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Protein

Solute carrier family 22 member 5

Gene

Slc22a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-MMU-549127 Organic cation transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 5
Alternative name(s):
High-affinity sodium-dependent carnitine cotransporter
Organic cation/carnitine transporter 2
Gene namesi
Name:Slc22a5
Synonyms:Octn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1329012 Slc22a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 142ExtracellularSequence analysisAdd BLAST101
Transmembranei143 – 163Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini164 – 172CytoplasmicSequence analysis9
Transmembranei173 – 193Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini194 – 197ExtracellularSequence analysis4
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini219 – 232CytoplasmicSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 257ExtracellularSequence analysis4
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 341CytoplasmicSequence analysisAdd BLAST63
Transmembranei342 – 362Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini363 – 373ExtracellularSequence analysisAdd BLAST11
Transmembranei374 – 394Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini395 – 406CytoplasmicSequence analysisAdd BLAST12
Transmembranei407 – 427Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini428 – 430ExtracellularSequence analysis3
Transmembranei431 – 451Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini452 – 462CytoplasmicSequence analysisAdd BLAST11
Transmembranei463 – 483Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini484 – 488ExtracellularSequence analysis5
Transmembranei489 – 509Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini510 – 557CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Slc22a5 are the cause of the juvenile visceral steatosis (JVS) phenotype. JVS is an autosomal recessive animal model of systemic carnitine deficiency.

Keywords - Diseasei

Disease mutation

Chemistry databases

ChEMBLiCHEMBL2073665

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205011 – 557Solute carrier family 22 member 5Add BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei486PhosphotyrosineBy similarity1
Modified residuei548PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z0E8
PaxDbiQ9Z0E8
PRIDEiQ9Z0E8

PTM databases

iPTMnetiQ9Z0E8
PhosphoSitePlusiQ9Z0E8

Expressioni

Tissue specificityi

Widely expressed. Expressed in kidney, liver and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000018900 Expressed in 128 organ(s), highest expression level in proximal tubule
ExpressionAtlasiQ9Z0E8 baseline and differential
GenevisibleiQ9Z0E8 MM

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019044

Structurei

3D structure databases

ProteinModelPortaliQ9Z0E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234570
HOVERGENiHBG061545
InParanoidiQ9Z0E8
KOiK08202
OMAiNIRMVTI
OrthoDBiEOG091G05AC
PhylomeDBiQ9Z0E8
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9Z0E8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFNGMSIV FLAGTPEHRC
60 70 80 90 100
LVPHTVNLSS AWRNHSIPLE TKDGRQVPQK CRRYRLATIA NFSELGLEPG
110 120 130 140 150
RDVDLEQLEQ ESCLDGWEYD KDVFLSTIVT EWDLVCKDDW KAPLTTSLFF
160 170 180 190 200
VGVLMGSFIS GQLSDRFGRK NVLFLTMGMQ TGFSFLQVFS VNFEMFTVLF
210 220 230 240 250
VLVGMGQISN YVAAFVLGTE ILSKSIRIIF ATLGVCIFYA FGFMVLPLFA
260 270 280 290 300
YFIRDWRMLL LALTVPGVLC GALWWFIPES PRWLISQGRI KEAEVIIRKA
310 320 330 340 350
AKINGIVAPS TIFDPSELQD LNSTKPQLHH IYDLIRTRNI RVITIMSIIL
360 370 380 390 400
WLTISVGYFG LSLDTPNLHG DIYVNCFLLA AVEVPAYVLA WLLLQYLPRR
410 420 430 440 450
YSISAALFLG GSVLLFMQLV PSELFYLSTA LVMVGKFGIT SAYSMVYVYT
460 470 480 490 500
AELYPTVVRN MGVGVSSTAS RLGSILSPYF VYLGAYDRFL PYILMGSLTI
510 520 530 540 550
LTAILTLFFP ESFGVPLPDT IDQMLRVKGI KQWQIQSQTR MQKDGEESPT

VLKSTAF
Length:557
Mass (Da):62,780
Last modified:May 1, 1999 - v1
Checksum:i6093F0EE9612B204
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RH54D6RH54_MOUSE
Solute carrier family 22 member 5
Slc22a5
146Annotation score:
F6TNN8F6TNN8_MOUSE
Solute carrier family 22 member 5
Slc22a5
36Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti352L → R in JVS. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015800 mRNA Translation: BAA36590.1
AF111425 mRNA Translation: AAC99787.1
AF110417 mRNA Translation: AAD54060.1
BC031118 mRNA Translation: AAH31118.1
CCDSiCCDS24687.1
RefSeqiNP_035526.1, NM_011396.3
UniGeneiMm.42253

Genome annotation databases

EnsembliENSMUST00000019044; ENSMUSP00000019044; ENSMUSG00000018900
GeneIDi20520
KEGGimmu:20520
UCSCiuc007ixc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015800 mRNA Translation: BAA36590.1
AF111425 mRNA Translation: AAC99787.1
AF110417 mRNA Translation: AAD54060.1
BC031118 mRNA Translation: AAH31118.1
CCDSiCCDS24687.1
RefSeqiNP_035526.1, NM_011396.3
UniGeneiMm.42253

3D structure databases

ProteinModelPortaliQ9Z0E8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019044

Chemistry databases

ChEMBLiCHEMBL2073665

PTM databases

iPTMnetiQ9Z0E8
PhosphoSitePlusiQ9Z0E8

Proteomic databases

MaxQBiQ9Z0E8
PaxDbiQ9Z0E8
PRIDEiQ9Z0E8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019044; ENSMUSP00000019044; ENSMUSG00000018900
GeneIDi20520
KEGGimmu:20520
UCSCiuc007ixc.2 mouse

Organism-specific databases

CTDi6584
MGIiMGI:1329012 Slc22a5

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234570
HOVERGENiHBG061545
InParanoidiQ9Z0E8
KOiK08202
OMAiNIRMVTI
OrthoDBiEOG091G05AC
PhylomeDBiQ9Z0E8
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-MMU-549127 Organic cation transport

Miscellaneous databases

PROiPR:Q9Z0E8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018900 Expressed in 128 organ(s), highest expression level in proximal tubule
ExpressionAtlasiQ9Z0E8 baseline and differential
GenevisibleiQ9Z0E8 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22A5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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