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Protein

Pantetheinase

Gene

Vnn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.1 Publication

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81Proton acceptorPROSITE-ProRule annotation1
Active sitei180Proton donorPROSITE-ProRule annotation1
Active sitei213NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • GPI anchor binding Source: BHF-UCL
  • pantetheine hydrolase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-199220 Vitamin B5 (pantothenate) metabolism
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pantetheinase (EC:3.5.1.921 Publication)
Alternative name(s):
Pantetheine hydrolase
Vascular non-inflammatory molecule 1
Short name:
Vanin-1
Gene namesi
Name:Vnn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:108395 Vnn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice lack detectable levels of cysteamine in liver and kidney.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001971424 – 488PantetheinaseAdd BLAST465
PropeptideiPRO_0000019715489 – 512Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi488GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9Z0K8
PaxDbiQ9Z0K8
PeptideAtlasiQ9Z0K8
PRIDEiQ9Z0K8

PTM databases

iPTMnetiQ9Z0K8
PhosphoSitePlusiQ9Z0K8

Expressioni

Tissue specificityi

Detected in kidney (at protein level). Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000037440 Expressed in 193 organ(s), highest expression level in cumulus cell
CleanExiMM_VNN1
GenevisibleiQ9Z0K8 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040599

Structurei

3D structure databases

ProteinModelPortaliQ9Z0K8
SMRiQ9Z0K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 308CN hydrolasePROSITE-ProRule annotationAdd BLAST277

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
HOGENOMiHOG000007627
HOVERGENiHBG003996
InParanoidiQ9Z0K8
KOiK08069
OMAiKDWASNA
OrthoDBiEOG091G04QD
TreeFamiTF323645

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0K8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMSWWLACA AAFSALCVLK ASSLDTFLAA VYEHAVILPK DTLLPVSHSE
60 70 80 90 100
ALALMNQNLD LLEGAIVSAA KQGAHIIVTP EDGIYGVRFT RDTIYPYLEE
110 120 130 140 150
IPDPQVNWIP CDNPKRFGST PVQERLSCLA KNNSIYVVAN MGDKKPCNTS
160 170 180 190 200
DSHCPPDGRF QYNTDVVFDS QGKLVARYHK QNIFMGEDQF NVPMEPEFVT
210 220 230 240 250
FDTPFGKFGV FTCFDILFHD PAVTLVTEFQ VDTILFPTAW MDVLPHLAAI
260 270 280 290 300
EFHSAWAMGM GVNFLAANLH NPSRRMTGSG IYAPDSPRVF HYDRKTQEGK
310 320 330 340 350
LLFAQLKSHP IHSPVNWTSY ASSVESTPTK TQEFQSIVFF DEFTFVELKG
360 370 380 390 400
IKGNYTVCQN DLCCHLSYQM SEKRADEVYA FGAFDGLHTV EGQYYLQICI
410 420 430 440 450
LLKCKTTNLR TCGSSVDTAF TRFEMFSLSG TFGTRYVFPE VLLSEVKLAP
460 470 480 490 500
GEFQVSSDGR LVSLKPTSGP VLTIGLFGRL YGKDWASNAS SDFIAHSLII
510
MLIVTPIIHY LC
Length:512
Mass (Da):57,091
Last modified:July 27, 2011 - v3
Checksum:iD55E192765A8282C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3M → T in CAA10567 (PubMed:8934567).Curated1
Sequence conflicti3M → T in AAH19203 (PubMed:15489334).Curated1
Sequence conflicti49S → G in CAA10567 (PubMed:8934567).Curated1
Sequence conflicti71 – 72KQ → NE in BAB22347 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132098 mRNA Translation: CAA10567.1
AK002773 mRNA Translation: BAB22347.1
AK145984 mRNA Translation: BAE26806.1
AK167427 mRNA Translation: BAE39515.1
CH466540 Genomic DNA Translation: EDL04771.1
BC019203 mRNA Translation: AAH19203.1
CCDSiCCDS35868.1
RefSeqiNP_035834.2, NM_011704.3
UniGeneiMm.27154

Genome annotation databases

EnsembliENSMUST00000041416; ENSMUSP00000040599; ENSMUSG00000037440
GeneIDi22361
KEGGimmu:22361
UCSCiuc007eqc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132098 mRNA Translation: CAA10567.1
AK002773 mRNA Translation: BAB22347.1
AK145984 mRNA Translation: BAE26806.1
AK167427 mRNA Translation: BAE39515.1
CH466540 Genomic DNA Translation: EDL04771.1
BC019203 mRNA Translation: AAH19203.1
CCDSiCCDS35868.1
RefSeqiNP_035834.2, NM_011704.3
UniGeneiMm.27154

3D structure databases

ProteinModelPortaliQ9Z0K8
SMRiQ9Z0K8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040599

PTM databases

iPTMnetiQ9Z0K8
PhosphoSitePlusiQ9Z0K8

Proteomic databases

MaxQBiQ9Z0K8
PaxDbiQ9Z0K8
PeptideAtlasiQ9Z0K8
PRIDEiQ9Z0K8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041416; ENSMUSP00000040599; ENSMUSG00000037440
GeneIDi22361
KEGGimmu:22361
UCSCiuc007eqc.2 mouse

Organism-specific databases

CTDi8876
MGIiMGI:108395 Vnn1

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
HOGENOMiHOG000007627
HOVERGENiHBG003996
InParanoidiQ9Z0K8
KOiK08069
OMAiKDWASNA
OrthoDBiEOG091G04QD
TreeFamiTF323645

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-199220 Vitamin B5 (pantothenate) metabolism
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q9Z0K8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037440 Expressed in 193 organ(s), highest expression level in cumulus cell
CleanExiMM_VNN1
GenevisibleiQ9Z0K8 MM

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVNN1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0K8
Secondary accession number(s): Q3TJI0, Q8VCT1, Q9DCH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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