UniProtKB - Q9YHU0 (CTBP1_XENLA)
Protein
C-terminal-binding protein 1
Gene
ctbp1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Corepressor targeting diverse transcription regulators. Has dehydrogenase activity.
Cofactori
NAD+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 100 | NADBy similarity | 1 | |
Binding sitei | 204 | NADBy similarity | 1 | |
Active sitei | 266 | By similarity | 1 | |
Binding sitei | 290 | NADBy similarity | 1 | |
Active sitei | 295 | By similarity | 1 | |
Active sitei | 315 | Proton donorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 180 – 185 | NADBy similarity | 6 | |
Nucleotide bindingi | 237 – 243 | NADBy similarity | 7 | |
Nucleotide bindingi | 264 – 266 | NADBy similarity | 3 | |
Nucleotide bindingi | 315 – 318 | NADBy similarity | 4 |
GO - Molecular functioni
- NAD binding Source: InterPro
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | Recommended name: C-terminal-binding protein 1 (EC:1.1.1.-)Short name: CtBP1 Alternative name(s): C-terminal-binding protein A |
Gene namesi | Name:ctbp1 Synonyms:ctbp-a |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-864974 ctbp1 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076046 | 1 – 440 | C-terminal-binding protein 1Add BLAST | 440 |
Proteomic databases
PRIDEi | Q9YHU0 |
Structurei
3D structure databases
ProteinModelPortali | Q9YHU0 |
SMRi | Q9YHU0 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.Curated
Phylogenomic databases
HOVERGENi | HBG001898 |
KOi | K04496 |
OrthoDBi | 700058at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9YHU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSSHLLNKG LPLGIRPPIM NGPMHPRPLV ALLDGRDCTV EMPILKDVAT
60 70 80 90 100
VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS
110 120 130 140 150
GFDNIDIKSA GDLGIAVCNV PAASVEETAD STMCHILNLY RRTTWLHQAL
160 170 180 190 200
REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKTFGFNV
210 220 230 240 250
FFYDPYLSDG IERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF
260 270 280 290 300
TIKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFT
310 320 330 340 350
QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC
360 370 380 390 400
VNKDHLTAAT HWASMDPGVV HPELNGGAYR YPQGVVSVAP AGLPAAVEGI
410 420 430 440
VPSAMSLSHA HPAVAHPPHA PSPGQTIKPE ADRDHPSDQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091554 mRNA Translation: AAD14596.1 |
RefSeqi | NP_001079151.1, NM_001085682.1 XP_018110260.1, XM_018254771.1 |
UniGenei | Xl.447 |
Genome annotation databases
GeneIDi | 373701 |
KEGGi | xla:373701 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091554 mRNA Translation: AAD14596.1 |
RefSeqi | NP_001079151.1, NM_001085682.1 XP_018110260.1, XM_018254771.1 |
UniGenei | Xl.447 |
3D structure databases
ProteinModelPortali | Q9YHU0 |
SMRi | Q9YHU0 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | Q9YHU0 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
GeneIDi | 373701 |
KEGGi | xla:373701 |
Organism-specific databases
CTDi | 373701 |
Xenbasei | XB-GENE-864974 ctbp1 |
Phylogenomic databases
HOVERGENi | HBG001898 |
KOi | K04496 |
OrthoDBi | 700058at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CTBP1_XENLA | |
Accessioni | Q9YHU0Primary (citable) accession number: Q9YHU0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | January 16, 2019 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |