Artn

Functionⁱ

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.By similarity1 Publication

GO - Molecular functionⁱ

glial cell-derived neurotrophic factor receptor binding
Source: MGI
Inferred from sequence orthologyⁱ
- 10673327
- 9883723
growth factor activity Source: UniProtKB-KW
signaling receptor binding
Source: MGI
Inferred from physical interactionⁱ
- 15204970

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance
Source: MGI
Inferred from direct assayⁱ
- 12160745
cell surface receptor signaling pathway
Source: MGI
Inferred from sequence orthologyⁱ
- 9883723
induction of positive chemotaxis
Source: MGI
Inferred from direct assayⁱ
- 12160745
lymphocyte migration into lymphoid organs
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17322904
peripheral nervous system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 12160745
Peyer's patch morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17322904

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor

Molecular function

Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5673001 RAF/MAP kinase cascade R-MMU-8853659 RET signaling

Reactomeⁱ

R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Artemin
Gene namesⁱ	Name:Artn
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1333791 Artn

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 39	Sequence analysisAdd BLAST	39
PropeptideⁱPRO_0000240288	40 – 111	Sequence analysisAdd BLAST	72
ChainⁱPRO_0000240289	112 – 224	ArteminAdd BLAST	113

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	127 ↔ 192	By similarity
Disulfide bondⁱ	154 ↔ 220	By similarity
Disulfide bondⁱ	158 ↔ 222	By similarity
Disulfide bondⁱ	191	InterchainBy similarity
Glycosylationⁱ	206	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9Z0L2
PeptideAtlas More...PeptideAtlasⁱ	Q9Z0L2
PRIDEⁱ	Q9Z0L2

PTM databases

PhosphoSitePlusⁱ	Q9Z0L2

PhosphoSitePlusⁱ

Q9Z0L2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028539 Expressed in 63 organ(s), highest expression level in spinal cord
CleanExⁱ	MM_ARTN
Genevisibleⁱ	Q9Z0L2 MM

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked (By similarity). Binds to RET.By similarity

GO - Molecular functionⁱ

glial cell-derived neurotrophic factor receptor binding
Source: MGI
Inferred from sequence orthologyⁱ
- 10673327
- 9883723
growth factor activity Source: UniProtKB-KW
signaling receptor binding
Source: MGI
Inferred from physical interactionⁱ
- 15204970

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198213, 1 interactor
STRINGⁱ	10090.ENSMUSP00000064521

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z0L2
SMRⁱ	Q9Z0L2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	43 – 101	Pro-richAdd BLAST		59

Sequence similaritiesⁱ

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J0YD Eukaryota ENOG4111W7C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055559
HOGENOMⁱ	HOG000220877
HOVERGENⁱ	HBG080137
InParanoidⁱ	Q9Z0L2
OMAⁱ	ISQPCCR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L16
PhylomeDBⁱ	Q9Z0L2
TreeFamⁱ	TF332366

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001839 TGF-b_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS51362 TGF_BETA_2, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9Z0L2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGLAEPTA LSHCLRPRWQ SAWWPTLAVL ALLSCVTEAS LDPMSRSPAA 
        60         70         80         90        100
RDGPSPVLAP PTDHLPGGHT AHLCSERTLR PPPQSPQPAP PPPGPALQSP 
       110        120        130        140        150
PAALRGARAA RAGTRSSRAR TTDARGCRLR SQLVPVSALG LGHSSDELIR 
       160        170        180        190        200
FRFCSGSCRR ARSQHDLSLA SLLGAGALRS PPGSRPISQP CCRPTRYEAV 
       210        220 
SFMDVNSTWR TVDHLSATAC GCLG

Length:224

Mass (Da):23,726

Last modified:May 1, 1999 - v1

Checksum:ⁱ3328FB794581DF0B

GO

Isoform 2 (identifier: Q9Z0L2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
67-79: GGHTAHLCSERTL → AGYGGCRAQAPGR
80-224: Missing.

« Hide

        10         20         30         40         50
MELGLAEPTA LSHCLRPRWQ SAWWPTLAVL ALLSCVTEAS LDPMSRSPAA 
        60         70 
RDGPSPVLAP PTDHLPAGYG GCRAQAPGR

Note: No experimental confirmation available.

Show »

Length:79

Mass (Da):8,332

Checksum:ⁱ46E0B1FCC18A06E1

GO

Isoform 3 (identifier: Q9Z0L2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     67-79: GGHTAHLCSERTL → GYGGCRAQAPGR
     80-224: Missing.

« Hide

        10         20         30 
MSRSPAARDG PSPVLAPPTD HLPGYGGCRA QAPGR

Note: No experimental confirmation available.

Show »

Length:35

Mass (Da):3,544

Checksum:ⁱEF371EAEDD356812

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019337	1 – 43	Missing in isoform 3. 1 PublicationAdd BLAST	43
Alternative sequenceⁱVSP_019338	67 – 79	GGHTA…SERTL → AGYGGCRAQAPGR in isoform 2. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_019339	67 – 79	GGHTA…SERTL → GYGGCRAQAPGR in isoform 3. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_019340	80 – 224	Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST	145

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF109402 mRNA Translation: AAC98691.1 AK015393 mRNA Translation: BAB29827.1 AK053914 mRNA Translation: BAC35590.1 AK156507 mRNA Translation: BAE33737.1 BC104328 mRNA Translation: AAI04329.1 BC104329 mRNA Translation: AAI04330.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18543.1 [Q9Z0L2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001271120.1, NM_001284191.1 [Q9Z0L2-1] NP_001271121.1, NM_001284192.1 NP_001271122.1, NM_001284193.1 [Q9Z0L2-1] NP_033841.1, NM_009711.4 [Q9Z0L2-1] XP_006502753.1, XM_006502690.3 [Q9Z0L2-1] XP_006502754.1, XM_006502691.3 [Q9Z0L2-1] XP_006502755.1, XM_006502692.3 [Q9Z0L2-1] XP_006502756.1, XM_006502693.3 [Q9Z0L2-1] XP_011238721.1, XM_011240419.2 [Q9Z0L2-1]
UniGeneⁱ	Mm.56897

Genome annotation databases

Ensemblⁱ	ENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539 [Q9Z0L2-1] ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539 [Q9Z0L2-1]
GeneIDⁱ	11876
KEGGⁱ	mmu:11876
UCSC genome browser More...UCSCⁱ	uc008ujh.2 mouse [Q9Z0L2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z0L2	Artemin		RAT		224	UniRef90_Q9Z0L2
artemin		MESAU		224
UPI00038BB662		MICOH		224
UPI000A304669		MUSPA		224
UPI000A31A921		MUSCR		224

Protein	Similar proteins		Species	Score	Length	Source
Q9Z0L2	Artemin	)	HUMAN		220	UniRef50_Q5T4W7
Artemin		RAT		224
Uncharacterized protein		PROCO		229
Artemin		PANTR		228
Artemin		GORGO		228
+112
Q9Z0L2-2	Artemin		HUMAN		76	UniRef50_Q9Z0L2-2
ARTN isoform 8		PONAB		76
ARTN isoform 7		PANTR		76
artemin		DIPOR		94
Q9Z0L2-3	Uncharacterized protein (Fragment)		Streptomyces sp. di188		37	UniRef50_Q9Z0L2-3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF109402 mRNA Translation: AAC98691.1 AK015393 mRNA Translation: BAB29827.1 AK053914 mRNA Translation: BAC35590.1 AK156507 mRNA Translation: BAE33737.1 BC104328 mRNA Translation: AAI04329.1 BC104329 mRNA Translation: AAI04330.1
CCDSⁱ	CCDS18543.1 [Q9Z0L2-1]
RefSeqⁱ	NP_001271120.1, NM_001284191.1 [Q9Z0L2-1] NP_001271121.1, NM_001284192.1 NP_001271122.1, NM_001284193.1 [Q9Z0L2-1] NP_033841.1, NM_009711.4 [Q9Z0L2-1] XP_006502753.1, XM_006502690.3 [Q9Z0L2-1] XP_006502754.1, XM_006502691.3 [Q9Z0L2-1] XP_006502755.1, XM_006502692.3 [Q9Z0L2-1] XP_006502756.1, XM_006502693.3 [Q9Z0L2-1] XP_011238721.1, XM_011240419.2 [Q9Z0L2-1]
UniGeneⁱ	Mm.56897

3D structure databases

ProteinModelPortalⁱ	Q9Z0L2
SMRⁱ	Q9Z0L2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198213, 1 interactor
STRINGⁱ	10090.ENSMUSP00000064521

PTM databases

PhosphoSitePlusⁱ	Q9Z0L2

PhosphoSitePlusⁱ

Q9Z0L2

Proteomic databases

PaxDbⁱ	Q9Z0L2
PeptideAtlasⁱ	Q9Z0L2
PRIDEⁱ	Q9Z0L2

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11876
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539 [Q9Z0L2-1] ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539 [Q9Z0L2-1]
GeneIDⁱ	11876
KEGGⁱ	mmu:11876
UCSCⁱ	uc008ujh.2 mouse [Q9Z0L2-1]

Organism-specific databases

CTDⁱ	9048
MGIⁱ	MGI:1333791 Artn

Phylogenomic databases

eggNOGⁱ	ENOG410J0YD Eukaryota ENOG4111W7C LUCA
GeneTreeⁱ	ENSGT00520000055559
HOGENOMⁱ	HOG000220877
HOVERGENⁱ	HBG080137
InParanoidⁱ	Q9Z0L2
OMAⁱ	ISQPCCR
OrthoDBⁱ	EOG091G0L16
PhylomeDBⁱ	Q9Z0L2
TreeFamⁱ	TF332366

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5673001 RAF/MAP kinase cascade R-MMU-8853659 RET signaling

Reactomeⁱ

R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9Z0L2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028539 Expressed in 63 organ(s), highest expression level in spinal cord
CleanExⁱ	MM_ARTN
Genevisibleⁱ	Q9Z0L2 MM

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001839 TGF-b_C
Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS51362 TGF_BETA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARTN_MOUSE
Accessionⁱ	Q9Z0L2Primary (citable) accession number: Q9Z0L2 Secondary accession number(s): Q3SXF4, Q3SXF5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	May 1, 1999
	Last modified:	September 12, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z0L2 (ARTN_MOUSE)

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Artemin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