Ncdn

Functionⁱ

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca²⁺-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.3 Publications

GO - Biological processⁱ

bone resorption
Source: MGI
Inferred from direct assayⁱ
- 10231559
neuron projection development
Source: UniProtKB
Inferred from direct assayⁱ
- 18572016
regulation of neuronal synaptic plasticity Source: MGI

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurochondrin Alternative name(s): M-Sema F-associating protein of 75 kDa Norbin
Gene namesⁱ	Name:Ncdn Synonyms:Kiaa0607, Sfap75
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1347351 Ncdn

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Death between 3.5 and 6.5 dpc. Heterozygous mutant do not display gross anatomic abnormalities. They however show abnormalities in developing cartilage. Nervous system-specific gene disruption by conditional knockout results in epileptic seizure. Displays no overt neurite outgrowth phenotype (PubMed:15790563). Shows a behavioral phenotype associated with a rodent model of schizophrenia, as observed in alterations in both sensorimotor gating and psychotomimetic-induced locomotor activity.3 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000324618	2 – 729	NeurochondrinAdd BLAST		728

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	2	PhosphoserineBy similarity	1
Modified residueⁱ	75	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	448	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9Z0E0
PeptideAtlas More...PeptideAtlasⁱ	Q9Z0E0
PRIDEⁱ	Q9Z0E0

PTM databases

iPTMnetⁱ	Q9Z0E0
PhosphoSitePlusⁱ	Q9Z0E0
SwissPalmⁱ	Q9Z0E0

Expressionⁱ

Tissue specificityⁱ

Expressed in the neuronal, chondral and bone tissues. Expressed in dendrites. Enriched in the brain in the surface layer I-IV. In brains, protein level increases in male but decreases in female with advancing age (at protein level). In adult brains, it is highly expressed in the forebrain and hindbrain. Highly expressed in the hippocampus, piriform cortex, septum, amygdaloid complex, medial geniculate nucleus, inferior colliculus, cerebellar nuclei and the nuclei of the Vth, VIIth, and XIIth cranial nerves. In bone tissues, it is expressed in osteoblasts and osteocytes.4 Publications

Developmental stageⁱ

In the developing brain, it is first expressed in the hindbrain and spinal cord at E10.5 followed by expression in the midbrain at E11.5. By E18 it is also expressed in the diencephalon and telencephalon, with a strongest expression in the hindbrain. Highly expressed in the developing olfactory bulb and in the lateral choroid plexus.3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000028833 Expressed in 271 organ(s), highest expression level in CA1 field of hippocampus
CleanExⁱ	MM_NCDN
Genevisibleⁱ	Q9Z0E0 MM

Interactionⁱ

Subunit structureⁱ

Interacts with MCHR1 and GRM5 (By similarity). Interacts with SEMA4C and DIAPH1 (via FH3 domain).By similarity2 Publications

Protein-protein interaction databases

BioGridⁱ	205020, 5 interactors
IntActⁱ	Q9Z0E0, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9Z0E0
STRINGⁱ	10090.ENSMUSP00000030637

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z0E0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the neurochondrin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2611 Eukaryota ENOG410XRYT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013601
HOGENOMⁱ	HOG000113742
HOVERGENⁱ	HBG097452
InParanoidⁱ	Q9Z0E0
OMAⁱ	YIQATIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04JK
PhylomeDBⁱ	Q9Z0E0
TreeFamⁱ	TF323752

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR008709 Neurochondrin
PANTHERⁱ	PTHR13109 PTHR13109, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05536 Neurochondrin, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9Z0E0-1) [UniParc]FASTA Add to basket

