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Protein

CAP-Gly domain-containing linker protein 2

Gene

Clip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).By similarity

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • microtubule plus-end binding Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 2
Alternative name(s):
Cytoplasmic linker protein 115
Short name:
CLIP-115
Cytoplasmic linker protein 2
Gene namesi
Name:Clip2
Synonyms:Cyln2, Kiaa0291
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1313136 Clip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835161 – 1047CAP-Gly domain-containing linker protein 2Add BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1
Modified residuei203PhosphoserineBy similarity1
Modified residuei208PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei924PhosphoserineBy similarity1
Modified residuei974PhosphoserineCombined sources1
Modified residuei980PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z0H8
PeptideAtlasiQ9Z0H8
PRIDEiQ9Z0H8

PTM databases

iPTMnetiQ9Z0H8
PhosphoSitePlusiQ9Z0H8
SwissPalmiQ9Z0H8

Expressioni

Tissue specificityi

Expressed in the brain, and very low levels in kidneys.1 Publication

Developmental stagei

Expressed at E10.5, expression declines until birth after which it suddenly increases. Expression gradually decreases until postnatal day 10, (the day when DLBs start to occur), then again increases and reaches the levels present in adult brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000063146 Expressed in 148 organ(s), highest expression level in spinal cord mantle layer
CleanExiMM_CLIP2
GenevisibleiQ9Z0H8 MM

Interactioni

Subunit structurei

Interacts with CLASP1 and CLASP2 (PubMed:11290329). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (PubMed:16954346).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234703, 4 interactors
IntActiQ9Z0H8, 7 interactors
MINTiQ9Z0H8
STRINGi10090.ENSMUSP00000098212

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H8
SMRiQ9Z0H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 142CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini240 – 282CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 525Sequence analysisAdd BLAST171
Coiled coili564 – 637Sequence analysisAdd BLAST74
Coiled coili677 – 1017Sequence analysisAdd BLAST341

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi315 – 346Ser-richAdd BLAST32

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG4568 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000092755
HOVERGENiHBG007123
InParanoidiQ9Z0H8
KOiK10422
OMAiNMIESND
OrthoDBiEOG091G0J1Y
PhylomeDBiQ9Z0H8
TreeFamiTF326096

