CX3C chemokine receptor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C-C chemokine binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• C-C chemokine receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• C-X3-C chemokine binding Source: ARUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation."
    Haskell C.A., Cleary M.D., Charo I.F.
    J. Biol. Chem. 274:10053-10058(1999) [PubMed] [Europe PMC] [Abstract]
• C-X3-C chemokine receptor activity Source: MGI
• cytokine receptor activity Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival."
    Landsman L., Bar-On L., Zernecke A., Kim K.W., Krauthgamer R., Shagdarsuren E., Lira S.A., Weissman I.L., Weber C., Jung S.
    Blood 113:963-972(2009) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation."
    Haskell C.A., Cleary M.D., Charo I.F.
    J. Biol. Chem. 274:10053-10058(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• autocrine signaling Source: MGI
• calcium-mediated signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell adhesion Source: ARUK-UCLInferred from physical interactionⁱ
  • "Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation."
    Haskell C.A., Cleary M.D., Charo I.F.
    J. Biol. Chem. 274:10053-10058(1999) [PubMed] [Europe PMC] [Abstract]
• cell chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice."
    Mattison H.A., Nie H., Gao H., Zhou H., Hong J.S., Zhang J.
    J. Neuroimmunol. 257:110-115(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to transforming growth factor beta stimulus Source: Ensembl
• central nervous system maturation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior."
    Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G., Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T.
    Nat. Neurosci. 17:400-406(2014) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex cell migration Source: MGIInferred from mutant phenotypeⁱ
  • "Control of microglial neurotoxicity by the fractalkine receptor."
    Cardona A.E., Pioro E.P., Sasse M.E., Kostenko V., Cardona S.M., Dijkstra I.M., Huang D., Kidd G., Dombrowski S., Dutta R., Lee J.C., Cook D.N., Jung S., Lira S.A., Littman D.R., Ransohoff R.M.
    Nat. Neurosci. 9:917-924(2006) [PubMed] [Europe PMC] [Abstract]
• chemotaxis Source: MGI
• cytokine-mediated signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival."
    Landsman L., Bar-On L., Zernecke A., Kim K.W., Krauthgamer R., Shagdarsuren E., Lira S.A., Weissman I.L., Weber C., Jung S.
    Blood 113:963-972(2009) [PubMed] [Europe PMC] [Abstract]
• immune response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• innate immune response Source: ARUK-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice."
    Mattison H.A., Nie H., Gao H., Zhou H., Hong J.S., Zhang J.
    J. Neuroimmunol. 257:110-115(2013) [PubMed] [Europe PMC] [Abstract]
• leukocyte tethering or rolling Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation."
    Haskell C.A., Cleary M.D., Charo I.F.
    J. Biol. Chem. 274:10053-10058(1999) [PubMed] [Europe PMC] [Abstract]
• macrophage chemotaxis Source: MGIInferred from mutant phenotypeⁱ
  • "Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression."
    Lu P., Li L., Kuno K., Wu Y., Baba T., Li Y.Y., Zhang X., Mukaida N.
    J. Immunol. 180:4283-4291(2008) [PubMed] [Europe PMC] [Abstract]
• memory Source: MGI
• microglial cell activation Source: MGI
• microglial cell activation involved in immune response Source: MGIInferred from mutant phenotypeⁱ
  • "Control of microglial neurotoxicity by the fractalkine receptor."
    Cardona A.E., Pioro E.P., Sasse M.E., Kostenko V., Cardona S.M., Dijkstra I.M., Huang D., Kidd G., Dombrowski S., Dutta R., Lee J.C., Cook D.N., Jung S., Lira S.A., Littman D.R., Ransohoff R.M.
    Nat. Neurosci. 9:917-924(2006) [PubMed] [Europe PMC] [Abstract]
• modulation of chemical synaptic transmission Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior."
    Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G., Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T.
    Nat. Neurosci. 17:400-406(2014) [PubMed] [Europe PMC] [Abstract]
• multiple spine synapse organization, single dendrite Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior."
    Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G., Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T.
    Nat. Neurosci. 17:400-406(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of angiogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression."
    Lu P., Li L., Kuno K., Wu Y., Baba T., Li Y.Y., Zhang X., Mukaida N.
    J. Immunol. 180:4283-4291(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic signaling pathway Source: MGI
• negative regulation of cell migration Source: MGI
• negative regulation of chronic inflammatory response to non-antigenic stimulus Source: MGI
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGIInferred from mutant phenotypeⁱ
  • "CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival."
    Landsman L., Bar-On L., Zernecke A., Kim K.W., Krauthgamer R., Shagdarsuren E., Lira S.A., Weissman I.L., Weber C., Jung S.
    Blood 113:963-972(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of hippocampal neuron apoptotic process Source: MGI
• negative regulation of interleukin-1 beta production Source: MGI
• negative regulation of long-term synaptic potentiation Source: MGI
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation."
    Haskell C.A., Cleary M.D., Charo I.F.
    J. Biol. Chem. 274:10053-10058(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: MGI
• positive regulation of cytosolic calcium ion concentration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of I-kappaB phosphorylation Source: MGI
• positive regulation of microglial cell migration Source: Ensembl
• positive regulation of neuroblast proliferation Source: MGI
• positive regulation of neurogenesis Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats."
    Bachstetter A.D., Morganti J.M., Jernberg J., Schlunk A., Mitchell S.H., Brewster K.W., Hudson C.E., Cole M.J., Harrison J.K., Bickford P.C., Gemma C.
    Neurobiol. Aging 32:2030-2044(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: MGI
• positive regulation of protein kinase B signaling Source: MGI
• regulation of nitric oxide biosynthetic process Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice."
    Mattison H.A., Nie H., Gao H., Zhou H., Hong J.S., Zhang J.
    J. Neuroimmunol. 257:110-115(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of tumor necrosis factor biosynthetic process Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice."
    Mattison H.A., Nie H., Gao H., Zhou H., Hong J.S., Zhang J.
    J. Neuroimmunol. 257:110-115(2013) [PubMed] [Europe PMC] [Abstract]
• response to ischemia Source: MGI
• social behavior Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior."
    Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G., Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T.
    Nat. Neurosci. 17:400-406(2014) [PubMed] [Europe PMC] [Abstract]
• synapse maturation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior."
    Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G., Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T.
    Nat. Neurosci. 17:400-406(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• C-C chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• C-X3-C chemokine binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation."
    Haskell C.A., Cleary M.D., Charo I.F.
    J. Biol. Chem. 274:10053-10058(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN 
        60         70         80         90        100
LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN 
       110        120        130        140        150
AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI 
       160        170        180        190        200
SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG 
       210        220        230        240        250
FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI 
       260        270        280        290        300
MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK 
       310        320        330        340        350
FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG 

SLLL                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot