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Entry version 131 (31 Jul 2019)
Sequence version 1 (01 May 1999)
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Protein
Submitted name:

Tight junction protein

Gene

ZO-2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tight junction proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZO-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9YHV2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 97PDZInterPro annotationAdd BLAST88
Domaini274 – 352PDZInterPro annotationAdd BLAST79
Domaini478 – 559PDZInterPro annotationAdd BLAST82
Domaini573 – 638SH3InterPro annotationAdd BLAST66
Domaini743 – 845Guanylate kinase-likeInterPro annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni128 – 271DisorderedSequence analysisAdd BLAST144
Regioni378 – 429DisorderedSequence analysisAdd BLAST52
Regioni891 – 1053DisorderedSequence analysisAdd BLAST163
Regioni1091 – 1163DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi135 – 157PolarSequence analysisAdd BLAST23
Compositional biasi158 – 216PolyampholyteSequence analysisAdd BLAST59
Compositional biasi232 – 263PolyampholyteSequence analysisAdd BLAST32
Compositional biasi378 – 412PolyampholyteSequence analysisAdd BLAST35
Compositional biasi921 – 950PolyampholyteSequence analysisAdd BLAST30
Compositional biasi966 – 980PolyampholyteSequence analysisAdd BLAST15
Compositional biasi985 – 1002PolarSequence analysisAdd BLAST18
Compositional biasi1127 – 1163PolyampholyteSequence analysisAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.SAAS annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3580 Eukaryota
ENOG410XQP3 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230923

KEGG Orthology (KO)

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KOi
K06098

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9YHV2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12027 SH3_ZO-2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005419 ZO-2
IPR035598 ZO-2_SH3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01597 ZONOCCLUDNS
PR01599 ZONOCCLUDNS2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9YHV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG
60 70 80 90 100
PADGLLQEND RVVIVNGTPM ENVPHSFAVQ QLRKSGKVAT IVVKRPRKVQ
110 120 130 140 150
AAALRKNPSL DYEDRALEVM DDHAEFDGKS ARSGYSERSW RSGNGGRSQS
160 170 180 190 200
WGNSLDQSYR DDQDREHNRS RGRSRGCSYS RDQSRGRSID RSLDQDYGRD
210 220 230 240 250
RSRGRSVDRD GGYGQDYRRD YSPASYRHGS QPDPRYVREV RSLSRDRLHS
260 270 280 290 300
RSPSPETRHQ HEYLGPQDQN GPISVLLTKG KHNEEYGLRL GSQIFIKEMT
310 320 330 340 350
STGLATKDGN LHEGDIILKI NGTVTENMSL ADARKLIEKS RGKLQLVVLR
360 370 380 390 400
DRKQTLLNIP SLNDSDSEMD DISEIESNRS FSPQDDRLHH SDLDLHSSNE
410 420 430 440 450
KLKEKTNAKD DPSNRMSRMG AMPTPFKSTG DIATTAVTVV DANKEPKYQD
460 470 480 490 500
DVAVPQPKAV TRTILKPSPE DEAIYGPNTK MVRFKKGDSV GLRLAGGNDV
510 520 530 540 550
GIFIAGIQEG TSADQEGLQE GDQILKVNAQ DFRGIVREDA VLYLLEIPKG
560 570 580 590 600
DTVTILAQSK YEVYRDIMAC GRGDSFFIRS HFECEKESPQ SLAFTRGEIF
610 620 630 640 650
RVVDTLYDGK LGNWLAVRIG NELEKGLIPN RSRAEQMASV QNAQKDGPSD
660 670 680 690 700
RADFWRTRGQ RSGVKKNLRK SREDLTAIVS VGTKFPAYER VQLREAGFKR
710 720 730 740 750
PVVIFGPIAD VAMEKLSTDL PHLYQTAKTE PRDAGSEKAT GVVRLNTVRQ
760 770 780 790 800
IIEQDKHALL DVTPKAVDLL NYTQWFPIVV FFNPDSKQGV KTMRQRLCST
810 820 830 840 850
SNKSSRKLYE QANKLKKTCS HLFTATINLN SANDSWYGSL KDTIQQQQGE
860 870 880 890 900
AVWVSEGKVD GMEDDADDRM SYLTAMGADY LSCDSRLISD LEDTDGEGGA
910 920 930 940 950
YTDNELDEPL DEPRISSVGR SSEPVHHEEN IKKFSLEQRT PLRKAGSREI
960 970 980 990 1000
LREPSPPPAF KPEPPKGKLQ NKEDLYDFPK NYDSKPSSIH VSSETSTVSA
1010 1020 1030 1040 1050
KAAPPPVSVK PTFGRPILRN TQPAVPSAEE EEEGKLEEEG SEQENTPKSV
1060 1070 1080 1090 1100
LRKVKIFEEM DHKARLQRMQ ELQEAQNARI EIAQKHPDIY AVPVKTQKSD
1110 1120 1130 1140 1150
QNWPQPISCR PPEPQKPPTR PYLEDRGSCG SDGEEEEEYR RQLSDHSKKG
1160
YYGQPPRYRD TEL
Length:1,163
Mass (Da):130,669
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3639431A560B1D4E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF085184 mRNA Translation: AAC95469.1

Protein sequence database of the Protein Information Resource

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PIRi
JE0366

NCBI Reference Sequences

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RefSeqi
NP_990249.1, NM_204918.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395751

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395751

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085184 mRNA Translation: AAC95469.1
PIRiJE0366
RefSeqiNP_990249.1, NM_204918.1

3D structure databases

SMRiQ9YHV2
ModBaseiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395751
KEGGigga:395751

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9414

Phylogenomic databases

eggNOGiKOG3580 Eukaryota
ENOG410XQP3 LUCA
HOGENOMiHOG000230923
KOiK06098
PhylomeDBiQ9YHV2

Family and domain databases

CDDicd12027 SH3_ZO-2, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005419 ZO-2
IPR035598 ZO-2_SH3
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01597 ZONOCCLUDNS
PR01599 ZONOCCLUDNS2
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9YHV2_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9YHV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 31, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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