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Protein

Polyprotein p69

Gene
N/A
Organism
Cryphonectria hypovirus 1 (strain Euro7) (CHV-1/Euro7) (Chestnut blight fungus hypovirulence-associated virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Papain-like protease p29 is a cysteine protease that contributes to hypovirulence-associated traits like the reduction in conidiation and laccase activity, but not to virulence attenuation. Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of viral defense that limits the accumulation of viral RNAs. Enhances viral dsRNA accumulation and virus transmission. Also involved in the reduction in orange pigmentation of the host, an effect independent of the intrinsic protease activity (By similarity).By similarity
P40 protein is involved in reduction of conidiation of the host. Not necessary for replication. Also involved in reduction of orange pigmentation of the host (By similarity).By similarity

Miscellaneous

Hypoviruses induce hypovirulence in their fungal host Cryphonectria parasitica. The consequence is attenuation of the related fungal disease, chestnut blight, that causes cankers that enlarge and kill branches and trunks. The virus-like genetic elements consist of cytoplasmically replicating double-stranded RNA.
CHV-1 strain Euro7 is a mild hypovirulent strain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162For papain-like protease p29 activitySequence analysis1
Active sitei215For papain-like protease p29 activitySequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Suppressor of RNA silencing, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprotein p69
Alternative name(s):
ORFA polyprotein
Cleaved into the following 2 chains:
OrganismiCryphonectria hypovirus 1 (strain Euro7) (CHV-1/Euro7) (Chestnut blight fungus hypovirulence-associated virus)
Taxonomic identifieri321609 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesHypoviridaeHypovirus
Virus hostiCryphonectria parasitica (Chestnut blight fungus) (Endothia parasitica) [TaxID: 5116]
Proteomesi
  • UP000008451 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000388791 – 248Papain-like protease p29By similarityAdd BLAST248
ChainiPRO_0000038880249 – 622p40 proteinBy similarityAdd BLAST374

Post-translational modificationi

Papain-like protease p29 is autocatalytically processed.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei248 – 249Cleavage; by papain-like protease p29By similarity2

Proteomic databases

PRIDEiQ9YTU3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 243Peptidase C7Sequence analysisAdd BLAST243

Phylogenomic databases

OrthoDBiVOG090002CP

Family and domain databases

InterProiView protein in InterPro
IPR002704 Peptidase_C7_dom
PfamiView protein in Pfam
PF01830 Peptidase_C7, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YTU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCLRKPSQS LVLSESVDPT TVDPFVDVRA EEVVPTGCMT LWEYRDSCGD
60 70 80 90 100
VPGPLSHGDL RRLRTPDGVC KCQIHFEFPT VLKSGSTGTV PEHPAVVAAF
110 120 130 140 150
MGRPRRCSLE QRTKELDFRF LQLVHEGLPV RPSYMIARPP RPVRGLCSSR
160 170 180 190 200
DGSLAQFGQG YCYLSAIVDS ARWRVARTTG WCVRVADYLR LLQWVGRRSF
210 220 230 240 250
GSFQIEESTV EHVYHVIVDT EHQSEQDGAL FYQAVSDLAA RDPLARIGNQ
260 270 280 290 300
LNPLAAEFCP RSARRVEPVT PQVTRRKGLA RMPGRSPTVV SVGNVGMAIT
310 320 330 340 350
SIQDALVATE LRNVNFGRRD TEAECRRLWA RYEVNDYFRR HKAELLKFDA
360 370 380 390 400
RLRSHMAKKP VSVRTRSSDA KIQCIGWRDR HLLPQRLAGL TKQKRSLIWS
410 420 430 440 450
RFATSNIRRK ASACTMTPSV DPMVHTWGDS AALAAKKISE ARRRQEICAA
460 470 480 490 500
AYAERAKARG QTNVVASISE AIETTLRRNG TRFALDGLHV AASVIVTTRL
510 520 530 540 550
RSWNQEEVLA GREFRKSTTS WIWRHMPSSI QDALNLTSVR DKLDPGRAFG
560 570 580 590 600
YVQAAVAQGM SDFRRAKRSL AIVAKPVIRN VRDPYDHGFV KRDGKLRHSR
610 620
DVSNKKLRTK AVAATKVHKI IF
Length:622
Mass (Da):69,993
Last modified:May 1, 1999 - v1
Checksum:i56500B4E5F6EB1DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082191 Genomic RNA Translation: AAD13749.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082191 Genomic RNA Translation: AAD13749.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9YTU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090002CP

Family and domain databases

InterProiView protein in InterPro
IPR002704 Peptidase_C7_dom
PfamiView protein in Pfam
PF01830 Peptidase_C7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOLA_CHPVU
AccessioniPrimary (citable) accession number: Q9YTU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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