Also known as: Neurochondrin-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCCDLAAAG QLGKAGIMAS DCEPALNQAE SRNPTLERYL GALREAKNDS 
        60         70         80         90        100
EQFAALLLVT KAVKAGDIDA KTRRRIFDAV GFTFPNRLLT TKEAPDGCPD 
       110        120        130        140        150
HVLRALGVAL LACFCSDPEL ASHPQVLNKI PILSTFLTAR GDPDDAARRS 
       160        170        180        190        200
MIDDTYQCLT AVAGTPRGPR HLIAGGTVSA LCQAYLGHGY GFDQALALLV 
       210        220        230        240        250
GLLAAAETQC WKEAEPDLLA VLRGLSEDFQ RAEDASKFEL CQLLPLFLPP 
       260        270        280        290        300
TTVPPECHRD LQAGLARILG SKLSSWQRNP ALKLAARLAH ACGSDWIPVG 
       310        320        330        340        350
SSGSKFLALL VNLACVEVRL ALEETGTEVK EDVVTACYAL MELGIQECTR 
       360        370        380        390        400
CEQSLLKEPQ KVQLVSIMKE AIGAVIHYLL QVGPEKQKEP FVFASVRILG 
       410        420        430        440        450
AWLAEETSSL RKEVCQLLPF LVRYAKTLYE EAEEASDISQ QVANLAISPT 
       460        470        480        490        500
TPGPSWPGDA LRLLLPGWCH LTVEDGPREI LIKEGAPSLL CKYFLQQWEL 
       510        520        530        540        550
TSPGHDTSVL PDSVEIGLQT CCHIFLNLVV TAPGLIKRDA CFTSLMNTLM 
       560        570        580        590        600
TSLPSLVQQQ GRLLLAANVA TLGLLMARLL STSPALQGTP ASRGFFAAAI 
       610        620        630        640        650
LFLSQSHVAR ATPGSDQAVL ALSPDYEGIW ADLQELWFLG MQAFTGCVPL 
       660        670        680        690        700
LPWLAPAALR SRWPQELLQL LGSVSPNSVK PEMVAAYQGV LVELARANRL 
       710        720 
CREAMRLQAG EETASHYRMA ALEQCLSEP

Length:729

Mass (Da):78,895

Last modified:May 1, 1999 - v1

Checksum:ⁱF23C439BDE1EDD9C

GO

Isoform 2 (identifier: Q9Z0E0-2) [UniParc]FASTA Add to basket

Also known as: Neurochondrin-2

The sequence of this isoform differs from the canonical sequence as follows:
1-17: Missing.

« Hide

        10         20         30         40         50
MASDCEPALN QAESRNPTLE RYLGALREAK NDSEQFAALL LVTKAVKAGD 
        60         70         80         90        100
IDAKTRRRIF DAVGFTFPNR LLTTKEAPDG CPDHVLRALG VALLACFCSD 
       110        120        130        140        150
PELASHPQVL NKIPILSTFL TARGDPDDAA RRSMIDDTYQ CLTAVAGTPR 
       160        170        180        190        200
GPRHLIAGGT VSALCQAYLG HGYGFDQALA LLVGLLAAAE TQCWKEAEPD 
       210        220        230        240        250
LLAVLRGLSE DFQRAEDASK FELCQLLPLF LPPTTVPPEC HRDLQAGLAR 
       260        270        280        290        300
ILGSKLSSWQ RNPALKLAAR LAHACGSDWI PVGSSGSKFL ALLVNLACVE 
       310        320        330        340        350
VRLALEETGT EVKEDVVTAC YALMELGIQE CTRCEQSLLK EPQKVQLVSI 
       360        370        380        390        400
MKEAIGAVIH YLLQVGPEKQ KEPFVFASVR ILGAWLAEET SSLRKEVCQL 
       410        420        430        440        450
LPFLVRYAKT LYEEAEEASD ISQQVANLAI SPTTPGPSWP GDALRLLLPG 
       460        470        480        490        500
WCHLTVEDGP REILIKEGAP SLLCKYFLQQ WELTSPGHDT SVLPDSVEIG 
       510        520        530        540        550
LQTCCHIFLN LVVTAPGLIK RDACFTSLMN TLMTSLPSLV QQQGRLLLAA 
       560        570        580        590        600
NVATLGLLMA RLLSTSPALQ GTPASRGFFA AAILFLSQSH VARATPGSDQ 
       610        620        630        640        650
AVLALSPDYE GIWADLQELW FLGMQAFTGC VPLLPWLAPA ALRSRWPQEL 
       660        670        680        690        700
LQLLGSVSPN SVKPEMVAAY QGVLVELARA NRLCREAMRL QAGEETASHY 
       710 
RMAALEQCLS EP

Show »

Length:712

Mass (Da):77,304

Checksum:ⁱ3622A879C105341E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	109	A → S in AAH17126 (PubMed:12693553).Curated		1
Sequence conflictⁱ	164	G → D in BAE41841 (PubMed:19468303).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_032317	1 – 17	Missing in isoform 2. CuratedAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB017608 Genomic DNA Translation: BAA75226.1 AB017609 Genomic DNA Translation: BAA75227.1 AB019041 Genomic DNA Translation: BAA75228.1 AB019041 Genomic DNA Translation: BAA75229.1 AK002938 mRNA Translation: BAB22468.2 AK154889 mRNA Translation: BAE32905.1 AK170502 mRNA Translation: BAE41841.1 AL606908 Genomic DNA Translation: CAM19265.1 BC017126 mRNA Translation: AAH17126.1 AK122327 mRNA Translation: BAC65609.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18659.1 [Q9Z0E0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_036116.3, NM_011986.4 [Q9Z0E0-1] XP_006503181.1, XM_006503118.3 XP_006503182.1, XM_006503119.3
UniGeneⁱ	Mm.206206 Mm.456184

