibodies |
DNASUi | 11876 |
Genome annotation databases
Ensembli | ENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539 [Q9Z0L2-1] ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539 [Q9Z0L2-1] |
GeneIDi | 11876 |
KEGGi | mmu:11876 |
UCSCi | uc008ujh.2, mouse [Q9Z0L2-1] |
Organism-specific databases
CTDi | 9048 |
MGIi | MGI:1333791, Artn |
Phylogenomic databases
eggNOGi | ENOG502S53F, Eukaryota |
GeneTreei | ENSGT00950000182993 |
HOGENOMi | CLU_102221_0_0_1 |
InParanoidi | Q9Z0L2 |
OMAi | PVTQPCC |
OrthoDBi | 1373819at2759 |
PhylomeDBi | Q9Z0L2 |
TreeFami | TF332366 |
Enzyme and pathway databases
Reactomei | R-MMU-5673001, RAF/MAP kinase cascade R-MMU-8853659, RET signaling |
Miscellaneous databases
BioGRID-ORCSi | 11876, 0 hits in 17 CRISPR screens |
PROi | PR:Q9Z0L2 |
RNActi | Q9Z0L2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028539, Expressed in spinal cord and 96 other tissues |
Genevisiblei | Q9Z0L2, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR043401, GDNF_fam IPR001839, TGF-b_C |
PANTHERi | PTHR12173, PTHR12173, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARTN_MOUSE | |
Accessioni | Q9Z0L2Primary (citable) accession number: Q9Z0L2 Secondary accession number(s): Q3SXF4, Q3SXF5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families