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Protein

CUGBP Elav-like family member 2

Gene

Celf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (By similarity). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (By similarity). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK (By similarity). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5 (By similarity). Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs (By similarity). Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity).By similarity3 Publications

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • pre-mRNA binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
CUGBP Elav-like family member 2
Short name:
CELF-2
Alternative name(s):
Bruno-like protein 3
CUG triplet repeat RNA-binding protein 2
Short name:
CUG-BP2
CUG-BP- and ETR-3-like factor 2
ELAV-type RNA-binding protein 3
Short name:
ETR-3
Short name:
mETR-3
Neuroblastoma apoptosis-related RNA-binding protein
Short name:
mNapor
RNA-binding protein BRUNOL-3
Gene namesi
Name:Celf2
Synonyms:Cugbp2, Napor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1338822 Celf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951901 – 508CUGBP Elav-like family member 2Add BLAST508

Proteomic databases

PaxDbiQ9Z0H4
PeptideAtlasiQ9Z0H4
PRIDEiQ9Z0H4

PTM databases

iPTMnetiQ9Z0H4
PhosphoSitePlusiQ9Z0H4
SwissPalmiQ9Z0H4

Expressioni

Tissue specificityi

Expressed in tongue, spleen and brain (at protein level). Expressed in liver, thigh, stomach, lung and heart to very low levels (at protein level). Expressed in heart, brain, lung and muscle.4 Publications

Developmental stagei

Expressed in heart, muscle, brain, liver, thigh, stomach and lung at 14 dpc (at protein level). Expressed in embryo at 7, 11 and 17 dpc. Expressed in the developing central nervous system from 12 to 16 dpc.2 Publications

Inductioni

Up-regulated following ionizing radiation in the crypt epithelial cells of the intestin. Down-regulated by bacterial lipopolysaccharides (LPS). Down-regulated by prostaglandin E2 following ionizing radiation.2 Publications

Gene expression databases

BgeeiENSMUSG00000002107 Expressed in 287 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CUGBP2
ExpressionAtlasiQ9Z0H4 baseline and differential
GenevisibleiQ9Z0H4 MM

Interactioni

Subunit structurei

Interacts with A1CF.By similarity

Protein-protein interaction databases

IntActiQ9Z0H4, 1 interactor
MINTiQ9Z0H4
STRINGi10090.ENSMUSP00000110574

Structurei

3D structure databases

ProteinModelPortaliQ9Z0H4
SMRiQ9Z0H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 123RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini132 – 212RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini423 – 501RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 283Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionBy similarityAdd BLAST283
Regioni357 – 508Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionBy similarityAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi284 – 397Ala-richAdd BLAST114

Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00560000076837
HOVERGENiHBG107646
InParanoidiQ9Z0H4
KOiK13207
OMAiMAXAAST
OrthoDBiEOG091G19O1
PhylomeDBiQ9Z0H4
TreeFamiTF314924

Family and domain databases

CDDicd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (10+)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z0H4-1) [UniParc]FASTAAdd to basket
Also known as: Napor-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRCPKSAVTM RNEELLLSNG TANKMNGALD HSDQPDPDAI KMFVGQIPRS
60 70 80 90 100
WSEKELKELF EPYGAVYQIN VLRDRSQNPP QSKGCCFVTF YTRKAALEAQ
110 120 130 140 150
NALHNIKTLP GMHHPIQMKP ADSEKSNAVE DRKLFIGMVS KKCNENDIRV
160 170 180 190 200
MFSPFGQIEE CRILRGPDGL SRGCAFVTFS TRAMAQNAIK AMHQSQTMEG
210 220 230 240 250
CSSPIVVKFA DTQKDKEQRR LQQQLAQQMQ QLNTATWGNL TGLGGLTPQY
260 270 280 290 300
LALLQQATSS SNLGAFSGIQ QMAGMNALQL QNLATLAAAA AAAQTSATST
310 320 330 340 350
NANPLSSTSS ALGALTSPVA ASTPNSTAGA AMNSLTSLGT LQGLAGATVG
360 370 380 390 400
LNNINALAGM AALNGGLGAT GLTNGTAGTM DALTQAYSGI QQYAAAALPT
410 420 430 440 450
LYSQSLLQQQ SAAGSQKEGP EGANLFIYHL PQEFGDQDIL QMFMPFGNVI
460 470 480 490 500
SAKVFIDKQT NLSKCFGFVS YDNPVSAQAA IQAMNGFQIG MKRLKVQLKR

SKNDSKPY
Length:508
Mass (Da):54,271
Last modified:May 1, 1999 - v1
Checksum:iC35CBEF598749A79
GO
Isoform 2 (identifier: Q9Z0H4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MRCPKSAVTMRNEELLL → MVSLISDLDSLRGWKALRETATELSGSPP

Show »
Length:520
Mass (Da):55,410
Checksum:iD953BE720659AA40
GO
Isoform 3 (identifier: Q9Z0H4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-274: Missing.
     359-359: G → GTINS

Show »
Length:238
Mass (Da):24,288
Checksum:iB481A9789044F18D
GO
Isoform 4 (identifier: Q9Z0H4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     358-358: A → AVAQMLS

Show »
Length:490
Mass (Da):52,254
Checksum:iE83296A0F13D90BE
GO
Isoform 5 (identifier: Q9Z0H4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     359-359: G → GTINS

Show »
Length:488
Mass (Da):52,040
Checksum:i6CED374F47024FCD
GO
Isoform 6 (identifier: Q9Z0H4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MRCPKSAVTMRNEELLL → MVSLISDLDSLRGWKALRETATELSGSPP
     359-359: G → GTINS

Show »
Length:524
Mass (Da):55,825
Checksum:iF410C2916232026B
GO
Isoform 7 (identifier: Q9Z0H4-7) [UniParc]FASTAAdd to basket
Also known as: Napor-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:484
Mass (Da):51,625
Checksum:i5C63F3D4F7203E56
GO
Isoform 8 (identifier: Q9Z0H4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: G → GTINS

Show »
Length:512
Mass (Da):54,686
Checksum:i3F0C1FB0483D02EC
GO
Isoform 9 (identifier: Q9Z0H4-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFERTSELAFVETISVESM

Note: Gene prediction based on similarity to rat ortholog. No experimental confirmation available.
Show »
Length:526
Mass (Da):56,328
Checksum:i8852489573C931B4
GO
Isoform 11 (identifier: Q9Z0H4-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: G → GTINS
     419-466: Missing.

Show »
Length:464
Mass (Da):49,254
Checksum:i5F95C63D5FF253D2
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QA47E9QA47_MOUSE
CUGBP Elav-like family member 2
Celf2
478Annotation score:
S4R1S7S4R1S7_MOUSE
CUGBP Elav-like family member 2
Celf2
472Annotation score:
A3KGT0A3KGT0_MOUSE
CUGBP Elav-like family member 2
Celf2
159Annotation score:
S4R2L5S4R2L5_MOUSE
CUGBP Elav-like family member 2
Celf2
134Annotation score:
V9GX43V9GX43_MOUSE
CUGBP Elav-like family member 2
Celf2
443Annotation score:
S4R2J2S4R2J2_MOUSE
CUGBP Elav-like family member 2
Celf2
92Annotation score:
A0A0R4J2B0A0A0R4J2B0_MOUSE
CUGBP Elav-like family member 2
Celf2
440Annotation score:
S4R2U7S4R2U7_MOUSE
CUGBP Elav-like family member 2
Celf2
460Annotation score:
S4R2S7S4R2S7_MOUSE
CUGBP Elav-like family member 2
Celf2
276Annotation score:
S4R2U1S4R2U1_MOUSE
CUGBP Elav-like family member 2
Celf2
46Annotation score:

Sequence cautioni

The sequence BAE31371 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Isoform 7 : The sequence CAA77110 differs from that shown. Reason: Frameshift at positions 395 and 415.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218Q → K in CAA77110 (PubMed:9887331).Curated1
Sequence conflicti245G → E in CAA77110 (PubMed:9887331).Curated1
Sequence conflicti420P → T in BAE30715 (PubMed:16141072).Curated1
Sequence conflicti420P → T in BAE31857 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0268011 – 274Missing in isoform 3. 1 PublicationAdd BLAST274
Alternative sequenceiVSP_0268021 – 24Missing in isoform 4, isoform 5 and isoform 7. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_0268031 – 17MRCPK…EELLL → MVSLISDLDSLRGWKALRET ATELSGSPP in isoform 2 and isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0268041M → MFERTSELAFVETISVESM in isoform 9. Curated1
Alternative sequenceiVSP_026805358A → AVAQMLS in isoform 4. 1 Publication1
Alternative sequenceiVSP_026806359G → GTINS in isoform 3, isoform 5, isoform 6, isoform 8 and isoform 11. 1 Publication1
Alternative sequenceiVSP_026808419 – 466Missing in isoform 11. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090696 mRNA Translation: AAD13763.1
AF090697 mRNA Translation: AAD13764.1
Y18298 mRNA Translation: CAA77110.1 Frameshift.
AK137292 mRNA Translation: BAE23295.1
AK151818 mRNA Translation: BAE30715.1
AK152628 mRNA Translation: BAE31371.1 Different initiation.
AK153267 mRNA Translation: BAE31857.1
AK160861 mRNA Translation: BAE36053.1
AK161349 mRNA Translation: BAE36341.1
AK164914 mRNA Translation: BAE37963.1
AL929240, AL845492, AL845515 Genomic DNA Translation: CAM18466.1
AL845515, AL845492, AL929240 Genomic DNA Translation: CAM18813.1
AL845515, AL845492 Genomic DNA Translation: CAM18816.1
AL845515, AL845492 Genomic DNA Translation: CAM18817.1
AL845515, AL845492 Genomic DNA Translation: CAM18818.1
AL845492, AL845515, AL929240 Genomic DNA Translation: CAM46032.1
AL845492, AL845515 Genomic DNA Translation: CAM46034.1
AL845492, AL845515 Genomic DNA Translation: CAM46035.1
AL845492, AL845515 Genomic DNA Translation: CAM46036.1
BC026856 mRNA Translation: AAH26856.1
CCDSiCCDS50491.1 [Q9Z0H4-7]
CCDS50492.1 [Q9Z0H4-4]
CCDS50494.1 [Q9Z0H4-9]
CCDS59633.1 [Q9Z0H4-2]
CCDS84468.1 [Q9Z0H4-5]
RefSeqiNP_001103698.1, NM_001110228.1 [Q9Z0H4-9]
NP_001103699.1, NM_001110229.1 [Q9Z0H4-6]
NP_001103700.1, NM_001110230.1 [Q9Z0H4-2]
NP_001103701.1, NM_001110231.1 [Q9Z0H4-4]
NP_001103702.1, NM_001110232.1 [Q9Z0H4-7]
NP_001153764.1, NM_001160292.1
NP_001153765.1, NM_001160293.1 [Q9Z0H4-9]
NP_001297376.1, NM_001310447.1
NP_001334023.1, NM_001347094.1 [Q9Z0H4-5]
NP_034290.2, NM_010160.2
XP_006497400.1, XM_006497337.3 [Q9Z0H4-9]
XP_017170933.1, XM_017315444.1
XP_017170953.1, XM_017315464.1 [Q9Z0H4-4]
UniGeneiMm.398543

Genome annotation databases

EnsembliENSMUST00000002176; ENSMUSP00000002176; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000100429; ENSMUSP00000097996; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000114924; ENSMUSP00000110574; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000114927; ENSMUSP00000110577; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000114934; ENSMUSP00000110584; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000142941; ENSMUSP00000120459; ENSMUSG00000002107 [Q9Z0H4-4]
ENSMUST00000150624; ENSMUSP00000138297; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000182706; ENSMUSP00000138764; ENSMUSG00000002107 [Q9Z0H4-2]
ENSMUST00000182851; ENSMUSP00000138363; ENSMUSG00000002107 [Q9Z0H4-1]
GeneIDi14007
KEGGimmu:14007
UCSCiuc008ign.2 mouse [Q9Z0H4-3]
uc008igp.2 mouse [Q9Z0H4-4]
uc008igq.3 mouse [Q9Z0H4-11]
uc008igr.3 mouse [Q9Z0H4-9]
uc008igs.3 mouse [Q9Z0H4-2]
uc008igt.3 mouse [Q9Z0H4-6]
uc008igv.3 mouse [Q9Z0H4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090696 mRNA Translation: AAD13763.1
AF090697 mRNA Translation: AAD13764.1
Y18298 mRNA Translation: CAA77110.1 Frameshift.
AK137292 mRNA Translation: BAE23295.1
AK151818 mRNA Translation: BAE30715.1
AK152628 mRNA Translation: BAE31371.1 Different initiation.
AK153267 mRNA Translation: BAE31857.1
AK160861 mRNA Translation: BAE36053.1
AK161349 mRNA Translation: BAE36341.1
AK164914 mRNA Translation: BAE37963.1
AL929240, AL845492, AL845515 Genomic DNA Translation: CAM18466.1
AL845515, AL845492, AL929240 Genomic DNA Translation: CAM18813.1
AL845515, AL845492 Genomic DNA Translation: CAM18816.1
AL845515, AL845492 Genomic DNA Translation: CAM18817.1
AL845515, AL845492 Genomic DNA Translation: CAM18818.1
AL845492, AL845515, AL929240 Genomic DNA Translation: CAM46032.1
AL845492, AL845515 Genomic DNA Translation: CAM46034.1
AL845492, AL845515 Genomic DNA Translation: CAM46035.1
AL845492, AL845515 Genomic DNA Translation: CAM46036.1
BC026856 mRNA Translation: AAH26856.1
CCDSiCCDS50491.1 [Q9Z0H4-7]
CCDS50492.1 [Q9Z0H4-4]
CCDS50494.1 [Q9Z0H4-9]
CCDS59633.1 [Q9Z0H4-2]
CCDS84468.1 [Q9Z0H4-5]
RefSeqiNP_001103698.1, NM_001110228.1 [Q9Z0H4-9]
NP_001103699.1, NM_001110229.1 [Q9Z0H4-6]
NP_001103700.1, NM_001110230.1 [Q9Z0H4-2]
NP_001103701.1, NM_001110231.1 [Q9Z0H4-4]
NP_001103702.1, NM_001110232.1 [Q9Z0H4-7]
NP_001153764.1, NM_001160292.1
NP_001153765.1, NM_001160293.1 [Q9Z0H4-9]
NP_001297376.1, NM_001310447.1
NP_001334023.1, NM_001347094.1 [Q9Z0H4-5]
NP_034290.2, NM_010160.2
XP_006497400.1, XM_006497337.3 [Q9Z0H4-9]
XP_017170933.1, XM_017315444.1
XP_017170953.1, XM_017315464.1 [Q9Z0H4-4]
UniGeneiMm.398543

