UniProtKB - Q9Z0E0 (NCDN_MOUSE)
Protein
Neurochondrin
Gene
Ncdn
Organism
Mus musculus (Mouse)
Status
Functioni
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.3 Publications
GO - Biological processi
- bone resorption Source: MGI
- neuron projection development Source: UniProtKB
- regulation of neuronal synaptic plasticity Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: NeurochondrinAlternative name(s): M-Sema F-associating protein of 75 kDa Norbin |
Gene namesi | Name:Ncdn Synonyms:Kiaa0607, Sfap75 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1347351, Ncdn |
Subcellular locationi
Cytosol
- cytosol By similarity
Endosome
- Endosome membrane By similarity; Lipid-anchor By similarity
Other locations
- dendrite By similarity
- postsynapse By similarity
Note: Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation.By similarity
Cytosol
- cytosol Source: UniProtKB
Endosome
- endosome membrane Source: MGI
Other locations
- dendrite Source: UniProtKB
- membrane Source: MGI
- neuron projection Source: UniProtKB
- neuronal cell body Source: UniProtKB
- perikaryon Source: MGI
- postsynapse Source: MGI
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Endosome, Membrane, SynapsePathology & Biotechi
Disruption phenotypei
Death between 3.5 and 6.5 dpc. Heterozygous mutant do not display gross anatomic abnormalities. They however show abnormalities in developing cartilage. Nervous system-specific gene disruption by conditional knockout results in epileptic seizure. Displays no overt neurite outgrowth phenotype (PubMed:15790563). Shows a behavioral phenotype associated with a rodent model of schizophrenia, as observed in alterations in both sensorimotor gating and psychotomimetic-induced locomotor activity.3 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000324618 | 2 – 729 | NeurochondrinAdd BLAST | 728 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Lipidationi | 3 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 4 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 75 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 448 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.By similarity
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, Palmitate, PhosphoproteinProteomic databases
EPDi | Q9Z0E0 |
PaxDbi | Q9Z0E0 |
PeptideAtlasi | Q9Z0E0 |
PRIDEi | Q9Z0E0 |
PTM databases
iPTMneti | Q9Z0E0 |
PhosphoSitePlusi | Q9Z0E0 |
SwissPalmi | Q9Z0E0 |
Expressioni
Tissue specificityi
Expressed in the neuronal, chondral and bone tissues. Expressed in dendrites. Enriched in the brain in the surface layer I-IV. In brains, protein level increases in male but decreases in female with advancing age (at protein level). In adult brains, it is highly expressed in the forebrain and hindbrain. Highly expressed in the hippocampus, piriform cortex, septum, amygdaloid complex, medial geniculate nucleus, inferior colliculus, cerebellar nuclei and the nuclei of the Vth, VIIth, and XIIth cranial nerves. In bone tissues, it is expressed in osteoblasts and osteocytes.4 Publications
Developmental stagei
In the developing brain, it is first expressed in the hindbrain and spinal cord at 10.5 dpc followed by expression in the midbrain at 11.5 dpc. By 18 dpc it is also expressed in the diencephalon and telencephalon, with a strongest expression in the hindbrain. Highly expressed in the developing olfactory bulb and in the lateral choroid plexus.3 Publications
Gene expression databases
Bgeei | ENSMUSG00000028833, Expressed in CA1 field of hippocampus and 288 other tissues |
Genevisiblei | Q9Z0E0, MM |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 205020, 11 interactors |
IntActi | Q9Z0E0, 9 interactors |
MINTi | Q9Z0E0 |
STRINGi | 10090.ENSMUSP00000030637 |
Miscellaneous databases
RNActi | Q9Z0E0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the neurochondrin family.Curated
Phylogenomic databases
eggNOGi | KOG2611, Eukaryota |
GeneTreei | ENSGT00390000013601 |
HOGENOMi | CLU_012443_0_0_1 |
InParanoidi | Q9Z0E0 |
OMAi | FLWDAYN |
OrthoDBi | 311670at2759 |
PhylomeDBi | Q9Z0E0 |
TreeFami | TF323752 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR008709, Neurochondrin |
PANTHERi | PTHR13109, PTHR13109, 1 hit |
Pfami | View protein in Pfam PF05536, Neurochondrin, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9Z0E0-1) [UniParc]FASTAAdd to basket
Also known as: Neurochondrin-1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSCCDLAAAG QLGKAGIMAS DCEPALNQAE SRNPTLERYL GALREAKNDS
