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Protein

Artemin

Gene

Artn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • induction of positive chemotaxis Source: MGI
  • lymphocyte migration into lymphoid organs Source: UniProtKB
  • peripheral nervous system development Source: MGI
  • Peyer's patch morphogenesis Source: UniProtKB

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Artemin
Gene namesi
Name:Artn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1333791 Artn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
PropeptideiPRO_000024028840 – 111Sequence analysisAdd BLAST72
ChainiPRO_0000240289112 – 224ArteminAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi127 ↔ 192By similarity
Disulfide bondi154 ↔ 220By similarity
Disulfide bondi158 ↔ 222By similarity
Disulfide bondi191InterchainBy similarity
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0L2
PeptideAtlasiQ9Z0L2
PRIDEiQ9Z0L2

PTM databases

PhosphoSitePlusiQ9Z0L2

Expressioni

Gene expression databases

BgeeiENSMUSG00000028539 Expressed in 63 organ(s), highest expression level in spinal cord
CleanExiMM_ARTN
GenevisibleiQ9Z0L2 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Binds to RET.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198213, 1 interactor
STRINGi10090.ENSMUSP00000064521

Structurei

3D structure databases

ProteinModelPortaliQ9Z0L2
SMRiQ9Z0L2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 101Pro-richAdd BLAST59

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0YD Eukaryota
ENOG4111W7C LUCA
GeneTreeiENSGT00520000055559
HOGENOMiHOG000220877
HOVERGENiHBG080137
InParanoidiQ9Z0L2
OMAiISQPCCR
OrthoDBiEOG091G0L16
PhylomeDBiQ9Z0L2
TreeFamiTF332366

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z0L2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELGLAEPTA LSHCLRPRWQ SAWWPTLAVL ALLSCVTEAS LDPMSRSPAA
60 70 80 90 100
RDGPSPVLAP PTDHLPGGHT AHLCSERTLR PPPQSPQPAP PPPGPALQSP
110 120 130 140 150
PAALRGARAA RAGTRSSRAR TTDARGCRLR SQLVPVSALG LGHSSDELIR
160 170 180 190 200
FRFCSGSCRR ARSQHDLSLA SLLGAGALRS PPGSRPISQP CCRPTRYEAV
210 220
SFMDVNSTWR TVDHLSATAC GCLG
Length:224
Mass (Da):23,726
Last modified:May 1, 1999 - v1
Checksum:i3328FB794581DF0B
GO
Isoform 2 (identifier: Q9Z0L2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: GGHTAHLCSERTL → AGYGGCRAQAPGR
     80-224: Missing.

Note: No experimental confirmation available.
Show »
Length:79
Mass (Da):8,332
Checksum:i46E0B1FCC18A06E1
GO
Isoform 3 (identifier: Q9Z0L2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     67-79: GGHTAHLCSERTL → GYGGCRAQAPGR
     80-224: Missing.

Note: No experimental confirmation available.
Show »
Length:35
Mass (Da):3,544
Checksum:iEF371EAEDD356812
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0193371 – 43Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_01933867 – 79GGHTA…SERTL → AGYGGCRAQAPGR in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_01933967 – 79GGHTA…SERTL → GYGGCRAQAPGR in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_01934080 – 224Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109402 mRNA Translation: AAC98691.1
AK015393 mRNA Translation: BAB29827.1
AK053914 mRNA Translation: BAC35590.1
AK156507 mRNA Translation: BAE33737.1
BC104328 mRNA Translation: AAI04329.1
BC104329 mRNA Translation: AAI04330.1
CCDSiCCDS18543.1 [Q9Z0L2-1]
RefSeqiNP_001271120.1, NM_001284191.1 [Q9Z0L2-1]
NP_001271121.1, NM_001284192.1
NP_001271122.1, NM_001284193.1 [Q9Z0L2-1]
NP_033841.1, NM_009711.4 [Q9Z0L2-1]
XP_006502753.1, XM_006502690.3 [Q9Z0L2-1]
XP_006502754.1, XM_006502691.3 [Q9Z0L2-1]
XP_006502755.1, XM_006502692.3 [Q9Z0L2-1]
XP_006502756.1, XM_006502693.3 [Q9Z0L2-1]
XP_011238721.1, XM_011240419.2 [Q9Z0L2-1]
UniGeneiMm.56897

Genome annotation databases

EnsembliENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539 [Q9Z0L2-1]
ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539 [Q9Z0L2-1]
GeneIDi11876
KEGGimmu:11876
UCSCiuc008ujh.2 mouse [Q9Z0L2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109402 mRNA Translation: AAC98691.1
AK015393 mRNA Translation: BAB29827.1
AK053914 mRNA Translation: BAC35590.1
AK156507 mRNA Translation: BAE33737.1
BC104328 mRNA Translation: AAI04329.1
BC104329 mRNA Translation: AAI04330.1
CCDSiCCDS18543.1 [Q9Z0L2-1]
RefSeqiNP_001271120.1, NM_001284191.1 [Q9Z0L2-1]
NP_001271121.1, NM_001284192.1
NP_001271122.1, NM_001284193.1 [Q9Z0L2-1]
NP_033841.1, NM_009711.4 [Q9Z0L2-1]
XP_006502753.1, XM_006502690.3 [Q9Z0L2-1]
XP_006502754.1, XM_006502691.3 [Q9Z0L2-1]
XP_006502755.1, XM_006502692.3 [Q9Z0L2-1]
XP_006502756.1, XM_006502693.3 [Q9Z0L2-1]
XP_011238721.1, XM_011240419.2 [Q9Z0L2-1]
UniGeneiMm.56897

3D structure databases

ProteinModelPortaliQ9Z0L2
SMRiQ9Z0L2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198213, 1 interactor
STRINGi10090.ENSMUSP00000064521

PTM databases

PhosphoSitePlusiQ9Z0L2

Proteomic databases

PaxDbiQ9Z0L2
PeptideAtlasiQ9Z0L2
PRIDEiQ9Z0L2

Protocols and materials databases

DNASUi11876
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539 [Q9Z0L2-1]
ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539 [Q9Z0L2-1]
GeneIDi11876
KEGGimmu:11876
UCSCiuc008ujh.2 mouse [Q9Z0L2-1]

Organism-specific databases

CTDi9048
MGIiMGI:1333791 Artn

Phylogenomic databases

eggNOGiENOG410J0YD Eukaryota
ENOG4111W7C LUCA
GeneTreeiENSGT00520000055559
HOGENOMiHOG000220877
HOVERGENiHBG080137
InParanoidiQ9Z0L2
OMAiISQPCCR
OrthoDBiEOG091G0L16
PhylomeDBiQ9Z0L2
TreeFamiTF332366

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Miscellaneous databases

PROiPR:Q9Z0L2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028539 Expressed in 63 organ(s), highest expression level in spinal cord
CleanExiMM_ARTN
GenevisibleiQ9Z0L2 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARTN_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L2
Secondary accession number(s): Q3SXF4, Q3SXF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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