Family and domain databases

Gene3Di2.30.30.190, 2 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028394 CLIP2
PANTHERiPTHR18916:SF10 PTHR18916:SF10, 1 hit
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
SMARTiView protein in SMART
SM01052 CAP_GLY, 2 hits
SUPFAMiSSF74924 SSF74924, 2 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z0H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKPSGLKPP GRGGKHSSPV GRPSVGSASS SVVASTSGSK EGSPLHKQAS
60 70 80 90 100
GPSSSGAATT VSEKPGPKAA EVGDDFLGDF VVGERVWVNG VKPGVVQYLG
110 120 130 140 150
ETQFAPGQWA GVVLDDPVGK NDGAVGGVRY FECPALQGIF TRPSKLTRQP
160 170 180 190 200
TAEGSGSDTH SVESLTAQNL SLHSGTATPP LTGRVIPLRE SVLNSSVKTG
210 220 230 240 250
NESGSNLSDS GSVKRGDKDL HLGDRVLVGG TKTGVVRYVG ETDFAKGEWC
260 270 280 290 300
GVELDEPLGK NDGAVAGTRY FQCPPKFGLF APIHKVIRIG FPSTSPAKAK
310 320 330 340 350
KTKRMAMGVS ALTHSPSSSS ISSVSSVASS VGGRPSRSGL LTETSSRYAR
360 370 380 390 400
KISGTTALQE ALKEKQQHIE QLLAERDLER AEVAKATSHI CEVEKEIALL
410 420 430 440 450
KAQHEQYVAE AEEKLQRARL LVENVRKEKV DLSNQLEEER RKVEDLQFRV
460 470 480 490 500
EEESITKGDL ETQTQLEHAR IGELEQSLLL EKAQAERLLR ELADNRLTTV
510 520 530 540 550
AEKSRVLQLE EELSLRRGEI EELQHCLLQS GPPPADHPEA AETLRLRERL
560 570 580 590 600
LSASKEHQRD STLLQDKYEH MLKTYQTEVD KLRAANEKYA QEVADLKAKV
610 620 630 640 650
QQATTENMGL MDNWKSKLDS LASDHQKSLE DLKATLNSGP GAQQKEIGEL
660 670 680 690 700
KALVEGIKME HQLELGNLQA KHDLETAMHG KEKEGLRQKL QEVQEELAGL
710 720 730 740 750
QQHWREQLEE QASQHRLELQ EAQDQCRDAQ LRAQELEGLD VEYRGQAQAI
760 770 780 790 800
EFLKEQISLA EKKMLDYEML QRAEAQSRQE AERLREKLLV AENRLQAAES
810 820 830 840 850
LCSAQHSHVI ESSDLSEETI RMKETVEGLQ DKLNKRDKEV TALTSQMDML
860 870 880 890 900
RAQVSALENK CKSGEKKIDS LLKEKRRLEA ELEAVSRKTH DASGQLVHIS
910 920 930 940 950
QELLRKERSL NELRVLLLEA NRHSPGPERD LSREVHKAEW RIKEQKLKDD
960 970 980 990 1000
IRGLREKLTG LDKEKSLSEQ RRYSLIDPAS PPELLKLQHQ LVSTEDALRD
1010 1020 1030 1040
ALNQAQQVER LVEALRGCSD RTQTISNSGS ANGIHQPDKA HKQEDKH
Length:1,047
Mass (Da):115,910
Last modified:September 27, 2005 - v2
Checksum:i8F46948122F58872
GO
Isoform 2 (identifier: Q9Z0H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-496: Missing.

Show »
Length:1,012
Mass (Da):111,855
Checksum:i5CD0F481CFE7CFB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → I in AAH39162 (PubMed:15489334).Curated1
Sequence conflicti59T → A in CAA13068 (PubMed:9799601).Curated1
Sequence conflicti59T → A in CAA13069 (PubMed:9799601).Curated1
Sequence conflicti79D → H in CAA13068 (PubMed:9799601).Curated1
Sequence conflicti79D → H in CAA13069 (PubMed:9799601).Curated1
Sequence conflicti127G → A in CAA13068 (PubMed:9799601).Curated1
Sequence conflicti127G → A in CAA13069 (PubMed:9799601).Curated1
Sequence conflicti334 – 335RP → PA in CAA13068 (PubMed:9799601).Curated2
Sequence conflicti334 – 335RP → PA in CAA13069 (PubMed:9799601).Curated2
Sequence conflicti356T → I in CAA13068 (PubMed:9799601).Curated1
Sequence conflicti356T → I in CAA13069 (PubMed:9799601).Curated1
Sequence conflicti559R → D in CAA13068 (PubMed:9799601).Curated1
Sequence conflicti559R → D in CAA13069 (PubMed:9799601).Curated1
Sequence conflicti713 – 719SQHRLEL → AASAEA in CAA13068 (PubMed:9799601).Curated7
Sequence conflicti733A → V in CAA13068 (PubMed:9799601).Curated1
Sequence conflicti733A → V in CAA13069 (PubMed:9799601).Curated1
Sequence conflicti856A → V in CAA13068 (PubMed:9799601).Curated1
Sequence conflicti856A → V in CAA13069 (PubMed:9799601).Curated1
Sequence conflicti1003N → D in AAH39162 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015683462 – 496Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ228863 Genomic DNA Translation: CAA13068.1
AJ228865
, AJ228868, AJ228869, AJ228870, AJ228872, AJ228876, AJ228880, AJ228867, AJ228875, AJ228871, AJ228873, AJ228877, AJ228866, AJ228879, AJ228878, AJ228874 Genomic DNA Translation: CAA13069.1
AF289667 Genomic DNA Translation: AAF99340.1
AF289664 Genomic DNA Translation: AAF99333.1
BC039162 mRNA Translation: AAH39162.1
BC053048 mRNA Translation: AAH53048.1
CCDSiCCDS39309.1 [Q9Z0H8-2]
CCDS39310.1 [Q9Z0H8-1]
PIRiT42720
RefSeqiNP_001034251.1, NM_001039162.2 [Q9Z0H8-2]
NP_034120.2, NM_009990.3 [Q9Z0H8-1]
UniGeneiMm.255138

