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Protein

Chordin

Gene

Chrd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.

GO - Molecular functioni

  • heparin binding Source: MGI
  • syndecan binding Source: MGI

GO - Biological processi

  • BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: MGI
  • central nervous system development Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • forebrain development Source: MGI
  • gastrulation with mouth forming second Source: MGI
  • mesoderm formation Source: MGI
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • osteoblast differentiation Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of cell adhesion Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • skeletal system development Source: MGI

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Gene namesi
Name:Chrd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1313268 Chrd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000536527 – 948ChordinAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi877N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Z0E2
PaxDbiQ9Z0E2
PRIDEiQ9Z0E2

PTM databases

PhosphoSitePlusiQ9Z0E2

Miscellaneous databases

PMAP-CutDBiQ9Z0E2

Expressioni

Developmental stagei

Detected at high levels of a in 7 dpc mouse embryos; its level decrease at later developmental stages and in adult tissues.

Gene expression databases

BgeeiENSMUSG00000006958
CleanExiMM_CHRD
ExpressionAtlasiQ9Z0E2 baseline and differential
GenevisibleiQ9Z0E2 MM

Interactioni

Subunit structurei

Interacts with TWSG1 and/or BMP4.1 Publication

GO - Molecular functioni

  • syndecan binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007171

Structurei

3D structure databases

ProteinModelPortaliQ9Z0E2
SMRiQ9Z0E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 126VWFC 1PROSITE-ProRule annotationAdd BLAST78
Domaini168 – 277CHRD 1PROSITE-ProRule annotationAdd BLAST110
Domaini279 – 398CHRD 2PROSITE-ProRule annotationAdd BLAST120
Domaini399 – 520CHRD 3PROSITE-ProRule annotationAdd BLAST122
Domaini526 – 646CHRD 4PROSITE-ProRule annotationAdd BLAST121
Domaini699 – 759VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini779 – 845VWFC 3PROSITE-ProRule annotationAdd BLAST67
Domaini867 – 927VWFC 4PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the chordin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEDE Eukaryota
ENOG410XSBA LUCA
GeneTreeiENSGT00730000110792
HOVERGENiHBG005330
InParanoidiQ9Z0E2
KOiK04657
OMAiQSWHPSV
OrthoDBiEOG091G11A0
TreeFamiTF106451

Family and domain databases

InterProiView protein in InterPro
IPR016353 Chordin
IPR010895 CHRD
IPR001007 VWF_dom
PfamiView protein in Pfam
PF07452 CHRD, 2 hits
PF00093 VWC, 3 hits
PIRSFiPIRSF002496 Chordin, 1 hit
SMARTiView protein in SMART
SM00754 CHRD, 4 hits
SM00214 VWC, 4 hits
PROSITEiView protein in PROSITE
PS50933 CHRD, 4 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLPAPPAP RLLLGLLLLG SRPASGTGPE PPALPIRSEK EPLPVRGAAG
60 70 80 90 100
CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK
110 120 130 140 150
NIKPQCPTLA CRQPRQLPGH CCQTCPQERS NLDPQPAGLV FEYPRDPEHR
160 170 180 190 200
SYSDRGEPGV GERTRADGHT DFVALLTGPR SQAVARARVS LLRSSLRFSV
210 220 230 240 250
SYQRLDRPSR VRFTDPTGNI LFEHPATPTQ DGLVCGVWRA VPRLSVRLLR
260 270 280 290 300
AEQLRVALVT STHPSGEVWG PLIWQGALAA ETFSAILTLE DPLQRGVGGI
310 320 330 340 350
ALLTLSDTED SLHFLLLFRG LLGGLAQAPL KLQILHQGQL LRELQANTSA
360 370 380 390 400
QEPGFAEVLP SLTDQEMDWL ELGELQMVLE KAGGPELRIS GYITTRQSCD
410 420 430 440 450
VLQSVLCGAD ALIPVQTGAA GSASFILLGN GSLIYQVQVV GTGSEVVAMT
460 470 480 490 500
LETKPQRKNQ RTVLCHMAGL QPGGHMAVGM CSGLGARGAH MLLQNELFLN
510 520 530 540 550
VGTKDFPDGE LRGHVTALCY SGHSARYDRL PVPLAGALVL PPVRSQAAGH
560 570 580 590 600
AWLSLDTHCH LHYEVLLAGL GGSEQGTVTA HLLGPPGMPG PQRLLKGFYG
610 620 630 640 650
SEAQGVVKDL EPVLLRHLAQ GTASLLITTK SSPRGELRGQ VHIASQCEAG
660 670 680 690 700
GLRLASEGVQ MPLAPNGEAA TSPMLPAGPG PEAPVPAKHG SPGRPRDPNT
710 720 730 740 750
CFFEGQQRPH GARWAPNYDP LCSLCICQRR TVICDPVVCP PPSCPHPVQA
760 770 780 790 800
LDQCCPVCPE KQRSRDLPSL PNLEPGEGCY FDGDRSWRAA GTRWHPVVPP
810 820 830 840 850
FGLIKCAVCT CKGATGEVHC EKVQCPRLAC AQPVRANPTD CCKQCPVGSG
860 870 880 890 900
TNAKLGDPMQ ADGPRGCRFA GQWFPENQSW HPSVPPFGEM SCITCRCGAG
910 920 930 940
VPHCERDDCS PPLSCGSGKE SRCCSHCTAQ RSSETRTLPE LEKEAEHS
Length:948
Mass (Da):101,513
Last modified:May 1, 1999 - v1
Checksum:i4DC2DA01D9BD2147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096276 mRNA Translation: AAD19895.1
AF069501 mRNA Translation: AAC68867.1
CCDSiCCDS28059.1
RefSeqiNP_001264970.1, NM_001278041.1
NP_034023.1, NM_009893.2
UniGeneiMm.20457

Genome annotation databases

EnsembliENSMUST00000007171; ENSMUSP00000007171; ENSMUSG00000006958
GeneIDi12667
KEGGimmu:12667
UCSCiuc007yre.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCHRD_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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