UniProtKB - Q9Z0L1 (S1PR4_MOUSE)
Protein
Sphingosine 1-phosphate receptor 4
Gene
S1pr4
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- sphingosine-1-phosphate receptor activity Source: InterPro
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-419408, Lysosphingolipid and LPA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Sphingosine 1-phosphate receptor 4Short name: S1P receptor 4 Short name: S1P4 Alternative name(s): Endothelial differentiation G-protein coupled receptor 6 Lysophospholipid receptor C1 Sphingosine 1-phosphate receptor Edg-6 Short name: S1P receptor Edg-6 |
Gene namesi | Name:S1pr4 Synonyms:Edg6, Lpc1, S1p4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333809, S1pr4 |
Subcellular locationi
Plasma membrane
Mitochondrion
- mitochondrion Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: MGI
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 56 | ExtracellularBy similarityAdd BLAST | 56 | |
Transmembranei | 57 – 77 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 78 – 87 | CytoplasmicBy similarity | 10 | |
Transmembranei | 88 – 108 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 109 – 120 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 121 – 141 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 142 – 163 | CytoplasmicBy similarityAdd BLAST | 22 | |
Transmembranei | 164 – 184 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 185 – 208 | ExtracellularBy similarityAdd BLAST | 24 | |
Transmembranei | 209 – 229 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 230 – 254 | CytoplasmicBy similarityAdd BLAST | 25 | |
Transmembranei | 255 – 275 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 276 – 290 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 291 – 311 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 312 – 386 | CytoplasmicBy similarityAdd BLAST | 75 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069432 | 1 – 386 | Sphingosine 1-phosphate receptor 4Add BLAST | 386 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 325 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | Q9Z0L1 |
PRIDEi | Q9Z0L1 |
PTM databases
GlyGeni | Q9Z0L1, 2 sites |
PhosphoSitePlusi | Q9Z0L1 |
Expressioni
Tissue specificityi
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000044199, Expressed in granulocyte and 116 other tissues |
Genevisiblei | Q9Z0L1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000050412 |
Miscellaneous databases
RNActi | Q9Z0L1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQUE, Eukaryota |
GeneTreei | ENSGT01010000222268 |
HOGENOMi | CLU_047979_1_1_1 |
InParanoidi | Q9Z0L1 |
OMAi | YVCIANI |
OrthoDBi | 981486at2759 |
PhylomeDBi | Q9Z0L1 |
TreeFami | TF330052 |
Family and domain databases
InterProi | View protein in InterPro IPR004064, EDG6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
PANTHERi | PTHR22750:SF13, PTHR22750:SF13, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01526, EDG6RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Z0L1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNISTWSTLV TPESCHRLAA SGHSLLIVLH YNHSGRLASR GGSEDGGGLG
60 70 80 90 100
MLRGPSVAAG CLVVLENAMV LAAIAIYMRS RRWVYYCLLN ITLSDLLTGL
110 120 130 140 150
AYVVNVLLSG TRTFQLSPVH WFLREGLLFM ALAASTFSLL FTAGERFATM
160 170 180 190 200
VRVAESGATK TSRVYGCIGL CWLLAAILGL LPLLGWNCVC AFPRCSSLLP
210 220 230 240 250
LYSKGYVLFC VVVFALILVA ILSLYGAIFR VVRANGQKSP RPPARRKSRR
260 270 280 290 300
LLNTVLMILV AFVVCWGPLF GLLLADIFGS NVWAQEYLRG MDWILALAVF
310 320 330 340 350
NSAINPLIYS FRSREVQRAV LAFLCCGCLW LGLRGPGDCL TRITEAHSGA
360 370 380
STTDSSLRPR DSFRTSRSLS FRMREPLSSI SSVRST
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 | R → A in CAD33254 (PubMed:12401211).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ006074 mRNA Translation: CAA06847.1 AJ489247 Genomic DNA Translation: CAD33254.1 AK154242 mRNA Translation: BAE32458.1 BC107000 mRNA Translation: AAI07001.1 |
CCDSi | CCDS24059.1 |
RefSeqi | NP_034232.1, NM_010102.2 |
Genome annotation databases
Ensembli | ENSMUST00000053646; ENSMUSP00000050412; ENSMUSG00000044199 |
GeneIDi | 13611 |
KEGGi | mmu:13611 |
UCSCi | uc007gih.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ006074 mRNA Translation: CAA06847.1 AJ489247 Genomic DNA Translation: CAD33254.1 AK154242 mRNA Translation: BAE32458.1 BC107000 mRNA Translation: AAI07001.1 |
CCDSi | CCDS24059.1 |
RefSeqi | NP_034232.1, NM_010102.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000050412 |
Chemistry databases
GuidetoPHARMACOLOGYi | 278 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9Z0L1, 2 sites |
PhosphoSitePlusi | Q9Z0L1 |
Proteomic databases
PaxDbi | Q9Z0L1 |
PRIDEi | Q9Z0L1 |
Protocols and materials databases
Antibodypediai | 10967, 362 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000053646; ENSMUSP00000050412; ENSMUSG00000044199 |
GeneIDi | 13611 |
KEGGi | mmu:13611 |
UCSCi | uc007gih.2, mouse |
Organism-specific databases
CTDi | 8698 |
MGIi | MGI:1333809, S1pr4 |
Phylogenomic databases
eggNOGi | ENOG502QQUE, Eukaryota |
GeneTreei | ENSGT01010000222268 |
HOGENOMi | CLU_047979_1_1_1 |
InParanoidi | Q9Z0L1 |
OMAi | YVCIANI |
OrthoDBi | 981486at2759 |
PhylomeDBi | Q9Z0L1 |
TreeFami | TF330052 |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-419408, Lysosphingolipid and LPA receptors |
Miscellaneous databases
BioGRID-ORCSi | 13611, 0 hits in 17 CRISPR screens |
PROi | PR:Q9Z0L1 |
RNActi | Q9Z0L1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000044199, Expressed in granulocyte and 116 other tissues |
Genevisiblei | Q9Z0L1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004064, EDG6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
PANTHERi | PTHR22750:SF13, PTHR22750:SF13, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01526, EDG6RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S1PR4_MOUSE | |
Accessioni | Q9Z0L1Primary (citable) accession number: Q9Z0L1 Secondary accession number(s): Q3U4H3, Q8C6E2, Q8K1R9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries