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Entry version 149 (08 May 2019)
Sequence version 1 (01 May 1999)
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Protein

CUGBP Elav-like family member 2

Gene

Celf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (By similarity). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (By similarity). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK (By similarity). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5 (By similarity). Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs (By similarity). Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • pre-mRNA binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUGBP Elav-like family member 2
Short name:
CELF-2
Alternative name(s):
Bruno-like protein 3
CUG triplet repeat RNA-binding protein 2
Short name:
CUG-BP2
CUG-BP- and ETR-3-like factor 2
ELAV-type RNA-binding protein 3
Short name:
ETR-3
Short name:
mETR-3
Neuroblastoma apoptosis-related RNA-binding protein
Short name:
mNapor
RNA-binding protein BRUNOL-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celf2
Synonyms:Cugbp2, Napor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1338822 Celf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002951901 – 508CUGBP Elav-like family member 2Add BLAST508

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z0H4

PeptideAtlas

More...
PeptideAtlasi
Q9Z0H4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z0H4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z0H4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Z0H4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Z0H4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in tongue, spleen and brain (at protein level). Expressed in liver, thigh, stomach, lung and heart to very low levels (at protein level). Expressed in heart, brain, lung and muscle.4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in heart, muscle, brain, liver, thigh, stomach and lung at 14 dpc (at protein level). Expressed in embryo at 7, 11 and 17 dpc. Expressed in the developing central nervous system from 12 to 16 dpc.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated following ionizing radiation in the crypt epithelial cells of the intestin. Down-regulated by bacterial lipopolysaccharides (LPS). Down-regulated by prostaglandin E2 following ionizing radiation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000002107 Expressed in 287 organ(s), highest expression level in rostral migratory stream

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Z0H4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Z0H4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with A1CF.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9Z0H4, 1 interactor

Molecular INTeraction database

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MINTi
Q9Z0H4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000110584

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z0H4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 123RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini132 – 212RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini423 – 501RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 283Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionBy similarityAdd BLAST283
Regioni357 – 508Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionBy similarityAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi284 – 397Ala-richAdd BLAST114

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0146 Eukaryota
ENOG410XNTW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155461

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Z0H4

KEGG Orthology (KO)

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KOi
K13207

Identification of Orthologs from Complete Genome Data

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OMAi
GVSKRCA

Database of Orthologous Groups

More...
OrthoDBi
1209165at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z0H4

TreeFam database of animal gene trees

More...
TreeFami
TF314924

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00961 HUDSXLRNA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z0H4-1) [UniParc]FASTAAdd to basket
Also known as: Napor-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRCPKSAVTM RNEELLLSNG TANKMNGALD HSDQPDPDAI KMFVGQIPRS
60 70 80 90 100
WSEKELKELF EPYGAVYQIN VLRDRSQNPP QSKGCCFVTF YTRKAALEAQ
110 120 130 140 150
NALHNIKTLP GMHHPIQMKP ADSEKSNAVE DRKLFIGMVS KKCNENDIRV
160 170 180 190 200
MFSPFGQIEE CRILRGPDGL SRGCAFVTFS TRAMAQNAIK AMHQSQTMEG
210 220 230 240 250
CSSPIVVKFA DTQKDKEQRR LQQQLAQQMQ QLNTATWGNL TGLGGLTPQY
260 270 280 290 300
LALLQQATSS SNLGAFSGIQ QMAGMNALQL QNLATLAAAA AAAQTSATST
310 320 330 340 350
NANPLSSTSS ALGALTSPVA ASTPNSTAGA AMNSLTSLGT LQGLAGATVG
360 370 380 390 400
LNNINALAGM AALNGGLGAT GLTNGTAGTM DALTQAYSGI QQYAAAALPT
410 420 430 440 450
LYSQSLLQQQ SAAGSQKEGP EGANLFIYHL PQEFGDQDIL QMFMPFGNVI
460 470 480 490 500
SAKVFIDKQT NLSKCFGFVS YDNPVSAQAA IQAMNGFQIG MKRLKVQLKR

SKNDSKPY
Length:508
Mass (Da):54,271
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC35CBEF598749A79
GO
Isoform 2 (identifier: Q9Z0H4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MRCPKSAVTMRNEELLL → MVSLISDLDSLRGWKALRETATELSGSPP

Show »
Length:520
Mass (Da):55,410
Checksum:iD953BE720659AA40
GO
Isoform 3 (identifier: Q9Z0H4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-274: Missing.
     359-359: G → GTINS

Show »
Length:238
Mass (Da):24,288
Checksum:iB481A9789044F18D
GO
Isoform 4 (identifier: Q9Z0H4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     358-358: A → AVAQMLS

Show »
Length:490
Mass (Da):52,254
Checksum:iE83296A0F13D90BE
GO
Isoform 5 (identifier: Q9Z0H4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     359-359: G → GTINS

Show »
Length:488
Mass (Da):52,040
Checksum:i6CED374F47024FCD
GO
Isoform 6 (identifier: Q9Z0H4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MRCPKSAVTMRNEELLL → MVSLISDLDSLRGWKALRETATELSGSPP
     359-359: G → GTINS

Show »
Length:524
Mass (Da):55,825
Checksum:iF410C2916232026B
GO
Isoform 7 (identifier: Q9Z0H4-7) [UniParc]FASTAAdd to basket
Also known as: Napor-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:484
Mass (Da):51,625
Checksum:i5C63F3D4F7203E56
GO
Isoform 8 (identifier: Q9Z0H4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: G → GTINS

Show »
Length:512
Mass (Da):54,686
Checksum:i3F0C1FB0483D02EC
GO
Isoform 9 (identifier: Q9Z0H4-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFERTSELAFVETISVESM

Note: Gene prediction based on similarity to rat ortholog. No experimental confirmation available.
Show »
Length:526
Mass (Da):56,328
Checksum:i8852489573C931B4
GO
Isoform 11 (identifier: Q9Z0H4-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: G → GTINS
     419-466: Missing.

Show »
Length:464
Mass (Da):49,254
Checksum:i5F95C63D5FF253D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1S7S4R1S7_MOUSE
CUGBP Elav-like family member 2
Celf2
472Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KGT0A3KGT0_MOUSE
CUGBP Elav-like family member 2
Celf2
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA47E9QA47_MOUSE
CUGBP Elav-like family member 2
Celf2
478Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GX43V9GX43_MOUSE
CUGBP Elav-like family member 2
Celf2
443Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2L5S4R2L5_MOUSE
CUGBP Elav-like family member 2
Celf2
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2B0A0A0R4J2B0_MOUSE
CUGBP Elav-like family member 2
Celf2
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2J2S4R2J2_MOUSE
CUGBP Elav-like family member 2
Celf2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2U7S4R2U7_MOUSE
CUGBP Elav-like family member 2
Celf2
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2S7S4R2S7_MOUSE
CUGBP Elav-like family member 2
Celf2
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2U1S4R2U1_MOUSE
CUGBP Elav-like family member 2
Celf2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE31371 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Isoform 7 : The sequence CAA77110 differs from that shown. Reason: Frameshift at positions 395 and 415.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218Q → K in CAA77110 (PubMed:9887331).Curated1
Sequence conflicti245G → E in CAA77110 (PubMed:9887331).Curated1
Sequence conflicti420P → T in BAE30715 (PubMed:16141072).Curated1
Sequence conflicti420P → T in BAE31857 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0268011 – 274Missing in isoform 3. 1 PublicationAdd BLAST274
Alternative sequenceiVSP_0268021 – 24Missing in isoform 4, isoform 5 and isoform 7. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_0268031 – 17MRCPK…EELLL → MVSLISDLDSLRGWKALRET ATELSGSPP in isoform 2 and isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0268041M → MFERTSELAFVETISVESM in isoform 9. Curated1
Alternative sequenceiVSP_026805358A → AVAQMLS in isoform 4. 1 Publication1
Alternative sequenceiVSP_026806359G → GTINS in isoform 3, isoform 5, isoform 6, isoform 8 and isoform 11. 1 Publication1
Alternative sequenceiVSP_026808419 – 466Missing in isoform 11. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF090696 mRNA Translation: AAD13763.1
AF090697 mRNA Translation: AAD13764.1
Y18298 mRNA Translation: CAA77110.1 Frameshift.
AK137292 mRNA Translation: BAE23295.1
AK151818 mRNA Translation: BAE30715.1
AK152628 mRNA Translation: BAE31371.1 Different initiation.
AK153267 mRNA Translation: BAE31857.1
AK160861 mRNA Translation: BAE36053.1
AK161349 mRNA Translation: BAE36341.1
AK164914 mRNA Translation: BAE37963.1
AL845492 Genomic DNA No translation available.
AL845515 Genomic DNA No translation available.
AL929240 Genomic DNA No translation available.
BC026856 mRNA Translation: AAH26856.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50491.1 [Q9Z0H4-7]
CCDS50492.1 [Q9Z0H4-4]
CCDS50494.1 [Q9Z0H4-9]
CCDS59633.1 [Q9Z0H4-2]
CCDS84468.1 [Q9Z0H4-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001103698.1, NM_001110228.1 [Q9Z0H4-9]
NP_001103699.1, NM_001110229.1 [Q9Z0H4-6]
NP_001103700.1, NM_001110230.1 [Q9Z0H4-2]
NP_001103701.1, NM_001110231.1 [Q9Z0H4-4]
NP_001103702.1, NM_001110232.1 [Q9Z0H4-7]
NP_001153764.1, NM_001160292.1
NP_001153765.1, NM_001160293.1 [Q9Z0H4-9]
NP_001297376.1, NM_001310447.1
NP_001334023.1, NM_001347094.1 [Q9Z0H4-5]
NP_034290.2, NM_010160.2
XP_006497400.1, XM_006497337.3 [Q9Z0H4-9]
XP_017170933.1, XM_017315444.1
XP_017170953.1, XM_017315464.1 [Q9Z0H4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000002176; ENSMUSP00000002176; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000100429; ENSMUSP00000097996; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000114924; ENSMUSP00000110574; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000114927; ENSMUSP00000110577; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000114934; ENSMUSP00000110584; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000142941; ENSMUSP00000120459; ENSMUSG00000002107 [Q9Z0H4-4]
ENSMUST00000150624; ENSMUSP00000138297; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000182706; ENSMUSP00000138764; ENSMUSG00000002107 [Q9Z0H4-2]
ENSMUST00000182851; ENSMUSP00000138363; ENSMUSG00000002107 [Q9Z0H4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14007