60 70 80 90 100
EQFAALLLVT KAVKAGDIDA KTRRRIFDAV GFTFPNRLLT TKEAPDGCPD
110 120 130 140 150
HVLRALGVAL LACFCSDPEL ASHPQVLNKI PILSTFLTAR GDPDDAARRS
160 170 180 190 200
MIDDTYQCLT AVAGTPRGPR HLIAGGTVSA LCQAYLGHGY GFDQALALLV
210 220 230 240 250
GLLAAAETQC WKEAEPDLLA VLRGLSEDFQ RAEDASKFEL CQLLPLFLPP
260 270 280 290 300
TTVPPECHRD LQAGLARILG SKLSSWQRNP ALKLAARLAH ACGSDWIPVG
310 320 330 340 350
SSGSKFLALL VNLACVEVRL ALEETGTEVK EDVVTACYAL MELGIQECTR
360 370 380 390 400
CEQSLLKEPQ KVQLVSIMKE AIGAVIHYLL QVGPEKQKEP FVFASVRILG
410 420 430 440 450
AWLAEETSSL RKEVCQLLPF LVRYAKTLYE EAEEASDISQ QVANLAISPT
460 470 480 490 500
TPGPSWPGDA LRLLLPGWCH LTVEDGPREI LIKEGAPSLL CKYFLQQWEL
510 520 530 540 550
TSPGHDTSVL PDSVEIGLQT CCHIFLNLVV TAPGLIKRDA CFTSLMNTLM
560 570 580 590 600
TSLPSLVQQQ GRLLLAANVA TLGLLMARLL STSPALQGTP ASRGFFAAAI
610 620 630 640 650
LFLSQSHVAR ATPGSDQAVL ALSPDYEGIW ADLQELWFLG MQAFTGCVPL
660 670 680 690 700
LPWLAPAALR SRWPQELLQL LGSVSPNSVK PEMVAAYQGV LVELARANRL
710 720
CREAMRLQAG EETASHYRMA ALEQCLSEP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | A → S in AAH17126 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 164 | G → D in BAE41841 (PubMed:19468303).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032317 | 1 – 17 | Missing in isoform 2. CuratedAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB017608 Genomic DNA Translation: BAA75226.1 AB017609 Genomic DNA Translation: BAA75227.1 AB019041 Genomic DNA Translation: BAA75228.1 AB019041 Genomic DNA Translation: BAA75229.1 AK002938 mRNA Translation: BAB22468.2 AK154889 mRNA Translation: BAE32905.1 AK170502 mRNA Translation: BAE41841.1 AL606908 Genomic DNA No translation available. BC017126 mRNA Translation: AAH17126.1 AK122327 mRNA Translation: BAC65609.1 |
CCDSi | CCDS18659.1 [Q9Z0E0-1] |
RefSeqi | NP_036116.3, NM_011986.4 [Q9Z0E0-1] XP_006503181.1, XM_006503118.3 XP_006503182.1, XM_006503119.3 |
Genome annotation databases
Ensembli | ENSMUST00000030637; ENSMUSP00000030637; ENSMUSG00000028833 [Q9Z0E0-1] ENSMUST00000106116; ENSMUSP00000101722; ENSMUSG00000028833 [Q9Z0E0-1] |
GeneIDi | 26562 |
KEGGi | mmu:26562 |
UCSCi | uc008utt.2, mouse [Q9Z0E0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB017608 Genomic DNA Translation: BAA75226.1 AB017609 Genomic DNA Translation: BAA75227.1 AB019041 Genomic DNA Translation: BAA75228.1 AB019041 Genomic DNA Translation: BAA75229.1 AK002938 mRNA Translation: BAB22468.2 AK154889 mRNA Translation: BAE32905.1 AK170502 mRNA Translation: BAE41841.1 AL606908 Genomic DNA No translation available. BC017126 mRNA Translation: AAH17126.1 AK122327 mRNA Translation: BAC65609.1 |
CCDSi | CCDS18659.1 [Q9Z0E0-1] |
RefSeqi | NP_036116.3, NM_011986.4 [Q9Z0E0-1] XP_006503181.1, XM_006503118.3 XP_006503182.1, XM_006503119.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 205020, 11 interactors |
IntActi | Q9Z0E0, 9 interactors |
MINTi | Q9Z0E0 |
STRINGi | 10090.ENSMUSP00000030637 |
PTM databases
iPTMneti | Q9Z0E0 |
PhosphoSitePlusi | Q9Z0E0 |
SwissPalmi | Q9Z0E0 |
Proteomic databases
EPDi | Q9Z0E0 |
PaxDbi | Q9Z0E0 |
PeptideAtlasi | Q9Z0E0 |
PRIDEi | Q9Z0E0 |
Protocols and materials databases
Antibodypediai | 17311, 199 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000030637; ENSMUSP00000030637; ENSMUSG00000028833 [Q9Z0E0-1] ENSMUST00000106116; ENSMUSP00000101722; ENSMUSG00000028833 [Q9Z0E0-1] |
GeneIDi | 26562 |
KEGGi | mmu:26562 |
UCSCi | uc008utt.2, mouse [Q9Z0E0-1] |
Organism-specific databases
CTDi | 23154 |
MGIi | MGI:1347351, Ncdn |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2611, Eukaryota |
GeneTreei | ENSGT00390000013601 |
HOGENOMi | CLU_012443_0_0_1 |
InParanoidi | Q9Z0E0 |
OMAi | FLWDAYN |
OrthoDBi | 311670at2759 |
PhylomeDBi | Q9Z0E0 |
TreeFami | TF323752 |
Miscellaneous databases
BioGRID-ORCSi | 26562, 4 hits in 17 CRISPR screens |
ChiTaRSi | Ncdn, mouse |
PROi | PR:Q9Z0E0 |
RNActi | Q9Z0E0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028833, Expressed in CA1 field of hippocampus and 288 other tissues |
Genevisiblei | Q9Z0E0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR008709, Neurochondrin |
PANTHERi | PTHR13109, PTHR13109, 1 hit |
Pfami | View protein in Pfam PF05536, Neurochondrin, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCDN_MOUSE | |
Accessioni | Q9Z0E0Primary (citable) accession number: Q9Z0E0 Secondary accession number(s): Q3TCW4 Q9QUQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families