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Protein

Cystatin-9

Gene

Cst9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in testis development (PubMed:9826679). May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243).By similarity1 Publication1 Publication

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral response Source: UniProtKB

Keywordsi

Molecular functionAntimicrobial, Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-9
Alternative name(s):
Testatin1 Publication
Gene namesi
Name:Cst9
Synonyms:Cresp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1340053 Cst9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; probably due to redundancy with other family members.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000665732 – 137Cystatin-9Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 102By similarity
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi116 ↔ 136By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0H6
PRIDEiQ9Z0H6

PTM databases

PhosphoSitePlusiQ9Z0H6

Expressioni

Tissue specificityi

Expression is restricted to fetal gonads and adult testis.1 Publication

Developmental stagei

Expressed during testis cord formation in pre-Sertoli cells, at a time immediately after the peak of SRY expression.1 Publication

Gene expression databases

BgeeiENSMUSG00000027445 Expressed in 22 organ(s), highest expression level in testis
CleanExiMM_CST9
GenevisibleiQ9Z0H6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028935

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H6
SMRiQ9Z0H6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1WW Eukaryota
ENOG4111DUC LUCA
GeneTreeiENSGT00430000031103
HOGENOMiHOG000231754
HOVERGENiHBG096568
InParanoidiQ9Z0H6
KOiK13905
OMAiRRTICKK
OrthoDBiEOG091G0YM0
PhylomeDBiQ9Z0H6

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0H6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCPLRKKAL PLTMLLLLLS FHVLITPVSK ANKETNRSVH FIPTVEFAVN
60 70 80 90 100
TFNQESQDEY AYRMEHIMSS WREKVNFPTV YSMRLQLRRT ICKKFEESLD
110 120 130
ICPFQESHGL NNTFTCLFTV GTYPWITKFK LFRSVCS
Length:137
Mass (Da):16,094
Last modified:May 1, 1999 - v1
Checksum:iAC1CDE5834C36FB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18243 mRNA Translation: CAA77090.1
AB017157 mRNA Translation: BAA37089.1
AK006429 mRNA Translation: BAB24584.1
AL844519 Genomic DNA No translation available.
BC048486 mRNA Translation: AAH48486.1
CCDSiCCDS16850.1
RefSeqiNP_034109.1, NM_009979.1
UniGeneiMm.21005

Genome annotation databases

EnsembliENSMUST00000028935; ENSMUSP00000028935; ENSMUSG00000027445
GeneIDi13013
KEGGimmu:13013
UCSCiuc008mtr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18243 mRNA Translation: CAA77090.1
AB017157 mRNA Translation: BAA37089.1
AK006429 mRNA Translation: BAB24584.1
AL844519 Genomic DNA No translation available.
BC048486 mRNA Translation: AAH48486.1
CCDSiCCDS16850.1
RefSeqiNP_034109.1, NM_009979.1
UniGeneiMm.21005

3D structure databases

ProteinModelPortaliQ9Z0H6
SMRiQ9Z0H6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028935

PTM databases

PhosphoSitePlusiQ9Z0H6

Proteomic databases

PaxDbiQ9Z0H6
PRIDEiQ9Z0H6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028935; ENSMUSP00000028935; ENSMUSG00000027445
GeneIDi13013
KEGGimmu:13013
UCSCiuc008mtr.1 mouse

Organism-specific databases

CTDi128822
MGIiMGI:1340053 Cst9

Phylogenomic databases

eggNOGiENOG410J1WW Eukaryota
ENOG4111DUC LUCA
GeneTreeiENSGT00430000031103
HOGENOMiHOG000231754
HOVERGENiHBG096568
InParanoidiQ9Z0H6
KOiK13905
OMAiRRTICKK
OrthoDBiEOG091G0YM0
PhylomeDBiQ9Z0H6

Miscellaneous databases

PROiPR:Q9Z0H6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027445 Expressed in 22 organ(s), highest expression level in testis
CleanExiMM_CST9
GenevisibleiQ9Z0H6 MM

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCST9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H6
Secondary accession number(s): Q545L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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