3D structure databases

ProteinModelPortaliQ9Z0H4
SMRiQ9Z0H4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z0H4, 1 interactor
MINTiQ9Z0H4
STRINGi10090.ENSMUSP00000110574

PTM databases

iPTMnetiQ9Z0H4
PhosphoSitePlusiQ9Z0H4
SwissPalmiQ9Z0H4

Proteomic databases

PaxDbiQ9Z0H4
PeptideAtlasiQ9Z0H4
PRIDEiQ9Z0H4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002176; ENSMUSP00000002176; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000100429; ENSMUSP00000097996; ENSMUSG00000002107 [Q9Z0H4-7]
ENSMUST00000114924; ENSMUSP00000110574; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000114927; ENSMUSP00000110577; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000114934; ENSMUSP00000110584; ENSMUSG00000002107 [Q9Z0H4-9]
ENSMUST00000142941; ENSMUSP00000120459; ENSMUSG00000002107 [Q9Z0H4-4]
ENSMUST00000150624; ENSMUSP00000138297; ENSMUSG00000002107 [Q9Z0H4-5]
ENSMUST00000182706; ENSMUSP00000138764; ENSMUSG00000002107 [Q9Z0H4-2]
ENSMUST00000182851; ENSMUSP00000138363; ENSMUSG00000002107 [Q9Z0H4-1]
GeneIDi14007
KEGGimmu:14007
UCSCiuc008ign.2 mouse [Q9Z0H4-3]
uc008igp.2 mouse [Q9Z0H4-4]
uc008igq.3 mouse [Q9Z0H4-11]
uc008igr.3 mouse [Q9Z0H4-9]
uc008igs.3 mouse [Q9Z0H4-2]
uc008igt.3 mouse [Q9Z0H4-6]
uc008igv.3 mouse [Q9Z0H4-1]

Organism-specific databases

CTDi10659
MGIiMGI:1338822 Celf2

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00560000076837
HOVERGENiHBG107646
InParanoidiQ9Z0H4
KOiK13207
OMAiMAXAAST
OrthoDBiEOG091G19O1
PhylomeDBiQ9Z0H4
TreeFamiTF314924

Miscellaneous databases

ChiTaRSiCelf2 mouse
PROiPR:Q9Z0H4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002107 Expressed in 287 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CUGBP2
ExpressionAtlasiQ9Z0H4 baseline and differential
GenevisibleiQ9Z0H4 MM

Family and domain databases

CDDicd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCELF2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0H4
Secondary accession number(s): A2AS10
, A2AS11, A2AS15, Q3TNX4, Q3TTI4, Q3TUB8, Q3U668, Q3U7J8, Q3U9F2, Q3UVH4, Q9R0B2, Q9Z187
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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