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Protein

Gamma-synuclein

Gene

Sncg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • chemical synaptic transmission Source: MGI
  • negative regulation of neuron death Source: MGI
  • protein secretion Source: UniProtKB
  • regulation of dopamine secretion Source: MGI
  • regulation of neurotransmitter secretion Source: MGI
  • synapse organization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-synuclein
Alternative name(s):
Persyn
Gene namesi
Name:Sncg
Synonyms:Persyn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1298397 Sncg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840391 – 123Gamma-synucleinAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei120Phosphoserine; by BARK1, CaMK2 and CK2By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z0F7
PaxDbiQ9Z0F7
PRIDEiQ9Z0F7

2D gel databases

SWISS-2DPAGEiQ9Z0F7

PTM databases

iPTMnetiQ9Z0F7
PhosphoSitePlusiQ9Z0F7

Expressioni

Tissue specificityi

Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. Expressed predominantly in the cell bodies and axons of primary sensory neurons, sympathetic neurons and motoneurons.

Developmental stagei

Developmentally expressed in primary sensory neurons and motoneurons. In trigeminal ganglia, expression increases between embryonic day 10 and day 12. High levels are maintained here throughout later stages of development and in adulthood.

Gene expression databases

BgeeiENSMUSG00000023064 Expressed in 228 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_SNCG
ExpressionAtlasiQ9Z0F7 baseline and differential
GenevisibleiQ9Z0F7 MM

Interactioni

Subunit structurei

May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023826

Structurei

3D structure databases

ProteinModelPortaliQ9Z0F7
SMRiQ9Z0F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYGN Eukaryota
ENOG4111VY5 LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiQ9Z0F7
OMAiMVSDAMV
OrthoDBiEOG091G11PA
PhylomeDBiQ9Z0F7
TreeFamiTF332776

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002462 Synuclein_gamma
PANTHERiPTHR13820 PTHR13820, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01214 GSYNUCLEIN
PR01211 SYNUCLEIN

Sequencei

Sequence statusi: Complete.

Q9Z0F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GTKTKENVVQ
60 70 80 90 100
SVTSVAEKTK EQANAVSEAV VSSVNTVANK TVEEAENIVV TTGVVRKEDL
110 120
EPPAQDQEAK EQEENEEAKS GED
Length:123
Mass (Da):13,160
Last modified:May 1, 1999 - v1
Checksum:iDCB93C78F8071EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017255 mRNA Translation: AAC98893.1
AF099986, AF099984, AF099985 Genomic DNA Translation: AAD19899.1
BC028508 mRNA Translation: AAH28508.1
CCDSiCCDS26937.1
RefSeqiNP_035560.1, NM_011430.3
UniGeneiMm.282800

Genome annotation databases

EnsembliENSMUST00000023826; ENSMUSP00000023826; ENSMUSG00000023064
GeneIDi20618
KEGGimmu:20618
UCSCiuc007tau.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017255 mRNA Translation: AAC98893.1
AF099986, AF099984, AF099985 Genomic DNA Translation: AAD19899.1
BC028508 mRNA Translation: AAH28508.1
CCDSiCCDS26937.1
RefSeqiNP_035560.1, NM_011430.3
UniGeneiMm.282800

3D structure databases

ProteinModelPortaliQ9Z0F7
SMRiQ9Z0F7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023826

PTM databases

iPTMnetiQ9Z0F7
PhosphoSitePlusiQ9Z0F7

2D gel databases

SWISS-2DPAGEiQ9Z0F7

Proteomic databases

MaxQBiQ9Z0F7
PaxDbiQ9Z0F7
PRIDEiQ9Z0F7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023826; ENSMUSP00000023826; ENSMUSG00000023064
GeneIDi20618
KEGGimmu:20618
UCSCiuc007tau.2 mouse

Organism-specific databases

CTDi6623
MGIiMGI:1298397 Sncg

Phylogenomic databases

eggNOGiENOG410IYGN Eukaryota
ENOG4111VY5 LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiQ9Z0F7
OMAiMVSDAMV
OrthoDBiEOG091G11PA
PhylomeDBiQ9Z0F7
TreeFamiTF332776

Miscellaneous databases

ChiTaRSiSncg mouse
PROiPR:Q9Z0F7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023064 Expressed in 228 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_SNCG
ExpressionAtlasiQ9Z0F7 baseline and differential
GenevisibleiQ9Z0F7 MM

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002462 Synuclein_gamma
PANTHERiPTHR13820 PTHR13820, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01214 GSYNUCLEIN
PR01211 SYNUCLEIN
ProtoNetiSearch...

Entry informationi

Entry nameiSYUG_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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