Genome annotation databases

Ensemblⁱ	ENSMUST00000030637; ENSMUSP00000030637; ENSMUSG00000028833 [Q9Z0E0-1] ENSMUST00000106116; ENSMUSP00000101722; ENSMUSG00000028833 [Q9Z0E0-1]
GeneIDⁱ	26562
KEGGⁱ	mmu:26562
UCSC genome browser More...UCSCⁱ	uc008utt.2 mouse [Q9Z0E0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z0E0	Neurochondrin		BOVIN		729	UniRef90_Q9Z0E0
Neurochondrin		HUMAN		729
Neurochondrin		RAT		729
Isoform 2 of Neurochondrin		MOUSE		712
Neurochondrin		FUKDA		848
+206

Protein	Similar proteins		Species	Score	Length	Source
Q9Z0E0	Neurochondrin		RAT		729	UniRef50_Q9Z0E0
Neurochondrin		HUMAN		729
Neurochondrin		BOVIN		729
Isoform 2 of Neurochondrin		MOUSE		712
Neurochondrin		FUKDA		848
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB017608 Genomic DNA Translation: BAA75226.1 AB017609 Genomic DNA Translation: BAA75227.1 AB019041 Genomic DNA Translation: BAA75228.1 AB019041 Genomic DNA Translation: BAA75229.1 AK002938 mRNA Translation: BAB22468.2 AK154889 mRNA Translation: BAE32905.1 AK170502 mRNA Translation: BAE41841.1 AL606908 Genomic DNA Translation: CAM19265.1 BC017126 mRNA Translation: AAH17126.1 AK122327 mRNA Translation: BAC65609.1
CCDSⁱ	CCDS18659.1 [Q9Z0E0-1]
RefSeqⁱ	NP_036116.3, NM_011986.4 [Q9Z0E0-1] XP_006503181.1, XM_006503118.3 XP_006503182.1, XM_006503119.3
UniGeneⁱ	Mm.206206 Mm.456184

3D structure databases

ProteinModelPortalⁱ	Q9Z0E0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205020, 5 interactors
IntActⁱ	Q9Z0E0, 9 interactors
MINTⁱ	Q9Z0E0
STRINGⁱ	10090.ENSMUSP00000030637

PTM databases

iPTMnetⁱ	Q9Z0E0
PhosphoSitePlusⁱ	Q9Z0E0
SwissPalmⁱ	Q9Z0E0

Proteomic databases

PaxDbⁱ	Q9Z0E0
PeptideAtlasⁱ	Q9Z0E0
PRIDEⁱ	Q9Z0E0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000030637; ENSMUSP00000030637; ENSMUSG00000028833 [Q9Z0E0-1] ENSMUST00000106116; ENSMUSP00000101722; ENSMUSG00000028833 [Q9Z0E0-1]
GeneIDⁱ	26562
KEGGⁱ	mmu:26562
UCSCⁱ	uc008utt.2 mouse [Q9Z0E0-1]

Organism-specific databases

CTDⁱ	23154
MGIⁱ	MGI:1347351 Ncdn
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2611 Eukaryota ENOG410XRYT LUCA
GeneTreeⁱ	ENSGT00390000013601
HOGENOMⁱ	HOG000113742
HOVERGENⁱ	HBG097452
InParanoidⁱ	Q9Z0E0
OMAⁱ	YIQATIR
OrthoDBⁱ	EOG091G04JK
PhylomeDBⁱ	Q9Z0E0
TreeFamⁱ	TF323752

Miscellaneous databases

ChiTaRSⁱ	Ncdn mouse
Protein Ontology More...PROⁱ	PR:Q9Z0E0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028833 Expressed in 271 organ(s), highest expression level in CA1 field of hippocampus
CleanExⁱ	MM_NCDN
Genevisibleⁱ	Q9Z0E0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR008709 Neurochondrin
PANTHERⁱ	PTHR13109 PTHR13109, 1 hit
Pfamⁱ	View protein in Pfam PF05536 Neurochondrin, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NCDN_MOUSE
Accessionⁱ	Q9Z0E0Primary (citable) accession number: Q9Z0E0 Secondary accession number(s): Q3TCW4 , Q80TW1, Q91YH7, Q9CW81, Q9QUQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	May 1, 1999
	Last modified:	September 12, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z0E0 (NCDN_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Neurochondrin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