Genome annotation databases

EnsembliENSMUST00000036999; ENSMUSP00000037431; ENSMUSG00000063146 [Q9Z0H8-2]
ENSMUST00000100647; ENSMUSP00000098212; ENSMUSG00000063146 [Q9Z0H8-1]
GeneIDi269713
KEGGimmu:269713
UCSCiuc008zwi.2 mouse [Q9Z0H8-1]
uc008zwj.2 mouse [Q9Z0H8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ228863 Genomic DNA Translation: CAA13068.1
AJ228865
, AJ228868, AJ228869, AJ228870, AJ228872, AJ228876, AJ228880, AJ228867, AJ228875, AJ228871, AJ228873, AJ228877, AJ228866, AJ228879, AJ228878, AJ228874 Genomic DNA Translation: CAA13069.1
AF289667 Genomic DNA Translation: AAF99340.1
AF289664 Genomic DNA Translation: AAF99333.1
BC039162 mRNA Translation: AAH39162.1
BC053048 mRNA Translation: AAH53048.1
CCDSiCCDS39309.1 [Q9Z0H8-2]
CCDS39310.1 [Q9Z0H8-1]
PIRiT42720
RefSeqiNP_001034251.1, NM_001039162.2 [Q9Z0H8-2]
NP_034120.2, NM_009990.3 [Q9Z0H8-1]
UniGeneiMm.255138

3D structure databases

ProteinModelPortaliQ9Z0H8
SMRiQ9Z0H8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234703, 4 interactors
IntActiQ9Z0H8, 7 interactors
MINTiQ9Z0H8
STRINGi10090.ENSMUSP00000098212

PTM databases

iPTMnetiQ9Z0H8
PhosphoSitePlusiQ9Z0H8
SwissPalmiQ9Z0H8

Proteomic databases

PaxDbiQ9Z0H8
PeptideAtlasiQ9Z0H8
PRIDEiQ9Z0H8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036999; ENSMUSP00000037431; ENSMUSG00000063146 [Q9Z0H8-2]
ENSMUST00000100647; ENSMUSP00000098212; ENSMUSG00000063146 [Q9Z0H8-1]
GeneIDi269713
KEGGimmu:269713
UCSCiuc008zwi.2 mouse [Q9Z0H8-1]
uc008zwj.2 mouse [Q9Z0H8-2]

Organism-specific databases

CTDi7461
MGIiMGI:1313136 Clip2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4568 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000092755
HOVERGENiHBG007123
InParanoidiQ9Z0H8
KOiK10422
OMAiNMIESND
OrthoDBiEOG091G0J1Y
PhylomeDBiQ9Z0H8
TreeFamiTF326096

Miscellaneous databases

PROiPR:Q9Z0H8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063146 Expressed in 148 organ(s), highest expression level in spinal cord mantle layer
CleanExiMM_CLIP2
GenevisibleiQ9Z0H8 MM

Family and domain databases

Gene3Di2.30.30.190, 2 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028394 CLIP2
PANTHERiPTHR18916:SF10 PTHR18916:SF10, 1 hit
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
SMARTiView protein in SMART
SM01052 CAP_GLY, 2 hits
SUPFAMiSSF74924 SSF74924, 2 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCLIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H8
Secondary accession number(s): Q7TSI9, Q8CHU1, Q9EP81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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