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Protein

Claudin-3

Gene

Cldn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Clostridium perfringens enterotoxin receptor 2
Short name:
CPE-R 2
Short name:
CPE-receptor 2
Gene namesi
Name:Cldn3
Synonyms:Cpetr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1329044 Cldn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 80ExtracellularSequence analysisAdd BLAST51
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 159ExtracellularSequence analysisAdd BLAST23
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 219CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447391 – 219Claudin-3Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphotyrosineCombined sources1
Modified residuei198PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z0G9
PRIDEiQ9Z0G9

PTM databases

iPTMnetiQ9Z0G9
PhosphoSitePlusiQ9Z0G9

Expressioni

Tissue specificityi

Expressed at high levels in liver and lung and, at lower levels, in kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000070473 Expressed in 166 organ(s), highest expression level in jejunum
CleanExiMM_CLDN3
ExpressionAtlasiQ9Z0G9 baseline and differential
GenevisibleiQ9Z0G9 MM

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.2 Publications
(Microbial infection) Interacts with Clostridium perfringens enterotoxin CPE; the interaction may disrupt claudin assembly in tight junctions.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-40779N
IntActiQ9Z0G9, 2 interactors
MINTiQ9Z0G9
STRINGi10090.ENSMUSP00000091799

Structurei

3D structure databases

ProteinModelPortaliQ9Z0G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 219Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z0G9
KOiK06087
OMAiTKILYSA
OrthoDBiEOG091G0MMR
PhylomeDBiQ9Z0G9
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003549 Claudin3
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01378 CLAUDIN3
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z0G9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDE TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPL
160 170 180 190 200
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPRDKY APTKILYSAP
210
RSTGPGTGTG TAYDRKDYV
Length:219
Mass (Da):23,285
Last modified:May 1, 1999 - v1
Checksum:i62F67810D9B9BD37
GO
Isoform 2 (identifier: Q9Z0G9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-91: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):21,227
Checksum:iE6F917AAE0098772
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00110172 – 91Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095905 mRNA Translation: AAD14608.1
AF087821 mRNA Translation: AAD09756.1
BC012650 mRNA Translation: AAH12650.1
CCDSiCCDS19729.1 [Q9Z0G9-1]
RefSeqiNP_034032.1, NM_009902.4 [Q9Z0G9-1]
UniGeneiMm.158662

Genome annotation databases

EnsembliENSMUST00000094245; ENSMUSP00000091799; ENSMUSG00000070473 [Q9Z0G9-1]
GeneIDi12739
KEGGimmu:12739
UCSCiuc008zxe.2 mouse [Q9Z0G9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095905 mRNA Translation: AAD14608.1
AF087821 mRNA Translation: AAD09756.1
BC012650 mRNA Translation: AAH12650.1
CCDSiCCDS19729.1 [Q9Z0G9-1]
RefSeqiNP_034032.1, NM_009902.4 [Q9Z0G9-1]
UniGeneiMm.158662

3D structure databases

ProteinModelPortaliQ9Z0G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-40779N
IntActiQ9Z0G9, 2 interactors
MINTiQ9Z0G9
STRINGi10090.ENSMUSP00000091799

PTM databases

iPTMnetiQ9Z0G9
PhosphoSitePlusiQ9Z0G9

Proteomic databases

PaxDbiQ9Z0G9
PRIDEiQ9Z0G9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094245; ENSMUSP00000091799; ENSMUSG00000070473 [Q9Z0G9-1]
GeneIDi12739
KEGGimmu:12739
UCSCiuc008zxe.2 mouse [Q9Z0G9-1]

Organism-specific databases

CTDi1365
MGIiMGI:1329044 Cldn3

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z0G9
KOiK06087
OMAiTKILYSA
OrthoDBiEOG091G0MMR
PhylomeDBiQ9Z0G9
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q9Z0G9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070473 Expressed in 166 organ(s), highest expression level in jejunum
CleanExiMM_CLDN3
ExpressionAtlasiQ9Z0G9 baseline and differential
GenevisibleiQ9Z0G9 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003549 Claudin3
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01378 CLAUDIN3
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0G9
Secondary accession number(s): Q91X40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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