UCSC genome browser

More...
UCSCi
uc008ign.2 mouse [Q9Z0H4-3]
uc008igp.2 mouse [Q9Z0H4-4]
uc008igq.3 mouse [Q9Z0H4-11]
uc008igr.3 mouse [Q9Z0H4-9]
uc008igs.3 mouse [Q9Z0H4-2]
uc008igt.3 mouse [Q9Z0H4-6]
uc008igv.3 mouse [Q9Z0H4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090696 mRNA Translation: AAD13763.1
AF090697 mRNA Translation: AAD13764.1
Y18298 mRNA Translation: CAA77110.1 Frameshift.
AK137292 mRNA Translation: BAE23295.1
AK151818 mRNA Translation: BAE30715.1
AK152628 mRNA Translation: BAE31371.1 Different initiation.
AK153267 mRNA Translation: BAE31857.1
AK160861 mRNA Translation: BAE36053.1
AK161349 mRNA Translation: BAE36341.1
AK164914 mRNA Translation: BAE37963.1
AL845492 Genomic DNA No translation available.
AL845515 Genomic DNA No translation available.
AL929240 Genomic DNA No translation available.
BC026856 mRNA Translation: AAH26856.1
CCDSiCCDS50491.1 [Q9Z0H4-7]
CCDS50492.1 [Q9Z0H4-4]
CCDS50494.1 [Q9Z0H4-9]
CCDS59633.1 [Q9Z0H4-2]
CCDS84468.1 [Q9Z0H4-5]
RefSeqiNP_001103698.1, NM_001110228.1 [Q9Z0H4-9]
NP_001103699.1, NM_001110229.1 [Q9Z0H4-6]
NP_001103700.1, NM_001110230.1 [Q9Z0H4-2]
NP_001103701.1, NM_001110231.1 [Q9Z0H4-4]
NP_001103702.1, NM_001110232.1 [Q9Z0H4-7]
NP_001153764.1, NM_001160292.1
NP_001153765.1, NM_001160293.1 [Q9Z0H4-9]
NP_001297376.1, NM_001310447.1
NP_001334023.1, NM_001347094.1 [Q9Z0H4-5]
NP_034290.2, NM_010160.2
XP_006497400.1, XM_006497337.3 [Q9Z0H4-9]
XP_017170933.1, XM_017315444.1
XP_017170953.1, XM_017315464.1 [Q9Z0H4-4]

3D structure databases

SMRiQ9Z0H4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z0H4, 1 interactor
MINTiQ9Z0H4
STRINGi10090.ENSMUSP00000110584

PTM databases

iPTMnetiQ9Z0H4
PhosphoSitePlusiQ9Z0H4
SwissPalmiQ9Z0H4

Proteomic databases

PaxDbiQ9Z0H4
PeptideAtlasiQ9Z0H4
PRIDEiQ9Z0H4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002176; ENSMUSP00000002176; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000100429; ENSMUSP00000097996; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000114924; ENSMUSP00000110574; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000114927; ENSMUSP00000110577; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000114934; ENSMUSP00000110584; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000142941; ENSMUSP00000120459; ENSMUSG00000002107 [Q9Z0H4-4]
ENSMUST00000150624; ENSMUSP00000138297; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000182706; ENSMUSP00000138764; ENSMUSG00000002107 [Q9Z0H4-2]
ENSMUST00000182851; ENSMUSP00000138363; ENSMUSG00000002107 [Q9Z0H4-1]
GeneIDi14007
KEGGimmu:14007
UCSCiuc008ign.2 mouse [Q9Z0H4-3]
uc008igp.2 mouse [Q9Z0H4-4]
uc008igq.3 mouse [Q9Z0H4-11]
uc008igr.3 mouse [Q9Z0H4-9]
uc008igs.3 mouse [Q9Z0H4-2]
uc008igt.3 mouse [Q9Z0H4-6]
uc008igv.3 mouse [Q9Z0H4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10659
MGIiMGI:1338822 Celf2

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00940000155461
InParanoidiQ9Z0H4
KOiK13207
OMAiGVSKRCA
OrthoDBi1209165at2759
PhylomeDBiQ9Z0H4
TreeFamiTF314924

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Celf2 mouse

Protein Ontology

More...
PROi
PR:Q9Z0H4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000002107 Expressed in 287 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiQ9Z0H4 baseline and differential
GenevisibleiQ9Z0H4 MM

Family and domain databases

CDDicd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELF2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z0H4
Secondary accession number(s): A2AS10
, A2AS11, A2AS15, Q3TNX4, Q3TTI4, Q3TUB8, Q3U668, Q3U7J8, Q3U9F2, Q3UVH4, Q9R0B2, Q9Z187
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 1999
Last modified: May 8, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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